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Research Paper

Tumor antigen specific iTreg accumulate in the tumor microenvironment and suppress therapeutic vaccination

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Pages 642-648 | Published online: 24 Aug 2012

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Jasmin Quandt, Christoph Schlude, Michael Bartoschek, Rainer Will, Angel Cid-Arregui, Sebastian Schölch, Christoph Reissfelder, Jürgen Weitz, Martin Schneider, Stefan Wiemann, Frank Momburg & Philipp Beckhove. (2018) Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses. OncoImmunology 7:12.
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Qingsheng Li & Nejat K. Egilmez. (2016) Ontogeny of Tumor-associated CD4+CD25+Foxp3+ T-regulatory Cells. Immunological Investigations 45:8, pages 729-745.
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Erika Vacchelli, Ilio Vitale, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fučíková, Isabelle Cremer, Jérôme Galon, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2013) Trial watch. OncoImmunology 2:10.
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Erika Vacchelli, Alexander Eggermont, Catherine Sautès-Fridman, Jerome Galon, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2013) Trial Watch. OncoImmunology 2:8.
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Laurence Zitvogel, Corinne Tanchot, Clemence Granier & Eric Tartour. (2013) Following up tumor-specific regulatory T cells in cancer patients. OncoImmunology 2:7.
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Hans-Henning Schmidt, Yingzi Ge, Felix J Hartmann, Heinke Conrad, Felix Klug, Sina Nittel, Helga Bernhard, Christoph Domschke, Florian Schuetz, Christof Sohn & Philipp Beckhove. (2013) HLA Class II tetramers reveal tissue-specific regulatory T cells that suppress T-cell responses in breast carcinoma patients. OncoImmunology 2:6.
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Le Li, Zezhong Xiong, Zhiquan Hu, Xing Zeng & Zhihua Wang. (2022) Metabolic reprogramming drives homeostasis and specialization of regulatory T cells in cancer. Oncology and Translational Medicine, pages 18-27.
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Varun Sasidharan Nair, Reem Saleh, Salman M. Toor, Farhan S. Cyprian & Eyad Elkord. (2021) Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment. Cancer Immunology, Immunotherapy 70:8, pages 2103-2121.
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E.Y. Yang, J.P. Kronenfeld, K.M. Gattás-Asfura, A.L. Bayer & C.L. Stabler. (2015) Engineering an “infectious” Treg biomimetic through chemoselective tethering of TGF-β1 to PEG brush surfaces. Biomaterials 67, pages 20-31.
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Qingsheng Li, Lauren P. Virtuoso, Charles D. Anderson & Nejat K. Egilmez. (2015) Regulatory Rebound in IL-12–Treated Tumors Is Driven by Uncommitted Peripheral Regulatory T Cells. The Journal of Immunology 195:3, pages 1293-1300.
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Rahul Roychoudhuri, Robert L Eil & Nicholas P Restifo. (2015) The interplay of effector and regulatory T cells in cancer. Current Opinion in Immunology 33, pages 101-111.
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P J Schuler, Z Saze, C-S Hong, L Muller, D G Gillespie, D Cheng, M Harasymczuk, M Mandapathil, S Lang, E K Jackson & T L Whiteside. (2014) Human CD4+CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells. Clinical and Experimental Immunology 177:2, pages 531-543.
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Taylor H. Schreiber & Eckhard R. Podack. (2013) Immunobiology of TNFSF15 and TNFRSF25. Immunologic Research 57:1-3, pages 3-11.
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Rachel Perret, Sophie R. Sierro, Natalia K. Botelho, Stéphanie Corgnac, Alena Donda & Pedro Romero. (2013) Adjuvants That Improve the Ratio of Antigen-Specific Effector to Regulatory T Cells Enhance Tumor Immunity. Cancer Research 73:22, pages 6597-6608.
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C. Tanchot, M. Terme, H. Pere, T. Tran, N. Benhamouda, M. Strioga, C. Banissi, L. Galluzzi, G. Kroemer & E. Tartour. (2012) Tumor-Infiltrating Regulatory T Cells: Phenotype, Role, Mechanism of Expansion In Situ and Clinical Significance. Cancer Microenvironment 6:2, pages 147-157.
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Lisanne Heim, Mircea T. Chiriac, Katerina Kachler, Sarah Mitsch, Zuqin Yang, Julia Koelle, Rakshin Kharwadkar, Carol-Immanuel Geppert, Patrick Tausche, Katja Hohenberger, Anna Graser, Juliane Friedrich, Ralf J. Rieker, Denis I. Trufa, Horia Sirbu, Markus F. Neurath, Mark H. Kaplan & Susetta Finotto. (2021) IL-9 Producing Tumor-Infiltrating Lymphocytes (Til) and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer. SSRN Electronic Journal.
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