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Review

The GPI-anchoring of PrP

Implications in sorting and pathogenesis

, &
Pages 11-18 | Received 06 Dec 2013, Accepted 16 Jan 2014, Published online: 07 Feb 2014

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Santra Brenna, Hermann C. Altmeppen, Behnam Mohammadi, Björn Rissiek, Florence Schlink, Peter Ludewig, Christoph Krisp, Hartmut Schlüter, Antonio Virgilio Failla, Carola Schneider, Markus Glatzel, Berta Puig & Tim Magnus. (2020) Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake. Journal of Extracellular Vesicles 9:1.
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Berta Puig, Hermann C. Altmeppen & Markus Glatzel. (2016) Misfolding leads the way to unraveling signaling pathways in the pathophysiology of prion diseases. Prion 10:6, pages 434-443.
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Markus Glatzel, Luise Linsenmeier, Frank Dohler, Susanne Krasemann, Berta Puig & Hermann C Altmeppen. (2015) Shedding light on prion disease. Prion 9:4, pages 244-256.
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Duri Lee, Sohee Lee, Yejin Shin, Youngsup Song & Sang-Wook Kang. (2019) Thiol‐disulfide status regulates quality control of prion protein at the plasma membrane. The FASEB Journal 33:10, pages 11567-11578.
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C. Araman & B.A. 't Hart. (2019) Neurodegeneration meets immunology – A chemical biology perspective. Bioorganic & Medicinal Chemistry 27:9, pages 1911-1924.
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Berta Puig, Hermann C. Altmeppen, Luise Linsenmeier, Karima Chakroun, Florian Wegwitz, Ulrike K. Piontek, Jörg Tatzelt, Clive Bate, Tim Magnus & Markus Glatzel. (2019) GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice. PLOS Pathogens 15:1, pages e1007520.
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Roger J. Morris. (2018) Thy-1, a Pathfinder Protein for the Post-genomic Era. Frontiers in Cell and Developmental Biology 6.
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Daniela Sarnataro. (2018) Attempt to Untangle the Prion-Like Misfolding Mechanism for Neurodegenerative Diseases. International Journal of Molecular Sciences 19:10, pages 3081.
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Erica Corda, Xiaotang Du, Su Yeon Shim, Antonia N. Klein, Jessica Siltberg-Liberles & Sabine Gilch. (2018) Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes α-Cleavage of PrPC. Molecular Neurobiology 55:10, pages 7758-7774.
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Frank F. Heisler, Yvonne Pechmann, Ines Wieser, Hermann C. Altmeppen, Leonhard Veenendaal, Mary Muhia, Michaela Schweizer, Markus Glatzel, Susanne Krasemann & Matthias Kneussel. (2018) Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression. Neuron 99:6, pages 1155-1169.e9.
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Sabareesan Ambadi Thody, M.K. Mathew & Jayant B. Udgaonkar. (2018) Mechanism of aggregation and membrane interactions of mammalian prion protein. Biochimica et Biophysica Acta (BBA) - Biomembranes 1860:9, pages 1927-1935.
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Robert Hnasko, Alice Lin, Jeffery McGarvey & Larry Stanker. (2018) Enhanced detection of infectious prions by direct ELISA from the brains of asymptomatic animals using DRM2-118 monoclonal antibody and Gdn-HCl. Journal of Immunological Methods 456, pages 38-43.
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Arjun Ray, Nidhi Jatana & Lipi Thukral. (2017) Lipidated proteins: Spotlight on protein-membrane binding interfaces. Progress in Biophysics and Molecular Biology 128, pages 74-84.
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Rafael Linden. (2017) The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling Modules. Frontiers in Molecular Neuroscience 10.
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Valerija Kovač, Blaž Zupančič, Gregor Ilc, Janez Plavec & Vladka Čurin Šerbec. (2017) Truncated prion protein PrP226* - A structural view on its role in amyloid disease. Biochemical and Biophysical Research Communications 484:1, pages 45-50.
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Can Araman, Robert E. Thompson, Siyao Wang, Stefanie Hackl, Richard J. Payne & Christian F. W. Becker. (2017) Semisynthetic prion protein (PrP) variants carrying glycan mimics at position 181 and 197 do not form fibrils. Chemical Science 8:9, pages 6626-6632.
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Stefanie Hackl, Alanca Schmid & Christian F. W. Becker. 2017. Split Inteins. Split Inteins 93 109 .
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Elizaveta Katorcha, Saurabh Srivastava, Nina Klimova & Ilia V. Baskakov. (2016) Sialylation of Glycosylphosphatidylinositol (GPI) Anchors of Mammalian Prions Is Regulated in a Host-, Tissue-, and Cell-specific Manner. Journal of Biological Chemistry 291:33, pages 17009-17019.
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Natalia Sikorska, Leticia Lemus, Auxiliadora Aguilera-Romero, Javier Manzano-Lopez, Howard Riezman, Manuel Muñiz & Veit Goder. (2016) Limited ER quality control for GPI-anchored proteins. Journal of Cell Biology 213:6, pages 693-704.
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Edward W Tate, Karunakaran A Kalesh, Thomas Lanyon-Hogg, Elisabeth M Storck & Emmanuelle Thinon. (2015) Global profiling of protein lipidation using chemical proteomic technologies. Current Opinion in Chemical Biology 24, pages 48-57.
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Sean R. Stowell, Tongzhong JuRichard D. Cummings. (2015) Protein Glycosylation in Cancer. Annual Review of Pathology: Mechanisms of Disease 10:1, pages 473-510.
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Théo Z. Hirsch, Julia Hernandez-Rapp, Séverine Martin-Lannerée, Jean-Marie Launay & Sophie Mouillet-Richard. (2014) PrPC signalling in neurons: From basics to clinical challenges. Biochimie 104, pages 2-11.
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