2,448
Views
35
CrossRef citations to date
0
Altmetric
Review

The Rac1 hypervariable region in targeting and signaling

A tail of many stories

&
Pages 78-89 | Received 05 Oct 2012, Accepted 17 Dec 2012, Published online: 25 Jan 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Manon C. A. Pronk, Jan S. M. van Bezu, Geerten P. van Nieuw Amerongen, Victor W. M. van Hinsbergh & Peter L. Hordijk. (2019) RhoA, RhoB and RhoC differentially regulate endothelial barrier function. Small GTPases 10:6, pages 466-484.
Read now
Kelsey N. Maxwell, Yong Zhou & John F. Hancock. (2018) Rac1 Nanoscale Organization on the Plasma Membrane Is Driven by Lipid Binding Specificity Encoded in the Membrane Anchor. Molecular and Cellular Biology 38:18.
Read now
Konstadinos Moissoglu & Martin Alexander Schwartz. (2014) Spatial and temporal control of Rho GTPase functions. Cellular Logistics 4:2.
Read now

Articles from other publishers (31)

Hana Valenta, Sophie Dupré-Crochet, Mouna Abdesselem, Tania Bizouarn, Laura Baciou, Oliver Nüsse, Ariane Deniset-Besseau & Marie Erard. (2022) Consequences of the constitutive NOX2 activity in living cells: Cytosol acidification, apoptosis, and localized lipid peroxidation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1869:9, pages 119276.
Crossref
Linnet Bischof, Franziska Schweitzer, Carolin C. Sterk & Jürgen J. Heinisch. (2022) The Intracellular Distribution of the Small GTPase Rho5 and Its Dimeric Guanidine Nucleotide Exchange Factor Dck1/Lmo1 Determine Their Function in Oxidative Stress Response. International Journal of Molecular Sciences 23:14, pages 7896.
Crossref
Vincent Sauzeau, Julien Beignet & Christian Bailly. (2022) Rac1 as a Target to Treat Dysfunctions and Cancer of the Bladder. Biomedicines 10:6, pages 1357.
Crossref
Niloufar Mosaddeghzadeh, Neda S. Kazemein Jasemi, Jisca Majolée, Si-Cai Zhang, Peter L. Hordijk, Radovan Dvorsky & Mohammad Reza Ahmadian. (2021) Electrostatic Forces Mediate the Specificity of RHO GTPase-GDI Interactions. International Journal of Molecular Sciences 22:22, pages 12493.
Crossref
Marius Musielak, Carolin C. Sterk, Felix Schubert, Christian Meyer, Achim Paululat & Jürgen J. Heinisch. (2021) The small GTPase KlRho5 responds to oxidative stress and affects cytokinesis. Journal of Cell Science 134:18.
Crossref
Iman F. Fergani & Luciana R. Frick. (2021) Wrestling and Wrapping: A Perspective on SUMO Proteins in Schwann Cells. Biomolecules 11:7, pages 1055.
Crossref
Natasha P. Murphy, Ana Masara binti Ahmad Mokhtar, Helen R. Mott & Darerca Owen. (2021) Molecular subversion of Cdc42 signalling in cancer. Biochemical Society Transactions 49:3, pages 1425-1442.
Crossref
Nurit Haspel, Hyunbum Jang & Ruth Nussinov. (2021) Active and Inactive Cdc42 Differ in Their Insert Region Conformational Dynamics. Biophysical Journal 120:2, pages 306-318.
Crossref
Jasmine CornishSamuel G. ChamberlainDarerca Owen & Helen R. Mott. (2020) Intrinsically disordered proteins and membranes: a marriage of convenience for cell signalling?. Biochemical Society Transactions 48:6, pages 2669-2689.
Crossref
Megan E. Arrington, Brenda Temple, Antje Schaefer & Sharon L. Campbell. (2020) The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2. Journal of Biological Chemistry 295:34, pages 12130-12142.
Crossref
Kristin M. Kohler, Miriam Kutsch, Anthony S. Piro, Graham D. Wallace, Jörn Coers & Matthew F. Barber. (2020) A Rapidly Evolving Polybasic Motif Modulates Bacterial Detection by Guanylate Binding Proteins. mBio 11:3.
Crossref
Joseph P. Albanesi, Barbara Barylko, George N. DeMartino & David M. Jameson. (2020) Palmitoylated Proteins in Dendritic Spine Remodeling. Frontiers in Synaptic Neuroscience 12.
Crossref
Makoto Endo, Joseph E. Druso & Richard A. Cerione. (2020) The two splice variant forms of Cdc42 exert distinct and essential functions in neurogenesis. Journal of Biological Chemistry 295:14, pages 4498-4512.
Crossref
Monilola A. Olayioye, Bettina Noll & Angelika Hausser. (2019) Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases. Cells 8:12, pages 1478.
Crossref
Carolin Sterk, Lauren Gräber, Hans-Peter Schmitz & Jürgen J. Heinisch. (2019) Analysis of Functional Domains in Rho5, the Yeast Homolog of Human Rac1 GTPase, in Oxidative Stress Response. International Journal of Molecular Sciences 20:22, pages 5550.
Crossref
Vania Braga. (2018) Signaling by Small GTPases at Cell–Cell Junctions: Protein Interactions Building Control and Networks. Cold Spring Harbor Perspectives in Biology 10:10, pages a028746.
Crossref
E. Sila Ozdemir, Hyunbum Jang, Attila Gursoy, Ozlem Keskin, Zhigang Li, David B. Sacks & Ruth Nussinov. (2018) Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2. Journal of Biological Chemistry 293:10, pages 3685-3699.
Crossref
Kelsey N. Maxwell, Yong Zhou & John F. Hancock. (2018) Clustering of Rac1: Selective Lipid Sorting Drives Signaling. Trends in Biochemical Sciences 43:2, pages 75-77.
Crossref
Alejandro Acevedo & Christian González-Billault. (2018) Crosstalk between Rac1-mediated actin regulation and ROS production. Free Radical Biology and Medicine 116, pages 101-113.
Crossref
Amanda S. Peretti, Dayna Dominguez, Martha M. Grimes, Helen J. Hathaway, Eric R. Prossnitz, Melanie R. Rivera, Angela Wandinger-Ness, Donna F. Kusewitt & Laurie G. Hudson. (2018) The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice. The American Journal of Pathology 188:2, pages 515-524.
Crossref
Chao Huang, Xingruo Zeng, Guosong Jiang, Xin Liao, Claire Liu, Jingxia Li, Honglei Jin, Junlan Zhu, Hong Sun, Xue-Ru Wu & Chuanshu Huang. (2017) XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. Journal of Hematology & Oncology 10:1.
Crossref
Yan Zhou, Chunfeng Huang, Li YinMuyang Wan, Xiaofei Wang, Lin LiYanhua LiuZhao Wang, Panhan FuNi ZhangShe ChenXiaoyun Liu, Feng ShaoYongqun Zhu. (2017) N ε -Fatty acylation of Rho GTPases by a MARTX toxin effector . Science 358:6362, pages 528-531.
Crossref
Li-Qiang Zheng, Su-Min Chi & Cheng-Xin Li. (2017) Rab23’s genetic structure, function and related diseases: a review. Bioscience Reports 37:2.
Crossref
Kazem Nouri, Eyad K. Fansa, Ehsan Amin, Radovan Dvorsky, Lothar Gremer, Dieter Willbold, Lutz Schmitt, David J. Timson & Mohammad R. Ahmadian. (2016) IQGAP1 Interaction with RHO Family Proteins Revisited. Journal of Biological Chemistry 291:51, pages 26364-26376.
Crossref
Minghao Wang, Qianze Dong & Yunjie Wang. (2016) Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1. Tumor Biology 37:8, pages 11049-11055.
Crossref
Nathalie R. Reinhard, Suzanne F. van Helden, Eloise C. Anthony, Taofei Yin, Yi I. Wu, Joachim Goedhart, Theodorus W. J. Gadella & Peter L. Hordijk. (2016) Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells. Scientific Reports 6:1.
Crossref
Emmanuel Lemichez. 2017. The Actin Cytoskeleton and Bacterial Infection. The Actin Cytoskeleton and Bacterial Infection 155 174 .
Kazem Nouri, Jens M. Moll, Lech-Gustav Milroy, Anika Hain, Radovan Dvorsky, Ehsan Amin, Michael Lenders, Luitgard Nagel-Steger, Sebastian Howe, Sander H. J. Smits, Hartmut Hengel, Lutz Schmitt, Carsten Münk, Luc Brunsveld & Mohammad R. Ahmadian. (2015) Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11. PLOS ONE 10:12, pages e0143634.
Crossref
Sulagna Das, Taofei Yin, Qingfen Yang, Jingqiao Zhang, Yi I. Wu & Ji Yu. (2015) Single-molecule tracking of small GTPase Rac1 uncovers spatial regulation of membrane translocation and mechanism for polarized signaling. Proceedings of the National Academy of Sciences 112:3.
Crossref
Si-Cai Zhang, Lothar Gremer, Henrike Heise, Petra Janning, Aliaksei Shymanets, Ion C. Cirstea, Eberhard Krause, Bernd Nürnberg & Mohammad Reza Ahmadian. (2014) Liposome Reconstitution and Modulation of Recombinant Prenylated Human Rac1 by GEFs, GDI1 and Pak1. PLoS ONE 9:7, pages e102425.
Crossref
Younes Zoughlami, Anne M. van Stalborgh, Paula B. van Hennik & Peter L. Hordijk. (2013) Nucleophosmin1 Is a Negative Regulator of the Small GTPase Rac1. PLoS ONE 8:7, pages e68477.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.