1,518
Views
42
CrossRef citations to date
0
Altmetric
Point of View

Phosphorylation of RNAPII

To P-TEFb or not to P-TEFb?

&
Pages 115-119 | Received 31 Dec 2010, Accepted 31 Jan 2011, Published online: 01 May 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Matthew D. Galbraith, Heather Bender & Joaquín M. Espinosa. (2019) Therapeutic targeting of transcriptional cyclin-dependent kinases. Transcription 10:2, pages 118-136.
Read now
Jing-Ping Hsin, Kehui Xiang & James L. Manley. (2014) Function and Control of RNA Polymerase II C-Terminal Domain Phosphorylation in Vertebrate Transcription and RNA Processing. Molecular and Cellular Biology 34:13, pages 2488-2498.
Read now
Elizabeth A Bowman & William G Kelly. (2014) RNA Polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation. Nucleus 5:3, pages 224-236.
Read now
Pierre Chymkowitch & Jorrit M. Enserink. (2013) The cell cycle rallies the transcription cycle. Transcription 4:1, pages 3-6.
Read now

Articles from other publishers (37)

Zheng Qin, Dongze Liu, Yueyao Zhang, Xiaoxu Chen, Xiao Zhu, Shengxian Xu, Baolong Peng, Shiqiang Dong, Dingkun Hou, Liang Zhu & Haitao Wang. (2023) Inhibitory function of CDK12i combined with WEE1i on castration-resistant prostate cancer cells in vitro and in vivo . Oncologie 25:6, pages 717-728.
Crossref
Onofrio Zanin, Matthew Eastham, Kinga Winczura, Mark Ashe, Rocio T. Martinez-Nunez, Daniel Hebenstreit & Pawel Grzechnik. (2023) Ceg1 depletion reveals mechanisms governing degradation of non-capped RNAs in Saccharomyces cerevisiae. Communications Biology 6:1.
Crossref
Corina Pascal, Jonathan Zonszain, Ofir Hameiri, Chen Gargi-Levi, Galit Lev-Maor, Luna Tammer, Tamar Levy, Anan Tarabeih, Vanessa Rachel Roy, Stav Ben-Salmon, Liraz Elbaz, Mireille Eid, Tamar Hakim, Salima Abu Rabe'a, Nana Shalev, Albert Jordan, Eran Meshorer & Gil Ast. (2023) Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation. Molecular Cell 83:21, pages 3801-3817.e8.
Crossref
Keerthihan Thiyagarajah, Michael Basic & Eberhard Hildt. (2023) Cellular Factors Involved in the Hepatitis D Virus Life Cycle. Viruses 15:8, pages 1687.
Crossref
Pan Zhang, Yongchuang Li, Duwei Zheng, Songsong Hua, Chongyang Song, Zhengmin Li, Tingting Shi, Panpan Wang, Binlun Yan, Jitao Li & Huan Gao. (2022) Cloning and function of the cyclin‐dependent kinase 9 gene in ovarian development of the ridgetail white prawn, Exopalaemon carinicauda . Aquaculture Research 53:17, pages 6029-6038.
Crossref
Chieh-Ren Hsia, Jawuanna McAllister, Ovais Hasan, Julius Judd, Seoyeon Lee, Richa Agrawal, Chao-Yuan Chang, Paul Soloway & Jan Lammerding. (2022) Confined migration induces heterochromatin formation and alters chromatin accessibility. iScience 25:9, pages 104978.
Crossref
Esin Orhan, Carolina Velazquez, Imene Tabet, Claude Sardet & Charles Theillet. (2021) Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy?. Cancers 13:12, pages 2930.
Crossref
Vaishnavi Sundar, Sanjana Vimal, M.s. Sai Mithlesh, Anupam Dutta, Ramasamy Tamizhselvi & Venkatraman Manickam. (2021) Transcriptional cyclin-dependent kinases as the mediators of inflammation-a review. Gene 769, pages 145200.
Crossref
C. Cassart, C. Yague-Sanz, F. BauerP. PonsardF. X. StubbeV. MigeotM. Wery, A. Morillon, F. PalladinoV. RobertD. Hermand. (2020) RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans . Science Advances 6:50.
Crossref
Ankita Saha, Christopher H. Seward, Lisa Stubbs & Craig A. Mizzen. (2020) Site-Specific Phosphorylation of Histone H1.4 Is Associated with Transcription Activation. International Journal of Molecular Sciences 21:22, pages 8861.
Crossref
Yi Gong, Geng Yang, Qizhi Wang, Yumeng Wang & Xiaobo Zhang. (2020) NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors. Molecular Cancer Research 18:2, pages 287-299.
Crossref
Victor Quereda, Simon Bayle, Francesca Vena, Sylvia M. Frydman, Andrii Monastyrskyi, William R. Roush & Derek R. Duckett. (2019) Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer. Cancer Cell 36:5, pages 545-558.e7.
Crossref
Seema Irani, Sarah N. Sipe, Wanjie Yang, Nathaniel T. Burkholder, Brian Lin, Kelly Sim, Wendy L. Matthews, Jennifer S. Brodbelt & Yan Zhang. (2019) Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription. Journal of Biological Chemistry 294:21, pages 8592-8605.
Crossref
Hana Paculová & Jiří Kohoutek. (2017) The emerging roles of CDK12 in tumorigenesis. Cell Division 12:1.
Crossref
Zhiyuan Zhao, Ka-Wei Tang, Isabella Muylaert, Tore Samuelsson & Per Elias. (2017) CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes. Journal of Biological Chemistry 292:37, pages 15489-15500.
Crossref
Steven R. Whittaker, Aurélie Mallinger, Paul Workman & Paul A. Clarke. (2017) Inhibitors of cyclin-dependent kinases as cancer therapeutics. Pharmacology & Therapeutics 173, pages 83-105.
Crossref
Célia Jeronimo, Pierre Collin & François Robert. (2016) The RNA Polymerase II CTD: The Increasing Complexity of a Low-Complexity Protein Domain. Journal of Molecular Biology 428:12, pages 2607-2622.
Crossref
Valérie J. Robert, Steve Garvis & Francesca Palladino. (2015) Repression of somatic cell fate in the germline. Cellular and Molecular Life Sciences 72:19, pages 3599-3620.
Crossref
Uri R. Mbonye, Benlian Wang, Giridharan Gokulrangan, Mark R. Chance & Jonathan Karn. (2015) Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression. PROTEOMICS 15:12, pages 2078-2086.
Crossref
S K Mungamuri, S Wang, J J Manfredi, W Gu & S A Aaronson. (2014) Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters. Oncogene 34:19, pages 2461-2470.
Crossref
Bartlomiej Bartkowiak & Arno L. Greenleaf. (2015) Expression, Purification, and Identification of Associated Proteins of the Full-length hCDK12/CyclinK Complex. Journal of Biological Chemistry 290:3, pages 1786-1795.
Crossref
Brian A. Lewis & John A. Hanover. (2014) O-GlcNAc and the Epigenetic Regulation of Gene Expression. Journal of Biological Chemistry 289:50, pages 34440-34448.
Crossref
Giuliana Napolitano, Luigi Lania & Barbara Majello. (2014) RNA Polymerase II CTD Modifications: How Many Tales From a Single Tail. Journal of Cellular Physiology 229:5, pages 538-544.
Crossref
Chunlin Yang & John W. Stiller. (2014) Evolutionary diversity and taxon-specific modifications of the RNA polymerase II C-terminal domain. Proceedings of the National Academy of Sciences 111:16, pages 5920-5925.
Crossref
Christian A. Bösken, Lucas Farnung, Corinna Hintermair, Miriam Merzel Schachter, Karin Vogel-Bachmayr, Dalibor Blazek, Kanchan Anand, Robert P. Fisher, Dirk Eick & Matthias Geyer. (2014) The structure and substrate specificity of human Cdk12/Cyclin K. Nature Communications 5:1.
Crossref
S. Yogesha, Joshua Mayfield & Yan Zhang. (2014) Cross-Talk of Phosphorylation and Prolyl Isomerization of the C-terminal Domain of RNA Polymerase II. Molecules 19:2, pages 1481-1511.
Crossref
Jeffry L. Corden. (2013) RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and Template. Chemical Reviews 113:11, pages 8423-8455.
Crossref
Célia Jeronimo, Alain R. Bataille & François Robert. (2013) The Writers, Readers, and Functions of the RNA Polymerase II C-Terminal Domain Code. Chemical Reviews 113:11, pages 8491-8522.
Crossref
Dirk Eick & Matthias Geyer. (2013) The RNA Polymerase II Carboxy-Terminal Domain (CTD) Code. Chemical Reviews 113:11, pages 8456-8490.
Crossref
Mohsen Hajheidari, Csaba Koncz & Dirk Eick. (2013) Emerging roles for RNA polymerase II CTD in Arabidopsis. Trends in Plant Science 18:11, pages 633-643.
Crossref
Tamara Salem, Tiphanie Gomard, Franck Court, Gabriel Moquet-Torcy, Frédérique Brockly, Thierry Forné & Marc Piechaczyk. (2013) Chromatin loop organization of the junb locus in mouse dendritic cells. Nucleic Acids Research 41:19, pages 8908-8925.
Crossref
Elizabeth Anne BowmanChristopher Ray BowmanJeong H. AhnWilliam G. Kelly. (2013) Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline . Development 140:17, pages 3703-3713.
Crossref
Martin Heidemann, Corinna Hintermair, Kirsten Voß & Dirk Eick. (2013) Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:1, pages 55-62.
Crossref
Qiang ZhouTiandao LiDavid H. Price. (2012) RNA Polymerase II Elongation Control. Annual Review of Biochemistry 81:1, pages 119-143.
Crossref
Sylvain Egloff, Martin Dienstbier & Shona Murphy. (2012) Updating the RNA polymerase CTD code: adding gene-specific layers. Trends in Genetics 28:7, pages 333-341.
Crossref
Julie Drogat & Damien Hermand. (2012) Gene-specific requirement of RNA polymerase II CTD phosphorylation. Molecular Microbiology 84:6, pages 995-1004.
Crossref
Alexander F. Palazzo & Abdalla Akef. (2012) Nuclear export as a key arbiter of “mRNA identity” in eukaryotes. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1819:6, pages 566-577.
Crossref