Milk Derived Antimicrobial Bioactive Peptides: A Review

Figures & data

TABLE 1 Casein-derived AMPs released by digestive protease action, and their main properties^[33,42,^76–81]

Antimicrobial peptides	Source	Enzymatic activity	Activity against pathogens
Casecidins	bovine αs1-casein	Chymosin	Gram positive bacteria
Isracidin f(1-23)	bovine αs1-casein	Chymosin	Gram positive, negative bacteria
Casocidin-I f(150-188)	bovine αs2-casein	Trypsin	Gram positive, negative, yeasts
Casocidin-I f(181-207)	bovine αs2-casein	Chymosin	Gram positive, negative bacteria
Casocidin-I f(175-207)	bovine αs2-casein	Chymosin	Mainly Gram positive bacteria
Casocidin-I f(165-170)	bovine αs2-casein	Pepsin	Mainly Gram positive bacteria
Casocidin-I f(165-181)	bovine αs2-casein	Pepsin	Gram positive and negative bacteria
Kappacin f(106-169)	bovine κ casein	Pepsin	Mainly gram positive bacteria
Kappacin f(42-49)	bovine κ casein	Chymosin	Gram positive and negative bacteria

TABLE 2 Antibacterial peptides derived from whey protein^[51,⁵²,^82–84]

Antimicrobial peptides	Source	Enzymaticactivity	Activity againstpathogens
β-lactoglobulin f(15–20)	β-lactoglobulin	Trypsin	Gram positive
β-lactoglobulin f(25–40)	β-lactoglobulin	Trypsin	Gram positive
Lactoferricin f(17-41)	Lactoferrin	Pepsin	Escherichia coli, Listeria monocytogenes,viruses, and fungi
β-lactoglobulin f(78–83)	β-lactoglobulin	Trypsin	Gram positive
β-lactoglobulin f(92–100)	β-lactoglobulin	Trypsin	Gram positive

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