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Epigenetics Volume 18, 2023 - Issue 1
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Brief report

Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO

Ashley Y. Songa Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;b Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAView further author information
,
Catherine M. Bulkac College of Public Health, University of South Florida, Tampa, FL, USAView further author information
,
Sierra S. Niemiecd Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USAView further author information
,
Katerina Kechrisd Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USAView further author information
,
Kristen E. Boylee Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USAView further author information
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Carmen J. Marsitf Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USAView further author information
,
T. Michael O’Sheag Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USAView further author information
,
Rebecca C. Fryh Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAView further author information
,
Kristen Lyalli A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USAView further author information
,
M. Daniele Fallinj Rollins School of Public Health, Emory University, Atlanta, GA, USView further author information
,
Heather E. Volka Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAView further author information
&
Christine Ladd-Acostaa Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;b Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;k Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7697-3998View further author information
ORCID Icon show all
Article: 2254971 | Received 15 Feb 2023, Accepted 29 Aug 2023, Published online: 10 Sep 2023

Figures & data

Figure 1. Results of random effects meta-analyses of the associations between epigenetic age acceleration at birth estimated by Knight clock and childhood behavior checklist a) total-T score b) pervasive development problems assessed in early childhood. Results of individual studies were from multivariable linear regression models, which adjusted for child sex, maternal education, maternal smoking during pregnancy, and maternal pre-pregnancy BMI status. Point estimates of individual study beta estimates are shown as black squares; area of squares indicates relative weights of individual studies; point and interval overall ratio estimates are horizontal apices of black diamonds.

Figure 1. Results of random effects meta-analyses of the associations between epigenetic age acceleration at birth estimated by Knight clock and childhood behavior checklist a) total-T score b) pervasive development problems assessed in early childhood. Results of individual studies were from multivariable linear regression models, which adjusted for child sex, maternal education, maternal smoking during pregnancy, and maternal pre-pregnancy BMI status. Point estimates of individual study beta estimates are shown as black squares; area of squares indicates relative weights of individual studies; point and interval overall ratio estimates are horizontal apices of black diamonds.
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