Figures & data
Figure 1. Expression of miR-15a in human osteoarthritic chondrocytes and normal tissues. *p < .05.
Figure 2. Overexpression of miR-15a inhibited chondrocyte proliferation. (A) The effect on the expression of miR-15a in chondrocytes cells transfected with miR-15a mimic; (B) the effect on cell proliferation ability in miR-15a-transfected chondrocytes cells. *p < .05.
Figure 3. The effect of over-expression of miR-15a on chondrocyte apoptosis. *p < .05.
Figure 4. MiR-15a targeted SMAD2. (A) complementary sequence; (B) the effect of miR-15a on the fluorescence activity in arthritis chondrocytes; (C) the effect of miR-15a on the expression of SMAD2 protein in arthritis chondrocytes. *p < .05.
Figure 5. Silencing SMAD2 inhibited chondrocyte proliferation and induced apoptosis. (A) effect of silencing SMAD2 on the expression of SMAD2 in chondrocytes; (B) effect of silencing SMAD2 on chondrocyte proliferation; (C) effect of silencing SMAD2 on chondrocyte apoptosis *p < .05.
Figure 6. Overexpression of SMAD2 partially reversed the inhibitory effect of overexpression of miR-15a on chondrocytes. (A) Overexpression of SMAD2 on the expression of SMAD2 in arthritis chondrocytes; (B) Overexpression of SMAD2 on the activity of arthritis chondrocytes; (C) Effect of overexpression of SMAD2 on the apoptosis of arthritis chondrocytes. *p < .05.
