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Research Article

Mechanism of miR-15a regulating the growth and apoptosis of human knee joint chondrocytes by targeting SMAD2

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Pages 3188-3193 | Received 11 Mar 2019, Accepted 22 Apr 2019, Published online: 01 Aug 2019

References

  • Li YP. Osteoarthritis genetic factors animal models mechanisms and therapies. Front Biosci. 2012;E4:74–100.
  • Kim HA, Blanco FJ. Cell death and apoptosis in osteoarthritic cartilage. Curr Drug Targets. 2007;8:333–345.
  • Chan WC, Lin WC. MetaMirClust: discovery and exploration of evolutionarily conserved miRNA Clusters. Methods Mol Biol. 2016;1375:75–89.
  • Vishnoi A, Rani S. MiRNA biogenesis and regulation of diseases: an overview. Methods Mol Biol. 2017;1509:1–10.
  • Seeliger C, Karpinski K, Haug AT, et al. Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures. J Bone Miner Res. 2014;29:1718–1728.
  • Lu X, Lin J, Jin J, et al. hsa-miR-15a exerts protective effects against osteoarthritis by targeting aggrecanase-2 (ADAMTS5) in human chondrocytes. Int J Mol Med. 2016;37:509–516.
  • Lo RS, Massagué J. Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat Cell Biol. 1999; 1:472–478.
  • Tsukazaki T, Chiang TA, Davison AF, et al. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 1998;95:779–791.
  • Zhu Y, Gu J, Zhu T, et al. Crosstalk between Smad2/3 and specific isoforms of ERK in TGF-β1-induced TIMP-3 expression in rat chondrocytes. J Cell Mol Med. 2017;21:1781–1790.
  • Qureshi HY, Ricci G, Zafarullah M. Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes. Biochim Biophys Acta. 2008;1783:1605–1612.
  • Le LT, Swingler TE, Clark IM. Review: the role of microRNAs in osteoarthritis and chondrogenesis. Arthritis Rheum. 2013;65:1963–1974.
  • Sethupathy P, Collins FS. MicroRNA target site polymorphisms and human disease. Trends Genet. 2008;24:489–497.
  • Djuranovic S, Nahvi A, Green R. miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science. 2012;336:237–240.
  • Yu C, Chen WP, Wang XH. MicroRNA in osteoarthritis. J Int Med Res. 2011;39:1–9.
  • Dudek KA, Lafont JE, Martinez-Sanchez A, et al. A. Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes. J Biol Chem. 2010;285:24381–24387.
  • Swingler TE, Wheeler G, Carmont V, et al. The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum. 2012;64:1909–1919.
  • Chen H, Tian Y. MiR-15a-5p regulates viability and matrix degradation of human osteoarthritis chondrocytes via targeting VEGFA. Bst. 2016;10:482–488.
  • Davidson ENB, Remst DFG, Vitters EL, et al. Increase in alk1/alk5 ratio as a cause for elevated mmp-13 expression in osteoarthritis in humans and mice. J Immunol. 2009;182:7937–7945.
  • Caam AV, Davidson EB, Vitters E. AB0119 BMP-9 induces both SMAD1/5/8 and SMAD2/3 phosphorylation, and specific response genes, in chondrocytes. Osteoarthritis Cartilage. 2012;20:S133–S133.
  • Madej W, Caam AV, Davidson ENB, et al. Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling. Osteoarthritis Cartilage. 2014;22:1018–1025.
  • Shi J, Guo K, Su S, et al. miR‑486‑5p is upregulated in osteoarthritis and inhibits chondrocyte proliferation and migration by suppressing SMAD2. Mol Med Rep. 2018;18:502–508.