Advanced colloidal technologies for the enhanced bioavailability of drugs

Figures & data

Figure 1. Scheme of strategies used for enhancing the bioavailability of poorly water-soluble drugs.

Figure 2. Nanoparticle: (A) freeze-dried liposome, (B) dendrimer, (C) SLN.

Figure 3. Schematic of polymeric nanomicelle.

Figure 4. Development of self-emulsifying drug delivery system.

Table 1. Bioavailability enhancement through complexation

S. no.	Drugs	Advantages of complexation	Reference
1	Naproxen	Enhance the solubility, dissolution and bioavailability More stable inclusion complex	Chen et al. (2011)
2	Piroxicam	Safer for CV and GI purposes Low-cost production	Yan et al. (2011)
3	Ketoconazole	Improved solubility and bioavailability Reduced local toxicities Low production cost	Agarwal et al. (2013)
4	Ibuprofen	Increased bioavailability Decreased degradation of drug Improved stability	Kanaujia et al. (2014)
5	Ketoprofen	Enhanced solubility and bioavailability Lower hemolytic activity Reduced nephrotoxicity	Thompson (1997)

Table 2. Categorization of hydrotropes

S. no.	Group	Example
1	Aromatic anionics	Sodium benzoate, sodium salicylate, sodium benzene sulfonate, sodium benzene disulfonate
2	Aromatic cationics	Para amino benzoic acid hydrochloride, procaine hydrochloride
3	Aliphatics and linear anionics	Sodium alkanoate

Chen, Y., Chen, C., Zheng, J., Chen, Z., Shi, Q., & Liu, H. (2011). Development of a solid supersaturatable self-emulsifying drug delivery system of docetaxel with improved dissolution and bioavailability. Biological and Pharmaceutical Bulletin, 34(2), 278. doi:10.1248/bpb.34.278

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Yan, Y. D., Kim, J. A., Kwak, M. K., Yoo, B. K., Yong, C. S., & Choi, H. G. (2011). Enhanced oral bioavailability of curcumin via a solid lipid-based self-emulsifying drug delivery system using a spray-drying technique. Biological and Pharmaceutical Bulletin, 34(8), 1179–1186. doi:10.1248/bpb.34.1179

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Agarwal, V., Alayoubi, A., Siddiqui, A., & Nazzal, S. (2013). Powdered self-emulsified lipid formulations of meloxicam as solid dosage forms for oral administration. Drug Development and Industrial Pharmacy, 39(11), 1681–1689. doi:10.3109/03639045.2012.729594

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Kanaujia, P., Ng, W. K., & Tan, R. B. (2014). Solid self-emulsifying drug delivery system (S-SEDDS) for improved dissolution rate of fenofibrate. Journal of Microencapsulation, 31(3), 293–298. doi:10.3109/02652048.2013.843601

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Thompson, D. O. (1997). Critical Reviews™ in Therapeutic Drug Carrier Systems, doi:10.1615/CritRevTherDrugCarrierSyst.v14.i1.10.

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