2,620
Views
10
CrossRef citations to date
0
Altmetric
Review Article

Advanced colloidal technologies for the enhanced bioavailability of drugs

ORCID Icon, , , , , , , ORCID Icon, , & | (Reviewing editor) show all
Article: 1480572 | Received 12 Mar 2018, Accepted 21 May 2018, Published online: 12 Jun 2018

References

  • Adams, M. L., Lavasanifar, A., & Kwon, G. S. (2003). Amphiphilic block copolymers for drug delivery. Journal of Pharmaceutical Sciences, 92(7), 1343–1355. doi:10.1002/jps.10397
  • Agarwal, V., Alayoubi, A., Siddiqui, A., & Nazzal, S. (2013). Powdered self-emulsified lipid formulations of meloxicam as solid dosage forms for oral administration. Drug Development and Industrial Pharmacy, 39(11), 1681–1689. doi:10.3109/03639045.2012.729594
  • Alam, Z., Salman, Q. O., Seo, K. H., Hye, C. J., Seong, K. H., & Ki, K. J. (2016). International Journal of Nanomedicine, 11, 3813–3824. doi:10.2147/IJN.S109565
  • Allam, A. N., El. Gamal, S., & Naggar, V. (2011). Bioavailability: A pharmaceutical review. International Journal Novel Drug Delivery Technical, 1(1), 77–93.
  • Ann, H. J., Kim, K. M., Choi, J.-S., & Kim, C. K. (1997). Effects of cyclodextrin derivatives on bioavailability of Ketoprofen. Drug Development and Industrial Pharmacy, 23(4), 397–401. doi:10.3109/03639049709146143
  • Ayushi, T., Faraz, J., Ritika, S., & Saurabh, S. (2012). International Research Journal of Pharmacy, 3(5), 32-36.
  • Badwan, A., El-Khordagui, L., Saleh, A., & Khalil, S. (1982). The solubility of benzodiazepines in sodium salicylate solution and a proposed mechanism for hydrotropic solubilization. International Journal of Pharmaceutics, 13(1), 67–74. doi:10.1016/0378-5173(82)90143-0
  • Bhatt, P. P. (2004). The Drug Delivery Companies Report Autumn/Winter. Pharma Ventures Ltd, 1, 26.
  • Bi, R., Shao, W., Wang, Q., & Zhang, N. (2008). Spray-freeze-dried dry powder inhalation of insulin-loaded liposomes for enhanced pulmonary delivery. Journal of Drug Targeting, 16(9), 639–648. doi:10.1080/10611860802201134
  • Breitenbach, J. (2002). Melt extrusion: From process to drug delivery technology. European Journal of Pharmaceutics and Biopharmaceutics, 54(2), 107–117. doi:10.1016/S0939-6411(02)00061-9
  • Bucar, D.-K., & MacGillivray, L. R. (2007). Preparation and reactivity of nanocrystalline cocrystals formed via sonocrystallization. Journal of the American Chemical Society, 129(1), 32–33. doi:10.1021/ja0671161
  • Calderara, F., Hruska, Z., Hurtrez, G., Lerch, J., Nugay, T., & Riess, G. (1994). Macromolecules, 27(5), 1210. doi:10.1021/ma00083a020
  • Chauhan, A. S., Sridevi, S., Chalasani, K. B., Jain, A. K., Jain, S. K., Jain, N., & Diwan, P. V. (2003). Dendrimer-mediated transdermal delivery: Enhanced bioavailability of indomethacin. Journal of Controlled Release, 90(3), 335–343. doi:10.1016/S0168-3659(03)00200-1
  • Chauhan, B., Shimpi, S., & Paradkar, A. (2005). Preparation and evaluation of glibenclamide-polyglycolized glycerides solid dispersions with silicon dioxide by spray drying technique. European Journal of Pharmaceutical Sciences, 26(2), 219–230. doi:10.1016/j.ejps.2005.06.005
  • Chen, H., Khemtong, C., Yang, X., Chang, X., & Gao, J. (2011). Nanonization strategies for poorly water-soluble drugs. Drug Discovery Today, 16(7), 354–360. doi:10.1016/j.drudis.2010.02.009
  • Chen, Y., Chen, C., Zheng, J., Chen, Z., Shi, Q., & Liu, H. (2011). Development of a solid supersaturatable self-emulsifying drug delivery system of docetaxel with improved dissolution and bioavailability. Biological and Pharmaceutical Bulletin, 34(2), 278. doi:10.1248/bpb.34.278
  • Danhier, F., Feron, O., & Preat, V. J. (2010). To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. Journal of Control Release, 148(2), 135–146. doi:10.1016/j.jconrel.2010.08.027
  • Das, S., Ng, W. K., Kanaujia, P., Kim, S., & Tan, R. B. (2011). Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: Effects of process variables. Colloids and Surfaces B: Biointerfaces, 88(1), 483–489. doi:10.1016/j.colsurfb.2011.07.036
  • Del Valle, E. M. (2004). Cyclodextrins and their uses: A review. Process Biochemistry, 39(9), 1033–1046. doi:10.1016/S0032-9592(03)00258-9
  • Fahr, A., & Liu, X. (2007). Drug delivery strategies for poorly water-soluble drugs. Expert Opinion on Drug Delivery, 4(4), 403–416. doi:10.1517/17425247.4.4.403
  • Frömming, K., & Szejtli, J. (1994). Cyclodextrins in pharmacy. Dordrecht: Kluwer Academic Publishers.
  • Gao, L., Zhang, D., & Chen, M. (2008). Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. Journal of Nanoparticle Research, 10(5), 845–862. doi:10.1007/s11051-008-9357-4
  • Gaucher, G., Dufresne, M.-H., Sant, V. P., Kang, N., Maysinger, D., & Leroux, J.-C. (2005). Block copolymer micelles: Preparation, characterization and application in drug delivery. Journal of Controlled Release, 109(1), 169–188. doi:10.1016/j.jconrel.2005.09.034
  • Ghanbarzadeh, S., Valizadeh, H., & Zakeri-Milani, P. (2013). Advanced Pharmaceutical Bulletin, 3(1), 25.
  • Ghorab, M. K., & Adeyeye, M. C. (2003). Enhanced bioavailability of process-induced fast-dissolving ibuprofen cogranulated with β-cyclodextrin. Journal of Pharmaceutical Sciences, 92(8), 1690–1697. doi:10.1002/jps.10443
  • Gothwal, A., Khan, I., & Gupta, U. (2016). Polymeric Micelles: Recent advancements in the delivery of anticancer drugs. Pharmaceutical Research, 33(1), 18–39. doi:10.1007/s11095-015-1784-1
  • Griffin, J. P., & O’Grady, J. (2006). The textbook of pharmaceutical medicine. Wiley Online Library, Blackwell Publishing Ltd. London. doi:10.1002/9780470987391.
  • Grove, M., Müllertz, A., Nielsen, J. L., & Pedersen, G. P. (2006). Bioavailability of seocalcitol. European Journal of Pharmaceutical Sciences, 28(3), 233–242. doi:10.1016/j.ejps.2006.02.005
  • Gupta, S., Kesarla, R., & Omri, A. (2013). Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self-emulsifying systems. ISRN Pharmaceutics, 2013. doi:10.1155/2013/848043
  • Gursoy, R. N., & Benita, S. (2004). Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomedicine & Pharmacotherapy, 58(3), 173–182. doi:10.1016/j.biopha.2004.02.001
  • Hu, J., Johnston, K. P., & Williams, R. O., III. (2004). Nanoparticle engineering processes for enhancing the dissolution rates of poorly water soluble drugs. Drug Development and Industrial Pharmacy, 30(3), 233–245. doi:10.1081/DDC-120030422
  • Jain, N. K., & Gupta, U. (2008). Application of dendrimer–drug complexation in the enhancement of drug solubility and bioavailability. Expert Opinion on Drug Metabolism & Toxicology, 4(8), 1035–1052. doi:10.1517/17425255.4.8.1035
  • Jones, M. C., & Leroux, J. C. (1999). Polymeric micelles – a new generation of colloidal drug carriers. European Journal of Pharmaceutics and Biopharmaceutics, 48(2), 101–111. doi:10.1016/S0939-6411(99)00039-9
  • Kakkar, V., Singh, S., Singla, D., & Kaur, I. P. (2011). Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Molecular Nutrition & Food Research, 55(3), 495–503. doi:10.1002/mnfr.v55.3
  • Kanaujia, P., Ng, W. K., & Tan, R. B. (2014). Solid self-emulsifying drug delivery system (S-SEDDS) for improved dissolution rate of fenofibrate. Journal of Microencapsulation, 31(3), 293–298. doi:10.3109/02652048.2013.843601
  • Kawabata, Y., Wada, K., Nakatani, M., Yamada, S., & Onoue, S. (2011). Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications. International Journal of Pharmaceutics, 420(1), 1–10. doi:10.1016/j.ijpharm.2011.08.032
  • Kawakami, K. (2012). Modification of physicochemical characteristics of active pharmaceutical ingredients and application of supersaturatable dosage forms for improving bioavailability of poorly absorbed drugs. Advanced Drug Delivery Reviews, 64(6), 480–495. doi:10.1016/j.addr.2011.10.009
  • Ke, W., Zhao, Y., Huang, R., Jiang, C., & Pei, Y. (2008). Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system. Journal of Pharmaceutical Sciences, 97(6), 2208–2216. doi:10.1002/jps.21155
  • Khasia, H., & Khasia, V. (2012). International Journal of Pharmaceutical and Chemical Sciences, 1(1), 353.
  • Kim, D. W., Kang, J. H., Oh, D. H., Yong, C. S., & Choi, H.-G. (2012). Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier. Journal of Microencapsulation, 29(4), 323–330. doi:10.3109/02652048.2011.651497
  • Komal, S., Abdul, W., Habiba, A., Kinza, M., Maria, M., Waseem, K. M., … Din, F. U. (2017). Pharmaceutical Nanotechnology, 6, 2018.
  • Krishnaiah, Y. S. (2012). Pharmaceutical Technologies for Enhancing Oral Bioavailability of Poorly Soluble Drugs. Journal of Bioequivalence & Bioavailability, 2.2, 028-036.
  • Lee, S. C., Huh, K. M., Lee, J., Cho, Y. W., Galinsky, R. E., & Park, K. (2007). Hydrotropic polymeric micelles for enhanced paclitaxel solubility: In vitro and in vivo characterization. Biomacromolecules, 8(1), 202–208. doi:10.1021/bm060307b
  • Li, H., Zhao, X., Ma, Y., Zhai, G., Li, L., & Lou, H. (2009). Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. Journal of Controlled Release, 133(3), 238–244. doi:10.1016/j.jconrel.2008.10.002
  • Loftsson, T., Sigurđsson, H., Másson, M., & Schipper, N. (2004). Die Pharmazie – An International Journal of Pharmaceutical Sciences, 59(1), 25.
  • Maria, M., Saba, I., Samreen, R., Ahmad, Z., Khan, G. M., Rehman, A., & Din, F. U. (2017). Nanoscale Research Letters, 12, 300. doi:10.1186/s11671-017-2046-4
  • Millard, J. W., Alvarez-Nunez, F., & Yalkowsky, S. H. (2002). Solubilization by cosolvents. International Journal of Pharmaceutics, 245(1), 153–166. doi:10.1016/S0378-5173(02)00334-4
  • Miller, D. A., McConville, J. T., Yang, W., Williams, R. O., & McGinity, J. W. (2007). Hot-melt extrusion for enhanced delivery of drug particles. Journal of Pharmaceutical Sciences, 96(2), 361–376. doi:10.1002/jps.20806
  • Miroshnyk, I., Mirza, S., & Sandler, N. (2009). Pharmaceutical co-crystals – an opportunity for drug product enhancement. Expert Opinion on Drug Delivery, 6(4), 333–341. doi:10.1517/17425240902828304
  • Mueller, E. A., Kovarik, J. M., van Bree, J. B., Tetzloff, W., Grevel, J., & Kutz, K. (1994). Pharmaceutical Research, 11(2), 301. doi:10.1023/A:1018923912135
  • Muèller, R. H., Maèder, K., & Gohla, S. (2000). European Journal of Pharmaceutics and Biopharmaceutics, 50(1), 161. doi:10.1016/S0939-6411(00)00087-4
  • Mura, P., Faucci, M. T., & Bettinetti, G. P. (2001). The influence of polyvinylpyrrolidone on naproxen complexation with hydroxypropyl-β-cyclodextrin. European Journal of Pharmaceutical Sciences, 13(2), 187–194. doi:10.1016/S0928-0987(01)00093-8
  • Mutalik, S., Anju, P., Manoj, K., & Usha, A. N. (2008). Enhancement of dissolution rate and bioavailability of aceclofenac: A chitosan-based solvent change approach. International Journal of Pharmaceutics, 350(1), 279–290. doi:10.1016/j.ijpharm.2007.09.006
  • Nidhi, K., Indrajeet, S., Khushboo, M., Gauri, K., & Sen, D. J. (2011). Hydrotropy: A promising tool for solubility Enhancement: A Review. International Journal of Drug Development and Research, 3(2), 26-33.
  • Nigade, P. M., Patil, S. L., & Tiwari, S. S. (2012). International Journal of Pharmacy and Biological Sciences, 2(2), 42.
  • Ober, C. A., & Gupta, R. B. (2012). Formation of itraconazole–succinic acid cocrystals by gas antisolvent cocrystallization. AAPS PharmSciTech, 13(4), 1396–1406. doi:10.1208/s12249-012-9866-4
  • Otsuka, H., Nagasaki, Y., & Kataoka, K. (2003). PEGylated nanoparticles for biological and pharmaceutical applications. Advanced Drug Delivery Reviews, 55(3), 403–419. doi:10.1016/S0169-409X(02)00226-0
  • Patel, J., Kevin, G., Patel, A., Raval, M., & Sheth, N. (2011). Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery. International Journal of Pharmaceutical Investigation, 1(2), 112. doi:10.4103/2230-973X.82431
  • Pitha, J., Milecki, J., Fales, H., Pannell, L., & Uekama, K. (1986). Hydroxypropyl-β-cyclodextrin: Preparation and characterization; effects on solubility of drugs. International Journal of Pharmaceutics, 29 (1), 73–82. doi:10.1016/0378-5173(86)90201-2
  • Rapoport, N. (2007). Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. Progress in Polymer Science, 22(8–9), 962–990. doi:10.1016/j.progpolymsci.2007.05.009
  • Rashid, R., Din, F. U., Mustapha, O., Kim, D. W., Yousaf, A. M., Park, J. H., … Choi, H. G. (2015). Effect of hydroxypropylcellulose and Tween 80 on physicochemical properties and bioavailability of ezetimibe-loaded solid dispersion. Carbohydrate Polymer, 130, 26–31. doi:10.1016/j.carbpol.2015.04.071
  • Rashid, R., Kim, D. W., Yousaf, A. M., Mustapha, O., Din, F. U., Park, J. H., … Choi, H. G. (2015). International Journal of Nanomedicine, 10, 6147–6159.
  • Rodriguez, L., Passerini, N., Cavallari, C., Cini, M., Sancin, P., & Fini, A. (1999). Description and preliminary evaluation of a new ultrasonic atomizer for spray-congealing processes. International Journal of Pharmaceutics, 183(2), 133. doi:10.1016/S0378-5173(99)00076-9
  • Saenger, W. (1980). Cyclodextrin inclusion compounds in research and industry. Angewandte Chemie International Edition in English, 19(5), 344–362. doi:10.1002/(ISSN)1521-3773
  • Salman, Q. O., Alam, Z., Muhammad, A., Sic, K. M., Ho, K. J., Seong, K. H., … Ki, K. J. (2016). European Journal O F Pharmaceutics and Biopharmaceutics, 108, 187–195. doi:10.1016/j.ejpb.2016.09.008
  • Sauceau, M., Rodier, E., & Fages, J. (2008). Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide. The Journal of Supercritical Fluids, 47(2), 326–332. doi:10.1016/j.supflu.2008.07.006
  • Savjani, K. T., Gajjar, A. K., & Savjani, J. K. (2012). Drug solubility: Importance and enhancement techniques. ISRN Pharmaceutics, 2012. doi:10.5402/2012/195727
  • Seedher, N., & Bhatia, S. (2003). Solubility enhancement of cox-2 inhibitors using various solvent systems. Aaps Pharmscitech, 4(3), 36–44. doi:10.1208/pt040333
  • Sekhon, B. S. (2005). International Bulletin of Drug Research, 1(2), 24.
  • Seo, A., & Schæfer, T. (2001). Melt agglomeration with polyethylene glycol beads at a low impeller speed in a high shear mixer. European Journal of Pharmaceutics and Biopharmaceutics, 52(3), 315–325. doi:10.1016/S0939-6411(01)00183-7
  • Shah, N., Carvajal, M., Patel, C., Infeld, M., & Malick, A. (1994). Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. International Journal of Pharmaceutics, 106(1), 15–23. doi:10.1016/0378-5173(94)90271-2
  • Shin, H. C., Alani, A. W., Rao, D. A., Rockich, N. C., & Kwon, G. S. (2009). Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs. Journal of Controlled Release, 140(3), 294–300. doi:10.1016/j.jconrel.2009.04.024
  • Shiraki, K., Takata, N., Takano, R., Hayashi, Y., & Terada, K. (2008). Dissolution improvement and the mechanism of the improvement from cocrystallization of poorly water-soluble compounds. Pharmaceutical Research, 25(11), 2581–2592. doi:10.1007/s11095-008-9676-2
  • Strickley, R. G. (2000). PDA-Journal of Pharmaceutical Science and Technology, 54(1), 69.
  • Strickley, R. G. (2004). Solubilizing excipients in oral and injectable formulations. Pharmaceutical Research, 21(2), 201–230. doi:10.1023/B:PHAM.0000016235.32639.23
  • Sun, S., & Zeng, H. (2002). Size-controlled synthesis of magnetite nanoparticles. Journal of the American Chemical Society, 124(28), 8204–8205. doi:10.1021/ja026501x
  • Takahashi, M., Uechi, S., Takara, K., Asikin, Y., & Wada, K. (2009). Evaluation of an oral carrier system in rats: Bioavailability and antioxidant properties of liposome-encapsulated curcumin. Journal of Agricultural and Food Chemistry, 57(19), 9141–9146. doi:10.1021/jf9013923
  • Talanov, V. S., Regino, C. A., Kobayashi, H., Bernardo, M., Choyke, P. L., & Brechbiel, M. W. (2006). Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging. Nano Letters, 6(7), 1459–1463. doi:10.1021/nl060765q
  • Taneri, F., Ozcan, I., & Guneri, T. (2010). In vitro and in vivo evaluation of oral tablet formulations prepared with ketoconazole and hydroxypropyl- β-cyclodextrin. Drug Delivery, 17(3), 152–157. doi:10.3109/10717541003604890
  • Tang, Y., Zhang, H., Lu, X., Jiang, L., Xi, X., Liu, J., & Zhu, J. (2015). Development and evaluation of a dry powder formulation of liposome-encapsulated oseltamivir phosphate for inhalation. Drug Delivery, 22(5), 608–618. doi:10.3109/10717544.2013.863526
  • Thompson, D. O. (1997). Critical Reviews™ in Therapeutic Drug Carrier Systems, doi:10.1615/CritRevTherDrugCarrierSyst.v14.i1.10.
  • Tomalia, D. A., & Frechet, J. M. (2002). Introduction to the dendritic state. Wiley Online Library, John Wiley & Sons Ltd Chichester UK. doi:10.1002/0470845821.ch1.
  • Tomasik, P., & Schilling, C. H. (1998). Complexes of Starch with Inorganic Guests.  Advances in Carbohydrate Chemistry and Biochemistry, 53, 263-345.
  • ud Din, F., Aman, W., Ullah, I., Salman, Q. O., Mustapha, O., & Zeb, A. (2017). Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. International Joiurnal of Nanomedicine, 12, 7291–7309.
  • ud Din, F. U., Cho, J. Y., Kim, D. W., Mustapha, O., Kim, D. S., RJ, T., … Choi, H. G. (2017). Drug Delivery, 24(1), 502–510. doi:10.1080/10717544.2016.1272651
  • ud Din, F. U., Mustapha, O., & Kim, D. W. (2017). Acta Biomaterialia, 54, 239–248. doi:10.1016/j.actbio.2017.03.007
  • ud Din, F. U., Mustapha, O., Kim, D. W., Rashid, R., Park, J. H., Choi, J. Y., … Choi, H.-G. (2015). Novel dual-reverse thermosensitive solid lipid nanoparticle-loaded hydrogel for rectal administration of flurbiprofen with improved bioavailability and reduced initial burst effect. European Journal of Pharmaceutics and Biopharmaceutics, 94, 64–72. doi:10.1016/j.ejpb.2015.04.019
  • ud Din, F. U., Rashid, R., Mustapha, O., Kim, D. W., Park, J. H., Ku, S. K., … Yong, C. S. (2015). Development of a novel solid lipid nanoparticles loaded dual-reverse thermosensitive nanomicellefor intramuscular administration with sustained release and reduced toxicity. RSC Advances, 5, 43687.
  • Üner, M., & Yener, G. (2007). International Journal of Nanomedicine, 2(3), 289.
  • Vemavarapu, C., Mollan, M. J., Lodaya, M., & Needham, T. E. (2005). Design and process aspects of laboratory scale SCF particle formation systems. Journal of Pharmaceutics, 292(1), 1–16. doi:10.1016/j.ijpharm.2004.07.021
  • Wakaskar, R. R. (2017a). Challenges Pertaining to Adverse Effects of Drugs. International Journal of Drug Development and Research, 9;01-02.
  • Wakaskar, R. R. (2017b). Polymeric Micelles and their properties. Journal of Nanomedicine & Nanotechnology, 8(2), 1000433. doi:10.4172/2157-7439
  • Wakaskar, R. R. (2017c). International Journal of Drug Development and Research, 9(3), 1–2.
  • Wakaskar, R. R. (2018a). General overview of lipid–Polymer hybrid nanoparticles, dendrimers, micelles, liposomes, spongosomes and cubosomes. Journal of Drug Targeting, 26(4), 311–318. doi:10.1080/1061186X.2017.1367006
  • Wakaskar, R. R. (2018b). Brief overview of nanoparticulate therapy in cancer. Journal of Drug Targeting, 26(2), 123–126. doi:10.1080/1061186X.2017.1347175
  • Williams, H. D., Trevaskis, N. L., Charman, S. A., Shanker, R. M., Charman, W. N., Pouton, C. W., & Porter, C. J. (2013). Strategies to address low drug solubility in discovery and development. Pharmacological Reviews, 65(1), 315–499. doi:10.1124/pr.112.005660
  • Xu, W., Ling, P., & Zhang, T. (2013). Polymeric Micelles, a promising drug delivery system to enhance bioavailability of poorly water-soluble drugs. Journal of Drug Delivery, 2013. doi:10.1155/2013/340315
  • Yan, Y. D., Kim, J. A., Kwak, M. K., Yoo, B. K., Yong, C. S., & Choi, H. G. (2011). Enhanced oral bioavailability of curcumin via a solid lipid-based self-emulsifying drug delivery system using a spray-drying technique. Biological and Pharmaceutical Bulletin, 34(8), 1179–1186. doi:10.1248/bpb.34.1179
  • Yang, T., Cui, F. D., Choi, M. K., Cho, J. W., Chung, S. J., Shim, C. K., & Kim, D. D. (2007). Enhanced solubility and stability of PEGylated liposomal paclitaxel: In vitro and in vivo evaluation. International Journal of Pharmaceutics, 338(1), 317–326. doi:10.1016/j.ijpharm.2007.02.011
  • Zaheer, A., Naveen, M., Santosh, M. K., & Imran, K. (2011). Solubility enhancement of poorly water soluble drugs: A review. International Journal Of Pharmacy & Technology. 3 (1), 807–823.
  • Zeb, A., Qureshi, O. S., Yu, C. H., Akram, M., Kim, H. S., Kim, M. S., … Kim, J. K. (2017). Enhanced anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel in adjuvant-induced arthritis rat model. International Journal of Pharmaceutics, 525(1), 92–100. doi:10.1016/j.ijpharm.2017.04.032
  • Zhang, J. A., Anyarambhatla, G., Ma, L., Ugwu, S., Xuan, T., Sardone, T., & Ahmad, I. (2005). Development and characterization of a novel Cremophor EL free liposome-based paclitaxel (LEP-ETU) formulation. European journal o f pharmaceutics and biopharmaceutics. 59(1), 177-187.doi: 10.1016/j.ejpb.2004.06.009