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ORIGINAL RESEARCH

Incorporating Inflammatory Markers and Clinical Indicators into a Predictive Model of Single Small Hepatocellular Carcinoma Recurrence After Primary Locoregional Treatments

ORCID Icon, , , &
Pages 1113-1125 | Received 02 Apr 2024, Accepted 30 May 2024, Published online: 13 Jun 2024

Figures & data

Table 1 Demographics and Clinical Characteristics for HCC Patients

Figure 1 Kaplan-Meier plot of RFS for HCC patients.

Notes: Group 1, patients with single small tumor; Group 2, patients with single large tumor; Group 3, patients with multiple small tumors; Group 4, patients with multiple large tumors.
Figure 1 Kaplan-Meier plot of RFS for HCC patients.

Table 2 Demographics and Clinical Characteristics for Training and Validation Sets

Table 3 Cox Proportional Hazards Regression to Predict Recurrence Based on Lasso Regression

Figure 2 Screening of variables based on Lasso regression. (A) The variation characteristics of the coefficient of variables. (B) the selection process of the optimum value of the parameter λ in the Lasso regression model by cross-validation method.

Figure 2 Screening of variables based on Lasso regression. (A) The variation characteristics of the coefficient of variables. (B) the selection process of the optimum value of the parameter λ in the Lasso regression model by cross-validation method.

Figure 3 Nomogram, including Age, MLR, GLR, RBC, and INR for 1-, 3-, and 5- years recurrence free survival (RFS) in HCC patients with high HBsAg levels in AFP. The nomogram is valued to obtain the probability of 1-, 3-, and 5- years recurrence by adding up the points identified on the points scale for each variable.

Abbreviations: RBC, red blood cell; INR, international normalized ratio; MLR, monocyte-to-lymphocyte; GLR, gamma-glutamyl transferase-to-lymphocyte.
Figure 3 Nomogram, including Age, MLR, GLR, RBC, and INR for 1-, 3-, and 5- years recurrence free survival (RFS) in HCC patients with high HBsAg levels in AFP. The nomogram is valued to obtain the probability of 1-, 3-, and 5- years recurrence by adding up the points identified on the points scale for each variable.

Figure 4 1-, 3-, and 5-year ROC curves of the nomogram in the training cohort.

Abbreviation: ROC, receiver operating characteristics.
Figure 4 1-, 3-, and 5-year ROC curves of the nomogram in the training cohort.

Figure 5 1-, 3-, and 5-year calibration curves of the nomogram in the training cohort.

Figure 5 1-, 3-, and 5-year calibration curves of the nomogram in the training cohort.

Figure 6 1-, 3-, and 5-year DCA curves of the nomogram in the training cohort. (A) One-year decision curve analysis in the training cohort. (B) Three-year decision curve analysis in the training cohort. (C) Five-year decision curve analysis in the training cohort.

Abbreviation: DCA, decision curve analysis.
Figure 6 1-, 3-, and 5-year DCA curves of the nomogram in the training cohort. (A) One-year decision curve analysis in the training cohort. (B) Three-year decision curve analysis in the training cohort. (C) Five-year decision curve analysis in the training cohort.

Figure 7 Kaplan-Meier plots of RFS for the low-risk group, intermediate-risk group and high-risk group in the training cohort.

Abbreviation: RFS, recurrence-free survival.
Figure 7 Kaplan-Meier plots of RFS for the low-risk group, intermediate-risk group and high-risk group in the training cohort.

Data Sharing Statement

All relevant data are available within the manuscript and its Supplementary Material Files. Further enquiries can be directed to the corresponding author (Yonghong Zhang, [email protected]).