Journal of Hepatocellular Carcinoma, Volume 11, Issue (2024)

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Journal of Hepatocellular Carcinoma, Volume 11, Issue (2024)

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Volume 11, 2024 Vol 10, 2023 Vol 9, 2022 Vol 8, 2021 Vol 7, 2020 Vol 6, 2019 Vol 5, 2018 Vol 4, 2017 Vol 3, 2016 Vol 2, 2015 Vol 1, 2014
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ORIGINAL RESEARCH

Article
Novel Preoperative Type IV Collagen to Predict the Risk of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhotic Portal Hypertension After Laparoscopic Splenectomy and Azygoportal Disconnection
Tian-Ming Gao, Sheng-Jie Jin, Fang Fang, Jian-Jun Qian, Chi Zhang, Bao-Huan Zhou, Dou-Sheng Bai & Guo-Qing Jiang
Pages: 2411-2420
Published online: 11 Jan 2024
AbstractforNovel Preoperative Type IV Collagen to Predict the Risk of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhotic Portal Hypertension After Laparoscopic Splenectomy and Azygoportal Disconnection | Full Text | References | PDF (2.7 MB) | EPUB
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Open Access
Article
Comparisons of Percutaneous Ablation, Open or Laparoscopic Liver Resection for Barcelona Clinic Liver Cancer Stage 0-A Hepatocellular Carcinoma: A Concurrent Generalized Propensity Score Analysis
Zhi-Hang Chen, Qian Zhou, Ze-Bin Chen, Wen-Xuan Xie, Zi-Min Song, Shui-Rong Lin, Wei Wang, Shun-Li Shen & Ming Kuang
Pages: 1459-1472
Published online: 25 Jul 2024
AbstractforComparisons of Percutaneous Ablation, Open or Laparoscopic Liver Resection for Barcelona Clinic Liver Cancer Stage 0-A Hepatocellular Carcinoma: A Concurrent Generalized Propensity Score Analysis | Full Text | References | PDF (1.5 MB) | EPUB
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Open Access
Article
MRI Radiomics Combined with Clinicopathological Factors for Predicting 3-Year Overall Survival of Hepatocellular Carcinoma After Hepatectomy
Fangyuan Kuang, Yang Gao, Qingyun Zhou, Chenying Lu, Qiaomei Lin, Abdullah Al Mamun, Junle Pan, Shuibo Shi, Chaoyong Tu & Chuxiao Shao
Pages: 1445-1457
Published online: 23 Jul 2024
AbstractforMRI Radiomics Combined with Clinicopathological Factors for Predicting 3-Year Overall Survival of Hepatocellular Carcinoma After Hepatectomy | Full Text | References | PDF (5.3 MB) | EPUB
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Open Access

PERSPECTIVES

Article Commentary
Why Liver Cancer Hits Home: Bridging Healthcare Disparities in the Asian American and Pacific Islander Community
Daneng Li, Spencer Cheng, Andrea Wilson Woods, Allyson Luong, Sarah Schiltz, Ruoding Tan & Zeena Huang Chi
Pages: 1439-1444
Published online: 23 Jul 2024
AbstractforWhy Liver Cancer Hits Home: Bridging Healthcare Disparities in the Asian American and Pacific Islander Community | Full Text | References | PDF (344.5 KB) | EPUB
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Open Access

REVIEW

Review
Research Progress in Predicting Hepatocellular Carcinoma with Portal Vein Tumour Thrombus in the Era of Artificial Intelligence
Yaduo Li, Ningning Fan, Xu He, Jianjun Zhu, Jie Zhang & Ligong Lu
Pages: 1429-1438
Published online: 23 Jul 2024
AbstractforResearch Progress in Predicting Hepatocellular Carcinoma with Portal Vein Tumour Thrombus in the Era of Artificial Intelligence | Full Text | References | PDF (412.6 KB) | EPUB
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Open Access

ORIGINAL RESEARCH

Article
Hepatic Arterial Infusion Chemotherapy Combined with Lenvatinib and PD-1 Inhibitors for Managing Arterioportal Shunt in Hepatocellular Carcinoma with Portal Vein Tumor Thrombus: A Retrospective Cohort Study
Guanxiong Liu, Duo Zhu, Quansheng He, Churen Zhou, Li He, Zhengran Li, Zaibo Jiang, Mingsheng Huang, Boyang Chang & Chun Wu
Pages: 1415-1428
Published online: 12 Jul 2024
AbstractforHepatic Arterial Infusion Chemotherapy Combined with Lenvatinib and PD-1 Inhibitors for Managing Arterioportal Shunt in Hepatocellular Carcinoma with Portal Vein Tumor Thrombus: A Retrospective Cohort Study | Full Text | References | PDF (3.1 MB) | EPUB
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Open Access
Article
A Simple Prognostic Scoring System for Hepatocellular Carcinoma Treated with DEB-TACE
Bo Jiang, Dong Lu, Jiaying Dai, Kunfeng Li, Qianqian Du, Bo Xie, Jun Xie, Xianhai Zhu & Xiang Xie
Pages: 1403-1414
Published online: 09 Jul 2024
AbstractforA Simple Prognostic Scoring System for Hepatocellular Carcinoma Treated with DEB-TACE | Full Text | References | PDF (6.2 MB) | EPUB
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Open Access
Article
Portal Venous and Hepatic Arterial Coefficients Predict Post-Hepatectomy Overall and Recurrence-Free Survival in Patients with Hepatocellular Carcinoma: A Retrospective Study
Yu-Kai Li, Song Wu, Yu-Shan Wu, Wei-Hu Zhang, Yan Wang, Yue-Hua Li, Qiang Kang, Song-Quan Huang, Kai Zheng, Gai-Ming Jiang, Qing-Bo Wang, Yu-Bo Liang, Jin Li, Yawhan Lakang, Chen Yang, Jing Li, Jia-Ping Wang, Xiang Kui & Yang Ke
Pages: 1389-1402
Published online: 09 Jul 2024
AbstractforPortal Venous and Hepatic Arterial Coefficients Predict Post-Hepatectomy Overall and Recurrence-Free Survival in Patients with Hepatocellular Carcinoma: A Retrospective Study | Full Text | References | PDF (7.7 MB) | EPUB
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Open Access
Article
Recurrence of Hepatocellular Carcinoma in Patients with Low Albumin-Bilirubin Grade in TACE Combined with Ablation: A Random Forest Cox Predictive Model
Yiqi Xiong, Wenying Qiao, Tingting Mei, Kang Li, Ronghua Jin & Yonghong Zhang
Pages: 1375-1388
Published online: 07 Jul 2024
AbstractforRecurrence of Hepatocellular Carcinoma in Patients with Low Albumin-Bilirubin Grade in TACE Combined with Ablation: A Random Forest Cox Predictive Model | Full Text | References | PDF (6.2 MB) | EPUB
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Open Access
Article
CD276 Promotes an Inhibitory Tumor Microenvironment in Hepatocellular Carcinoma and is Associated with Poor Prognosis
Wen-Feng Liu, Qiu-Yu Jiang, Zhuo-Ran Qi, Feng Zhang, Wen-Qing Tang, Hao-Qi Wang & Ling Dong
Pages: 1357-1373
Published online: 08 Jul 2024
AbstractforCD276 Promotes an Inhibitory Tumor Microenvironment in Hepatocellular Carcinoma and is Associated with Poor Prognosis | Full Text | References | PDF (14.4 MB) | EPUB
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Open Access
Article
New HCC Subtypes Based on CD8 Tex-Related lncRNA Signature Could Predict Prognosis, Immunological and Drug Sensitivity Characteristics of Hepatocellular Carcinoma
Jiachen Ge, Ming Tao, Gaolei Zhang, Jianping Cai, Deyu Li & Lianyuan Tao
Pages: 1331-1355
Published online: 05 Jul 2024
AbstractforNew HCC Subtypes Based on CD8 Tex-Related lncRNA Signature Could Predict Prognosis, Immunological and Drug Sensitivity Characteristics of Hepatocellular Carcinoma | Full Text | References | PDF (25.2 MB) | EPUB
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Open Access
Article
Utility of Machine Learning in the Prediction of Post-Hepatectomy Liver Failure in Liver Cancer
Hirotaka Tashiro, Takashi Onoe, Naoki Tanimine, Sho Tazuma, Yoshiyuki Shibata, Takeshi Sudo, Haruki Sada, Norimitsu Shimada, Hirofumi Tazawa, Takahisa Suzuki & Yosuke Shimizu
Pages: 1323-1330
Published online: 04 Jul 2024
AbstractforUtility of Machine Learning in the Prediction of Post-Hepatectomy Liver Failure in Liver Cancer | Full Text | References | PDF (1.1 MB) | EPUB
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Open Access
Article
The Impact of Proton Pump Inhibitors on the Efficacy of Immune Checkpoint Inhibitor Combinations in Patients with HBV-Associated Advanced Hepatocellular Carcinoma
Ningning Wang, Yuanyuan Xu, Guangde Yang, He Chen, Xia Wang, Juanjuan Fu, Li Li & Xiucheng Pan
Pages: 1311-1321
Published online: 04 Jul 2024
AbstractforThe Impact of Proton Pump Inhibitors on the Efficacy of Immune Checkpoint Inhibitor Combinations in Patients with HBV-Associated Advanced Hepatocellular Carcinoma | Full Text | References | PDF (4.2 MB) | EPUB
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Open Access
Article
IL-6 Released from Hepatic Stellate Cells Promotes Glycolysis and Migration of HCC Through the JAK1/vWF/TGFB1 Axis
Yifei Zhu, Jiayi Gu, Yuxin Lu, Qianying Tao, Xinliang Cao, Yanqing Zhu, Mu-qing Yang & Xin Liang
Pages: 1295-1310
Published online: 04 Jul 2024
AbstractforIL-6 Released from Hepatic Stellate Cells Promotes Glycolysis and Migration of HCC Through the JAK1/vWF/TGFB1 Axis | Full Text | References | PDF (14.8 MB) | EPUB
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Open Access
Article
Decision-Tree Models Indicative of Microvascular Invasion on MRI Predict Survival in Patients with Hepatocellular Carcinoma Following Tumor Ablation
Robin Schmidt, Charlie Alexander Hamm, Christopher Rueger, Han Xu, Yubei He, Luzie Alexandra Gottwald, Bernhard Gebauer & Lynn Jeanette Savic
Pages: 1279-1293
Published online: 03 Jul 2024
AbstractforDecision-Tree Models Indicative of Microvascular Invasion on MRI Predict Survival in Patients with Hepatocellular Carcinoma Following Tumor Ablation | Full Text | References | PDF (4.2 MB) | EPUB
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Open Access

REVIEW

Review
Breaking the Barriers of Therapy Resistance: Harnessing Ferroptosis for Effective Hepatocellular Carcinoma Therapy
Xianmei Lv, Gaochen Lan, Lujian Zhu & Qiusheng Guo
Pages: 1265-1278
Published online: 02 Jul 2024
AbstractforBreaking the Barriers of Therapy Resistance: Harnessing Ferroptosis for Effective Hepatocellular Carcinoma Therapy | Full Text | References | PDF (4.7 MB) | EPUB
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Open Access

ORIGINAL RESEARCH

Article
Prognostic Value of Alpha-Fetoprotein in Unresectable Hepatocellular Carcinoma Treated with Hepatic Artery Infusion Chemotherapy Combined with Lenvatinib and Camrelizumab
Yongqiang Xiao, Wanqing Chen, Wei Deng, Guoqing Zhu, Jin Xie, Laihui Luo, Liucong Lin, Jiahao Tao, Zhigao Hu & Renfeng Shan
Pages: 1251-1263
Published online: 01 Jul 2024
AbstractforPrognostic Value of Alpha-Fetoprotein in Unresectable Hepatocellular Carcinoma Treated with Hepatic Artery Infusion Chemotherapy Combined with Lenvatinib and Camrelizumab | Full Text | References | PDF (4.1 MB) | EPUB
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Open Access
Article
Limited Generalizability of Retrospective Single-Center Cohort Study in Comparison to Multicenter Cohort Study on Prognosis of Hepatocellular Carcinoma
Ye Rim Kim, Sung Won Chung, Min-Ju Kim, Won-Mook Choi, Jonggi Choi, Danbi Lee, Han Chu Lee & Ju Hyun Shim
Pages: 1235-1249
Published online: 01 Jul 2024
AbstractforLimited Generalizability of Retrospective Single-Center Cohort Study in Comparison to Multicenter Cohort Study on Prognosis of Hepatocellular Carcinoma | Full Text | References | PDF (2.5 MB) | EPUB
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Open Access
Article
The Potential of the lncRNAs ADAMTSL4-AS1, AC067931 and SOCS2-AS1 in Peripheral Blood Mononuclear Cells as Novel Diagnostic Biomarkers for Hepatitis B Virus-Associated Hepatocellular Carcinoma
Weiwei Guan, Congyue Zhang, Tongguo Miao, Chen Dong, Lu Li, Xiwei Yuan, Dandan Zhao, Rong Ai, Xiaoxiao Zhang, Mengjiao Sun, Haiyan Kang & Yuemin Nan
Pages: 1221-1233
Published online: 28 Jun 2024
AbstractforThe Potential of the lncRNAs ADAMTSL4-AS1, AC067931 and SOCS2-AS1 in Peripheral Blood Mononuclear Cells as Novel Diagnostic Biomarkers for Hepatitis B Virus-Associated Hepatocellular Carcinoma | Full Text | References | PDF (5.3 MB) | EPUB
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Open Access
Article
Efficacy and Safety Analysis of Transarterial Chemoembolization Plus Donafenib With or Without Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma: A Prospective, Single-Arm, Single-Center, Phase II Clinical Study
Jinpeng Li, Yan Li, Jinlong Song & Lujun Zhao
Pages: 1207-1219
Published online: 26 Jun 2024
AbstractforEfficacy and Safety Analysis of Transarterial Chemoembolization Plus Donafenib With or Without Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma: A Prospective, Single-Arm, Single-Center, Phase II Clinical Study | Full Text | References | PDF (2.7 MB) | EPUB
  • 38 Views
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Open Access
Article
The Influence of Visceral Adiposity on Overall Survival: Exploring “Obesity Paradox” Among Hepatocellular Carcinoma Patients Who Receiving Immunotherapy
Yanzhao Zhou, Jingzhong Ouyang, Hongcai Yang, Zhengzheng Wang, Yi Yang, Qingjun Li, Haitao Zhao, Jinxue Zhou & Qiang Li
Pages: 1193-1206
Published online: 24 Jun 2024
AbstractforThe Influence of Visceral Adiposity on Overall Survival: Exploring “Obesity Paradox” Among Hepatocellular Carcinoma Patients Who Receiving Immunotherapy | Full Text | References | PDF (3 MB) | EPUB
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Open Access
Article
Radiomics-Based Prediction of Microvascular Invasion Grade in Nodular Hepatocellular Carcinoma Using Contrast-Enhanced Magnetic Resonance Imaging
Zhao Zhang, Xiu-Fen Jia, Xiao-Yu Chen, Yong-Hua Chen & Ke-Hua Pan
Pages: 1185-1192
Published online: 20 Jun 2024
AbstractforRadiomics-Based Prediction of Microvascular Invasion Grade in Nodular Hepatocellular Carcinoma Using Contrast-Enhanced Magnetic Resonance Imaging | Full Text | References | PDF (3.4 MB) | EPUB
  • 27 Views
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Open Access

REVIEW

Review
GDF15: Immunomodulatory Role in Hepatocellular Carcinoma Pathogenesis and Therapeutic Implications
Yi-Ning Du & Jin-Wei Zhao
Pages: 1171-1183
Published online: 19 Jun 2024
AbstractforGDF15: Immunomodulatory Role in Hepatocellular Carcinoma Pathogenesis and Therapeutic Implications | Full Text | References | PDF (2.9 MB) | EPUB
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ORIGINAL RESEARCH

Article
PD-1 Inhibitors Combined with Tyrosine Kinase Inhibitors with or without Hepatic Artery Infusion Chemotherapy for the First-Line Treatment of HBV-Related Advanced Hepatocellular Carcinoma: A Retrospective Study
Dazhen Wang, Zhengfeng Zhang, Liu Yang, Lu Zhao, Ze Liu & ChangJie Lou
Pages: 1157-1170
Published online: 17 Jun 2024
AbstractforPD-1 Inhibitors Combined with Tyrosine Kinase Inhibitors with or without Hepatic Artery Infusion Chemotherapy for the First-Line Treatment of HBV-Related Advanced Hepatocellular Carcinoma: A Retrospective Study | Full Text | References | PDF (2.7 MB) | EPUB
  • 32 Views
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REVIEW

Review
Research Progress on the Role of Epigenetic Methylation Modification in Hepatocellular Carcinoma
Jing Wang, Wenyue Gao, Hongbo Yu, Yuting Xu, Changchuan Bai, Qingwei Cong & Ying Zhu
Pages: 1143-1156
Published online: 16 Jun 2024
AbstractforResearch Progress on the Role of Epigenetic Methylation Modification in Hepatocellular Carcinoma | Full Text | References | PDF (1.6 MB) | EPUB
  • 51 Views
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ORIGINAL RESEARCH

Article
Establishing and Externally Validating a Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score-Based Nomogram for Predicting Early Recurrence in BCLC Stage 0/A Hepatocellular Carcinoma Patients After Radical Liver Resection: A Multi-Center Study
Xulin Liu, Zhancheng Qiu, Elijah Ndhlovu, Yunyan Wan, Huapeng Sun, Shuai Wang, Yugang Cao & Peng Zhu
Pages: 1127-1141
Published online: 14 Jun 2024
AbstractforEstablishing and Externally Validating a Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score-Based Nomogram for Predicting Early Recurrence in BCLC Stage 0/A Hepatocellular Carcinoma Patients After Radical Liver Resection: A Multi-Center Study | Full Text | References | PDF (5.8 MB) | EPUB
  • 28 Views
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Open Access
Article
Incorporating Inflammatory Markers and Clinical Indicators into a Predictive Model of Single Small Hepatocellular Carcinoma Recurrence After Primary Locoregional Treatments
Wenying Qiao, Yiqi Xiong, Kang Li, Ronghua Jin & Yonghong Zhang
Pages: 1113-1125
Published online: 13 Jun 2024
AbstractforIncorporating Inflammatory Markers and Clinical Indicators into a Predictive Model of Single Small Hepatocellular Carcinoma Recurrence After Primary Locoregional Treatments | Full Text | References | PDF (6.9 MB) | EPUB
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Article
Circ_0007386 Promotes the Progression of Hepatocellular Carcinoma Through the miR-507/ CCNT2 Axis
Yanzhi Feng, Litao Liang, Wenbo Jia, Jinyi Wang, Chao Xu, Deming Zhu, Bin Xu, Wenhu Zhao, Xiangyu Ling, Yongping Zhou, Lianbao Kong & Wenzhou Ding
Pages: 1095-1112
Published online: 02 Jul 2024
AbstractforCirc_0007386 Promotes the Progression of Hepatocellular Carcinoma Through the miR-507/ CCNT2 Axis | Full Text | References | PDF (16.5 MB) | EPUB
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Open Access
Article
Transarterial Chemoembolization Combined with Atezolizumab Plus Bevacizumab versus Transarterial Chemoembolization Alone in Intermediate‐stage Hepatocellular Carcinoma: A Multicenter Retrospective Study
Yitao Zheng, Yanjun Xiang, Hongqi Shi, Zhuoqun Lin, Shuqun Cheng & Jiuting Zhu
Pages: 1079-1093
Published online: 11 Jun 2024
AbstractforTransarterial Chemoembolization Combined with Atezolizumab Plus Bevacizumab versus Transarterial Chemoembolization Alone in Intermediate‐stage Hepatocellular Carcinoma: A Multicenter Retrospective Study | Full Text | References | PDF (6.9 MB) | EPUB
  • 58 Views
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Article
Efficacy and Safety of Transarterial Chemoembolization and Repeated Partial Splenic Embolization for Hepatocellular Carcinoma with Hypersplenism and Thrombocytopenia
Wei Hong, Zizhuo Wang, Wei Yao, Xin Zhang, Lijie Zhang & Bin Liang
Pages: 1065-1078
Published online: 11 Jun 2024
AbstractforEfficacy and Safety of Transarterial Chemoembolization and Repeated Partial Splenic Embolization for Hepatocellular Carcinoma with Hypersplenism and Thrombocytopenia | Full Text | References | PDF (5 MB) | EPUB
  • 42 Views
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Article
Development and Validation of a Novel Prognostic Nomogram Based on Platelet and CD8+T Cell Counts in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombosis
Wanxin Shi, Huiwen Yan, Xiaoli Liu, Lihua Yu, Yuqing Xie, Yuan Wu, Yuling Liang & Zhiyun Yang
Pages: 1049-1063
Published online: 07 Jun 2024
AbstractforDevelopment and Validation of a Novel Prognostic Nomogram Based on Platelet and CD8+T Cell Counts in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombosis | Full Text | References | PDF (5.7 MB) | EPUB
  • 32 Views
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Open Access
Article
LAYN Serves as a Prognostic Biomarker and Downregulates Tumor-Infiltrating CD8+ T Cell Function in Hepatocellular Carcinoma
Shuxiu Xiao, Lili Lu, Zhiyuan Lin, Xinming Ye, Sheng Su, Chenlu Zhang, Yang You, Wei Li, Xiaowu Huang, Weizhong Wu & Yuhong Zhou
Pages: 1031-1048
Published online: 06 Jun 2024
AbstractforLAYN Serves as a Prognostic Biomarker and Downregulates Tumor-Infiltrating CD8+ T Cell Function in Hepatocellular Carcinoma | Full Text | References | PDF (16.2 MB) | EPUB
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Article
Changes in Posttreatment Spleen Volume Associated with Immunotherapy Outcomes for Advanced Hepatocellular Carcinoma
Bang-Bin Chen, Po-Chin Liang, Tiffany Ting-Fang Shih, Tsung-Hao Liu, Ying-Chun Shen, Li-Chun Lu, Zhong-Zhe Lin, Chiun Hsu, Chih-Hung Hsu, Ann-Lii Cheng & Yu-Yun Shao
Pages: 1015-1029
Published online: 04 Jun 2024
AbstractforChanges in Posttreatment Spleen Volume Associated with Immunotherapy Outcomes for Advanced Hepatocellular Carcinoma | Full Text | References | PDF (4.2 MB) | EPUB
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CASE REPORT

Case Report
Prolonged Complete Remission Using Tislelizumab for Hepatocellular Carcinoma After Adjuvant Chemotherapy Failure: A Case Report
Xianmin Zhu, Shuang Dong, Jing Tang, Rong Xie, Huijing Wu, Jun Guan & Sheng Hu
Pages: 1005-1013
Published online: 03 Jun 2024
AbstractforProlonged Complete Remission Using Tislelizumab for Hepatocellular Carcinoma After Adjuvant Chemotherapy Failure: A Case Report | Full Text | References | PDF (3 MB) | EPUB
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RAPID COMMUNICATION

Rapid Communication
A Comparison of Presentation, Treatment, and Survival After Hepatocellular Carcinoma of Viral and Non-Viral Etiology in Damietta, Egypt, 2007–2019
Kévin Jean, Ahmed Tawheed, Liem Binh Luong Nguyen, Tarek Heikal, Usama Eldaly, Neveen Gaber Elhadidy, Ahmed Elghaieb, Ahmed Aboudonia, Laura Tondeur, Amélie Dublineau, Arnaud Fontanet & Mohamed El-Kassas
Pages: 997-1004
Published online: 01 Jun 2024
AbstractforA Comparison of Presentation, Treatment, and Survival After Hepatocellular Carcinoma of Viral and Non-Viral Etiology in Damietta, Egypt, 2007–2019 | Full Text | References | PDF (1.5 MB) | EPUB
  • 63 Views
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REVIEW

Review
CRISPR in Targeted Therapy and Adoptive T Cell Immunotherapy for Hepatocellular Carcinoma
Fahreddin Palaz, Mehmet Ozsoz, Ali Zarrinpar & Ilyas Sahin
Pages: 975-995
Published online: 30 May 2024
AbstractforCRISPR in Targeted Therapy and Adoptive T Cell Immunotherapy for Hepatocellular Carcinoma | Full Text | References | PDF (2.9 MB) | EPUB
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EXPERT OPINION

A Post-International Gastrointestinal Cancers’ Conference (IGICC) Position Statements
Suayib Yalcin, Sahin Lacin, Ahmed Omar Kaseb, Bora Peynircioğlu, Murat Cantasdemir, Barbaros Erhan Çil, Pervin Hurmuz, Ahmet Bülent Doğrul, Murat Fani Bozkurt, Hüseyin Abali, Okan Akhan, Halis Şimşek, Berksoy Sahin, Faruk N Aykan, İdris Yücel, Gürkan Tellioğlu, Fatih Selçukbiricik & Philip A Philip
Pages: 953-974
Published online: 30 May 2024
AbstractforA Post-International Gastrointestinal Cancers’ Conference (IGICC) Position Statements | Full Text | References | PDF (665.1 KB) | EPUB
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ORIGINAL RESEARCH

Article
Prediction of Microvascular Invasion and Recurrence After Curative Resection of LI-RADS Category 5 Hepatocellular Carcinoma on Gd-BOPTA Enhanced MRI
Juan Zhang, Yinqiao Li, Jinju Xia, Xingpeng Pan, Lun Lu, Jiazhao Fu & Ningyang Jia
Pages: 941-952
Published online: 24 May 2024
AbstractforPrediction of Microvascular Invasion and Recurrence After Curative Resection of LI-RADS Category 5 Hepatocellular Carcinoma on Gd-BOPTA Enhanced MRI | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Preoperative Antiviral Therapy and Long-Term Outcomes for Hepatitis B Virus-Related Hepatocellular Carcinoma After Curative Liver Resection: A Multicenter Analysis
Mu-Gen Dai, Si-Yu Liu, Lin Zhu, Wen-Feng Lu, Gui-Lin Xie, Lei Liang, Jun-Wei Liu & Bin Ye
Pages: 927-939
Published online: 23 May 2024
AbstractforPreoperative Antiviral Therapy and Long-Term Outcomes for Hepatitis B Virus-Related Hepatocellular Carcinoma After Curative Liver Resection: A Multicenter Analysis | Full Text | References | PDF (1.8 MB) | EPUB
  • 52 Views
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Article
A Novel Nomogram to Predict Prognosis of Advanced Hepatocellular Carcinoma Treated with Intensity-Modulated Radiotherapy Plus Anti-PD1
Meiling He, Chunfeng Liang, Yadan Pang, Mengjie Jiang, Meiying Long, Zhongqiang Yao, Xiaoting Wang, Ruijun Zhang, Qiaoyuan Wu, Shixiong Liang & Jianxu Li
Pages: 913-925
Published online: 23 May 2024
AbstractforA Novel Nomogram to Predict Prognosis of Advanced Hepatocellular Carcinoma Treated with Intensity-Modulated Radiotherapy Plus Anti-PD1 | Full Text | References | PDF (3.6 MB) | EPUB
  • 37 Views
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Article
A Novel Nomogram to Predict Prognosis in Elderly Early-Stage Hepatocellular Carcinoma Patients After Ablation Therapy
Xiaomeng Tang, Qi Wang, Ronghua Jin & Caixia Hu
Pages: 901-911
Published online: 16 May 2024
AbstractforA Novel Nomogram to Predict Prognosis in Elderly Early-Stage Hepatocellular Carcinoma Patients After Ablation Therapy | Full Text | References | PDF (2.2 MB) | EPUB
  • 58 Views
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Article
Integration of Single-Cell RNA Sequencing and Bulk RNA Sequencing to Identify an Immunogenic Cell Death-Related 5-Gene Prognostic Signature in Hepatocellular Carcinoma
Liqun Peng, Shaohua Xu & Jian-Liang Xu
Pages: 879-900
Published online: 16 May 2024
AbstractforIntegration of Single-Cell RNA Sequencing and Bulk RNA Sequencing to Identify an Immunogenic Cell Death-Related 5-Gene Prognostic Signature in Hepatocellular Carcinoma | Full Text | References | PDF (19.2 MB) | EPUB
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Article
Construction of a Prognostic Model for Hepatocellular Carcinoma Based on Macrophage Polarization-Related Genes
Han Chen, Jianhao Li, Dan Cao & Hong Tang
Pages: 857-878
Published online: 11 May 2024
AbstractforConstruction of a Prognostic Model for Hepatocellular Carcinoma Based on Macrophage Polarization-Related Genes | Full Text | References | PDF (13.9 MB) | EPUB
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Article
Mechanisms of Sorafenib Resistance in HCC Culture Relate to the Impaired Membrane Expression of Organic Cation Transporter 1 (OCT1)
Srinivas Chava, Nergiz Ekmen, Pauline Ferraris, Yucel Aydin, Krzysztof Moroz, Tong Wu, Swan N Thung & Srikanta Dash
Pages: 839-855
Published online: 09 May 2024
AbstractforMechanisms of Sorafenib Resistance in HCC Culture Relate to the Impaired Membrane Expression of Organic Cation Transporter 1 (OCT1) | Full Text | References | PDF (10.2 MB) | EPUB
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Article
PVALB Was Identified as an Independent Prognostic Factor for HCC Closely Related to Immunity, and Its Absence Accelerates Tumor Progression by Regulating NK Cell Infiltration
Yiyang Gong, Minqin Zhou, Yanting Zhu, Jingying Pan, Xuanrui Zhou, Yike Jiang, Hong Zeng, Hao Zheng, Xitong Geng & Da Huang
Pages: 813-838
Published online: 07 May 2024
AbstractforPVALB Was Identified as an Independent Prognostic Factor for HCC Closely Related to Immunity, and Its Absence Accelerates Tumor Progression by Regulating NK Cell Infiltration | Full Text | References | PDF (17.2 MB) | EPUB
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Article
Patterns, Risk Factors, and Outcomes of Recurrence After Hepatectomy for Hepatocellular Carcinoma with and without Microvascular Invasion
Yang Yu, Xiao-Hui Wang, Wen-Jie Hu, De-Hua Chen, Zi-Li Hu & Shao-Qiang Li
Pages: 801-812
Published online: 07 May 2024
AbstractforPatterns, Risk Factors, and Outcomes of Recurrence After Hepatectomy for Hepatocellular Carcinoma with and without Microvascular Invasion | Full Text | References | PDF (4.8 MB) | EPUB
  • 55 Views
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Article
CXCL9 Overexpression Predicts Better HCC Response to Anti-PD-1 Therapy and Promotes N1 Polarization of Neutrophils
Pei Wang, Ming-Hao Xu, Wen-Xin Xu, Zi-Ying Dong, Ying-Hao Shen & Wen-Zheng Qin
Pages: 787-800
Published online: 07 May 2024
AbstractforCXCL9 Overexpression Predicts Better HCC Response to Anti-PD-1 Therapy and Promotes N1 Polarization of Neutrophils | Full Text | References | PDF (5 MB) | EPUB
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Article
A Modified Targetoid Feature Emphasizing Thin-Rim APHE to Improve the Diagnostic Performance of LI-RADS for Malignant Hepatic Tumors
Runqian Huang, Chunling Zheng, Guixiao Xu, Xuanwei Chen, Jingxian Shen & Siyue Mao
Pages: 775-786
Published online: 25 Apr 2024
AbstractforA Modified Targetoid Feature Emphasizing Thin-Rim APHE to Improve the Diagnostic Performance of LI-RADS for Malignant Hepatic Tumors | Full Text | References | PDF (2.5 MB) | EPUB
  • 43 Views
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Article
Clinical Characteristics of Non-B and Non-C Biopsy-Proven Primary Liver Cancers in an HBV- Endemic Area: A Retrospective Study
Zhen Hu & Huaying Zhou
Pages: 767-774
Published online: 24 Apr 2024
AbstractforClinical Characteristics of Non-B and Non-C Biopsy-Proven Primary Liver Cancers in an HBV- Endemic Area: A Retrospective Study | Full Text | References | PDF (1,013.9 KB) | EPUB
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Article
A Novel Four-Gene Signature Based on Nonsense-Mediated RNA Decay for Predicting Prognosis in Hepatocellular Carcinoma: Bioinformatics Analysis and Functional Validation
Jiaxin Zhao, Cheng Wang, Liang Zhao, Huiying Zhou, Rui Wu, Tao Zhang, Jiawei Ding, Junjie Zhou, Huilin Zheng, Lei Zhang, Tianci Kong, Jie Zhou & Zhenhua Hu
Pages: 747-766
Published online: 22 Apr 2024
AbstractforA Novel Four-Gene Signature Based on Nonsense-Mediated RNA Decay for Predicting Prognosis in Hepatocellular Carcinoma: Bioinformatics Analysis and Functional Validation | Full Text | References | PDF (17.7 MB) | EPUB
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Article
Triglyceride-Glucose Index is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients with HBV-Related Liver Cirrhosis
Su-Hua Yang, Yi-Shan He, Shu-Qin Zheng, Xiu-Jun Zhang, Hong Dai & Yuan Xue
Pages: 737-746
Published online: 18 Apr 2024
AbstractforTriglyceride-Glucose Index is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients with HBV-Related Liver Cirrhosis | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Adjuvant Transarterial Chemoembolization Plus Immunotherapy for Huge Hepatocellular Carcinoma: A Propensity Score Matching Cohort Study
Hongwei Huang, Wei Liao, Kaiyue Zhang, Hao Wang, Qi Cheng & Bin Mei
Pages: 721-735
Published online: 07 Apr 2024
AbstractforAdjuvant Transarterial Chemoembolization Plus Immunotherapy for Huge Hepatocellular Carcinoma: A Propensity Score Matching Cohort Study | Full Text | References | PDF (1.9 MB) | EPUB
  • 87 Views
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REVIEW

Review
Macroscopic Characterization of Hepatocellular Carcinoma: An Underexploited Source of Prognostic Factors
Stéphanie Gonvers, Sebastiao N Martins-Filho, André Hirayama, Julien Calderaro, Rebecca Phillips, Emilie Uldry, Nicolas Demartines, Emmanuel Melloul, Young Nyun Park, Valérie Paradis, Swan N Thung, Venancio Alves, Christine Sempoux & Ismail Labgaa
Pages: 707-719
Published online: 09 Apr 2024
AbstractforMacroscopic Characterization of Hepatocellular Carcinoma: An Underexploited Source of Prognostic Factors | Full Text | References | PDF (5.6 MB) | EPUB
  • 58 Views
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ORIGINAL RESEARCH

Article
Development and Validation of a Nomogram for Patients Undergoing Transarterial Chemoembolization for Recurrent Hepatocellular Carcinoma After Hepatectomy
Diyang Xie, Zhongchen Li, Jia Yuan, Xin Yin, Rongxin Chen, Lan Zhang & Zhenggang Ren
Pages: 693-705
Published online: 04 Apr 2024
AbstractforDevelopment and Validation of a Nomogram for Patients Undergoing Transarterial Chemoembolization for Recurrent Hepatocellular Carcinoma After Hepatectomy | Full Text | References | PDF (6.3 MB) | EPUB
  • 46 Views
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Article
Machine Learning Model Based on the Neutrophil-to-Eosinophil Ratio Predicts the Recurrence of Hepatocellular Carcinoma After Surgery
Guanming Shao, Yonghui Ma, Chao Qu, Ruiqian Gao, Chengzhan Zhu, Linlin Qu, Kui Liu, Na Li, Peng Sun & Jingyu Cao
Pages: 679-691
Published online: 03 Apr 2024
AbstractforMachine Learning Model Based on the Neutrophil-to-Eosinophil Ratio Predicts the Recurrence of Hepatocellular Carcinoma After Surgery | Full Text | References | PDF (6.5 MB) | EPUB
  • 72 Views
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Article
Hepatic Arterial Infusion Chemotherapy vs Transcatheter Arterial Chemoembolization as Adjuvant Therapy Following Surgery for MVI-Positive Hepatocellular Carcinoma: A Multicenter Propensity Score Matching Analysis
Yuhua Wen, Lianghe Lu, Jie Mei, Yihong Ling, Renguo Guan, Wenping Lin, Wei Wei & Rongping Guo
Pages: 665-678
Published online: 03 Apr 2024
AbstractforHepatic Arterial Infusion Chemotherapy vs Transcatheter Arterial Chemoembolization as Adjuvant Therapy Following Surgery for MVI-Positive Hepatocellular Carcinoma: A Multicenter Propensity Score Matching Analysis | Full Text | References | PDF (3.6 MB) | EPUB
  • 82 Views
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Article
High-Risk Hepatocellular Carcinoma: Hepatic Arterial Infusion Chemotherapy versus Transarterial Chemoembolization
Baogen Zhang, Biqing Huang, Fan Yang, Jiandong Yang, Man Kong, Jing Wang, Yaoxian Xiang, Kangjie Wang, Ruchen Peng, Kun Yang, Chao An & Dong Yan
Pages: 651-663
Published online: 27 Mar 2024
AbstractforHigh-Risk Hepatocellular Carcinoma: Hepatic Arterial Infusion Chemotherapy versus Transarterial Chemoembolization | Full Text | References | PDF (3.6 MB) | EPUB
  • 99 Views
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REVIEW

Review
The State of Systematic Therapies in Clinic for Hepatobiliary Cancers
Weixun Chen, Zhengnan Hu, Ganxun Li, Lei Zhang & Tao Li
Pages: 629-649
Published online: 27 Mar 2024
AbstractforThe State of Systematic Therapies in Clinic for Hepatobiliary Cancers | Full Text | References | PDF (750.2 KB) | EPUB
  • 113 Views
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ORIGINAL RESEARCH

Article
The Influence of Drug-Eluting Beads Transarterial Chemoembolization on Serum Levels of Soluble Programmed Cell Death Protein-1 in Advanced Hepatocellular Carcinoma Patients
Xiaochen Ma, Xiangyang Sun, Fubo Xie, Wencheng Jian, Qingliang Wang, Yang Xie, Caixia Li & Kai Zhang
Pages: 619-628
Published online: 25 Mar 2024
AbstractforThe Influence of Drug-Eluting Beads Transarterial Chemoembolization on Serum Levels of Soluble Programmed Cell Death Protein-1 in Advanced Hepatocellular Carcinoma Patients | Full Text | References | PDF (3.7 MB) | EPUB
  • 45 Views
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Article
Development of a Reliable GADSAH Model for Differentiating AFP-negative Hepatic Benign and Malignant Occupying Lesions
Xiaoling Long, Huan Zeng, Yun Zhang, Qiulong Lu, Zhao Cao & Hong Shu
Pages: 607-618
Published online: 23 Mar 2024
AbstractforDevelopment of a Reliable GADSAH Model for Differentiating AFP-negative Hepatic Benign and Malignant Occupying Lesions | Full Text | References | PDF (3.1 MB) | EPUB
  • 54 Views
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Article
Enhancement Pattern Mapping for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis
Newsha Nikzad, David Thomas Fuentes, Millicent Roach, Tasadduk Chowdhury, Matthew Cagley, Mohamed Badawy, Ahmed Elkhesen, Manal Hassan, Khaled M Elsayes, Laura Beretta, Eugene Jon Koay & Prasun Kumar Jalal
Pages: 595-606
Published online: 19 Mar 2024
AbstractforEnhancement Pattern Mapping for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis | Full Text | References | PDF (2.4 MB) | EPUB
  • 114 Views
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REVIEW

Review
Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma
Pinggui Chen, Yaoxuan Li, Yunyan Dai, Zhiming Wang, Yunpeng Zhou, Yi Wang & Gaopeng Li
Pages: 581-594
Published online: 19 Mar 2024
AbstractforAdvances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma | Full Text | References | PDF (6.9 MB) | EPUB
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ORIGINAL RESEARCH

Article
Plumbagin Regulates Snail to Inhibit Hepatocellular Carcinoma Epithelial-Mesenchymal Transition in vivo and in vitro
Yuan-Qin Du, Bin Yuan, Yi-Xian Ye, Feng-ling Zhou, Hong Liu, Jing-Jing Huang & Yan-Fei Wei
Pages: 565-580
Published online: 19 Mar 2024
AbstractforPlumbagin Regulates Snail to Inhibit Hepatocellular Carcinoma Epithelial-Mesenchymal Transition in vivo and in vitro | Full Text | References | PDF (10.3 MB) | EPUB
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CORRIGENDUM

Correction
Prognostic Effect of Sarcopenia in Hepatocellular Carcinoma Patients Targeted with Interventional Therapy Combined with Immunotherapy and Targeted Therapy [Corrigendum]
Pages: 563-564
Published online: 13 Mar 2024
CitationforPrognostic Effect of Sarcopenia in Hepatocellular Carcinoma Patients Targeted with Interventional Therapy Combined with Immunotherapy and Targeted Therapy [Corrigendum] | Full Text | PDF (246.2 KB) | EPUB
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ORIGINAL RESEARCH

Article
LncRNA MEG3 Reduces the Ratio of M2/M1 Macrophages Through the HuR/CCL5 Axis in Hepatocellular Carcinoma
Huamei Wei, Xianjian Wu, Lizheng Huang, Chen Long, Qi Lu, Zheng Huang, Yanyan Huang, Wenchuan Li & Jian Pu
Pages: 543-562
Published online: 11 Mar 2024
AbstractforLncRNA MEG3 Reduces the Ratio of M2/M1 Macrophages Through the HuR/CCL5 Axis in Hepatocellular Carcinoma | Full Text | References | PDF (15.3 MB) | EPUB
  • 105 Views
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Open Access
Article
A Hypoxia-Related miRNA-mRNA Signature for Predicting the Response and Prognosis of Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma
Shaoqi Zong, Guokai Huang, Bo Pan, Shasha Zhao, Changquan Ling & Binbin Cheng
Pages: 525-542
Published online: 11 Mar 2024
AbstractforA Hypoxia-Related miRNA-mRNA Signature for Predicting the Response and Prognosis of Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma | Full Text | References | PDF (9.4 MB) | EPUB
  • 93 Views
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Article
Machine Learning-Based Nomogram for Predicting Overall Survival in Elderly Patients with Cirrhotic Hepatocellular Carcinoma Undergoing Ablation Therapy
Wenying Qiao, Shugui Sheng, Junnan Li, Ronghua Jin & Caixia Hu
Pages: 509-523
Published online: 06 Mar 2024
AbstractforMachine Learning-Based Nomogram for Predicting Overall Survival in Elderly Patients with Cirrhotic Hepatocellular Carcinoma Undergoing Ablation Therapy | Full Text | References | PDF (7.4 MB) | EPUB
  • 107 Views
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Article
Construction and Validation of a Novel Nomogram Predicting Recurrence in Alpha-Fetoprotein-Negative Hepatocellular Carcinoma Post-Surgery Using an Innovative Liver Function-Nutrition-Inflammation-Immune (LFNII) Score: A Bicentric Investigation
Bo-Lun Zhang, Jia Liu, Guanghao Diao, Jianping Chang, Junshuai Xue, Zhen Huang, Hong Zhao, Lingxiang Yu & Jianqiang Cai
Pages: 489-508
Published online: 05 Mar 2024
AbstractforConstruction and Validation of a Novel Nomogram Predicting Recurrence in Alpha-Fetoprotein-Negative Hepatocellular Carcinoma Post-Surgery Using an Innovative Liver Function-Nutrition-Inflammation-Immune (LFNII) Score: A Bicentric Investigation | Full Text | References | PDF (12.3 MB) | EPUB
  • 96 Views
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Article
Efficacy and Safety of HepaSphere Drug-Eluting Bead Transarterial Chemoembolization Combined with Hepatic Arterial Infusion Chemotherapy as the Second-Line Treatment in Advanced Hepatocellular Carcinoma
Baojiang Liu, Song Gao, Jianhai Guo, Fuxin Kou, Shaoxing Liu, Xin Zhang, Aiwei Feng, Xiaodong Wang, Guang Cao, Hui Chen, Peng Liu, Haifeng Xu, Qinzong Gao, Renjie Yang, Liang Xu & Xu Zhu
Pages: 477-488
Published online: 04 Mar 2024
AbstractforEfficacy and Safety of HepaSphere Drug-Eluting Bead Transarterial Chemoembolization Combined with Hepatic Arterial Infusion Chemotherapy as the Second-Line Treatment in Advanced Hepatocellular Carcinoma | Full Text | References | PDF (2.5 MB) | EPUB
  • 107 Views
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Article
Efficacy and Safety of Conversion Surgery for Advanced Hepatocellular Carcinoma After Hepatic Arterial Infusion Chemotherapy
Wenxuan Li, Zhikai Zheng, Jiongliang Wang, Tianqing Wu, Juncheng Wang, Yangxun Pan, Jinbin Chen, Dandan Hu, Li Xu, Yaojun Zhang, Minshan Chen & Zhongguo Zhou
Pages: 463-475
Published online: 04 Mar 2024
AbstractforEfficacy and Safety of Conversion Surgery for Advanced Hepatocellular Carcinoma After Hepatic Arterial Infusion Chemotherapy | Full Text | References | PDF (2.6 MB) | EPUB
  • 76 Views
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Article
Plasma Growth Hormone as a Prognostic Biomarker to Durvalumab and Tremelimumab in Patients with Advanced Hepatocellular Carcinoma
Shadi Chamseddine, Michael LaPelusa, Lianchun Xiao, Yehia I Mohamed, Sunyoung S Lee, Zishuo Ian Hu, Rikita I Hatia, Manal Hassan, James C Yao, Dan G Duda, Saumil Datar, Hesham M Amin & Ahmed O Kaseb
Pages: 455-461
Published online: 04 Mar 2024
AbstractforPlasma Growth Hormone as a Prognostic Biomarker to Durvalumab and Tremelimumab in Patients with Advanced Hepatocellular Carcinoma | Full Text | References | PDF (1.1 MB) | EPUB
  • 95 Views
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Article
Biochemical Safety of SBRT to Multiple Intrahepatic Lesions for Hepatocellular Carcinoma
Jacob T Hall, Andrew M Moon, Michael Young, Xianming Tan, Rami Darawsheh, Flora Danquah, Joel E Tepper & Ted K Yanagihara
Pages: 443-454
Published online: 05 Mar 2024
AbstractforBiochemical Safety of SBRT to Multiple Intrahepatic Lesions for Hepatocellular Carcinoma | Full Text | References | PDF (472.2 KB) | EPUB
  • 117 Views
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Article
Multiple Machine-Learning Fusion Model Based on Gd-EOB-DTPA-Enhanced MRI and Aminotransferase-to-Platelet Ratio and Gamma-Glutamyl Transferase-to-Platelet Ratio to Predict Microvascular Invasion in Solitary Hepatocellular Carcinoma: A Multicenter Study
Fei Wang, Chun Yue Yan, Yuan Qin, Zheng Ming Wang, Dan Liu, Ying He, Ming Yang, Li Wen & Dong Zhang
Pages: 427-442
Published online: 29 Feb 2024
AbstractforMultiple Machine-Learning Fusion Model Based on Gd-EOB-DTPA-Enhanced MRI and Aminotransferase-to-Platelet Ratio and Gamma-Glutamyl Transferase-to-Platelet Ratio to Predict Microvascular Invasion in Solitary Hepatocellular Carcinoma: A Multicenter Study | Full Text | References | PDF (7.4 MB) | EPUB
  • 84 Views
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Article
Risks and Clinical Predictors of Hepatocellular Carcinoma in Chinese Populations: A Real-World Study of 10,359 Patients in Six Medical Centers
Chenjun Huang, Xiao Xiao, Lin Tong, Zhiyuan Gao, Jun Ji, Lin Zhou, Ya Li, Lijuan Liu, Huijuan Feng, Meng Fang & Chunfang Gao
Pages: 411-425
Published online: 26 Feb 2024
AbstractforRisks and Clinical Predictors of Hepatocellular Carcinoma in Chinese Populations: A Real-World Study of 10,359 Patients in Six Medical Centers | Full Text | References | PDF (3 MB) | EPUB
  • 107 Views
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Article
Atezolizumab Plus Bevacizumab Combined with Transarterial Embolization Plus Hepatic Arterial Infusion Chemotherapy for Unresectable Hepatocellular Carcinoma with a Diameter >8 Cm: A Retrospective Study
Hongjie Cai, Song Chen, Zhiqiang Wu, Fan Wang, Shuangyan Tang, Ludan Chen & Wenbo Guo
Pages: 399-409
Published online: 26 Feb 2024
AbstractforAtezolizumab Plus Bevacizumab Combined with Transarterial Embolization Plus Hepatic Arterial Infusion Chemotherapy for Unresectable Hepatocellular Carcinoma with a Diameter >8 Cm: A Retrospective Study | Full Text | References | PDF (2.8 MB) | EPUB
  • 112 Views
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Article
A Deep Learning Model Combining Multimodal Factors to Predict the Overall Survival of Transarterial Chemoembolization
Zhongqi Sun, Xin Li, Hongwei Liang, Zhongxing Shi & Hongjia Ren
Pages: 385-397
Published online: 25 Feb 2024
AbstractforA Deep Learning Model Combining Multimodal Factors to Predict the Overall Survival of Transarterial Chemoembolization | Full Text | References | PDF (5.2 MB) | EPUB
  • 141 Views
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Article
Single-Cell RNA Sequencing Revealed That the Enrichment of TPI1+ Malignant Hepatocytes Was Linked to HCC Metastasis and Immunosuppressive Microenvironment
Yuxin Liang, Deyuan Zhong, Qinyan Yang, Yuan Tang, Yingying Qin, Yuhao Su, Xiaolun Huang & Jin Shang
Pages: 373-383
Published online: 21 Feb 2024
AbstractforSingle-Cell RNA Sequencing Revealed That the Enrichment of TPI1+ Malignant Hepatocytes Was Linked to HCC Metastasis and Immunosuppressive Microenvironment | Full Text | References | PDF (9.2 MB) | EPUB
  • 130 Views
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REVIEW

Review
Systemic Drugs for Hepatocellular Carcinoma: What Do Recent Clinical Trials Reveal About Sequencing and the Emerging Complexities of Clinical Decisions?
Vera Himmelsbach, Christine Koch, Jörg Trojan & Fabian Finkelmeier
Pages: 363-372
Published online: 18 Feb 2024
AbstractforSystemic Drugs for Hepatocellular Carcinoma: What Do Recent Clinical Trials Reveal About Sequencing and the Emerging Complexities of Clinical Decisions? | Full Text | References | PDF (543 KB) | EPUB
  • 182 Views
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EXPERT OPINION

Treatment Patterns and Recommendations for Improving the Management of Hepatocellular Carcinoma in Saudi Arabia
Ashwaq Alolyan, Kanan Alshammari, Mohammad Arabi, Ahmed Alshehri, Hamad Alsuhaibani, Fahad Ibnshamsah, Abdullah Alsharm, Mervat Mahrous, Adnan Al Zanbagi, Mazen Hassanain & Shouki Bazarbashi
Pages: 349-362
Published online: 16 Feb 2024
AbstractforTreatment Patterns and Recommendations for Improving the Management of Hepatocellular Carcinoma in Saudi Arabia | Full Text | References | PDF (4.8 MB) | EPUB
  • 178 Views
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RESPONSE TO LETTER

Letter
Effect of Different Liver Resection Modalities on the Prognosis of Patients with Hepatocellular Carcinoma on the Left Lateral Lobe [Response to Letter]
Jianwei Liu, Minmin Sun, Kunpeng Fang, Jie Wang, Bowen Ma, Li Song, Ting Liu, Ming Tang, Kui Wang & Yong Xia
Pages: 347-348
Published online: 14 Feb 2024
CitationforEffect of Different Liver Resection Modalities on the Prognosis of Patients with Hepatocellular Carcinoma on the Left Lateral Lobe [Response to Letter] | Full Text | PDF (257.8 KB) | EPUB
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REVIEW

Review
Lipid Metabolism as a Potential Target of Liver Cancer
Kangze Wu & Feizhuan Lin
Pages: 327-346
Published online: 13 Feb 2024
AbstractforLipid Metabolism as a Potential Target of Liver Cancer | Full Text | References | PDF (4.2 MB) | EPUB
  • 193 Views
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ORIGINAL RESEARCH

Article
The Index sAGP is Valuable for Distinguishing Atypical Hepatocellular Carcinoma from Atypical Benign Focal Hepatic Lesions
Qing-Qing Luo, Qiao-Nan Li, Dan Cai, Song Jiang, Shao-Song Liu, Mao-Sheng Liu, Cong Lv, Jin-Ke Wang, Kun-He Zhang & Ting Wang
Pages: 317-325
Published online: 08 Feb 2024
AbstractforThe Index sAGP is Valuable for Distinguishing Atypical Hepatocellular Carcinoma from Atypical Benign Focal Hepatic Lesions | Full Text | References | PDF (3.2 MB) | EPUB
  • 72 Views
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Article
Lymphocyte-to-C Reactive Protein Ratio is an Independent Predictor of Survival Benefits for Hepatocellular Carcinoma Patients Receiving Radiotherapy
Zhan Shi, Sihui Zhu, Yuncheng Jin, Liang Qi, Mingzhen Zhou, Ziyan Zhou, Juan Zhang, Baorui Liu & Jie Shen
Pages: 305-316
Published online: 12 Feb 2024
AbstractforLymphocyte-to-C Reactive Protein Ratio is an Independent Predictor of Survival Benefits for Hepatocellular Carcinoma Patients Receiving Radiotherapy | Full Text | References | PDF (3.9 MB) | EPUB
  • 88 Views
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Article
RAD21: A Key Transcriptional Regulator in the Development of Residual Liver Cancer
Jin-Shu Pang, Xiu-Mei Bai, Wei-Jun Wan, Tong Kang, Rong Wen, Li-Peng Li, Hai-Hui Yin, Chun-Miao Lu, Dong-Yue Wen, Yun He & Hong Yang
Pages: 285-304
Published online: 05 Feb 2024
AbstractforRAD21: A Key Transcriptional Regulator in the Development of Residual Liver Cancer | Full Text | References | PDF (17.4 MB) | EPUB
  • 125 Views
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Article
Development and Validation of a Prognostic Nomogram for Patients with AFP and DCP Double-Negative Hepatocellular Carcinoma After Local Ablation
Wenying Qiao, Jiashuo Li, Qi Wang, Ronghua Jin & Honghai Zhang
Pages: 271-284
Published online: 03 Feb 2024
AbstractforDevelopment and Validation of a Prognostic Nomogram for Patients with AFP and DCP Double-Negative Hepatocellular Carcinoma After Local Ablation | Full Text | References | PDF (6.8 MB) | EPUB
  • 90 Views
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Article
Immunotherapy Efficacy in Advanced Hepatocellular Carcinoma in a Diverse and Underserved Population in the United States
Fernand Bteich, Kush Desai, Chenxin Zhang, Anahat Kaur, Rachel A Levy, Lydia Bioh, Aaron Wang, Sharmin Sultana, Andreas Kaubisch, Milan Kinkhabwala, Sarah Bellemare, Shabnam Fidvi, Devaraju Kanmaniraja, Robert Berkenblit, Jee-Young Moon, Adebola Adedimeji, Clara Y Tow & Yvonne Saenger
Pages: 257-269
Published online: 03 Feb 2024
AbstractforImmunotherapy Efficacy in Advanced Hepatocellular Carcinoma in a Diverse and Underserved Population in the United States | Full Text | References | PDF (4.2 MB) | EPUB
  • 133 Views
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Article
Development and Validation of a Novel Nomogram Integrated with Hypoxic and Lactate Metabolic Characteristics for Prognosis Prediction in Hepatocellular Carcinoma
Xun Qiu, Libin Dong, Kai Wang, Xinyang Zhong, Hanzhi Xu, Shengjun Xu, Haijun Guo, Xuyong Wei, Wei Chen & Xiao Xu
Pages: 241-255
Published online: 01 Feb 2024
AbstractforDevelopment and Validation of a Novel Nomogram Integrated with Hypoxic and Lactate Metabolic Characteristics for Prognosis Prediction in Hepatocellular Carcinoma | Full Text | References | PDF (13.3 MB) | EPUB
  • 125 Views
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Article
Prediction of Non-Transplantable Recurrence After Liver Resection for Solitary Hepatocellular Carcinoma
Chunhui Zhang, Yuqing Tao, Rui Yang, Yueqi Wang, Yanyan Yu & Yang Zhou
Pages: 229-240
Published online: 25 Jan 2024
AbstractforPrediction of Non-Transplantable Recurrence After Liver Resection for Solitary Hepatocellular Carcinoma | Full Text | References | PDF (3.5 MB) | EPUB
  • 94 Views
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Article
A Longitudinal Study of AFP Trajectories and Clinical Outcomes in Intermediate-Stage Hepatocellular Carcinoma After Hepatectomy
Hongyi Yang, Linbin Lu, Wanting Guo, Baocuo Gong, Xuewen Wang, Yaying Chen & Xiong Chen
Pages: 219-228
Published online: 25 Jan 2024
AbstractforA Longitudinal Study of AFP Trajectories and Clinical Outcomes in Intermediate-Stage Hepatocellular Carcinoma After Hepatectomy | Full Text | References | PDF (4 MB) | EPUB
  • 111 Views
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Article
Liver Injury and Its Impact on Prognosis in Patients with HBV-Related Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitors Plus Immune Checkpoint Inhibitors
Jiaming Shen, Xia Wang, Guangde Yang, Li Li, Juanjuan Fu, Wei Xu, Qingqiao Zhang & Xiucheng Pan
Pages: 207-217
Published online: 24 Jan 2024
AbstractforLiver Injury and Its Impact on Prognosis in Patients with HBV-Related Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitors Plus Immune Checkpoint Inhibitors | Full Text | References | PDF (2.2 MB) | EPUB
  • 118 Views
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Article
A Grading System of Microvascular Invasion for Patients with Hepatocellular Carcinoma Undergoing Liver Resection with Curative Intent: A Multicenter Study
Han Wang, Jun-Jie Chen, Shu-Yi Yin, Xia Sheng, Hong-Xia Wang, Wan Yee Lau, Hui Dong & Wen-Ming Cong
Pages: 191-206
Published online: 24 Jan 2024
AbstractforA Grading System of Microvascular Invasion for Patients with Hepatocellular Carcinoma Undergoing Liver Resection with Curative Intent: A Multicenter Study | Full Text | References | PDF (8 MB) | EPUB
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Article
Prognostic Effect of Sarcopenia in Hepatocellular Carcinoma Patients Targeted with Interventional Therapy Combined with Immunotherapy and Targeted Therapy
Hongcai Yang, Tianhao Cong, Yingen Luo, Chao Yang, Jinrui Ren & Xiao Li
Pages: 175-189
Published online: 24 Jan 2024
AbstractforPrognostic Effect of Sarcopenia in Hepatocellular Carcinoma Patients Targeted with Interventional Therapy Combined with Immunotherapy and Targeted Therapy | Full Text | References | PDF (3.4 MB) | EPUB
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LETTER

Effect of Different Liver Resection Modalities on the Prognosis of Patients with Hepatocellular Carcinoma on the Left Lateral Lobe [Letter]
Changzhi Chen, Jieyun Cai & Ling Li
Pages: 173-174
Published online: 23 Jan 2024
CitationforEffect of Different Liver Resection Modalities on the Prognosis of Patients with Hepatocellular Carcinoma on the Left Lateral Lobe [Letter] | Full Text | References | PDF (265.2 KB) | EPUB
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REVIEW

Review
The Role of Type 2 Diabetes Mellitus–Related Risk Factors and Drugs in Hepatocellular Carcinoma
Yuhua Mai, Liheng Meng, Ganlu Deng & Yingfen Qin
Pages: 159-171
Published online: 23 Jan 2024
AbstractforThe Role of Type 2 Diabetes Mellitus–Related Risk Factors and Drugs in Hepatocellular Carcinoma | Full Text | References | PDF (2.1 MB) | EPUB
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ORIGINAL RESEARCH

Article
Monocyte-to-High-Density Lipoprotein-Cholesterol Ratio Predicts Prognosis of Hepatocellular Carcinoma in Patients with Metabolic-Associated Fatty Liver Disease
Tongguo Miao, Xianzhe Lou, Shiming Dong, Xiaoxiao Zhang, Weiwei Guan, Ying Zhang, Lu Li, Xiwei Yuan, Dong Ma & Yuemin Nan
Pages: 145-157
Published online: 23 Jan 2024
AbstractforMonocyte-to-High-Density Lipoprotein-Cholesterol Ratio Predicts Prognosis of Hepatocellular Carcinoma in Patients with Metabolic-Associated Fatty Liver Disease | Full Text | References | PDF (6.6 MB) | EPUB
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Article
Serum Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) as a Potential Biomarker for Diagnosis of Hepatocellular Carcinoma
Ziran Wang, Lingjun Kong, Rui Zhang, Xiaobo Yang, Zhe Cao, Tengda Xu, Han Zhang & Yaling Dou
Pages: 131-143
Published online: 16 Jan 2024
AbstractforSerum Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) as a Potential Biomarker for Diagnosis of Hepatocellular Carcinoma | Full Text | References | PDF (4.3 MB) | EPUB
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REVIEW

Review
Advances in Targeted Drug Resistance Associated with Dysregulation of Lipid Metabolism in Hepatocellular Carcinoma
Xiaoju Huang, Mengmeng Wang, Dan Zhang, Chen Zhang & Pian Liu
Pages: 113-129
Published online: 15 Jan 2024
AbstractforAdvances in Targeted Drug Resistance Associated with Dysregulation of Lipid Metabolism in Hepatocellular Carcinoma | Full Text | References | PDF (1.6 MB) | EPUB
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ORIGINAL RESEARCH

Article
The Role of GNMT and MMP12 Expression in Determining TACE Efficacy: Validation at Transcription and Protein Levels
Tianhao Cong, Chao Yang, Qi Cao, Jinrui Ren, Yingen Luo, Pei Yuan, Bo Zheng, Yu Liu, Hongcai Yang, Wendi Kang, Aixin Ou & Xiao Li
Pages: 95-111
Published online: 16 Jan 2024
AbstractforThe Role of GNMT and MMP12 Expression in Determining TACE Efficacy: Validation at Transcription and Protein Levels | Full Text | References | PDF (10.1 MB) | EPUB
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Article
First-Line Treatment for Advanced Hepatocellular Carcinoma: A Three-Armed Real-World Comparison
Robert Mahn, Oscar André Glüer, Farsaneh Sadeghlar, Christian Möhring, Taotao Zhou, Thomas Anhalt, Malte Benedikt Monin, Alexander Kania, Tim R Glowka, Georg Feldmann, Peter Brossart, Joerg C Kalff, Ingo GH Schmidt-Wolf, Christian P Strassburg & Maria A Gonzalez-Carmona
Pages: 81-94
Published online: 12 Jan 2024
AbstractforFirst-Line Treatment for Advanced Hepatocellular Carcinoma: A Three-Armed Real-World Comparison | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Development and Validation of a Nomogram to Predict the Recurrence of HCC Patients Undergoing CECT After Ablation
Wenying Qiao, Zibo Fan, Qi Wang, Ronghua Jin & Caixia Hu
Pages: 65-79
Published online: 12 Jan 2024
AbstractforDevelopment and Validation of a Nomogram to Predict the Recurrence of HCC Patients Undergoing CECT After Ablation | Full Text | References | PDF (8.8 MB) | EPUB
  • 115 Views
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Article
A Retrospective Study on Predicting Recurrence of Intermediate-Stage Hepatocellular Carcinoma After Radical Therapy
Ruyu Han, Leijuan Gan, Mengran Lang, Guangtao Li, Lu Chen, Xindi Tian, Kangwei Zhu, Liyu Sun & Tianqiang Song
Pages: 51-64
Published online: 11 Jan 2024
AbstractforA Retrospective Study on Predicting Recurrence of Intermediate-Stage Hepatocellular Carcinoma After Radical Therapy | Full Text | References | PDF (4.9 MB) | EPUB
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Article
PD1 and TIM3 Expression is Associated with Very Early Hepatocellular Carcinoma Recurrence After Percutaneous Thermal Ablation
Julien Ghelfi, Zuzana Macek Jilkova, Christian Sengel, Bleuenn Brusset, Yann Teyssier, Charlotte Costentin, Marion Mercey-Ressejac, Lucile Dumolard, Marc Manceau, Eliott Mathieu, Ivan Bricault & Thomas Decaens
Pages: 39-50
Published online: 08 Jan 2024
AbstractforPD1 and TIM3 Expression is Associated with Very Early Hepatocellular Carcinoma Recurrence After Percutaneous Thermal Ablation | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Efficacy and Safety of Transarterial Chemoembolization Plus Donafenib with or without Immune Checkpoint Inhibitors as the First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Propensity Score Matching Analysis
Liwei Deng, Yanyuan Sun, Haiqing Wang, Changli Liao, Deshan Li, Guohui Xu & Xuegang Yang
Pages: 29-38
Published online: 08 Jan 2024
AbstractforEfficacy and Safety of Transarterial Chemoembolization Plus Donafenib with or without Immune Checkpoint Inhibitors as the First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Propensity Score Matching Analysis | Full Text | References | PDF (2 MB) | EPUB
  • 132 Views
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Article
PRMT1 Integrates Immune Microenvironment and Fatty Acid Metabolism Response in Progression of Hepatocellular Carcinoma
Jia Yan, Ke xin Li, Lei Yu, Heng ye Yuan, Zhi min Zhao, Jing Lin & Chang Shan Wang
Pages: 15-27
Published online: 05 Jan 2024
AbstractforPRMT1 Integrates Immune Microenvironment and Fatty Acid Metabolism Response in Progression of Hepatocellular Carcinoma | Full Text | References | PDF (9.4 MB) | EPUB
  • 155 Views
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Article
An Engineered Influenza a Virus Expressing the Co-Stimulator OX40L as an Oncolytic Agent Against Hepatocellular Carcinoma
Hao Yang, Guanglin Lei, Zhuoya Deng, Fang Sun, Yuying Tian, Jinxia Cheng, Hongyu Yu, Cong Li, Changqing Bai, Shaogeng Zhang, Guangwen An & Penghui Yang
Pages: 1-13
Published online: 08 Jan 2024
AbstractforAn Engineered Influenza a Virus Expressing the Co-Stimulator OX40L as an Oncolytic Agent Against Hepatocellular Carcinoma | Full Text | References | PDF (5.7 MB) | EPUB
  • 188 Views
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