Incorporating Inflammatory Markers and Clinical Indicators into a Predictive Model of Single Small Hepatocellular Carcinoma Recurrence After Primary Locoregional Treatments

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Moon AM, Singal AG, Tapper EB. Contemporary epidemiology of chronic liver disease and cirrhosis. Clin Gastroenterol Hepatol. 2020;18(12):2650–2666. doi:10.1016/j.cgh.2019.07.060
   PubMed Web of Science ®Google Scholar
• Omata M, Cheng AL, Kokudo N, et al. Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Hepatol Int. 2017;11(4):317–370. doi:10.1007/s12072-017-9799-9
   PubMed Web of Science ®Google Scholar
• Reig M, Forner A, Rimola J, et al. BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update. J Hepatol. 2022;76(3):681–693. doi:10.1016/j.jhep.2021.11.018
   PubMed Web of Science ®Google Scholar
• Sapisochin G, Bruix J. Liver transplantation for hepatocellular carcinoma: outcomes and novel surgical approaches. Nat Rev Gastroenterol Hepatol. 2017;14(4):203–217. doi:10.1038/nrgastro.2016.193
   PubMed Web of Science ®Google Scholar
• Wu S, Li Z, Yao C, et al. Progression of hepatocellular carcinoma after radiofrequency ablation: current status of research. Front Oncol. 2022;12:1032746. doi:10.3389/fonc.2022.1032746
   PubMedGoogle Scholar
• Bai XM, Cui M, Yang W, et al. The 10-year survival analysis of radiofrequency ablation for solitary hepatocellular carcinoma 5 cm or smaller: primary versus recurrent HCC. Radiology. 2021;300(2):458–469. doi:10.1148/radiol.2021200153
   PubMed Web of Science ®Google Scholar
• Erstad DJ, Tanabe KK. Hepatocellular carcinoma: early-stage management challenges. J Hepatocell Carcinoma. 2017;4:81–92. doi:10.2147/jhc.S107370
   PubMed Web of Science ®Google Scholar
• Llovet JM, Kelley RK, Villanueva A, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7(1):6. doi:10.1038/s41572-020-00240-3
   PubMed Web of Science ®Google Scholar
• Bruix J, Reig M, Sherman M. Evidence-based diagnosis, staging, and treatment of patients with hepatocellular carcinoma. Gastroenterology. 2016;150(4):835–853. doi:10.1053/j.gastro.2015.12.041
   PubMed Web of Science ®Google Scholar
• Marrero JA, Kulik LM, Sirlin CB, et al. Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American association for the study of liver diseases. Hepatology. 2018;68(2):723–750. doi:10.1002/hep.29913
   PubMed Web of Science ®Google Scholar
• Tsilimigras DI, Bagante F, Sahara K, et al. Prognosis after resection of Barcelona clinic liver cancer (BCLC) Stage 0, A, and B hepatocellular carcinoma: a comprehensive assessment of the current BCLC classification. Ann Surg Oncol. 2019;26(11):3693–3700. doi:10.1245/s10434-019-07580-9
   PubMed Web of Science ®Google Scholar
• Feng LH, Sun HC, Zhu XD, et al. Prognostic nomograms and risk classifications of outcomes in very early-stage hepatocellular carcinoma patients after hepatectomy. Eur J Surg Oncol. 2021;47(3):681–689. doi:10.1016/j.ejso.2020.10.039
   PubMed Web of Science ®Google Scholar
• Galle PR, Forner A, Llovet JM, et al. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69(1):182–236. doi:10.1016/j.jhep.2018.03.019
   PubMed Web of Science ®Google Scholar
• Wang Q, Qiao W, Zhang H, et al. Nomogram established on account of Lasso-Cox regression for predicting recurrence in patients with early-stage hepatocellular carcinoma. Front Immunol. 2022;13:1019638. doi:10.3389/fimmu.2022.1019638
   PubMed Web of Science ®Google Scholar
• Sun Y, Xiong Y, Wang Q, Qiao W, Zhang H, Zhang Y. Development and validation of a nomogram to predict the recurrence of hepatocellular carcinoma patients with dynamic changes in AFP undergoing locoregional treatments. Front Oncol. 2023;13:1206345. doi:10.3389/fonc.2023.1206345
   PubMedGoogle Scholar
• Johnson P, Zhou Q, Dao DY, Lo YMD. Circulating biomarkers in the diagnosis and management of hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2022;19(10):670–681. doi:10.1038/s41575-022-00620-y
   PubMed Web of Science ®Google Scholar
• Vogel A, Meyer T, Sapisochin G, Salem R, Saborowski A. Hepatocellular carcinoma. Lancet. 2022;400(10360):1345–1362. doi:10.1016/s0140-6736(22)01200-4
   PubMed Web of Science ®Google Scholar
• Heimbach JK, Kulik LM, Finn RS, et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018;67(1):358–380. doi:10.1002/hep.29086
   PubMed Web of Science ®Google Scholar
• Villanueva A. Hepatocellular Carcinoma. N Engl J Med. 2019;380(15):1450–1462. doi:10.1056/NEJMra1713263
   PubMed Web of Science ®Google Scholar
• Toh MR, Wong EYT, Wong SH, et al. Global epidemiology and genetics of hepatocellular carcinoma. Gastroenterology. 2023;164(5):766–782. doi:10.1053/j.gastro.2023.01.033
   PubMed Web of Science ®Google Scholar
• Yamashita YI, Imai K, Yusa T, et al. Microvascular invasion of single small hepatocellular carcinoma ≤3 cm: predictors and optimal treatments. Ann Gastroenterol Surg. 2018;2(3):197–203. doi:10.1002/ags3.12057
   PubMed Web of Science ®Google Scholar
• Wang Q, Xia D, Bai W, et al. Development of a prognostic score for recommended TACE candidates with hepatocellular carcinoma: a multicentre observational study. J Hepatol. 2019;70(5):893–903. doi:10.1016/j.jhep.2019.01.013
   PubMed Web of Science ®Google Scholar
• Kadalayil L, Benini R, Pallan L, et al. A simple prognostic scoring system for patients receiving transarterial embolisation for hepatocellular cancer. Ann Oncol. 2013;24(10):2565–2570. doi:10.1093/annonc/mdt247
   PubMed Web of Science ®Google Scholar
• Müller L, Hahn F, Auer TA, et al. Tumor burden in patients with hepatocellular carcinoma undergoing transarterial chemoembolization: head-to-head comparison of current scoring systems. Front Oncol. 2022;12:850454. doi:10.3389/fonc.2022.850454
   PubMed Web of Science ®Google Scholar
• Hung YW, Lee IC, Chi CT, et al. Redefining tumor burden in patients with intermediate-stage hepatocellular carcinoma: the seven-eleven criteria. Liver Cancer. 2021;10(6):629–640. doi:10.1159/000517393
   PubMed Web of Science ®Google Scholar
• Ho SY, Liu PH, Hsu CY, et al. Tumor burden score as a new prognostic marker for patients with hepatocellular carcinoma undergoing transarterial chemoembolization. J Gastroenterol Hepatol. 2021;36(11):3196–3203. doi:10.1111/jgh.15593
   PubMed Web of Science ®Google Scholar
• Kaewdech A, Sripongpun P, Assawasuwannakit S, et al. FAIL-T (AFP, AST, tumor sIze, ALT, and Tumor number): a model to predict intermediate-stage HCC patients who are not good candidates for TACE. Front Med Lausanne. 2023;10:1077842. doi:10.3389/fmed.2023.1077842
   PubMed Web of Science ®Google Scholar
• Tung-Ping Poon R, Fan ST, Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg. 2000;232(1):10–24. doi:10.1097/00000658-200007000-00003
   PubMed Web of Science ®Google Scholar
• Schmucker DL. Aging and the liver: an update. J Gerontol a Biol Sci Med Sci. 1998;53(5):B315–20. doi:10.1093/gerona/53a.5.b315
   PubMed Web of Science ®Google Scholar
• Llovet JM, Zucman-Rossi J, Pikarsky E, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2016;2:16018. doi:10.1038/nrdp.2016.18
   PubMed Web of Science ®Google Scholar
• Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:6917):860–7. doi:10.1038/nature01322
   Web of Science ®Google Scholar
• Chen Q, Li F, Zhong C, et al. Inflammation score system using preoperative inflammatory markers to predict prognosis for hepatocellular carcinoma after hepatectomy: a cohort study. J Cancer. 2020;11(17):4947–4956. doi:10.7150/jca.45274
   PubMed Web of Science ®Google Scholar
• Mao S, Yu X, Shan Y, Fan R, Wu S, Lu C. Albumin-Bilirubin (ALBI) and monocyte to lymphocyte ratio (MLR)-based nomogram model to predict tumor recurrence of AFP-negative hepatocellular carcinoma. J Hepatocell Carcinoma. 2021;8:1355–1365. doi:10.2147/jhc.S339707
   PubMed Web of Science ®Google Scholar
• Jiang S, Yang Y, Fang M, Li X, Yuan X, Yuan J. Co-evolution of tumor-associated macrophages and tumor neo-vessels during cervical cancer invasion. Oncol Lett. 2016;12(4):2625–2631. doi:10.3892/ol.2016.5014
   PubMed Web of Science ®Google Scholar
• Lippitz BE, Harris RA. Cytokine patterns in cancer patients: a review of the correlation between interleukin 6 and prognosis. Oncoimmunology. 2016;5(5):e1093722. doi:10.1080/2162402x.2015.1093722
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhang S, Wang Q, Zhang X. Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein. J Hematol Oncol. 2017;10(1):36. doi:10.1186/s13045-017-0408-0
   PubMed Web of Science ®Google Scholar
• Wang Q, Qiao W, Liu B, et al. The monocyte to lymphocyte ratio not only at baseline but also at relapse predicts poor outcomes in patients with hepatocellular carcinoma receiving locoregional therapy. BMC Gastroenterol. 2022;22(1):98. doi:10.1186/s12876-022-02180-6
   PubMed Web of Science ®Google Scholar
• Zhao Z, Zhu Y, Ni X, et al. Serum GGT/ALT ratio predicts vascular invasion in HBV-related HCC. Cancer Cell Int. 2021;21(1):517. doi:10.1186/s12935-021-02214-1
   PubMed Web of Science ®Google Scholar
• Li S, Xu W, Liao M, et al. The significance of gamma-glutamyl transpeptidase to lymphocyte count ratio in the early postoperative recurrence monitoring and prognosis prediction of AFP-negative hepatocellular carcinoma. J Hepatocell Carcinoma. 2021;8:23–33. doi:10.2147/jhc.S286213
   PubMed Web of Science ®Google Scholar
• Zhao H, Liu X, Xu R, Guo X, Shen A. Predictive value of and relationship between the gamma-glutamyl transpeptidase to lymphocyte ratio and CT features in hepatocellular carcinoma patients with postoperative adjuvant TACE. J buon. 2021;26(4):1346–1354.
   PubMedGoogle Scholar
• Zhang W, Bi Y, Yang K, et al. A new model based on gamma-glutamyl transpeptidase to lymphocyte ratio and systemic immune-inflammation index can effectively predict the recurrence of hepatocellular carcinoma after liver transplantation. Front Oncol. 2023;13:1178123. doi:10.3389/fonc.2023.1178123
   PubMed Web of Science ®Google Scholar
• Zhang XP, Zhou TF, Wang ZH, et al. Association of preoperative hypercoagulability with poor prognosis in hepatocellular carcinoma patients with microvascular invasion after liver resection: a multicenter study. Ann Surg Oncol. 2019;26(12):4117–4125. doi:10.1245/s10434-019-07504-7
   PubMed Web of Science ®Google Scholar
• Liu S, Xu Z, Fang Z, et al. The combination of age, international standardized ratio, albumin and γ-glutamyl transpeptidase (AIAG), tumor size and alpha fetoprotein (AFP) stage as the prognostic model for hepatitis B-related hepatocellular carcinoma. Int J Gen Med. 2021;14:4291–4301. doi:10.2147/ijgm.S323293
   PubMed Web of Science ®Google Scholar
• Emlen W, Burdick G, Carl V, Lachmann PJ. Binding of model immune complexes to erythrocyte CR1 facilitates immune complex uptake by U937 cells. J Immunol. 1989;142(12):4366–4371. doi:10.4049/jimmunol.142.12.4366
   PubMed Web of Science ®Google Scholar
• Wei J, Wang Z. Establishment of a predictive model for short-term efficacy of transcatheter arterial chemoembolization treatment in hepatocellular carcinoma and its clinical application. J Cancer Res Ther. 2019;15(4):941–946. doi:10.4103/jcrt.JCRT_52_19
   PubMed Web of Science ®Google Scholar
• Chen S, Zeng X, Su T, et al. Combinatory local ablation and immunotherapies for hepatocellular carcinoma: rationale, efficacy, and perspective. Front Immunol. 2022;13:1033000. doi:10.3389/fimmu.2022.1033000
   PubMed Web of Science ®Google Scholar
• Kim AR, Park E, Kwon SY, et al. Efficacy and safety of combined radiofrequency ablation with transarterial chemoembolization in patients with Barcelona clinic liver cancer stage a hepatocellular carcinoma ineligible for curative treatment. Korean J Gastroenterol. 2019;73(3):167–176. doi:10.4166/kjg.2019.73.3.167
   PubMedGoogle Scholar