Circadian rhythms in cardiac metabolic flexibility

ABSTRACT

Numerous aspects of cardiovascular physiology (e.g., heart rate, blood pressure) and pathology (e.g., myocardial infarction and sudden cardiac death) exhibit time-of-day-dependency. In association with day-night differences in energetic demand and substrate availability, the healthy heart displays remarkable metabolic flexibility through temporal partitioning of the metabolic fate of common substrates (glucose, lipid, amino acids). The purpose of this review is to highlight the contribution that circadian clocks provide toward 24-hr fluctuations in cardiac metabolism and to discuss whether attenuation and/or augmentation of these metabolic rhythms through adjustment of nutrient intake timing impacts cardiovascular disease development.

KEYWORDS:

• Circadian
• heart
• metabolism
• nutrients

Additional information

Funding

This work was supported by the National Heart, Lung, and Blood Institute (R01HL123574 and R01HL122975 for MEY; T32HL129948 for MNL). Figures were created with BioRender.com.