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REVIEW ARTICLE

Intestinal organoid technology and applications in probiotics

Han Tana College of Food Science, Southwest University, Chongqing, ChinaView further author information
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Xiaoyong Chena College of Food Science, Southwest University, Chongqing, China;b Chongqing Agricultural Product Processing Technology Innovation Platform, Chongqing, China;c Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing, China;d Citrus Research Institute, National Citrus Engineering Research Center, Southwest University, Chongqing, ChinaView further author information
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Chen Wanga College of Food Science, Southwest University, Chongqing, China;b Chongqing Agricultural Product Processing Technology Innovation Platform, Chongqing, China;c Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing, China;d Citrus Research Institute, National Citrus Engineering Research Center, Southwest University, Chongqing, ChinaView further author information
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Jiajia Songa College of Food Science, Southwest University, Chongqing, China;b Chongqing Agricultural Product Processing Technology Innovation Platform, Chongqing, China;c Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing, China;d Citrus Research Institute, National Citrus Engineering Research Center, Southwest University, Chongqing, ChinaORCID Iconhttps://orcid.org/0000-0001-6753-518XView further author information
ORCID Icon,
Jiahui Xua College of Food Science, Southwest University, Chongqing, ChinaView further author information
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Yuhong Zhange Institute of Food Sciences and Technology, Tibet Academy of Agricultural and Animal Husbandry Sciences, Lhasa, ChinaView further author information
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Huayi Suoa College of Food Science, Southwest University, Chongqing, China;b Chongqing Agricultural Product Processing Technology Innovation Platform, Chongqing, China;c Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing, China;d Citrus Research Institute, National Citrus Engineering Research Center, Southwest University, Chongqing, ChinaCorrespondence[email protected]
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Published online: 30 Nov 2023
 
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Abstract

The impacts of probiotics on maintaining the host’s intestinal health have been extensively confirmed. Organoid technology revolutionizes intestinal health research by providing a unique platform to study the effects of probiotics. It overcomes challenges posed by animal models and 2D cell models in accurately simulating the in vivo environment. This review summarizes the development of intestinal organoid technology and its potential applications in intestinal health research as well as highlights the regulatory mechanisms of probiotics on intestinal health, which have been revealed using intestinal organoid technology. Furthermore, an overview of its potential applications in probiotic research has also been provided. This review aims to improve the understanding of intestinal organoid technology’s applications in this field as well as to contribute to its further development.

GRAPHICAL ABSTRACT

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Funding

This work was supported by Major Science and Technology Special Projects in Tibet Autonomous Region grant numbers [XZ202201ZD0001N], University Innovation Research Group in Chongqing [CXQT21007], the Sichuan Science and Technology Program [2023YFS0399], the Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX1600].

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