Hypoglycemic Effect of Polysaccharides from Porphyra yezoensis Associated with Reduced Intestinal α-Amylase Activity in Diabetes Mellitus KKAy Mice

ABSTRACT

This study investigated the hypoglycaemic activity of Porphyra yezoensis polysaccharides (PPs). Forty eight KKAy mice were randomly assigned to four groups: one control group gavaged once daily with distilled water and three treatment groups gavaged once daily with different doses of PPs (100, 300 and 500 mg/kg) for 6 weeks. PPs administration decreased body weight, serum insulin, glucose, triglycerides, cholesterol, low-density lipoprotein cholesterol and intestinal α-amylase activity, increased high-density lipoprotein cholesterol and oral glucose tolerance. Intestinal α-amylase activities were positively correlated with serum glucose levels. Results indicated that PPs had hypoglycaemic activity and might be used for diabetes mellitus treatment.

KEYWORDS:

• Polysaccharides
• hypoglycemic activity
• diabetes mellitus
• α-amylase

Acknowledgments

This research was supported by A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethics statement

This study was approved by the ethics committee of Jiangsu Ocean University of Technology, China (JOU.N020200328i0180520). All procedures were conducted in compliance with relevant laws and institutional guidelines.