Exploring the activities of ruthenium nanomaterials as reactive oxygen species scavengers

ABSTRACT

Research on noble metal nanoparticles (NPs) able to scavenge reactive oxygen species (ROS) has undergone a tremendous growth recently. However, the interactions between ruthenium nanoparticles (Ru NPs) and ROS have never been systematically explored thus far. This research focused on the decomposition of hydrogen peroxide (H₂O₂), scavenging of hydroxyl radicals (^•OH), superoxide radical (O₂^•−), singlet oxygen (¹O₂), 2,2′-azino-bis(3-ethylbenzenothiazoline- 6-sulfonic acid ion (ABTS^•+), and 1,1-diphenyl-2-picrylhydrazyl radical (^•DPPH) in the presence of commercial Ru NPs using the electron spin resonance technique. In vitro cell studies demonstrated that Ru NPs have excellent biocompatibility and exert a cytoprotective effect against oxidative stress. These findings may spark fresh enthusiasm for the applications of Ru NPs under relevant physiologically conditions.

KEYWORDS:

• ROS
• Ru NPs
• scavenging ability
• cytoprotective effect

Acknowledgments

G.-J. Cao appreciates the National Natural Science Foundation of China (Grant No. 21601035) and Natural Science Foundation of Fujian Province (Grant No. 2016J01043) for partial support. This work was also supported by a regulatory science grant under the FDA Nanotechnology CORES Program. This paper is not an official U.S. FDA guidance or policy statement. No official support or endorsement by the U.S. FDA is intended or should be inferred.