Improving the antioxidant and anti-tyrosinase activities of Stemonae Radix by solid-state fermentation with Mucor circinelloides T2-12

Abstract

Stemonae Radix, a medicinal and edible herb, has been reported to possess various pharmacological effects. In the present study, Stemonae Radix was fermented by fungi to improve the antioxidant and anti-tyrosinase activities. The results showed that Stemonae Radix fermented by Mucor circinelloides T2-12 exhibited two-folds more antioxidant and anti-tyrosinase activities than non-fermented material. The increased activity might be ascribed to the improvement of total phenolic content, hydrolyzation of glucosides and esters of phenolics and metabolism of saccharides according to ultraviolet and nuclear paramagnetic resonance spectroscopy. This paper suggested that fermenting Stemonae Radix with M. circinelloides T2-12 is effective to increase antioxidant and anti-tyrosinase effects and Stemonae Radix fermented by M. circinelloides T2-12 might be newly alternative of natural antioxidant and tyrosinase inhibitor. The present study is the first to report that pure strain fermentation processing is effective in improving the antioxidant and anti-tyrosinase activities of Stemonae Radix.

Keywords:

• Antioxidant activity
• anti-tyrosinase activity
• fermentation
• Mucor circinelloides
• Stemonae Radix

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by two Yunnan Local Colleges Applied Basic Research Projects (Nos. 2019FH001, 017FH001-092), a grant from the Science and Technology Project of Yunnan Provincial Department of Science and Technology [2018FD081], a Youth Research Foundation of Qujing Normal University in 2019 [2019QN004], an Undergraduates Innovative Experiment Project from MOE [201810684006], and a grant from Chinese Education Ministry Key Laboratory of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials.