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ABSTRACT
Nowadays, for chloasma, the conventional treatment methods are external drugs, chemical stripping and oral drugs, but for refractory chloasma, the treatment effect is poor and the recurrence rate is high. Therefore, it is necessary to understand the benefits of natural bioactive compounds in inhibiting chloasma through different mechanisms, and to develop new products to solve the problem of pigmentation. This paper first reviewed the pathogenesis of chloasma and the effects of natural bioactive compounds such as phlorotannins, procyanidins, tranexamic acid, curcumin, vitamin C, catechin, resveratrol and fucoxanthin on pigmentation, and discussed their effects on chloasma. These natural bioactive compounds were finally proved to have the effect of inhibiting pigmentation, especially the potential application of fucoxanthin in the treatment of chloasma, which provided a new idea for further research on inhibiting the formation of chloasma in the future.
Acknowledgments
This research was supported by Young Scholars Program for Changjiang Scholars Program of Ministry of Education of China (Q2020259), Key Science and Technology Program of Liaoning Province (2020JH1/10200001), the National Key Research and Development Program of China (grant number 2019YFD-0902001) and Dalian Outstanding Young Science and Technology Talents Project (grant number2018RJ07).
Disclosure statement
No potential conflict of interest was reported by the author(s).