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Autophagy Volume 12, 2016 - Issue 11
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Translational Research Paper

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Sonia Hernández-TiedraDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
,
Gemma FabriàsResearch Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain
,
David DávilaDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
,
Íñigo J. SalanuevaDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
,
Josefina CasasResearch Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain
,
L. Ruth MontesBiofisika Institute (UPV/EHU, CSIC), and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n, Leioa, Spain
,
Zuriñe AntónBiofisika Institute (UPV/EHU, CSIC), and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n, Leioa, Spain
,
Elena García-TaboadaDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
,
María Salazar-RoaDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
,
Mar LorenteDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
,
Jesper NylandstedUnit of Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center (DCRC), Copenhagen, Denmark
,
Jane ArmstrongDermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK;Faculty of Applied Sciences, University of Sunderland, Sunderland, UK
,
Israel López-ValeroDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
,
Christopher S. McKeeDermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK
,
Ana Serrano-PueblaDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Departament of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
,
Roberto García-LópezDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
,
José González-MartínezDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
,
José L. AbadResearch Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain
,
Kentaro HanadaDepartment of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan
,
Patricia BoyaDepartament of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
,
Félix GoñiBiofisika Institute (UPV/EHU, CSIC), and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n, Leioa, Spain
,
Manuel GuzmánDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain, Instituto Universitario de Investigación Neuroquímica, Complutense University, Madrid, Spain
,
Penny LovatDermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK
,
Marja JäätteläUnit of Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center (DCRC), Copenhagen, Denmark
,
Alicia AlonsoBiofisika Institute (UPV/EHU, CSIC), and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n, Leioa, Spain
&
Guillermo VelascoDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, SpainCorrespondence[email protected]
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Pages 2213-2229 | Received 21 Oct 2015, Accepted 13 Jul 2016, Published online: 16 Sep 2016

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