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Translational Research Paper
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Sonia Hernández-TiedraDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
, Gemma FabriàsResearch Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain
, David DávilaDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
, Íñigo J. SalanuevaDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
, Josefina CasasResearch Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain
, L. Ruth MontesBiofisika Institute (UPV/EHU, CSIC), and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n, Leioa, Spain
, Zuriñe AntónBiofisika Institute (UPV/EHU, CSIC), and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n, Leioa, Spain
, Elena García-TaboadaDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
, María Salazar-RoaDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
, Mar LorenteDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
, Jesper NylandstedUnit of Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center (DCRC), Copenhagen, Denmark
, Jane ArmstrongDermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK;Faculty of Applied Sciences, University of Sunderland, Sunderland, UK
, Israel López-ValeroDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
, Christopher S. McKeeDermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK
, Ana Serrano-PueblaDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Departament of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
, Roberto García-LópezDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
, José González-MartínezDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
, José L. AbadResearch Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain
, Kentaro HanadaDepartment of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan
, Patricia BoyaDepartament of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
, Félix GoñiBiofisika Institute (UPV/EHU, CSIC), and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n, Leioa, Spain
, Manuel GuzmánDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain, Instituto Universitario de Investigación Neuroquímica, Complutense University, Madrid, Spain
, Penny LovatDermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK
, Marja JäätteläUnit of Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center (DCRC), Copenhagen, Denmark
, Alicia AlonsoBiofisika Institute (UPV/EHU, CSIC), and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n, Leioa, Spain
& Guillermo VelascoDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain;Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, SpainCorrespondence[email protected]
show all
Pages 2213-2229
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Received 21 Oct 2015, Accepted 13 Jul 2016, Published online: 16 Sep 2016
Related Research Data
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization.
Source:
Taylor & Francis
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Source:
Figshare
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