Proteotoxic stress disrupts epithelial integrity by inducing MTOR sequestration and autophagy overactivation

Xiaoxiang Chenga Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China;b National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, ChinaView further author information

Pei Zhanga Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, ChinaView further author information

Hongyu Zhaob National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, ChinaView further author information

Hui Zhengb National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, ChinaView further author information

Kai Zhenga Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, ChinaView further author information

Hong Zhangb National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, ChinaView further author information

Hongjie Zhanga Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China;c MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, ChinaCorrespondence[email protected]