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Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function

Phillippa J Carlinga Department of Physiology, Anatomy and Genetics, Oxford Parkinson’s Disease Centre, University of Oxford, Oxford, UK;b Oxford Drug Discovery Institute, Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Oxford, UKView further author information
,
Brent J Ryana Department of Physiology, Anatomy and Genetics, Oxford Parkinson’s Disease Centre, University of Oxford, Oxford, UKORCID Iconhttps://orcid.org/0000-0002-6703-3718View further author information
ORCID Icon,
William McGuinnessa Department of Physiology, Anatomy and Genetics, Oxford Parkinson’s Disease Centre, University of Oxford, Oxford, UKView further author information
,
Shikha Katariaa Department of Physiology, Anatomy and Genetics, Oxford Parkinson’s Disease Centre, University of Oxford, Oxford, UK;b Oxford Drug Discovery Institute, Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Oxford, UKORCID Iconhttps://orcid.org/0000-0001-7889-3070View further author information
ORCID Icon,
Stewart W Humblea Department of Physiology, Anatomy and Genetics, Oxford Parkinson’s Disease Centre, University of Oxford, Oxford, UK;c Inherited Neurodegenerative Diseases Unit, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MDUSAView further author information
,
Stefan Milded ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, CambridgeView further author information
,
James A Duced ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, CambridgeView further author information
,
Nirav Kapadiae Structural Genomics Consortium, UNC, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NCUSAView further author information
,
William J Zuerchere Structural Genomics Consortium, UNC, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NCUSAView further author information
,
John B. Davisb Oxford Drug Discovery Institute, Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Oxford, UKView further author information
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Elena Di Danielb Oxford Drug Discovery Institute, Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Oxford, UKORCID Iconhttps://orcid.org/0000-0002-0535-2123View further author information
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Richard Wade-Martinsa Department of Physiology, Anatomy and Genetics, Oxford Parkinson’s Disease Centre, University of Oxford, Oxford, UKCorrespondence[email protected]
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Pages 692-705 | Received 28 May 2020, Accepted 24 Jun 2022, Published online: 25 Jul 2022

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