Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action

James C. GeogheganDepartment of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD, USA

Gundo DiedrichDepartment of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD, USA

Xiaojun LuDepartment of Analytical Biotechnology, MedImmune LLC, Gaithersburg, MD, USA

Kim RosenthalDepartment of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD, USA

Kris F. SachsenmeierDepartment of Oncology Research, MedImmune LLC, Gaithersburg, MD, USA

Herren WuDepartment of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD, USA

William F. Dall'AcquaDepartment of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD, USA

Melissa M. DamschroderDepartment of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD, USACorrespondence[email protected]

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