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Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members
Yanli YangDepartments of Antibody Engineering, Genentech Inc., South San Francisco, CA, USAView further author information
, Sherry H. YehBiochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA, USAhttps://orcid.org/0000-0002-2015-4563View further author information
, Shravan MadireddiCancer Immunology, Genentech Inc., South San Francisco, CA, USAhttps://orcid.org/0000-0002-7069-1252View further author information
, Wadim L. MatochkoDepartments of Antibody Engineering, Genentech Inc., South San Francisco, CA, USAhttps://orcid.org/0000-0001-7387-9106View further author information
, Chen GuProtein Chemistry, Genentech Inc., South San Francisco, CA, USAView further author information
, Patricia Pacheco SanchezTranslational Oncology, Genentech Inc., South San Francisco, CA, USAView further author information
, Mark UltschStructural Biology, Genentech Inc., South San Francisco, CA, USAhttps://orcid.org/0000-0002-8290-5908View further author information
, Gladys De Leon BoenigStructural Biology, Genentech Inc., South San Francisco, CA, USAhttps://orcid.org/0000-0002-8314-1188View further author information
, Seth F. HarrisStructural Biology, Genentech Inc., South San Francisco, CA, USAView further author information
, Brandon LeonardDepartments of Antibody Engineering, Genentech Inc., South San Francisco, CA, USAView further author information
, Suzie J. ScalesMolecular Biology, Genentech Inc., South San Francisco, CA, USAhttps://orcid.org/0000-0003-2544-0283View further author information
, Jing W. ZhuCancer Immunology, Genentech Inc., South San Francisco, CA, USAView further author information
, Erin ChristensenProtein Chemistry, Genentech Inc., South San Francisco, CA, USAView further author information
, Julie Q. HangProtein Chemistry, Genentech Inc., South San Francisco, CA, USAView further author information
, Randall J. BrezskiDepartments of Antibody Engineering, Genentech Inc., South San Francisco, CA, USAView further author information
, Scot MarstersCancer Immunology, Genentech Inc., South San Francisco, CA, USAhttps://orcid.org/0000-0002-8517-0994View further author information
, Avi AshkenaziCancer Immunology, Genentech Inc., South San Francisco, CA, USAView further author information
, Siddharth SukumaranPre-Clinical and Translational Pharmacokinetics, Genentech Inc., South San Francisco, CA, USAView further author information
, Henry ChiuBiochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA, USAView further author information
, Rafael CubasTranslational Oncology, Genentech Inc., South San Francisco, CA, USAhttps://orcid.org/0000-0002-3450-9054View further author information
, Jeong M. KimCancer Immunology, Genentech Inc., South San Francisco, CA, USAView further author information
& Greg A. LazarDepartments of Antibody Engineering, Genentech Inc., South San Francisco, CA, USACorrespondence[email protected]
View further author information
show allView further author information
Pages 996-1011
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Received 08 Jan 2019, Accepted 18 May 2019, Published online: 20 Jun 2019
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