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mAbs Volume 12, 2020 - Issue 1
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Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

Aman P. Singha Discovery and Translational Research, Biologics Development Sciences, Janssen Biotherapeutics, Spring House, PA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1886-2624View further author information
ORCID Icon,
Xirong Zhenga Discovery and Translational Research, Biologics Development Sciences, Janssen Biotherapeutics, Spring House, PA, USAView further author information
,
Xiefan Lin-Schmidtb Exploratory Biology, Janssen Biotherapeutics, Spring House, PA, USAView further author information
,
Wenbo Chena Discovery and Translational Research, Biologics Development Sciences, Janssen Biotherapeutics, Spring House, PA, USAView further author information
,
Thomas J. Carpentera Discovery and Translational Research, Biologics Development Sciences, Janssen Biotherapeutics, Spring House, PA, USAView further author information
,
Alice Zonga Discovery and Translational Research, Biologics Development Sciences, Janssen Biotherapeutics, Spring House, PA, USAView further author information
,
Weirong Wangc Clinical Pharmacology and Pharmacometrics, Janssen Research and Development, Spring House, PA, USAView further author information
&
Donald L. Healda Discovery and Translational Research, Biologics Development Sciences, Janssen Biotherapeutics, Spring House, PA, USAView further author information
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Article: 1688616 | Received 03 Aug 2019, Accepted 31 Oct 2019, Published online: 18 Dec 2019

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