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Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action

Mark Austina Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UK;b Antibody Discovery & Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UKCorrespondence[email protected]
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Daniel Burschowskyc Leicester Institute of Structural and Chemical Biology and the Department of Molecular and Cell Biology, University of Leicester, Leicester, UKView further author information

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Denice T.Y. Chana Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Lesley Jenkinsona Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Stuart Haynesa Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Agata Diamandakisa Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Chitra Seewooruthunc Leicester Institute of Structural and Chemical Biology and the Department of Molecular and Cell Biology, University of Leicester, Leicester, UKView further author information

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Alexandra Addymana Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Sebastian Fiedlera Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Stephanie Rymana Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Jessica Whitehousea Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Louise H. Slatera Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Andreas V. Hadjinicolaoud MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKView further author information

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Uzi Gileadid MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKView further author information

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Ellen Gowansa Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Yoko Shibataa Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Michelle Barnarda Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Teresa Kaserere Cancer Research UK, Cancer Therapeutics Unit, The Institute of Cancer Research, London, UKView further author information

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Pooja Sharmaa Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Nadia M. Luheshif Early Oncology Discovery, Oncology R&D, AstraZeneca, Cambridge, UKView further author information

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Robert W. Wilkinsonf Early Oncology Discovery, Oncology R&D, AstraZeneca, Cambridge, UKView further author information

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Tristan J. Vaughanb Antibody Discovery & Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UKView further author information

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Sarah V. Holta Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UKView further author information

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Vincenzo Cerundolod MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKView further author information

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Mark D. Carrc Leicester Institute of Structural and Chemical Biology and the Department of Molecular and Cell Biology, University of Leicester, Leicester, UKCorrespondence[email protected]
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Maria A. T. Grovesa Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UK;b Antibody Discovery & Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UKCorrespondence[email protected]
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