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Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure features
Ameya Harmalkara Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USAhttps://orcid.org/0000-0001-6863-9634View further author information
, Roshan Raob Electrical Engineering and Computer Science, University of California, Berkeley, CA, USAhttps://orcid.org/0000-0003-4412-3742View further author information
, Yuxuan Richard Xiec Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USAhttps://orcid.org/0000-0003-1664-9114View further author information
, Jonas Honerd Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, GermanyView further author information
, Wibke Deistingd Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, GermanyView further author information
, Jonas Anlahrd Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, GermanyView further author information
, Anja Hoenigd Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, GermanyView further author information
, Julia Czwiklad Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, Germanyhttps://orcid.org/0000-0001-7856-789XView further author information
, Eva Sienz-Widmannd Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, GermanyView further author information
, Doris Raud Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, GermanyView further author information
, Austin J. Ricee Therapeutic Discovery, Amgen Research, Amgen Inc, Thousand Oaks, CA, USAhttps://orcid.org/0000-0002-4165-4241View further author information
, Timothy P. Rileye Therapeutic Discovery, Amgen Research, Amgen Inc, Thousand Oaks, CA, USAView further author information
, Danqing Lie Therapeutic Discovery, Amgen Research, Amgen Inc, Thousand Oaks, CA, USAView further author information
, Hannah B. Catteralle Therapeutic Discovery, Amgen Research, Amgen Inc, Thousand Oaks, CA, USAView further author information
, Christine E. Tinbergf Therapeutic Discovery, Amgen Research, Amgen Inc, South San Francisco, CA, USAhttps://orcid.org/0000-0002-6179-0435View further author information
, Jeffrey J. Graya Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USAhttps://orcid.org/0000-0001-6380-2324View further author information
& Kathy Y. Weif Therapeutic Discovery, Amgen Research, Amgen Inc, South San Francisco, CA, USACorrespondence[email protected]
https://orcid.org/0000-0002-8794-1385View further author information
show allhttps://orcid.org/0000-0002-8794-1385View further author information
Article: 2163584
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Received 16 Jun 2022, Accepted 26 Dec 2022, Published online: 22 Jan 2023
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