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Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen
Mark Hutchinsona Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USAView further author information
, Jeffrey A. Ruffolob Program in Molecular Biophysics, The Johns Hopkins University, Baltimore, MD, USA;c Profluent Bio, Machine Learning, Berkeley, CA, USA
https://orcid.org/0000-0002-3385-9191View further author information
Nantaporn Haskinsa Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA;d Currently at Protein Engineering, R&D, Amgen Inc, Rockville, MD, USAView further author information
, Michael Iannottia Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA;e Honigman LLP, Intellectual Property, Washington, DC, United StatesView further author information
, Giuliana Vozzaf Biopharmaceuticals Development, R&D, AstraZeneca, Cambridge, UKView further author information
, Tony Phama Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USAView further author information
, Nurjahan Mehzabeena Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USAView further author information
, Harini Shandilyaa Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USAView further author information
, Keith Rickerta Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USAView further author information
, Rebecca Croasdale-Woodg Biologics Engineering, R&D, AstraZeneca, Cambridge, UKView further author information
, Melissa Damschrodera Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USAView further author information
, Ying Fua Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USAView further author information
, Andrew Dippela Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA
https://orcid.org/0000-0003-3453-0803View further author information
Jeffrey J. Grayb Program in Molecular Biophysics, The Johns Hopkins University, Baltimore, MD, USA;h Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USACorrespondence[email protected]
https://orcid.org/0000-0001-6380-2324View further author information
Gilad Kaplana Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USACorrespondence[email protected]
https://orcid.org/0000-0003-1374-305XView further author information
Article: 2362775
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Received 22 Dec 2023, Accepted 29 May 2024, Published online: 20 Jun 2024
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