Possible data-generating models of longitudinal continuous outcomes and intercurrent events to investigate estimands

Marian Mitroiua Methodology Working Group, Medicines Evaluation Board, The Netherlands;b Clinical Trial Methodology Department, Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, Biostatistics and Research Support, University Medical Center Utrecht, Utrecht University, The NetherlandsCorrespondence[email protected]

https://orcid.org/0000-0002-6479-4757

Steven Teerenstraa Methodology Working Group, Medicines Evaluation Board, The Netherlands;c Department for Health Evidence, section Biostatistics, Radboud University Medical Center, The Netherlands

Katrien Oude Rengerinka Methodology Working Group, Medicines Evaluation Board, The Netherlands;b Clinical Trial Methodology Department, Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, Biostatistics and Research Support, University Medical Center Utrecht, Utrecht University, The Netherlands

Frank Pétavyd Data Analytics and Methods Taskforce, European Medicines Agency, The Netherlands

Kit CB Roesa Methodology Working Group, Medicines Evaluation Board, The Netherlands;c Department for Health Evidence, section Biostatistics, Radboud University Medical Center, The Netherlands

Possible data-generating models of longitudinal continuous outcomes and intercurrent events to investigate estimands

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