Streptococcus mutans PrsA mediates AtlA secretion contributing to extracellular DNA release and biofilm formation in the pathogenesis of infective endocarditis

Chih-Chieh Hsua Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan;b Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, TaiwanView further author information

Ron-Bin Hsuc Department of Surgery, Division of Cardiovascular Surgery, National Taiwan University Hospital , College of Medicine, National Taiwan University, Taipei, TaiwanView further author information

Xoong-Harng Oond Graduate Institute of Medical Sciences, College of Medicine, Taipei medical University, Taipei, Taiwan;e Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanView further author information

Ya-Tang Chend Graduate Institute of Medical Sciences, College of Medicine, Taipei medical University, Taipei, TaiwanView further author information

Jeng-Wei Chenc Department of Surgery, Division of Cardiovascular Surgery, National Taiwan University Hospital , College of Medicine, National Taiwan University, Taipei, Taiwan;f Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, TaiwanView further author information

Che-Hao Hsud Graduate Institute of Medical Sciences, College of Medicine, Taipei medical University, Taipei, TaiwanView further author information

Yu-Min Kuof Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan;g Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanView further author information

Yi-Hsien Shihh Department of Dermatology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan;i Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanView further author information

Jean-San Chiaa Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan;f Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, TaiwanView further author information

Chiau-Jing Jungd Graduate Institute of Medical Sciences, College of Medicine, Taipei medical University, Taipei, Taiwan;e Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanCorrespondence[email protected]