Effects of Double Mutation at Two Distant IgE-binding Sites in the Three-dimensional Structure of the Major House Dust Mite Allergen Der f 2 on IgE-binding and Histamine-releasing Activity

Toshiro TAKAIBioscience Research and Development Laboratory, Asahi Breweries, Ltd.;Present address: Allergy Research Center, Juntendo University School of Medicine

Hideki HATANAKADepartment of Molecular Physiology, Tokyo Metropolitan Institute of Medical Science

Saori ICHIKAWADepartment of Molecular Physiology, Tokyo Metropolitan Institute of Medical Science;Department of Material and Biological Science, Faculty of Science, Japan Women’s University

Toyokazu YOKOTABioscience Research and Development Laboratory, Asahi Breweries, Ltd.

Fuyuhiko INAGAKIDepartment of Molecular Physiology, Tokyo Metropolitan Institute of Medical Science;Division of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University

Yasushi OKUMURABioscience Research and Development Laboratory, Asahi Breweries, Ltd.

Effects of Double Mutation at Two Distant IgE-binding Sites in the Three-dimensional Structure of the Major House Dust Mite Allergen Der f 2 on IgE-binding and Histamine-releasing Activity

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Effects of Double Mutation at Two Distant IgE-binding Sites in the Three-dimensional Structure of the Major House Dust Mite Allergen Der f 2 on IgE-binding and Histamine-releasing Activity

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