Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 65, 2001 - Issue 7
Journal homepage
170
Views
8
CrossRef citations to date
0
Altmetric
Original Articles

Effects of Double Mutation at Two Distant IgE-binding Sites in the Three-dimensional Structure of the Major House Dust Mite Allergen Der f 2 on IgE-binding and Histamine-releasing Activity

Toshiro TAKAIBioscience Research and Development Laboratory, Asahi Breweries, Ltd.;Present address: Allergy Research Center, Juntendo University School of Medicine
,
Hideki HATANAKADepartment of Molecular Physiology, Tokyo Metropolitan Institute of Medical Science
,
Saori ICHIKAWADepartment of Molecular Physiology, Tokyo Metropolitan Institute of Medical Science;Department of Material and Biological Science, Faculty of Science, Japan Women’s University
,
Toyokazu YOKOTABioscience Research and Development Laboratory, Asahi Breweries, Ltd.
,
Fuyuhiko INAGAKIDepartment of Molecular Physiology, Tokyo Metropolitan Institute of Medical Science;Division of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University
&
Yasushi OKUMURABioscience Research and Development Laboratory, Asahi Breweries, Ltd.
Pages 1601-1609 | Received 19 Jan 2001, Accepted 21 Feb 2001, Published online: 22 May 2014

  • 1) Ishizaka, T., and Ishizaka, K., Activation of mast cells for mediator release through IgE receptors. Prog. Allergy, 34, 188-235 (1984).
  • 2) Metzger, H., Alcaraz, G., Hohman, R., Kinet, J.P., Pribluda, V., and Quarto, R., The receptor with high affinity for immunoglobulin E. Annu. Rev. Immunol., 4, 419-470 (1986).
  • 3) Platts-Mills, T.A.E., and Weck, A.L., Dust mite allergens and asthma-A worldwide problem. J. Allergy Clin. Immunol., 83, 755-775 (1989).
  • 4) Voorhorst, R., Spieksma, F.T.M., Vanekamp, M.J., Leupen, M.J., and Lyklema, A.W., The house dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house dust allergen. J. Allergy, 39, 325-328 (1967).
  • 5) Miyamoto, T., Oshima, S., Ishizaki, T., Sato, S.H., Allergenic identity between the common floor mite (Dermatophagoides farinae Hughes, 1961) and house dust as a causative antigen in bronchial asthma. J. Allergy, 42, 14-28 (1968).
  • 6) Tovey, E.R., Chapman, M.D., and Platts-Mills, T.A., Mite faeces are a major source of house dust allergens. Nature, 289, 592-593 (1981).
  • 7) Thomas, W.R., and Smith, W., House-dust-mite allergens. Allergy, 53, 821-832 (1998).
  • 8) Chapman, M.D., and Platts-Mills, T.A., Purification and characterization of the major allergen from Dermatophagoides pteronyssinus-antigen P1. J. Immunol., 125, 587-592 (1980).
  • 9) Haida, M., Okudaira, H., Ogita, T., Ito, K., Miyamoto, T., Nakajima, T., and Hongo, O., Allergens of the house dust mite Dermatophagoides farinae-immunochemical studies of four allergenic fractions. J. Allergy Clin. Immunol., 75, 686-692 (1985).
  • 10) Yasueda, H., Mita, H., Yui, Y., and Shida, T., Isolation and characterization of two allergens from Dermatophagoides farinae. Int. Arch. Allergy Appl. Immunol., 81, 214-223 (1986).
  • 11) Yamashita, N., Haida, M., Suko, M., Okudaira, H., and Miyamoto, T., Allergens of the house dust mite Dermatophagoides farinae. II. Immunological characterization of four allergenic molecules. Int. Arch. Allergy Appl. Immunol., 88, 173-175 (1989).
  • 12) Yasueda, H., Mita, H., Yui, Y., and Shida, T., Comparative analysis of physicochemical and immunochemical properties of the two major allergens from Dermatophagoides pteronyssinus and the corresponding allergens from Dermatophagoides farinae. Int. Arch. Allergy Appl. Immunol., 88, 402-407 (1989).
  • 13) Yuuki, T., Okumura, Y., Ando, T., Yamakawa, H., Suko, M., Haida, M., and Okudaira, H., Cloning and sequencing of cDNA corresponding to mite major allergen Der f II. Jpn. J. Allergol., 39, 557-561 (1990).
  • 14) Yuuki, T., Okumura, Y., Ando, T., Yamakawa, H., Suko, M., Haida, M., and Okudaira, H., Cloning and expression of cDNA coding for the major house dust mite allergen Der f II in Escherichia coli. Agric. Biol. Chem., 55, 1233-1238 (1991).
  • 15) Yuuki, T., Okumura, Y., Ando, T., Yamakawa, H., Suko, M., Haida, M., Dohi, M., and Okudaira, H., Synthesis of biologically active recombinant Der f II. Int. Arch. Allergy Appl. Immunol., 94, 354-356 (1991).
  • 16) Chua, K.Y., Doyle, C.R., Simpson, R.J., Turner, K.J., Stewart, G.A., and Thomas, W.R., Isolation of cDNA coding for the major mite allergen Der p II by IgE plaque immunoassay. Int. Arch. Allergy Appl. Immunol., 91, 118-123 (1990).
  • 17) Chua, K.Y., Greene, W.K., Kehal, P., and Thomas, W.R., IgE binding studies with large peptides expressed from Der p II cDNA constructs. Clin. Exp. Allergy, 21, 161-166 (1991).
  • 18) van’t Hof, W., Driedijk, P.C., van den Berg, M., Beck-Sickinger, A.G., Jung, G., and Aalberse, R.C., Epitope mapping of the Dermatophagoides pteronyssinus house dust mite major allergen Der p II using overlapping synthetic peptides. Mol. Immunol., 28, 1225-1232 (1991).
  • 19) Smith, A.M., and Chapman, M.D., Reduction in IgE binding to allergen variants generated by site-directed mutagenesis: contribution of disulfide bonds to the antigenic structure of the major house dust mite allergen Der p 2. Mol. Immunol., 33, 399-405 (1996).
  • 20) Takai, T., Yokota, T., Yasue, M., Nishiyama, C., Yuuki, T., Mori, A., Okudaira, H., and Okumura, Y., Engineering of the major house dust mite allergen Der f 2 for allergen- specific immunotherapy. Nat. Biotechnol., 15, 754-758 (1997).
  • 21) Takai, T., Yuuki, T., Okumura, Y., Mori, A., and Okudaira, H., Determination of the N- and C-terminal sequences required to bind human IgE of the major house dust mite allergen Der f 2 and epitope mapping for monoclonal antibodies. Mol. Immunol., 34, 255-261 (1997).
  • 22) Takai, T., Mori, A., Yuuki, T., Okudaira, H., and Okumura, Y., Non-anaphylactic combination of partially deleted fragments of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy. Mol. Immunol., 36, 1055-1065 (1999).
  • 23) Takai, T., Ichikawa, S., Yokota, T., Hatanaka, H., Inagaki, F., and Okumura, Y., Unlocking the allergenic structure of the major house dust mite allergen Der f 2. FEBS Lett., 482, 102-107 (2000).
  • 24) Takai, T., Ichikawa, S., Hatanaka, H., Inagaki, F., and Okumura, Y., Effects of proline mutations in the major house dust mite allergen Der f 2 on IgE-binding and histamine releasing activity. Eur. J. Biochem., 267, 6650-6656 (2000).
  • 25) Nishiyama, C., Yuuki, T., Takai, T., Okumura, Y., and Okudaira, H., Determination of three disulfide bonds in a major house dust mite allergen, Der f II. Int. Arch. Allergy Immunol., 101, 159-166 (1993).
  • 26) Nishiyama, C., Fukada, M., Usui, Y., Iwamoto, N., Yuuki, T., Okumura, Y., and Okudaira, H., Analysis of the IgE-epitope of Der f 2, a major mite allergen, by in vitro mutagenesis. Mol. Immunol., 32, 1021-1029 (1995).
  • 27) Ichikawa, S., Hatanaka, H., Yuuki, T., Iwamoto, N., Kojima, S., Nishiyama, C., Ogura, K., Okumura, Y., and Inagaki, F., Solution structure of Der f 2, the major mite allergen for atopic diseases. J. Biol. Chem., 273, 356-360 (1998).
  • 28) Nishiyama, C., Yuuki, T., Usui, Y., Iwamoto, N., Okumura, Y., and Okudaira, H., Effects of amino acid variations in recombinant Der f II on its human IgE and mouse IgG recognition. Int. Arch. Allergy Immunol., 105, 62-69 (1994).
  • 29) Shoji, H., Hanawa, M., Shibuya, I., Hirai, M., Yasuhara, T., Okumura, Y., and Yamakawa, H., Production of recombinant mite allergen Der f I in insect cells and characterization of products-removal of pro-sequence is essential to IgE-binding activity. Biosci. Biotechnol. Biochem., 60, 621-625 (1996).
  • 30) Yasuhara, T., Takai, T., Yuuki, T., Okudaira, H., and Okumura, Y., Cloning and Expression of cDNA encoding the complete prepro-form of an isoform of Der f 1, the major group 1 allergen from house dust mite Dermatophagoides farinae. Biosci. Biotechnol. Biochem., 65, 563-569 (2001).
  • 31) Yasuhara, T., Takai, T., Yuuki, T., Okudaira, H., and Okumura, Y., Biologically active recombinant forms of a major house dust mite group 1 allergen Der f 1 with full activities of both cysteine protease and IgE binding. Clin. Exp. Allergy, 31, 116-124 (2001).
  • 32) Takahashi, K., Takai, T., Yasuhara, T., Yuuki, T., Ohtake, Y., Yokota, T., and Okumura, Y., Production of enzymatically and immunologically active Der f 1 in Escherichia coli. Int. Arch. Allergy Immunol., 122, 108-114 (2000).
  • 33) Takahashi, K., Takai, T., Yasuhara, T., Yokota, T., and Okumura, Y., Effects of site-directed mutagenesis in the cysteine residues and the N-glycosylation motif in recombinant Der f 1 on secretion and protease activity. Int. Arch. Allergy Immunol., 124, 454-460 (2001).
  • 34) Ferreira, F., Ebner, C., Kramer, B., Casari, G., Briza, P., Kungl, A.J., Grimm, R., Jahn-Schmid, B., Breiteneder, H., Kraft, D., Breitenbach, M., Rheinberger, H., J., and Scheiner, O., Modulation of IgE reactivity of allergens by site-directed mutagenesis: potential use of hypoallergenic variants for immunotherapy. FASEB J., 12, 231-242 (1998).
  • 35) Kraft, D., Ferreira, F., Ebner, C., Valenta, R., Breiteneder, H., Susani, M., Breitenbach, M., and Scheiner, O., Recombinant allergens: the future of the diagnosis and treatment of atopic allergy. Allergy, 53, 62-66 (1998).
  • 36) Valenta, R., Almo, S., Ball, T., Dolecek, C., Steinberger, P., Laffer, S., Eibensteiner, P., Flicker, S., Vrtala, S., Spitzauer S,, Valent, P., Denepoux, S., Kraft, D., Banchereau, J., and Lebecque, S., The immunoglobulin E-allergen interaction: a target for therapy of type I allergic diseases. Int. Arch. Allergy Immunol., 116, 167-176 (1998).
  • 37) Takai, T., Akagawa-Chihara, M., Yokota, T., and Okumura, Y., Reactivities of mutants of a major house dust mite allergen Der f 2 to mouse anti-Der f 2 monoclonal antibodies analyzed by immunoblotting. Biosci. Biotechnol. Biochem., 65, 694-697 (2001).
  • 38) Nishiyama, C., Hatanaka, H., Ichikawa, S., Fukada, M., Akagawa-Chihara, M., Yuuki, T., Yokota, T., Inagaki, F., and Okumura, Y., Analysis of human IgE epitope of Der f 2 with anti-Der f 2 mouse monoclonal antibodies. Mol. Immunol., 36, 53-60 (1999).
  • 39) Akagawa, M., Mori, T., Ando, T., and Okudaira, H., Specific measurement of a major mite allergen, Der f II, by an enzyme linked immunosorbent assay system using monoclonal anti-Der f II antibodies. Biosci. Biotechnol. Biochem., 56, 1725-1727 (1992).
  • 40) Kraulis, P.J., MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr., 24, 946-950 (1991).
  • 41) Merrit, E.A., and Murphy, M.E.P., Raster3D version 2.0. A program for photorealistic molecular graphics. Acta. Crystallogr., D50, 869-873 (1994).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.