Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 3
303
Views
8
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Metabolomics reveals the effect of valproic acid on MCF-7 and MDA-MB-231 cells

ORCID Icon, , , , &
Pages 252-260 | Received 05 Mar 2019, Accepted 09 May 2019, Published online: 04 Jun 2019

References

  • Aztopal N, Erkisa M, Erturk E, et al. (2018). Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells. Chem Biol Interact 280:51–8.
  • Bouza M, Gonzalez-Soto J, Pereiro R, et al. (2017). Exhaled breath and oral cavity VOCs as potential biomarkers in oral cancer patients. J Breath Res 11:016015.
  • Cardoso MR, Santos JC, Ribeiro ML, et al. (2018). A metabolomic approach to predict breast cancer behavior and chemotherapy response. Int J Mol Sci 19:617.
  • Chen WQ, Zheng RS, Baade PD, et al. (2016). Cancer statistics in China, 2015. CA Cancer J Clin 66:115–32.
  • Chen XR, Wang HD, Zhou ML, et al. (2018). Valproic acid attenuates traumatic brain injury-induced inflammation: involvement of autophagy and the Nrf2/ARE signaling pathway. Front Mol Neurosci 11:117.
  • Chen ZX, Lin JH, Feng SY, et al. (2019). SIRT4 inhibits the proliferation, migration, and invasion abilities of thyroid cancer cells by inhibiting glutamine metabolism. Onco Targets Ther 12:2397–408.
  • Cohen AL, Soldi R, Zhang H, et al. (2011). A pharmacogenomic method for individualized prediction of drug sensitivity. Mol Syst Biol 7:513.
  • Cramer SL, Saha A, Liu J, et al. (2017). Systemic depletion of serum L-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice. Nat Med 23:120–7.
  • Fortunati N, Bertino S, Costantino L, et al. (2008). Valproic acid is a selective antiproliferative agent in estrogen-sensitive breast cancer cells. Cancer Lett 259:156–64.
  • Hadi NI, Jamal Q, Iqbal A, et al. (2017). Serum metabolomic profiles for breast cancer diagnosis, grading and staging by gas chromatography-mass spectrometry. Sci Rep 7:1715.
  • Haspel JA, Chettimada S, Shaik RS, et al. (2014). Circadian rhythm reprogramming during lung inflammation. Nat Commun 5:4753.
  • Jang S, Jin H, Roy M, et al. (2017). Antineoplastic effects of histone deacetylase inhibitors in neuroendocrine cancer cells are mediated through transcriptional regulation of Notch1 by activator protein 1. Cancer Med 6:2142–52.
  • Jawaid K, Crane SR, Nowers JL, et al. (2010). Long-term genistein treatment of MCF-7 cells decreases acetylated histone 3 expression and alters growth responses to mitogens and histone deacetylase inhibitors. J Steroid Biochem Mol Biol 120:164–71.
  • Jiang X, Huang YM, Wang XJ, et al. (2017). Dianhydrogalactitol, a potential multitarget agent, inhibits glioblastoma migration, invasion, and angiogenesis. Biomed Pharmacother 91:1065–74.
  • Jove M, Collado R, Quiles JL, et al. (2017). A plasma metabolomic signature discloses human breast cancer. Oncotarget 8:19522–33.
  • Curley RW Jr, Humphries KA, Koolemans-Beynan A, et al. (1994). Activity of d-glucarate analogues: synergistic antiproliferative effects with retinoid in cultured human mammary tumor cells appear to specifically require the d-glucarate structure. Life Sci 54:1299–303.
  • Lee A, Djamgoz M. (2018). Triple negative breast cancer: emerging therapeutic modalities and novel combination therapies. Cancer Treat Rev 62:110.
  • Li CW, He J, Li SX, et al. (2019). Novel metabolites are associated with augmentation index and pulse wave velocity: findings from the Bogalusa heart study. Am J Hypertens 32:547–56.
  • Liu HL, Liu Y, Zhang JT. (2008). A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction. Mol Cancer Ther 7:263–70.
  • Luciani-Torres MG, Moore DH, Goodson WH, et al. (2015). Exposure to the polyester PET precursor-terephthalic acid induces and perpetuates DNA damage-harboring non-malignant human breast cells. Carcinogenesis 36:168–76.
  • Ma C, Yan X, Yin G, et al. (2019). Non-targeted metabolomic analysis on multidrug resistance hepatocellular carcinoma cell and reversal effect of annonaceous acetogenins. J Pharm Biomed Anal 164:489–95.
  • Ma CY, Li Y, Wu HQ, et al. (2018). Metabolomics analysis of the potential anticancer mechanism of annonaceous acetogenins on a multidrug resistant mammary adenocarcinoma cell. Anal Biochem 553:1–6.
  • Majidinia M, Yousefi B. (2017). Breast tumor stroma: a driving force in the development of resistance to therapies. Chem Biol Drug Des 89:309–18.
  • Perucca E. (2002). Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs 16:695–714.
  • Rao GD, Sui JK, Zhang JG. (2016). Metabolomics reveals significant variations in metabolites and correlations regarding the maturation of walnuts (Juglans regia L.). Biol Open 5:829–36.
  • Robertson GD. (2005). Metabonomics in toxicology: a review. Toxicol Sci 85:809–22.
  • Rodrigues C, Chhun S, Chiron C, et al. (2018). A population pharmacokinetic model taking into account protein binding for the sustained-release granule formulation of valproic acid in children with epilepsy. Eur J Clin Pharmacol 74:793–803.
  • Shajahan-Haq AN, Cheema MS, Clarke R. (2015). Application of metabolomics in drug resistant breast cancer research. Metabolites 5:100–18.
  • Siegel RL, Miller KD, Jemal A. (2017). Cancer statistics, 2017. CA Cancer J Clin 67:7–30.
  • Tarasenko N, Chekroun-Setti H, Nudelman A, et al. (2018). Comparison of the anticancer properties of a novel valproic acid prodrug to leading histone deacetylase inhibitors. J Cell Biochem 119:3417–28.
  • Torre LA, Bray F, Siegel RL, et al. (2015). Global cancer statistics, 2012. CA Cancer J Clin 65:87–108.
  • Tran LNK, Kichenadasse G, Butler LM, et al. (2017). The combination of metformin and valproic acid induces synergistic apoptosis in the presence of p53 and androgen signaling in prostate cancer. Mol Cancer Ther 16:2689–700.
  • Trygg J, Wold S. (2002). Orthogonal projections to latent structures (O-PLS). J Chemometr 16:119–28.
  • Van Breda SGJ, Claessen SMH, Van Herwijnen M, et al. (2018). Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology 393:160–70.
  • Wang G, Li YF, Yang ZY, et al. (2018a). ROS mediated EGFR/MEK/ERK/HIF-1α loop regulates glucose metabolism in pancreatic cancer. Biochem Biophys Res Commun 500:873–8.
  • Wang JB, Erickson JW, Fuji R, et al. (2010). Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18:207–19.
  • Wang WB, Zhao LL, He ZY, et al. (2018b). Metabolomics-based evidence of the hypoglycemic effect of Ge-Gen-Jiao-Tai-Wan in type 2 diabetic rats via UHPLC-QTOF/MS analysis. J Ethnopharmacol 219:299–318.
  • Wilson ID, Gika H, Theodoridis G, et al. (2010). Global metabolic profiling procedures for urine using UPLC-MS. Nat Protoc 5:1005–18.
  • Yardley DA. (2017). Drug resistance and the role of combination chemotherapy in improving patient outcomes. Int J Breast Cancer 6797:137–414.
  • Zhao L, Chen JP, Su JY, et al. (2013). In vitro antioxidant and antiproliferative activities of 5-hydroxymethylfurfural. J Agric Food Chem 61:10604–11.
  • Zheng WJ, Feng Q, Liu J, et al. (2017). Inhibition of 6-phosphogluconate dehydrogenase reverses cisplatin resistance in ovarian and lung cancer. Front Pharmacol 8:421.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.