546
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Long-term patient outcomes following buprenorphine/naloxone treatment for opioid use disorder: a retrospective analysis in a commercially insured population

, ORCID Icon, , &
Pages 481-491 | Received 02 Jul 2021, Accepted 05 Apr 2022, Published online: 07 Jun 2022

References

  • Degenhardt L, Charlson F, Mathers B, Hall WD, Flaxman AD, Johns N, Vos T. The global epidemiology and burden of opioid dependence: results from the global burden of disease 2010 study. Addiction. 2014;109:1320–33. doi:10.1111/add.12551.
  • Welty L, Harrison A, Abram K, Olson N, Aaby D, McCoy K. Substance abuse and mental health services administration. (2017). Key substance use and mental health indicators in the United States: results from the 2016 national survey on drug use and health (HHS Publication No. SMA 17-5044, NSDUH Series H-52). Rockville, MD: Center for Behavioral Health Statistics and Quality. Subst Abuse Mental Health Serv Administration Retrieved Coll Health Sci. 2019;106:128.
  • Birnbaum HG, White AG, Schiller M, Waldman T, Cleveland JM, Roland CL. Societal costs of prescription opioid abuse, dependence, and misuse in the United States. Pain Med. 2011;12:657–67.doi:10.1111/j.1526-4637.2011.01075.x.
  • Florence C, Luo F, Xu L, Zhou C. The economic burden of prescription opioid overdose, abuse and dependence in the United States, 2013. Med Care. 2016;54:901. doi:10.1097/MLR.0000000000000625.
  • Hansen RN, Oster G, Edelsberg J, Woody GE, Sullivan SD. Economic costs of nonmedical use of prescription opioids. Clin J Pain. 2011;27:194–202. doi:10.1097/AJP.0b013e3181ff04ca.
  • McAdam-Marx C, Roland CL, Cleveland J, Oderda GM. Costs of opioid abuse and misuse determined from a medicaid database. J Pain Palliative Care Pharmacother. 2010;24:5–18. doi:10.3109/15360280903544877.
  • Oderda GM, Lake J, Rüdell K, Roland CL, Masters ET. Economic burden of prescription opioid misuse and abuse: a systematic review. J Pain Palliative Care Pharmacother. 2015;29:388–400. doi:10.3109/15360288.2015.1101641.
  • Strassels S.Economic burden of prescription opioid misuse and abuse. J Managed Care Pharm. 2009;15:556–62. doi:10.18553/jmcp.2009.15.7.556.
  • White AG, Birnbaum HG, Mareva MN, Daher M, Vallow S, Schein J, Katz N. Direct costs of opioid abuse in an insured population in the United States. J Managed Care Pharm. 2005;11:469–79.doi:10.18553/jmcp.2005.11.6.469.
  • Parran T, Adelman C, Merkin B, Pagano M, Defranco R, Ionescu R, Mace AG. Long-Term outcomes of office-based buprenorphine/naloxone maintenance therapy. Drug Alcohol Depend. 2010;106:56–60. doi:10.1016/j.drugalcdep.2009.07.013.
  • Fudala PJ, Bridge TP, Herbert S, Williford WO, Chiang CN, Jones K, Collins J, Raisch D, Casadonte P, Goldsmith RJ. Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone. N Engl J Med. 2003;349:949–58. doi:10.1056/NEJMoa022164.
  • Barnett PG. Comparison of costs and utilization among buprenorphine and methadone patients. Addiction. 2009;104:982–92. doi:10.1111/j.1360-0443.2009.02539.x.
  • Mattick RP, Breen C, Kimber J, Davoli M. Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. Cochrane Database Syst Rev. 2014;(2): CD002207. doi:10.1002/14651858.CD002207.pub4.
  • Volkow ND, Frieden TR, Hyde PS, Cha SS. Medication-assisted therapies—tackling the opioid-overdose epidemic. N Engl J Med. 2014;370:2063–66. doi:10.1056/NEJMp1402780.
  • Johnson RE, McCagh JC. Buprenorphine and naloxone for heroin dependence. Curr Psychiatry Rep. 2000;2:519–26. doi:10.1007/s11920-000-0012-8.
  • McCance-Katz EF. Office-Based buprenorphine treatment for opioid-dependent patients. Harv Rev Psychiatry. 2004;12:321–38. doi:10.1080/10673220490905688.
  • Lo‐ciganic WH, Gellad WF, Gordon AJ, Cochran G, Zemaitis MA, Cathers T, Kelley D, Donohue JM. Association between trajectories of buprenorphine treatment and emergency department and in‐patient utilization. Addiction. 2016;111:892–902. doi:10.1111/add.13270.
  • Chang H-Y, Daubresse M, Saloner B, Alexander GC. Chronic disease medication adherence after initiation of buprenorphine for opioid use disorder. Med Care. 2019;57:667–72. doi:10.1097/MLR.0000000000001165.
  • Tkacz J, Severt J, Kassed C, Ruetsch C. Clinical differences between opioid abuse classes ameliorated after 1 year of buprenorphine-medication assisted treatment. J Addict Dis. 2012;31:100–11. doi:10.1080/10550887.2012.665729.
  • Larochelle MR, Bernson D, Land T, Stopka TJ, Wang N, Xuan Z, Bagley SM, Liebschutz JM, Walley AY. Medication for opioid use disorder after nonfatal opioid overdose and association with mortality: a cohort study. Ann Intern Med. 2018;169:137–45. doi:10.7326/M17-3107.
  • Sordo L, Barrio G, Bravo MJ, Indave BI, Degenhardt L, Wiessing L, Ferri M, Pastor-Barriuso R. Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies. BMJ (Clin Res Ed). 2017;357. doi:10.1136/bmj.j1550
  • Williams AR, Samples H, Crystal S, Olfson M. Acute care, prescription opioid use, and overdose following discontinuation of long-term buprenorphine treatment for opioid use disorder. Am J Psychiatry. 2020;177:117–24. doi:10.1176/appi.ajp.2019.19060612.
  • Connery HS, Weiss RD. Discontinuing buprenorphine treatment of opioid use disorder: what do we (not) know?. Am Psychiatric Assoc. 2020;177(2): 104–106. doi:10.1176/appi.ajp.2019.19121245.
  • Kraus ML, Alford DP, Kotz MM, Levounis P, Mandell TW, Meyer M, Salsitz EA, Wetterau N, Wyatt SA. Statement of the American Society of Addiction Medicine Consensus Panel on the use of buprenorphine in office-based treatment of opioid addiction. J Addict Med. 2011;5:254–63. doi:10.1097/ADM.0b013e3182312983.
  • Forum NQ. Behavioral health 2016-2017 final report 2022 [accessed 2022 Feb 1].
  • Pietras S, Azur M, Brown J. Review of medication-assisted treatment guidelines and measures for opioid and alcohol use [Internet]. Washington (DC): Department of Health and Human Services, Office of the Assistant Secretary for Planning and Evaluation; 2015 Nov 25 [accessed 2020 Mar 6].
  • Hser YI, Saxon AJ, Huang D, Hasson A, Thomas C, Hillhouse M, Jacobs P, Teruya C, McLaughlin P, Wiest K. Treatment retention among patients randomized to buprenorphine/naloxone compared to methadone in a multi‐site trial. Addiction. 2014;109:79–87. doi:10.1111/add.12333.
  • Morgan JR, Schackman BR, Leff JA, Linas BP, Walley AY. Injectable naltrexone, oral naltrexone, and buprenorphine utilization and discontinuation among individuals treated for opioid use disorder in a United States commercially insured population. J Subst Abuse Treat. 2018;85:90–96. doi:10.1016/j.jsat.2017.07.001.
  • Saloner B, Daubresse M, Alexander GC.Patterns of buprenorphine-naloxone treatment for opioid use disorder in a multi-state population. Med Care. 2017;55:669. doi:10.1097/MLR.0000000000000727.
  • Shcherbakova N, Tereso G, Spain J, Roose RJ. Treatment persistence among insured patients newly starting buprenorphine/naloxone for opioid use disorder. Ann Pharmacother. 2018;52:405–14. doi:10.1177/1060028017751913.
  • Gryczynski J, Mitchell SG, Jaffe JH, O’-Grady KE, Olsen YK, Schwartz RP.Leaving buprenorphine treatment: patients’ reasons for cessation of care. J Subst Abuse Treat. 2014;46:356–61. doi:10.1016/j.jsat.2013.10.004.
  • Kakko J, Svanborg KD, Kreek MJ, Heilig M. 1-Year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial. Lancet. 2003;361:662–68. doi:10.1016/S0140-6736(03)12600-1.
  • Hasan MM, Noor-E-Alam M, Mohite P, Islam MS, Modestino AS, Peckham AM, … Young GJ. Patterns of patient discontinuation from buprenorphine/naloxone treatment for opioid use disorder: a study of a commercially insured population in Massachusetts. J Subst Abuse Treat. 2021;131:108416.doi:10.1016/j.jsat.2021.108416.
  • Johnson RE, Jaffe JH, Fudala PJ. A controlled trial of buprenorphine treatment for opioid dependence. JAMA. 1992;267:2750–55. doi:10.1001/jama.1992.03480200058024.
  • Liebschutz JM, Crooks D, Herman D, Anderson B, Tsui J, Meshesha LZ, Dossabhoy S, Stein M. Buprenorphine treatment for hospitalized, opioid-dependent patients: a randomized clinical trial. JAMA Intern Med. 2014;174:1369–76. doi:10.1001/jamainternmed.2014.2556.
  • Samples H, Williams AR, Olfson M, Crystal S. Risk factors for discontinuation of buprenorphine treatment for opioid use disorders in a multi-state sample of medicaid enrollees. J Subst Abuse Treat. 2018;95:9–17. doi:10.1016/j.jsat.2018.09.001.
  • Tkacz J, Volpicelli J, Un H, Ruetsch C. Relationship between buprenorphine adherence and health service utilization and costs among opioid dependent patients. J Subst Abuse Treat. 2014;46:456–62. doi:10.1016/j.jsat.2013.10.014.
  • Ronquest NA, Willson TM, Montejano LB, Nadipelli VR, Wollschlaeger BA. Relationship between buprenorphine adherence and relapse, health care utilization and costs in privately and publicly insured patients with opioid use disorder. Subst Abuse Rehabil. 2018;9:59. doi:10.2147/SAR.S150253.
  • Meinhofer A, Williams AR, Johnson P, Schackman BR, Bao Y. Prescribing decisions at buprenorphine treatment initiation: do they matter for treatment discontinuation and adverse opioid-related events? J Subst Abuse Treat. 2019;105:37–43. doi:10.1016/j.jsat.2019.07.010.
  • Weiss RD, Potter JS, Griffin ML, Provost SE, Fitzmaurice GM, McDermott KA, Srisarajivakul EN, Dodd DR, Dreifuss JA, McHugh RK. Long-Term outcomes from the national drug abuse treatment clinical trials network prescription opioid addiction treatment study. Drug Alcohol Depend. 2015;150:112–19.
  • Tibshirani R, Walther G, Hastie T. Estimating the number of clusters in a data set via the gap statistic. J Royal Stat Soc Ser B (Stat Methodol). 2001;63:411–23. doi:10.1111/1467-9868.00293.
  • Ho D, Imai K, King G, Stuart E, Greifer N. Package ‘MatchIt’; 2021 [accessed 2021 May 12]. https://cran.r-project.org/web/packages/MatchIt/MatchIt.pdf
  • Zhang Z, Kim HJ, Lonjon G, Zhu Y, written on behalf of AMEB-DCTCG. Balance diagnostics after propensity score matching. Ann Transl Med. 2019; 7:16.
  • Dakwar E, Kleber HD. Naltrexone-Facilitated buprenorphine discontinuation: a feasibility trial. J Subst Abuse Treat. 2015;53:60–63. doi:10.1016/j.jsat.2015.01.004.
  • Brown S-E, Altice FL. Self-Management of buprenorphine/naloxone among online discussion board users. Subst Use Misuse. 2014;49:1017–24. doi:10.3109/10826084.2014.888449.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.