Folate administration ameliorates neurobehavioral effects of prenatal ethanol exposure

References

• Popova S, Lange S, Probst C, Gmel G, Rehm J. Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis. Lancet Glob Health. 2017;5:e290–99. doi:10.1016/S2214-109X(17)30021-9.
   PubMed Web of Science ®Google Scholar
• Dominguez HD, Lopez MF, Chotro MG, Molina JC. Perinatal responsiveness to alcohol’s chemosensory cues as a function of prenatal alcohol administration during gestational days 17-20 in the rat. Neurobiol Learn Mem. 1996;65:103–12. doi:10.1006/nlme.1996.0012.
   PubMed Web of Science ®Google Scholar
• Gangisetty O, Chaudhary S, Palagani A, Sarkar DK. Transgenerational inheritance of fetal alcohol effects on proopiomelanocortin gene expression and methylation, cortisol response to stress, and anxiety-like behaviors in offspring for three generations in rats: evidence for male germline transmission. PloS One. 2022;17:e0263340. doi:10.1371/journal.pone.0263340.
   PubMed Web of Science ®Google Scholar
• Kruithof P, Ban S. A brief overview of fetal alcohol syndrome for health professionals. Br J Nurs. 2021;30:890–93. doi:10.12968/bjon.2021.30.15.890.
   PubMedGoogle Scholar
• Pascual M, Boix J, Felipo V, Guerri C. Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat. J Neurochem. 2009;108:920–31. doi:10.1111/j.1471-4159.2008.05835.x.
   PubMed Web of Science ®Google Scholar
• Pascual M, Blanco AM, Cauli O, Minarro J, Guerri C. Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats. Eur J Neurosci. 2007;25:541–50. doi:10.1111/j.1460-9568.2006.05298.x.
   PubMed Web of Science ®Google Scholar
• Wille-Bille A, Miranda-Morales RS, Pucci M, Bellia F, D’Addario C, Pautassi RM. Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Progr neuro-psychopharmacol biol psychiatry. 2018;85:77–88. doi:10.1016/j.pnpbp.2018.04.005.
   PubMed Web of Science ®Google Scholar
• Wille-Bille A, Bellia F, Jimenez Garcia AM, Miranda-Morales RS, D’Addario C, Pautassi RM. Early exposure to environmental enrichment modulates the effects of prenatal ethanol exposure upon opioid gene expression and adolescent ethanol intake. Neuropharmacology. 2020;165:107917. doi:10.1016/j.neuropharm.2019.107917.
   PubMed Web of Science ®Google Scholar
• Krahe TE, Wang W, Medina AE. Phosphodiesterase inhibition increases CREB phosphorylation and restores orientation selectivity in a model of fetal alcohol spectrum disorders. PloS One. 2009;4:e6643. doi:10.1371/journal.pone.0006643.
   PubMed Web of Science ®Google Scholar
• Ratuski AS, Weary DM. Environmental enrichment for rats and mice housed in laboratories: a metareview. Anim open access j MDPI. 2022;12:414. doi:10.3390/ani12040414.
   PubMedGoogle Scholar
• Peng Y, Kwok KH, Yang PH, Ng SS, Liu J, Wong OG, He ML, Kung HF, Lin MC. Ascorbic acid inhibits ROS production, NF-kappa B activation and prevents ethanol-induced growth retardation and microencephaly. Neuropharmacology. 2005;48:426–34. doi:10.1016/j.neuropharm.2004.10.018.
   PubMed Web of Science ®Google Scholar
• Wentzel P, Rydberg U, Eriksson UJ. Antioxidative treatment diminishes ethanol-induced congenital malformations in the rat. Alcohol Clin Exp Res. 2006;30:1752–60. doi:10.1111/j.1530-0277.2006.00208.x.
   PubMed Web of Science ®Google Scholar
• Kang H, Lee Y, Bae M, Park YK, Lee JY. Astaxanthin inhibits alcohol-induced inflammation and oxidative stress in macrophages in a sirtuin 1-dependent manner. J Nutr Biochem. 2020;85:108477. doi:10.1016/j.jnutbio.2020.108477.
   PubMed Web of Science ®Google Scholar
• Thomas JD, Biane JS, O’Bryan KA, O’Neill TM, Dominguez HD. Choline supplementation following third-trimester-equivalent alcohol exposure attenuates behavioral alterations in rats. Behav Neurosci. 2007;121:120–30. doi:10.1037/0735-7044.121.1.120.
   PubMed Web of Science ®Google Scholar
• Fila M, Chojnacki C, Chojnacki J, Blasiak J. Is an “Epigenetic Diet” for migraines justified? The case of folate and DNA methylation. Nutrients. 2019;11:2763. doi:10.3390/nu11112763.
   PubMed Web of Science ®Google Scholar
• Kim YI. Folate and cancer prevention: a new medical application of folate beyond hyperhomocysteinemia and neural tube defects. Nutr Rev. 1999;57:314–21.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Kang MH, Min H. Folic acid supplementation reduces oxidative stress and hepatic toxicity in rats treated chronically with ethanol. Nutr Res Pract. 2011;5:520–26. doi:10.4162/nrp.2011.5.6.520.
   PubMed Web of Science ®Google Scholar
• Silva C, Keating E, Pinto E. The impact of folic acid supplementation on gestational and long term health: critical temporal windows, benefits and risks. Porto Biomed J. 2017;2:315–32. doi:10.1016/j.pbj.2017.05.006.
   PubMedGoogle Scholar
• Budni J, Zomkowski AD, Engel D, Santos DB, dos Santos AA, Moretti M, Valvassori SS, Ornell F, Quevedo J, Farina M, et al. Folic acid prevents depressive-like behavior and hippocampal antioxidant imbalance induced by restraint stress in mice. Exp Neurol. 2013;240:112–21. doi:10.1016/j.expneurol.2012.10.024.
   PubMed Web of Science ®Google Scholar
• Linask KK, Han M. Acute alcohol exposure during mouse gastrulation alters lipid metabolism in placental and heart development: folate prevention. Birth Defects Res A Clin Mol Teratol. 2016;106:749–60. doi:10.1002/bdra.23526.
   PubMed Web of Science ®Google Scholar
• Ojeda ML, Rua RM, Nogales F, Diaz-Castro J, Murillo ML, Carreras O. The benefits of administering folic acid in order to combat the oxidative damage caused by binge drinking in adolescent rats. Alcohol alcohol. 2016;51:235–41. doi:10.1093/alcalc/agv111.
   PubMed Web of Science ®Google Scholar
• Wang LL, Zhang Z, Li Q, Yang R, Pei X, Xu Y, Wang J, Zhou SF, Li Y. Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum Reprod. 2009;24:562–79. doi:10.1093/humrep/den439.
   PubMed Web of Science ®Google Scholar
• Sogut I, Uysal O, Oglakci A, Yucel F, Kartkaya K, Kanbak G. Prenatal alcohol-induced neuroapoptosis in rat brain cerebral cortex: protective effect of folic acid and betaine. Childs Nerv Syst. 2017;33:407–17. doi:10.1007/s00381-016-3309-6.
   PubMed Web of Science ®Google Scholar
• Garcez ML, Mina F, Bellettini-Santos T, Ribeiro FM, Ghisi Frassetto AZ, Batista-Silva H, da Luz AP, Schiavo GL, Medeiros EB, Zabot GC, et al. Folic acid supplementation in the gestational phase of female rats improves age-related memory impairment and neuroinflammation in their adult and aged offspring. J Gerontol A Biol Sci Med Sci. 2021;76:991–95. doi:10.1093/gerona/glaa298.
   PubMed Web of Science ®Google Scholar
• Spear LP. The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev. 2000;24:417–63. doi:10.1016/S0149-7634(00)00014-2.
   PubMed Web of Science ®Google Scholar
• Kim EU, Varlinskaya EI, Dannenhoffer CA, Spear LP. Adolescent intermittent ethanol exposure: effects on pubertal development, novelty seeking, and social interaction in adulthood. Alcohol. 2019;75:19–29. doi:10.1016/j.alcohol.2018.05.002.
   PubMed Web of Science ®Google Scholar
• Broadwater M, Varlinskaya EI, Spear LP. Chronic intermittent ethanol exposure in early adolescent and adult male rats: effects on tolerance, social behavior, and ethanol intake. Alcohol Clin Exp Res. 2011;35:1392–403. doi:10.1111/j.1530-0277.2011.01474.x.
   PubMed Web of Science ®Google Scholar
• Acevedo MB, Nizhnikov ME, Molina JC, Pautassi RM. Relationship between ethanol-induced activity and anxiolysis in the open field, elevated plus maze, light-dark box, and ethanol intake in adolescent rats. Behav Brain Res. 2014;265:203–15. doi:10.1016/j.bbr.2014.02.032.
   PubMed Web of Science ®Google Scholar
• Karlsson O, Roman E. Dose-dependent effects of alcohol administration on behavioral profiles in the MCSF test. Alcohol. 2016;50:51–56. doi:10.1016/j.alcohol.2015.10.003.
   PubMed Web of Science ®Google Scholar
• Walker BM, Ehlers CL. Age-related differences in the blood alcohol levels of Wistar rats. Pharmacol Biochem Behav. 2009;91:560–65. doi:10.1016/j.pbb.2008.09.017.
   PubMed Web of Science ®Google Scholar
• Lakens D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol. 2013;4:863. doi:10.3389/fpsyg.2013.00863.
   PubMed Web of Science ®Google Scholar
• Fernandez MS, Baez B, Bordon A, Espinosa L, Martinez E, Pautassi RM. Short-term selection for high and low ethanol intake yields differential sensitivity to ethanol’s motivational effects and anxiety-like responses in adolescent Wistar rats. Progr Neuro-Psychopharmacol Biol Psychiatry. 2017;79:220–33. doi:10.1016/j.pnpbp.2017.06.027.
   PubMed Web of Science ®Google Scholar
• Acevedo MB, Fabio MC, Fernandez MS, Pautassi RM. Anxiety response and restraint-induced stress differentially affect ethanol intake in female adolescent rats. Neuroscience. 2016;334:259–74. doi:10.1016/j.neuroscience.2016.08.011.
   PubMed Web of Science ®Google Scholar
• Godel JC, Lee BE, McCallum DE, Lee SL, Macneil CW, Liddell GA, Shea DR. Exposure to alcohol in utero: influence on cognitive function and learning in a northern elementary school population. Paediatr Child Health. 2000;5:93–100. doi:10.1093/pch/5.2.93.
   PubMedGoogle Scholar
• Wang R, Martin CD, Lei AL, Hausknecht KA, Turk M, Micov V, Kwarteng F, Ishiwari K, Oubraim S, Wang A-L, et al. Prenatal ethanol exposure impairs sensory processing and habituation to visual stimuli, effects normalized by enrichment of postnatal environmental. Alcohol Clin Exp Res. 2022;46:891–906. doi:10.1111/acer.14818.
   PubMed Web of Science ®Google Scholar
• Fernández MS, Bellia F, Ferreyra A, Chiner F, Jiménez García AM, D’Addario C, Pautassi RM. Short-term selection for high and low ethanol intake during adolescence exerts lingering effects in stress-induced ethanol drinking and yields an anxiety-prone phenotype. Behav Brain Res. 2020;380:112445. doi:10.1016/j.bbr.2019.112445.
   PubMed Web of Science ®Google Scholar
• Pueta M, Abate P, Haymal OB, Spear NE, Molina JC. Ethanol exposure during late gestation and nursing in the rat: effects upon maternal care, ethanol metabolism and infantile milk intake. Pharmacol Biochem Behav. 2008;91:21–31. doi:10.1016/j.pbb.2008.06.007.
   PubMed Web of Science ®Google Scholar
• Girotto F, Scott L, Avchalumov Y, Harris J, Iannattone S, Drummond-Main C, Tobias R, Bello-Espinosa L, Rho JM, Davidsen J, et al. High dose folic acid supplementation of rats alters synaptic transmission and seizure susceptibility in offspring. Sci Rep. 2013;3:1465. doi:10.1038/srep01465.
   PubMed Web of Science ®Google Scholar
• Lindzon GM, Medline A, Sohn KJ, Depeint F, Croxford R, Kim YI. Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci. Carcinogenesis. 2009;30:1536–43. doi:10.1093/carcin/bgp152.
   PubMed Web of Science ®Google Scholar
• Mikael LG, Deng L, Paul L, Selhub J, Rozen R. Moderately high intake of folic acid has a negative impact on mouse embryonic development. Birth Defects Res A Clin Mol Teratol. 2013;97:47–52. doi:10.1002/bdra.23092.
   PubMed Web of Science ®Google Scholar
• Mohebbi E, Molavi M, Mohammadzadeh M, Hosseinzadeh H, Amin B. Clavulanic acid improves ethanol withdrawal symptoms in rats. Iran J Basic Med Sci. 2020;23:730–36. doi:10.22038/ijbms.2020.39129.9287.
   PubMed Web of Science ®Google Scholar
• Hamid A, Wani NA, Kaur J. New perspectives on folate transport in relation to alcoholism-induced folate malabsorption–association with epigenome stability and cancer development. FEBS J. 2009;276:2175–91. doi:10.1111/j.1742-4658.2009.06959.x.
   PubMed Web of Science ®Google Scholar
• Sharma J, Krupenko SA. Folate pathways mediating the effects of ethanol in tumorigenesis. Chem Biol Interact. 2020;324:109091. doi:10.1016/j.cbi.2020.109091.
   PubMed Web of Science ®Google Scholar
• Lawton A, Morgan CR, Schreiner CR, Schreiner CG, Baumann J, Upchurch B, Xu F, Price MS, Isaacs GD. Folate-dependent cognitive impairment associated with specific gene networks in the adult mouse hippocampus. Front Nutr. 2020;7:574730. doi:10.3389/fnut.2020.574730.
   PubMed Web of Science ®Google Scholar
• Mira RG, Lira M, Tapia-Rojas C, Rebolledo DL, Quintanilla RA, Cerpa W. Effect of alcohol on hippocampal-dependent plasticity and behavior: role of glutamatergic synaptic transmission. Front Behav Neurosci. 2019;13:288. doi:10.3389/fnbeh.2019.00288.
   PubMed Web of Science ®Google Scholar
• Lichtenberger A, Conde K, Peltzer RI, Biscarra MA, Gonzáles S, Cremonte M. Alcohol drinking in pregnant women from an Argentinian city. Health Addict/Salud Y Drogas. 2020;20:87–94. doi:10.21134/haaj.v20i1.474.
   Google Scholar