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Review

Ancient medicine for a modern disease: traditional Amazonian medicine to treat substance use disorders

Medicina Ancestral para una Enfermedad Moderna: Medicina Tradicional Amazónica para los Trastornos por el Uso de Sustancias

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Pages 691-704 | Received 18 Feb 2023, Accepted 24 Sep 2023, Published online: 10 Nov 2023

References

  • Degenhardt L, Charlson F, Ferrari A, Santomauro D, Erskine H, Mantilla-Herrara A, Whiteford H, Leung J, Naghavi M, Griswold M, et al. The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet Psychiatry. 2018 Dec 1;5:987–1012. doi:10.1016/S2215-0366(18)30337-7.
  • Funk M. Global burden of mental disorders and the need for a comprehensive, coordinated response from health and social sectors at the country level. Available at: https://apps.who.int/gb/ebwha/pdf_files/EB130/B130_9-en.pdf
  • Castillo H. Situación de la atención de salud mental en el Perú: Resultados preliminares del Estudio Epidemiológico de Salud Mental en Lima Replicación 2012. Ciclo de Conferencias de la Academia Nacional de Medicina y el Instituto Nacional de Salud. 2012.
  • Instituto Nacional de Salud Mental. Estudio Epidemiológico de Salud Mental en la Selva Peruana. Anales de Salud Mental. 2005;21:1–214.
  • Keynejad RC, Dua T, Barbui C, Thornicroft G. WHO mental health Gap Action Programme (mhGAP) intervention guide: a systematic review of evidence from low and middle-income countries. BMJ Ment Health. 2018 Feb 1;21:30–34. doi:10.1136/eb-2017-102750.
  • Labate BC, Feeney K. Ayahuasca and the process of regulation in Brazil and internationally: implications and challenges. J Drug Policy. 2012 Mar 1;23:154–61. doi:10.1016/j.drugpo.2011.06.006.
  • Winkelman M. Drug tourism or spiritual healing? Ayahuasca seekers in Amazonia. J Psychoactive Drugs. 2005 Jun 1;37:209–18. doi:10.1080/02791072.2005.10399803.
  • Kavenská V, Simonová H. Ayahuasca tourism: participants in shamanic rituals and their personality styles, motivation, benefits and risks. J Psychoactive Drugs. 2015 Oct 20;47:351–59. doi:10.1080/02791072.2015.1094590.
  • Nunes AA, Dos Santos RG, Osório FL, Sanches RF, Crippa JA, Hallak JE. Effects of ayahuasca and its alkaloids on drug dependence: a systematic literature review of quantitative studies in animals and humans. J Psychoactive Drugs. 2016 May 26;48:195–205. doi:10.1080/02791072.2016.1188225.
  • Doering-Silveira E, Grob CS, de Rios MD, Lopez E, Alonso LK, Tacla C, Da Silveira DX. Report on psychoactive drug use among adolescents using ayahuasca within a religious context. J Psychoactive Drugs. 2005 Jun 1;37:141–44. doi:10.1080/02791072.2005.10399794.
  • Thomas G, Lucas P, Capler NR, Tupper KW, Martin G. Ayahuasca-assisted therapy for addiction: results from a preliminary observational study in Canada. Curr Drug Abuse Rev. 2013 Mar 1;6:30–42. doi:10.2174/15733998113099990003.
  • Fernández X, Fábregas JM. Experience of treatment with ayahuasca for drug addiction in the Brazilian Amazon. The Therapeutic use of ayahuasca. 2014:161–82.
  • Palhano-Fontes F, Barreto D, Onias H, Andrade KC, Novaes MM, Pessoa JA, Mota-Rolim SA, Osório FL, Sanches R, Dos Santos RG, et al. Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychol Med. 2019 Mar;49:655–63. doi:10.1017/S0033291718001356.
  • Fotiou E, Gearin AK. Purging and the body in the therapeutic use of ayahuasca. Social Sci Med. 2019 Oct 1;239:112532. doi:10.1016/j.socscimed.2019.112532.
  • Berlowitz I, Walt H, Ghasarian C, Mendive F, Martin-Soelch C. Short-term treatment effects of a substance use disorder therapy involving traditional Amazonian medicine. J Psychoactive Drugs. 2019 Aug 8;51:323–34. doi:10.1080/02791072.2019.1607956.
  • Dupuis D. Practices in search of legitimacy: the contemporary use of ayahuasca, between religious and therapeutic vindications. Salud Colect. 2018 Jan 1;14:341–54. doi:10.18294/sc.2018.1539.
  • Timmermann C, Watts R, Dupuis D. Towards psychedelic apprenticeship: developing a gentle touch for the mediation and validation of psychedelic-induced insights and revelations. Transcult Psychiatry. 2022 Oct;59:691–704. doi:10.1177/13634615221082796.
  • Dupuis D. Psychedelics as tools for belief transmission. set, setting, suggestibility, and persuasion in the ritual use of hallucinogens. Front Psychol. 2021 Nov 23;12:730031. doi:10.3389/fpsyg.2021.730031.
  • Devida. Comisión Nacional para el Desarrollo y Vida sin Drogas. n.d.
  • Takiwasi a. Documentation produced by external researchers. n.d. https://takiwasi.com/es/investiga04.php.
  • Rush B, Marcus O, García S, Loizaga-Velder A, Loewinger G, Spitalier A, Mendive F. Protocol for outcome evaluation of ayahuasca-assisted addiction treatment: the case of Takiwasi center. Front Pharmacol. 2021;12:1203. doi:10.3389/fphar.2021.659644.
  • Mabit J, Sieber C. The evolution of a pilot program utilizing ayahuasca in the treatment of drug addictions. Shaman’s Drum J. 2006;73:23–31.
  • Pontual AA, Tófoli LF, Corradi-Webster CM, van Oorsouw K, Delgado AR, Ramaekers JG. The influence of ceremonial settings on mystical and challenging experiences occasioned by ayahuasca: a survey among ritualistic and religious ayahuasca users. Front Psychol. 2022;13:4239. doi:10.3389/fpsyg.2022.857372.
  • O’Shaughnessy DM, Berlowitz I, Rodd R, Sarnyai Z, Quirk F. Within-treatment changes in a novel addiction treatment program using traditional Amazonian medicine. Ther Adv Psychopharmacol. 2021 Jan;11:2045125320986634. doi:10.1177/2045125320986634.
  • Deane FP, Kelly PJ, Crowe TP, Coulson JC, Lyons GC. Clinical and reliable change in an Australian residential substance use program using the addiction severity index. J Addict Dis. 2013 Apr 1;32:194–205. doi:10.1080/10550887.2013.795470.
  • Denys A. Des plantes médicinales au service d’une action thérapeutique dans la prise en charge de l’addiction. Ethnopharmacologia. 2013;50:69–78.
  • Loizaga-Velder A, Verres R. Therapeutic effects of ritual ayahuasca use in the treatment of substance dependence—qualitative results. J Psychoactive Drugs. 2014 Jan 1;46:63–72. doi:10.1080/02791072.2013.873157.
  • https://www.takiwasi.com/en/tto01-2.php.
  • Sanz-Biset J, Cañigueral S. Plants as medicinal stressors, the case of depurative practices in Chazuta valley (Peruvian Amazonia). J Ethnopharmacol. 2013 Jan 9;145:67–76. doi:10.1016/j.jep.2012.09.053.
  • Giove R. La liana de los muertos al rescate de la vida. Peru: Ed. Devida; 2002.
  • O’Shaughnessy DM, Berlowitz I. Amazonian medicine and the psychedelic revival: considering the “dieta”. Front Pharmacol. 2021 May 28;12:639124. doi:10.3389/fphar.2021.639124.
  • Politi M, Tresca G, Menghini L, Ferrante C. Beyond the psychoactive effects of ayahuasca: cultural and pharmacological relevance of its emetic and purging properties. Planta Med. 2021 Nov 18;88:1275–86. doi:10.1055/a-1675-3840.
  • Perkins D, Ruffell SG, Day K, Pinzon Rubiano D, Sarris J. Psychotherapeutic and neurobiological processes associated with ayahuasca: a proposed model and implications for therapeutic use. Front Neurosci. 2023 Jan 31;16:2255. doi:10.3389/fnins.2022.879221.
  • Thomas McLellan A, Cacciola JC, Alterman AI, Rikoon SH, Carise D. The addiction severity index at 25: origins, contributions and transitions. Am J Addict. 2006 Jan 1;15:113–24. doi:10.1080/10550490500528316.
  • Giovannetti C, Garcia Arce S, Rush B, Mendive F. Pilot evaluation of a residential drug addiction treatment combining traditional Amazonian medicine, ayahuasca and psychotherapy on depression and anxiety. J Psychoactive Drugs. 2020 Oct 19;52:472–81. doi:10.1080/02791072.2020.1789247.
  • Berlowitz I, Walt H, Ghasarian C, O’Shaughnessy DM, Mabit J, Rush B, Martin-Soelch C. Who turns to Amazonian medicine for treatment of substance use disorder? Patient characteristics at the Takiwasi addiction treatment center. J Stud Alcohol Drugs. 2020 Jul;81:416–25. doi:10.15288/jsad.2020.81.416.
  • Beckers T, Kindt M. Memory reconsolidation interference as an emerging treatment for emotional disorders: strengths, limitations, challenges, and opportunities. Annu Rev Clin Psychol. 2017 May 8;13:99–121. doi:10.1146/annurev-clinpsy-032816-045209.
  • Torchalla I, Nosen L, Rostam H, Allen P. Integrated treatment programs for individuals with concurrent substance use disorders and trauma experiences: a systematic review and meta-analysis. J Subst Abuse Treat. 2012 Jan 1;42:65–77. doi:10.1016/j.jsat.2011.09.001.
  • Krediet E, Bostoen T, Breeksema J, van Schagen A, Passie T, Vermetten E. Reviewing the potential of psychedelics for the treatment of PTSD. The Int J Neuropsychopharmacol. 2020 Jun;23:385–400. doi:10.1093/ijnp/pyaa018.
  • Perrotta G. Accepting “change” in psychotherapy: from consciousness to awareness. J Addict Res And Adolesc Behav. 2020;3:1–08. doi:10.31579/2688-7517/018.
  • Diament M, Gomes BR, Tófoli LF. Ayahuasca and psychotherapy: beyond integration. In: Labate BC, Cavnar C, eds. Ayahuasca healing and science. Switzerland: Springer Nature; 2021:63–79.
  • Van Gordon W, Shonin E, Dunn TJ, Sheffield D, Garcia-Campayo J, Griffiths MD. Meditation-induced near-death experiences: a 3-year longitudinal study. Mindfulness. 2018 Dec;9:1794–806. doi:10.1007/s12671-018-0922-3.
  • McPeake JD, Kennedy BP, Gordon SM. Altered states of consciousness therapy. A missing component in alcohol and drug rehabilitation treatment. J Subst Abuse Treat. 1991;8:75–82. doi:10.1016/0740-5472(91)90030-E.
  • Winkelman M. Alternative and traditional medicine approaches for substance abuse programs: a shamanic perspective. J Drug Policy. 2001 Oct 1;12:337–51. doi:10.1016/S0955-3959(01)00100-1.
  • Griffiths RR, Richards WA, McCann U, Jesse R. Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacol. 2006 Aug;187:268–83. doi:10.1007/s00213-006-0457-5.
  • Lyvers M, Meester M. Illicit use of LSD or psilocybin, but not MDMA or nonpsychedelic drugs, is associated with mystical experiences in a dose-dependent manner. J Psychoactive Drugs. 2012 Nov 1;44:410–17. doi:10.1080/02791072.2012.736842.
  • Johnson MW, Hendricks PS, Barrett FS, Griffiths RR. Classic psychedelics: an integrative review of epidemiology, therapeutics, mystical experience, and brain network function. Pharmacol Ther. 2019 May 1;197:83–102. doi:10.1016/j.pharmthera.2018.11.010.
  • Liechti ME, Dolder PC, Schmid Y. Alterations of consciousness and mystical-type experiences after acute LSD in humans. Psychopharmacology. 2017 May;234:1499–510. doi:10.1007/s00213-016-4453-0.
  • Griffiths RR, Hurwitz ES, Davis AK, Johnson MW, Jesse R, Frey R. Survey of subjective“God encounter experiences”: comparisons among naturally occurring experiences and those occasioned by the classic psychedelic psilocybin, LSD, ayahuasca, or DMT. PloS One. 2019 Apr 23;14:e0214377. doi:10.1371/journal.pone.0214377.
  • Krippner S, Sulla J. Identifying spiritual content in first-person reports from ayahuasca sessions. NeuroQuantology. 2011 Mar 4;9. doi:10.14704/nq.2011.9.2.410.
  • Schoenthaler SJ, Blum K, Braverman ER, Giordano J, Thompson B, Oscar-Berman M, Badgaiyan RD, Madigan MA, Dushaj K, Li M, et al. NIDA-Drug Addiction Treatment Outcome Study (DATOS) relapse as a function of spirituality/religiosity. J Reward Defic Syndr. 2015;1:36. doi:10.17756/jrds.2015-007.
  • Babic T, Browning KN. The role of vagal neurocircuits in the regulation of nausea and vomiting. Eur J Pharmacol. 2014 Jan 5;722:38–47. doi:10.1016/j.ejphar.2013.08.047.
  • Sanger GJ, Andrews PL. Treatment of nausea and vomiting: gaps in our knowledge. Auton Neurosci. 2006 Oct 30;129:3–16. doi:10.1016/j.autneu.2006.07.009.
  • Horn CC. Why is the neurobiology of nausea and vomiting so important? Appetite. 2008 Mar 1;50:430–34. doi:10.1016/j.appet.2007.09.015.
  • De Feo V. Ethnomedical field study in northern Peruvian Andes with particular reference to divination practices. J Ethnopharmacol. 2003 Apr 1;85:243–56. doi:10.1016/S0378-8741(03)00017-5.
  • Bussmann RW, Glenn A. Medicinal plants used in northern Peru for reproductive problems and female health. J Ethnobiol Ethnomed. 2010 Dec;6:1–2. doi:10.1186/1746-4269-6-30.
  • Kamali MA, Mazaheri M, Borhani M, Babaeian M, Sharifi AM, Elsagh M, Haji Heydari MR, Yavari M, Avijgan M, Adibi P, et al. Nausea and vomiting from the perspective of modern and traditional medicine. J Islamic Iran Tradit Med. 2012 Sep 10;3:148–54.
  • Chai D, Jiang H, Li Q. Induced vomiting: a therapeutic option. Int J Clin Exp Med. 2016 Jan 1;9:17098–105.
  • Loheide‐Niesmann L, Vrijkotte TG, De Rooij SR, Wiers RW, Huizink A. Associations between autonomic nervous system activity and risk‐taking and internalizing behavior in young adolescents. Psychophysiology. 2021 Sep;58:e13882. doi:10.1111/psyp.13882.
  • Ortiz A, Bradler K, Moorti P, MacLean S, Husain MI, Sanches M, Goldstein BI, Alda M, Mulsant BH. Increased sympathetic tone is associated with illness burden in bipolar disorder. J Affect Disord. 2022 Jan 15;297:471–76. doi:10.1016/j.jad.2021.10.089.
  • Alvares GA, Quintana DS, Hickie IB, Guastella AJ. Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis. J Psychiatry Neurosci. 2016 Mar;41:89–104. doi:10.1503/jpn.140217. PMID: 26447819; PMCID: PMC4764485.
  • Eddie D, Bates ME, Buckman JF. Closing the brain–heart loop: towards more holistic models of addiction and addiction recovery. Addict Biol. 2022 Jan;27:e12958. doi:10.1111/adb.12958.
  • Ashare RL, Sinha R, Lampert R, Weinberger AH, Anderson GM, Lavery ME, Yanagisawa K, McKee SA. Blunted vagal reactivity predicts stress-precipitated tobacco smoking. Psychopharmacol (Berl). 2012 Mar;220:259–68. doi:10.1007/s00213-011-2473-3. Epub 2011 Sep 21. PMID: 21938416; PMCID: PMC3260347.
  • Lehrer PM, Gevirtz R. Heart rate variability biofeedback: how and why does it work? Front Psychol. 2014 Jul 21;5:756. doi:10.3389/fpsyg.2014.00756. PMID: 25101026; PMCID: PMC4104929.
  • Gitler A, Vanacker L, De Couck M, De Leeuw I, Gidron Y. Neuromodulation applied to diseases: the case of HRV biofeedback. J Clin Med. 2022 Oct 8;11:5927. doi:10.3390/jcm11195927. PMID: 36233794; PMCID: PMC9571900.
  • Zope SA, Zope RA. Sudarshan kriya yoga: breathing for health. Int J Yoga. 2013 Jan;6:4. doi:10.4103/0973-6131.105935.
  • Yap JYY, Keatch C, Lambert E, Woods W, Stoddart PR, Kameneva T. Critical review of transcutaneous vagus nerve stimulation: challenges for translation to clinical practice. Front Neurosci. 2020 Apr 28;14:284. doi:10.3389/fnins.2020.00284.
  • Rumlerová T, Kube E, Simonet N, Friso F, Politi M. Use of tobacco purge in a therapeutic community for the treatment of substance use disorders. Anthropol Conscious. 2023 Mar;34:7–34. doi:10.1111/anoc.12169.
  • Thomas T, Aggar C, Baker J, Massey D, Thomas M, D’Appio D, Brymer E. Social prescribing of nature therapy for adults with mental illness living in the community: a scoping review of peer-reviewed international evidence. Front Psychol. 2022 Dec 6;13:1041675. doi:10.3389/fpsyg.2022.1041675.
  • Ochiai H, Ikei H, Jo H, Ohishi M, Miyazaki Y. Relaxation effect of nature sound exposure on gambling disorder patients: a crossover study. J Integr Complement Med. 2023 Mar 27;29:518–25. doi:10.1089/jicm.2022.0611.
  • Overbey TA, Diekmann F, Lekies KS. Nature-based interventions for vulnerable youth: a scoping review. Int J Environ Health Res. 2023 Jan;33:15–53. doi:10.1080/09603123.2021.1998390.
  • Kotera Y, Rhodes C. Commentary: suggesting shinrin-yoku (forest bathing) for treating addiction. Addict Behav. 2020 Dec;111:106556. doi:10.1016/j.addbeh.2020.106556.
  • Ducarmon QR, Grundler F, Le Maho Y, Wilhelmi de Toledo F, Zeller G, Habold C, Mesnage R. Remodelling of the intestinal ecosystem during caloric restriction and fasting. Trends Microbiol. 2023 Mar 21;31:S0966-842X(23)00057–4. doi:10.1016/j.tim.2023.02.009.
  • Fernández-Rodríguez R, Martínez-Vizcaíno V, Mesas AE, Notario-Pacheco B, Medrano M, Heilbronn LK. Does intermittent fasting impact mental disorders? A systematic review with meta-analysis. Crit Rev Food Sci Nutr. 2022 Jun;17:1–16. doi:10.1080/10408398.2022.2088687.
  • Berthelot E, Etchecopar-Etchart D, Thellier D, Lancon C, Boyer L, Fond G. Fasting interventions for stress, anxiety and depressive symptoms: a systematic review and meta-analysis. Nutrients. 2021 Nov 5;13:3947. doi:10.3390/nu13113947.
  • Ganson KT, Rodgers RF, Murray SB, Nagata JM. Prevalence and demographic, substance use, and mental health correlates of fasting among U.S. college students. J Eat Disord. 2021 Jul 21;9:88. doi:10.1186/s40337-021-00443-3.
  • Winkelman MJ. The evolved psychology of psychedelic set and setting: inferences regarding the roles of shamanism and entheogenic ecopsychology. Front Pharmacol. 2021 Feb 23;12:619890. doi:10.3389/fphar.2021.619890.
  • Fotiou E. Plant use and shamanic dietas in contemporary ayahuasca shamanism in Peru. In: Prance G, McKenna D, Davis W, De Loenen B, eds. Ethnopharmacologic search for psychoactive drugs. Santa Fe, New Mexico: Synergetic Press;2018:55–69.
  • Rush BR, Marcus O, Garcia S, Loizaga-Velder A, Spitalier A, Mendive F. Ayahuasca Treatment Outcome Project (ATOP) one-year results from Takiwasi center and implications for psychedelic science. J Stud Alcohol Drugs. 2023; 10.15288/jsad.23–00005. Advance online publication. doi:10.15288/jsad.23-00005.
  • Messina N, Wish E, Nemes S. Predictors of treatment outcomes in men and women admitted to a therapeutic community. Am J Drug Alcohol Abuse. 2000 May;26:207–27. doi:10.1081/ada-100100601. PMID: 10852357.
  • Malivert M, Fatséas M, Denis C, Langlois E, Auriacombe M. Effectiveness of therapeutic communities: a systematic review. Eur Addict Res. 2012;18:1–11. doi:10.1159/000331007.
  • Loera S, Muñoz LM, Nott E, Sandefur BK. Call the curandero: improving mental health services for Mexican immigrants. Where Reflection Pract Meet the Changing Nat Social Work. 2009;9:6–20.

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