1,974
Views
1
CrossRef citations to date
0
Altmetric
Reviews

Methodological Approaches to Ketogenic Dietary Treatments in Glioma Patients from a Nutritional Point of View

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 112-122 | Received 09 May 2022, Accepted 27 Jul 2022, Published online: 12 Aug 2022

References

  • Gusyatiner O, Hegi ME. Glioma epigenetics: from subclassification to novel treatment options. Semin Cancer Biol. 2018;51:50–8. doi:10.1016/j.semcancer.2017.11.010
  • Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, et al. The epidemiology of glioma in adults: a "state of the science" review. Neuro Oncol. 2014;16(7):896–913. doi:10.1093/neuonc/nou087
  • Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231–51. doi:10.1093/neuonc/noab106
  • Ostrom QT, Cote DJ, Ascha M, Kruchko C, Barnholtz-Sloan JS. Adult glioma incidence and survival by race or ethnicity in the United States from 2000 to 2014. JAMA Oncol. 2018;4(9):1254–62. doi:10.1001/jamaoncol.2018.1789
  • Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G, Bendszus M, Balana C, Chinot O, Dirven L, et al. EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nat Rev Clin Oncol. 2021;18(3):170–86. doi:10.1038/s41571-020-00447-z
  • Wang TJC, Mehta MP. Low-grade glioma radiotherapy treatment and trials. Neurosurg Clin N Am. 2019;30(1):111–8. doi:10.1016/j.nec.2018.08.008
  • Klement RJ, Kämmerer U. Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Nutr Metab (Lond). 2011;8(1):75. doi:10.1186/1743-7075-8-75
  • Strowd RE, Cervenka MC, Henry BJ, Kossoff EH, Hartman AL, Blakeley JO. Glycemic modulation in neuro-oncology: experience and future directions using a modified Atkins diet for high-grade brain tumors. Neurooncol Pract. 2015;2(3):127–36. doi:10.1093/nop/npv010
  • Branco AF, Ferreira A, Simões RF, Magalhães-Novais S, Zehowski C, Cope E, Silva AM, Pereira D, Sardão VA, Cunha-Oliveira T, et al. Ketogenic diets: from cancer to mitochondrial diseases and beyond. Eur J Clin Invest. 2016;46(3):285–98. doi:10.1111/eci.12591
  • Verrotti A, Iapadre G, Pisano S, Coppola G. Ketogenic diet and childhood neurological disorders other than epilepsy: an overview. Expert Rev Neurother. 2017;17(5):461–73. doi:10.1080/14737175.2017.1260004
  • Paoli A, Bianco A, Damiani E, Bosco G. Ketogenic diet in neuromuscular and neurodegenerative diseases. Biomed Res Int. 2014;2014:474296. doi:10.1155/2014/474296
  • Levy RG, Cooper PN, Giri P. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev. 2012;(3):CD001903. doi:10.1002/14651858.CD001903.pub2
  • Ułamek-Kozioł M, Czuczwar SJ, Januszewski S, Pluta R. Ketogenic diet and epilepsy. Nutrients. 2019;11(10):2510. doi:10.3390/nu11102510
  • Lee PR, Kossoff EH. Dietary treatments for epilepsy: management guidelines for the general practitioner. Epilepsy Behav. 2011;21(2):115–21. doi:10.1016/j.yebeh.2011.03.008
  • Payne NE, Cross JH, Sander JW, Sisodiya SM. The ketogenic and related diets in adolescents and adults – a review. Epilepsia. 2011;52(11):1941–8. doi:10.1111/j.1528-1167.2011.03287.x
  • Martin-McGill KJ, Bresnahan R, Levy RG, Cooper PN. Ketogenic diets for drug‐resistant epilepsy. Cochrane Database Syst Rev. 2020;2020(6). Art. No.: CD001903. doi:10.1002/14651858.CD001903.pub5 (Accessed 05 August 2022).
  • Sremanakova J, Sowerbutts AM, Burden S. A systematic review of the use of ketogenic diets in adult patients with cancer. J Hum Nutr Diet. 2018;31(6):793–802. doi:10.1111/jhn.12587
  • Schwartz KA, Noel M, Nikolai M, Chang HT. Investigating the ketogenic diet as treatment for primary aggressive brain cancer: challenges and ­lessons learned. Front Nutr. 2018;5:11. doi:10.3389/fnut.2018.00011
  • Kossoff EH, Krauss GL, McGrogan JR, Freeman JM. Efficacy of the Atkins diet as therapy for intractable epilepsy. Neurology. 2003;61(12):1789–91. doi:10.1212/01.wnl.0000098889.35155.72
  • Kossoff EH, Dorward JL. The modified Atkins diet. Epilepsia. 2008;49(Suppl 8):37–41. doi:10.1111/j.1528-1167.2008.01831.x
  • Kang HC, Chung DE, Kim DW, Kim HD. Early- and late-onset complications of the ketogenic diet for intractable epilepsy. Epilepsia. 2004;45(9):1116–23. doi:10.1111/j.0013-9580.2004.10004.x
  • Liu YM, Wang HS. Medium-chain triglyceride ketogenic diet, an effective treatment for drug-resistant epilepsy and a comparison with other ketogenic diets. Biomed J. 2013;36(1):9–15. doi:10.4103/2319-4170.107154
  • Kverneland M. Modified ketogenic (Atkins) diet as a treatment option for adults with drug-resistant epilepsy [dissertation on the Internet]. Oslo: University of Oslo; 2019. [cited 2021 Apr 27]. Available from: http://urn.nb.no/URN:NBN:no-76817.
  • Weber DD, Aminzadeh-Gohari S, Tulipan J, Catalano L, Feichtinger RG, Kofler B. Ketogenic diet in the treatment of cancer - where do we stand? Mol Metab. 2020;33:102–21.
  • Pfeifer HH, Thiele EA. Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy. Neurology. 2005;65(11):1810–2. doi:10.1212/01.wnl.0000187071.24292.9e
  • Abdelwahab MG, Fenton KE, Preul MC, Rho JM, Lynch A, Stafford P, Scheck AC. The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma. PLoS One. 2012;7(5):e36197. doi:10.1371/journal.pone.0036197
  • Seyfried TN, Flores R, Poff AM, D’Agostino DP, Mukherjee P. Metabolic therapy: a new paradigm for managing malignant brain cancer. Cancer Lett. 2015;356(2 Pt A):289–300. doi:10.1016/j.canlet.2014.07.015
  • Thomas JG, Veznedaroglu E. Ketogenic diet for malignant gliomas: a review. Curr Nutr Rep. 2020;9(3):258–63. doi:10.1007/s13668-020-00332-2
  • Noorlag L, De Vos FY, Kok A, Broekman MLD, Seute T, Robe PA, Snijders TJ. Treatment of malignant gliomas with ketogenic or caloric restricted diets: a systematic review of preclinical and early clinical studies. Clin Nutr. 2019;38(5):1986–94. doi:10.1016/j.clnu.2018.10.024
  • Varshneya K, Carico C, Ortega A, Patil CG. The efficacy of ketogenic diet and associated hypoglycemia as an adjuvant therapy for high-grade gliomas: a review of the literature. Cureus. 2015;7(2):e251.
  • Sargaço B, Oliveira PA, Antunes ML, Moreira AC. Effects of the ketogenic diet in the treatment of gliomas: a systematic review. Nutrients. 2022;14(5):1007. doi:10.3390/nu14051007
  • Chung HY, Park YK. Rationale, feasibility and acceptability of ketogenic diet for cancer treatment. J Cancer Prev. 2017;22(3):127–34. doi:10.15430/JCP.2017.22.3.127
  • Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic ­reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62(10):1006–12. doi:10.1016/j.jclinepi.2009.06.005
  • Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi:https://doi.org/10.1136/bmj.n71.
  • Klein P, Tyrlikova I, Zuccoli G, Tyrlik A, Maroon JC. Treatment of glioblastoma multiforme with "classic" 4:1 ketogenic diet total meal replacement. Cancer Metab. 2020;8(1):24. doi:10.1186/s40170-020-00230-9
  • Artzi M, Liberman G, Vaisman N, Bokstein F, Vitinshtein F, Aizenstein O, Ben Bashat D. Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumors: (1)H-MRS study. J Neurooncol. 2017;132(2):267–75. doi:10.1007/s11060-016-2364-x
  • Foppiani A, De Amicis R, Lessa C, Leone A, Ravella S, Ciusani E, Silvani A, Zuccoli G, Battezzati A, Lamperti E, et al. Isocaloric ketogenic diet in adults with high-grade gliomas: a prospective metabolic study. Nutr Cancer. 2021;73(6):1004–14. doi:10.1080/01635581.2020.1779759
  • Martin-McGill KJ, Marson AG, Tudur Smith C, Jenkinson MD. The modified ketogenic diet in adults with glioblastoma: an evaluation of feasibility and deliverability within the National Health Service. Nutr Cancer. 2018;70(4):643–9. doi:10.1080/01635581.2018.1460677
  • Martin-McGill KJ, Marson AG, Tudur Smith C, Young B, Mills SJ, Cherry MG, Jenkinson MD. Ketogenic diets as an adjuvant therapy for glioblastoma (KEATING): a randomized, mixed methods, feasibility study. J Neurooncol. 2020;147(1):213–27. doi:10.1007/s11060-020-03417-8
  • Panhans CM, Gresham G, Amaral LJ, Hu J. Exploring the feasibility and effects of a ketogenic diet in patients with CNS malignancies: a retrospective case series. Front Neurosci. 2020;14:390. doi:10.3389/fnins.2020.00390
  • Porper K, Shpatz Y, Plotkin L, Pechthold RG, Talianski A, Champ CE, Furman O, Shimoni-Sebag A, Symon Z, Amit U, et al. A phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma. J Neurooncol. 2021;153(3):487–96. doi:10.1007/s11060-021-03786-8
  • Rieger J, Bähr O, Maurer GD, Hattingen E, Franz K, Brucker D, Walenta S, Kämmerer U, Coy JF, Weller M, et al. ERGO: a pilot study of ketogenic diet in recurrent glioblastoma. Int J Oncol. 2014;44(6):1843–52. doi:10.3892/ijo.2014.2382
  • Santos JG, Da Cruz WMS, Schönthal AH, Salazar MD, Fontes CAP, Quirico-Santos T, Da Fonseca CO. Efficacy of a ketogenic diet with concomitant intranasal perillyl alcohol as a novel strategy for the therapy of recurrent glioblastoma. Oncol Lett. 2018;15(1):1263–70.
  • Schreck KC, Hsu F-C, Berrington A, Henry-Barron B, Vizthum D, Blair L, Kossoff EH, Easter L, Whitlow CT, Barker PB, et al. Feasibility and biological activity of a ketogenic/intermittent-fasting diet in patients with glioma. Neurology. 2021;97(9):e953–e63. doi:10.1212/WNL.0000000000012386
  • van der Louw EJTM, Reddingius RE, Olieman JF, Neuteboom RF, Catsman-Berrevoets CE. Ketogenic diet treatment in recurrent diffuse intrinsic pontine glioma in children: a safety and feasibility study. Pediatr Blood Cancer. 2019;66(3):e27561. doi: 10.1002/pbc.27561
  • Voss M, Wagner M, von Mettenheim N, Harter PN, Wenger KJ, Franz K, Bojunga J, Vetter M, Gerlach R, Glatzel M, et al. ERGO2: a prospective, randomized trial of calorie-restricted ketogenic diet and fasting in addition to reirradiation for malignant glioma. Int J Radiat Oncol Biol Phys. 2020;108(4):987–95. doi:10.1016/j.ijrobp.2020.06.021
  • Woodhouse C, Ward T, Gaskill-Shipley M, Chaudhary R. Feasibility of a modified atkins diet in glioma patients during radiation and its effect on radiation sensitization. Curr Oncol. 2019;26(4):e433–e438.
  • Wells J, Swaminathan A, Paseka J, Hanson C. Efficacy and safety of a ketogenic diet in children and adolescents with refractory epilepsy - a review. Nutrients. 2020;12(6):1809. doi:10.3390/nu12061809
  • Schoeler NE, Cross JH. Ketogenic dietary therapies in adults with epilepsy: a practical guide. Pract Neurol. 2016;16(3):208–14. doi:10.1136/practneurol-2015-001288
  • Zupec-Kania B, Neal E, Schultz R, Roan ME, Turner Z, Welborn M. An update on diets in clinical practice. J Child Neurol. 2013;28(8):1015–26. doi:10.1177/0883073813487597
  • Schwartz K, Chang HT, Nikolai M, Pernicone J, Rhee S, Olson K, Kurniali PC, Hord NG, Noel M. Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature. Cancer Metab. 2015;3:3. doi:10.1186/s40170-015-0129-1
  • Clemente Fuentes RW, Broszko CM, Pietralcyzk ES, Nashelsky J. Efficacy of a low-carbohydrate or ketogenic diet in preventing patient morbidity and mortality. Can Fam Physician. 2020;66(4):262–3.