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Review

Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health – a comprehensive review

ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 1-29 | Received 27 Apr 2020, Accepted 26 Nov 2020, Published online: 13 Dec 2020

References

  • Abbaspour N, Hurrell R, Kelishadi R. 2014. Review on iron and its importance for human health. J Res Med Sci: J Isfahan Uni Med Sci. 19(2):164.
  • Abd El-Hack ME, Alagawany M, Amer SA, Arif M, Wahdan KMM, El-Kholy MS. 2018b. Effect of dietary supplementation of organic zinc on laying performance, egg quality and some biochemical parameters of laying hens. J Anim Physiol Anim Nutr. 102(2):e12793–549.
  • Abd El-Hack MA, Alagawany M, Arif M, Chaudhry MT, Emam M, Patra A. 2017b. Organic or inorganic zinc in poultry nutrition: a review. World Poult Sci J. 73(4):904–915.
  • Abd El-Hack ME, Alagawany M, Chaudhry MT, Saeed M, Ahmad EAM, El-Sayed SAA. 2020b. Does the gradual increase in dietary zinc oxide supplementation can affect egg quality, serum indices and productive performance of laying hens? Trop Anim Health Prod. 52(2):525–531.
  • Abd El-Hack ME, El-Hindawy MM, Attia AI, Mahrose KM. 2015. Effects of feeding dried distillers grains with solubles with or without enzyme or vitamin E supplementation on productive performance of Hisex Brown laying hens. Zag J Agri Res. 42(1):71–79.
  • Abd El-Hack ME, Alagawany M, Abdel-Moneim A-ME, Mohammed NG, Khafaga AF, Bin-Jumah M, Othman SI, Allam AA, Elnesr SS. 2020a. Cinnamon (Cinnamomum zeylanicum) oil as a potential alternative to antibiotics in poultry. Antibiotics. 9(5):210.
  • Abd El-Hack ME, Alagawany M, Arif M, Emam M, Saeed M, Arain MA, Siyal FA, Patra A, Elnesr SS, Khan RU. 2018a. The uses of microbial phytase as a feed additive in poultry nutrition–a review. Annals Anim Sci. 18(3):639–658.
  • Abd El-Hack ME, Alagawany M, Mahrose KM, Arif M, Saeed M, Arain MA, Soomro RN, Siyal FA, Fazlani SA, Fowler J. 2019. Productive performance, egg quality, hematological parameters and serum chemistry of laying hens fed diets supplemented with certain fat-soluble vitamins, individually or combined, during summer season. Anim Nutr. 5(1):49–55.
  • Abd El-Hack ME, Alagawany M, Ragab Fara M, Arif M, Emam M, Dhama K, Sarwar M, Sayab M. 2017c. Nutritional and pharmaceutical applications of nanotechnology: trends and advances. Int J Pharmacol. 13(4):340–350.
  • Abd El-Hack ME, Mahrose K, Askar AA, Alagawany M, Arif M, Saeed M, Abbasi F, Soomro RN, Siyal FA, Chaudhry MT. 2017a. Single and combined impacts of vitamin A and selenium in diet on productive performance, egg quality, and some blood parameters of laying hens during hot season. Biol Trace Elem Res. 177(1):169–179.
  • Abou-Kassem DE, Mahrose KM, Alagawany M. 2016. The role of vitamin E or clay in growing Japanese quail fed diets polluted by cadmium at various levels. Animal. 10(3):508–519.
  • Adedokun SA, Helmbrecht A, Applegate TJ. 2016. Investigation of the effect of coccidial vaccine challenge on apparent and standardized ileal amino acid digestibility in grower and finisher broilers and its evaluation in 21-day-old broilers. Poult Sci. 95(8):1825–1835.
  • Adhikari R, White D, House JD, Kim WK. 2020. Effects of additional dosage of vitamin D3, vitamin D2, and 25-hydroxyvitamin D3 on calcium and phosphorus utilization, egg quality and bone mineralization in laying hens. Poult Sci. 99(1):364–373.
  • Ahmad Z, Xie M, Wu Y, Hou S. 2019. Effect of supplemental cyanocobalamin on the growth performance and hematological indicators of the white Pekin ducks from hatch to day 21. Animals. 9(9):633.
  • Ahmadu S, Mohammed AA, Buhari H, Auwal A. 2016. An overview of vitamin C as an antistress in poultry. Malays J Vet Res. 7:9–22.
  • Ahmed ME, Abbas TE. 2011. Effects of dietary levels of methionine on broiler performance and carcass characteristics. Int J Poult Sci. 10(2):147–151.
  • Ahmed I, Qaisrani SN, Azam F, Pasha TN, Bibi F, Naveed S, Murtaza S. 2020. Interactive effects of threonine levels and protein source on growth performance and carcass traits, gut morphology, ileal digestibility of protein and amino acids, and immunity in broilers. Poult Sci. 99(1):280–289.
  • Aklakur M, Rather MA, Kumar N. 2016. Nanodelivery: an emerging avenue for nutraceuticals and drug delivery. Crit Rev Food Sci Nutr. 56(14):2352–2361.
  • Akter M, Iji PA, Graham H. 2017. Increasing zinc levels in phytase supplemented diets improves the performance and nutrient utilization of broiler chicken. SA J Anim Sci. 47(5):648–660.
  • Alagawany M, Abd El-Hack ME, Laudadio V, Tufarelli V. 2014. Effect of low-protein diets with crystalline amino acid supplementation on egg production, blood parameters and nitrogen balance in laying Japanese quail. Avian Biol Res. 7(4):235–243.
  • Alagawany M, Elnesr SS, Farag MR. 2018a. The role of exogenous enzymes in promoting growth and improving nutrient digestibility in poultry. Iran J Vet Res. 19(3):157–164.
  • Alagawany M, Elnesr SS, Farag MR, El-Hack MEA, Khafaga AF, Taha AE, Tiwari R, Yatoo MI, Bhatt P, Khurana SK, et al. 2019. Omega-3 and Omega-6 fatty acids in poultry nutrition: effect on production performance and health. Animals. 9(8):573.
  • Alagawany M, Farag MR, Dhama K, Patra A. 2018c. Nutritional significance and health benefits of designer eggs. World Poult Sci J. 74(2):317–330.
  • Alagawany M, Abd El-Hack ME, Farag MR, Sachan S, Karthik K, Dhama K. 2018b. The use of probiotics as eco-friendly alternatives for antibiotics in poultry nutrition. Environ Sci Pollut Res Int. 25(11):10611–10618.
  • Al-Hayani WK. 2017. Effect of threonine supplementation on broiler chicken productivity traits. Int J Poult Sci. 16(4):160–168.
  • Al-Khalaifah H, Al-Nasser A, Givens DI, Rymer C, Yaqoob P. 2020. Comparison of different dietary sources of n-3 polyunsaturated fatty acids on immune response in broiler chickens. Heliyon. 6(1):e03326.
  • Alkhatib A, Tsang C, Tiss A, Bahorun T, Arefanian H, Barake R, Khadir A, Tuomilehto J. 2017. Functional foods and lifestyle approaches for diabetes prevention and management. Nutrients. 9(12):1310.
  • Anwar MI, Awais MM, Akhtar M, Navid MT, Muhammad F. 2019. Nutritional and immunological effects of nano-particles in commercial poultry birds. World Poult Sci J. 75(2):261–272.
  • Arif M, Hussain I, Mahmood MA, Abd El-Hack ME, Swelum AA, Alagawany M, Komany A. 2019. Effect of varying levels of chromium propionate on growth performance and blood biochemistry of broilers. Animals. 9(11):935.
  • Aronson K. 2017. Defining 'nutraceuticals': neither nutritious nor pharmaceutical. Br J Clin Pharmacol. 83(1):8–19.
  • Aslam S, Shukat R, Khan MI, Shahid M. 2020. Effect of dietary supplementation of bioactive peptides on antioxidant potential of broiler breast meat and physicochemical characteristics of nuggets. Food Sci Anim Resour. 40(1):55–73.
  • Azzam MMM, El-Gogary MR. 2015. Effects of dietary threonine levels and stocking density on the performance, metabolic status and immunity of broiler chickens. Asian J Anim Vet Adv. 10(5):215–225.
  • Babiker MS, Abbas SA, Kijora C, Danier J. 2011. The effect of dietary protein and energy levels during the growing period of egg-type pullets on internal egg characteristics of phase one of production in arid hot climate. Int J Poult Sci. 10(9):697–704.
  • Bao YM, Choct M, Iji PA, Bruerton K. 2007. Effect of organically complexed copper, iron, manganese, and zinc on broiler performance, mineral excretion, and accumulation in tissues. J Appl Poult Res. 16(3):448–455.
  • Baradaran N, Shahir MH, Asadi Kermani Z. 2017. Subsequent bone and metabolic responses of broilers to high-non-phytate phosphorus diets in the starter period. Br Poult Sci. 58(4):435–441.
  • Baxter MFA, Greene ES, Kidd MT, Tellez-Isaias G, Orlowski S, Dridi S. 2020. Water amino acid-chelated trace mineral supplementation decreases circulating and intestinal HSP70 and proinflammatory cytokine gene expression in heat-stressed broiler chickens. J Anim Sci. 98(3):skaa049.
  • Belinda TJ. 2014. Significance of riboflavin (vitamin-B2) for health. J Pharm Sci Res. 6:285–287.
  • Belloir P, Lessire M, Lambert W, Corrent E, Berri C, Tesseraud S. 2019. Changes in body composition and meat quality in response to dietary amino acid provision in finishing broilers . Animal. 13(5):1094–1102.
  • Beski SS, Swick RA, Iji PA. 2015. Specialized protein products in broiler chicken nutrition: A review. Anim Nutr. 1(2):47–53.
  • Bess F, Vieira SL, Favero A, Cruz RA, Nascimento PC. 2012. Dietary iron effects on broiler breeder performance and egg iron contents. Anim Feed Sci Technol. 178(1-2):67–73.
  • Bhanja SK, Mandal AB, Majumdar S, Mehra M, Goel A. 2012. Effect of in ovo injection of vitamins on the chick weight and post-hatch growth performance in broiler chickens. Ind J Poult Sci. 47(3):306–310.
  • Bintvihok A, Kositcharoenkul S. 2006. Effect of dietary calcium propionate on performance, hepatic enzyme activities and aflatoxin residues in broilers fed a diet containing low levels of aflatoxin B1. Toxicon. 47(1):41–46.
  • Bortoluzzi C, Rochell SJ, Applegate TJ. 2018. Threonine, arginine, and glutamine: Influences on intestinal physiology, immunology, and microbiology in broilers. Poult Sci. 0:1–9.
  • Bouyeh M. 2012. Effect of excess lysine and methionine on immune system and performance of broilers. Ann Biol Res. 3:3218–3224.
  • Bouyeh M, Gevorgyan OK. 2016. Performance hematology and correlation between traits under the effects of dietary lysine and methionine in broilers. Iran J Appl Anim Sci. 6:917–923.
  • Browning LC, Antipatis C, Cowieson AJ. 2012. The interactive effects of vitamin D, phytase, calcium, and phosphorus in broiler performance and skeletal integrity. In 23rd Annual Australian Poultry Science Symposium, 81.
  • Bulbul A, Bulbul T, Kucukersan S, Sireli M. 2008. Effects of dietary supplementation of organic and inorganic Zn, Cu and Mn on oxidant/antioxidant balance in laying hens. Kafkas Univ Vet Fak Derg. 14:19–24.
  • Cai S, Wu C, Gong L, Song T, Wu H, Zhang L. 2012. Effects of nano-selenium on performance, meat quality, immune function, oxidation resistance, and tissue selenium content in broilers. Poult Sci. 91(10):2532–2539.
  • Castro FLS, Kim HY, Hong YG, Kim WK. 2019. The effect of total sulfur amino acid levels on growth performance, egg quality, and bone metabolism in laying hens subjected to high environmental temperature. Poult Sci. 98(10):4982–4993.
  • Cencic A, Chingwaru W. 2010. The role of functional foods, nutraceuticals, and food supplements in intestinal health. Nutrients. 2(6):611–625.
  • Chandrasekar S, Balakrishnan U. 2019. Chromium nutrition in alleviating the effect of stressors in poultry production: a review. Int J Anim Sci. 3(1):1040.
  • Chen W, Fouad AM, Ruan D, Wang S, Xia WG, Zheng CT. 2018a. Effects of dietary thiamine supplementation on performance, egg quality, and antioxidant-related enzymes in Chinese egg-laying ducks. JAPS, J Anim Plant Sci. 28(6):1597–1601.
  • Chen Y, Zhang H, Cheng Y, Li Y, Wen C, Zhou Y. 2018b. Dietary L-threonine supplementation attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier damage of broiler chickens at an early age. Br J Nutr. 119(11):1254–1262.
  • Choct M, Naylor AJ. 2004. The effect of dietary selenium source and vitamin E levels on performance of male broilers. Asian Australas J Anim Sci. 17(7):1000–1006.
  • Chrystal PV, Moss AF, Khoddami A, Naranjo VD, Selle PH, Liu SY. 2020. Effects of reduced crude protein levels, dietary electrolyte balance, and energy density on the performance of broiler chickens offered maize-based diets with evaluations of starch, protein, and amino acid metabolism. Poult Sci. 99(3):1421–1431.
  • Čobanová K, Petrovič V, Mellen M, Arpášova H, Grešáková Ľ, Faix Š. 2011. Effects of dietaryform of selenium on its distribution in eggs. Biol Trace Elem Res. 144(1-3):736–746.
  • Colombo ML. 2010. An update on vitamin E, tocopherol and tocotrienol-perspectives. Molecules. 15(4):2103–2113.
  • Corzo A, Kidd MT, Dozier WA, III, Vieira SL. 2007. Marginality and needs of dietary valine for broilers fed certain all-vegetable diets. J Appl Poult Res. 16(4):546–554.
  • Coto C, Yan F, Cerrate S, Wang Z, Sacakli P, Waldroup PW, Halley JT, Wiernusz CJ, Martinez A. 2008. Effects of dietary levels of calcium and nonphytate phosphorus in broiler starter diets on live performance, bone development and growth plate conditions in male chicks fed a corn-based diet. Int J Poult Sci. 7(2):101–109.
  • Crowley JD, Traynor DA, Weatherburn DC. 2000. Enzymes and proteins containing manganese: an overview. In Metal ions in biological systems, 257–326. CRC Press.
  • Das S, Palai TK, Mishra SR, Das D, Jena B. 2011. Nutrition in relation to diseases and heat stress in poultry. Vet World. 4(9):429.
  • Debnath BC, Biswas P, Roy B. 2019. The effects of supplemental threonine on performance, carcass characteristics, immune response and gut health of broilers in subtropics during pre-starter and starter period. J Anim Physiol Anim Nutr. 103(1):29–40.
  • Delange F. 1998. Risks and benefits of iodine supplementation. The Lancet. 351(9107):923–924.
  • Deniz G, Gezen SS, Turkmen II. 2005. Effects of two supplemental dietary selenium sources (mineral and organic) on broiler performance and drip-loss. Revue Méd Vét. 156:423.
  • Dhama K, Chakraborty S, Tiwari R, Verma AK, Saminathan M, Amarpal Malik YS, Nikousefat Z, Javdani M, Khan RU. 2014b. A concept paper on novel technologies boosting production and safeguarding health of humans and animals. Res Op Vet Sci. 4(7):353–370.
  • Dhama K, Saminathan M, Jacob SS, Singh M, Karthik K, A, Tiwari R, Sunkara LT, Malik YS, Singh RK, et al. 2015. Effect of immunomodulation and immunomodulatory agents on health with some bioactive principles, modes of action and potent biomedical applications. Int J Pharmacol. 11(4):253–290.
  • Dhama K, Tiwari R, Khan RU, Chakrabort S, Gopi M, Karthik K, Saminathan M, Desingu PA, Sunkara LT. 2014a. Growth promoters and novel feed additives improving poultry production and health, bioactive principles and beneficial applications: the trends and advances-a review. Int J Pharmacol. 10(3):129–159.
  • Dibner JJ, Richards JD, Kitchell ML, Quiroz MA. 2007. Metabolic challenges and early bone development. J Appl Poult Res. 16(1):126–137.
  • DiNicolantonio JJ, O'Keefe JH. 2018. Importance of maintaining a low omega-6/omega-3 ratio for reducing inflammation. Open Heart. 5(2):e000946.
  • Diplock AT, Charuleux J-L, Crozier-Willi G, Kok FJ, Rice-Evans C, Roberfroid M, Stahl W, Viña-Ribes J. 1998. Functional food science and defence against reactive oxidative species. Br J Nutr. 80(S1):S77–S112.
  • Dozier WA, III, Moran ET, Jr, Kidd MT. 2001. Comparisons of male and female broiler responses to dietary threonine from 42 to 56 days of age. J Appl Poult Res. 10(1):53–59.
  • Driver JP, Atencio A, Pesti GM, Edwards HM, Jr, Bakalli RI. 2006. The effect of maternal dietary vitamin D3 supplementation on performance and tibial dyschondroplasia of broiler chicks. Poult Sci. 85(1):39–47.
  • Driver JP, Pesti GM, Bakalli RI, Edwards HM. Jr. 2006. The effect of feeding calcium- and phosphorus-deficient diets to broiler chickens during the starting and growing-finishing phases on carcass quality. Poult Sci. 85(11):1939–1946.
  • Drygalski AV, Adamson JW. 2013. Iron metabolism in man. JPEN J Parenter Enteral Nutr. 37(5):599–606.
  • Ebeid TA. 2009. Organic selenium enhances the antioxidative status and quality of cockerel semen under high ambient temperature. Br Poult Sci. 50(5):641–647.
  • Ebeid TA. 2012. Vitamin E and organic selenium enhances the antioxidative status and quality of chicken semen under high ambient temperature. Br Poult Sci. 53(5):708–714.
  • Elgeddawy SA, Shaheen HM, El-Sayed YS, Abd Elaziz M, Darwish A, Samak D, Batiha GE, Mady RA, Bin-Jumah M, Allam AA, Alagawany M, et al. 2020. Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken. J Anim Physiol Anim Nutr (Berl)). 104(2):549–557.
  • El-Kholy MS, Ibrahim ZAEG, El-Mekkawy MM, Alagawany M. 2019. Influence of in-ovo administration of some water-soluble vitamins on hatchability traits, growth, carcass traits and blood chemistry of Japanese quails. Ann Anim Sci. 19(1):97–111.
  • Elnesr SS, Alagawany M, Elwan HAM, Fathi MA, Farag MR. 2020. Sodium butyrate improves the intestinal health of poultry. Ann Anim Sci. 20(1):1–13.
  • Elnesr SS, Elwan HAM, Xu QQ, Xie C, Dong XY, Zou XT. 2019b. Effects of in ovo injection of sulfur-containing amino acids on heat shock protein 70, corticosterone hormone, antioxidant indices, and lipid profile of newly hatched broiler chicks exposed to heat stress during incubation. Poult Sci. 98(5):2290–2298.
  • Elnesr SS, Ropy A, Abdel-Razik AH. 2019a. Effect of dietary sodium butyrate supplementation on growth, blood biochemistry, haematology and histomorphometry of intestine and immune organs of Japanese quail. Animal. 13(6):1234–1244.
  • Elsayed MA, Wakwak MM, Mahrose KHM. 2010. Effect of pyridoxine injection in Japanese quail eggs on hatchability, performance and some physiological parameters. Isotope Rad Res. 472(1):109–123.
  • El-Senousey HK, Chen B, Wang JV, Atta AM, Mohamed FR, Nie QH. 2018. Effect of dietary vitamin C, vitamin E and alpha-lipoic acid supplementation on the antioxidant defense system and immune related gene expression in broilers exposed to oxidative stress by dexamethasone. Poult Sci. 97(1):30–38.
  • Elwan HA, Elnesr SS, Xu Q, Xie C, Dong X, Zou X. 2019. Effects of in ovo methionine-cysteine injection on embryonic development, antioxidant status, IGF-I and TLR4 gene expression, and jejunum histomorphometry in newly hatched broiler chicks exposed to heat stress during incubation. Animals. 9(1):25.
  • Erf GF, Bottje WG, Bersi TK, Headrick MD, Fritts CA. 1998. Effects of dietary vitamin E on the immune system in broilers: altered proportions of CD4 T cells in the thymus and spleen. Poult Sci. 77(4):529–537.
  • Estalkhzir FM, Khojasteh S, Jafari M. 2013. The effect of different levels of threonine on performance and carcass characteristics of broiler chickens. J Nov Appl Sci. 2:382–386.
  • Fagundes NS, Milfort MC, Williams SM, Da Costa MJ, Fuller AL, Menten JF, Rekaya R, Aggrey SE. 2020. Dietary methionine level alters growth, digestibility, and gene expression of amino acid transporters in meat-type chickens. Poult Sci. 99(1):67–75.
  • Faluyi OB, Agbede JO, Adebayo IA. 2015. Growth performance and immunological response to Newcastle disease vaccinations of broiler chickens fed lysine supplemented diets. J Vet Med Anim Health. 7(3):77–84.
  • Farag MR, Alagawany M, Abd El-Hac ME, Arif M, Ayasan T, Dhama K, Patra A, Karthik K. 2017. Role of chromium in poultry nutrition and health: beneficial applications and toxic effects. Int J Pharmacol. 13(7):907–915.
  • Faria BD, Silva LM, Ribeiro Junior V, Ferreira AHDN, Rostagno HS, Albino LFT, Hannas MI. 2020. Organic trace minerals and calcium levels in broilers' diets to 21 days old. Sci Agric (Piracicaba, Braz).). 77(1)
  • Feng J, Ma WQ, Niu HH, Wu XM, Wang Y, Feng J. 2010. Effects of zinc glycine chelate on growth, hematological, and immunological characteristics in broilers. Biol Trace Elem Res. 133(2):203–211.
  • Ferdous Z, Aktaruzzaman M, Rahman MM, Howlader MMR. 2018. Effects of multivitamins and enzymes on growth performance and hematological parameters of broilers at Meherpur in Bangladesh. J Dairy Vet Sci. 5(5):555674.
  • Fernandez ML. 2015. Egg consumption and human health. Nutrients. :1–168.
  • Figueiredo GO, Bertechini AG, Fassani EJ, Rodrigues PB, Brito JÁG, Castro SF. 2012. Performance and egg quality of laying hens fed with dietary levels of digestible lysine and threonine. Arq Bras Med Vet Zootec. 64(3):743–750.
  • Fleming RH, McCormack HA, McTeir L, Whitehead CC. 2003. Effects of dietary particulate limestone, vitamin K3 and fluoride and photostimulation on skeletal morphology and osteoporosis in laying hens. Br Poult Sci. 44(5):683–689.
  • Frei R, Akdis M, O'Mahony L. 2015. Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence. Curr Opin Gastroenterol. 31(2):153–158.
  • Friedman A, Sklan D. 1997. Effects of retinoids on immune responses in birds. World Poult Sci J. 53(2):185–195.
  • Fritts CA, Waldroup PW. 2003. Effect of source and level of vitamin D on live performance and bone development in growing broilers. J Appl Poult Res. 12(1):45–52.
  • Fu Z, Kato H, Sugahara K, Kubo T. 2000. Retinoic acid accelerates the development of reproductive organs and egg production in Japanese quail (Coturnix coturnix japonica). Biol Rep. 63(6):1795–1800.
  • Gangadoo S, Stanley D, Hughes RJ, Moore RJ, Chapman J. 2016. Nanoparticles in feed: Progress and prospects in poultry research. Trends Food Sci Technol. 58:115–126.
  • Gao J, Lin H, Wang XJ, Song ZG, Jiao HC. 2010. Vitamin E supplementation alleviates the oxidative stress induced by dexamethasone treatment and improves meat quality in broiler chickens. Poult Sci. 89(2):318–327.
  • Garcia AFQM, Murakami AE, do Amaral Duarte CR, Rojas ICO, Picoli KP, Puzotti MM. 2013. Use of vitamin D3 and its metabolites in broiler chicken feed on performance, bone parameters and meat quality. Asian Australas J Anim Sci. 26(3):408–415.
  • Ghoreyshi SM, Omri B, Chalghoumi R, Bouyeh M, Seidavi A, Dadashbeiki M, Lucarini M, Durazzo A, Hoven RVD, Santini A. 2019. Effects of dietary supplementation of L-carnitine and excess lysine-methionine on growth performance, carcass characteristics, and immunity markers of broiler chicken. Animals. 9(9):608.
  • Gottardo ET, Burin Junior ÁM, Lemke BV, Silva AM, Busatta Pasa CL, Muller Fernandes JI. 2017. Immune response in Eimeria sp. and E. coli challenged broilers supplemented with amino acids. Austral J Vet Sci. 49(3):175–184.
  • Gottardo ET, Prokoski K, Horn D, Viott AD, Santos TC, Fernandes JI. 2016. Regeneration of the intestinal mucosa in Eimeria and E. Coli challenged broilers supplemented with amino acids. Poult Sci. 95(5):1056–1065.
  • Goulart CC, Costa FGP, Silva JHV, Souza JG, Rodrigues VP, Oliveira CFS. 2011. Requirements of digestible methionine + cystine for broiler chickens at 1 to 42 days of age. R Bras Zootec. 40(4):797–803.
  • Gundberg CM, Nishimoto SK. 2006. Vitamin K dependent proteins of bone and cartilage. Dynam Bone Cartil Met. 55–70.
  • Haas RH. 1988. Thiamin and the brain. Annu Rev Nutr. 8(1):483–515.
  • Habibian M, Ghazi S, Moeini MM, Abdolmohammadi A. 2014. Effects of dietary selenium and vitamin E on immune response and biological blood parameters of broilers reared under thermoneutral or heat stress conditions. Int J Biometeorol. 58(5):741–752.
  • Halliwell B. 1987. Oxidants and human disease: some new concepts. Faseb J. 1(5):358–364.
  • Hamano Y, Okada S, Tanaka T. 1999. Effects of thiamine and clenbuterol on body composition, plasma metabolites and hepatic oxygen consumption in broiler chicks. Br Poult Sci. 40(1):127–130.
  • Han IK, Lee JH. 2000. The role of synthetic amino acids in monogastric animal production-review. Asian Australas J Anim Sci. 13(4):543–560.
  • Haq Z, Jain RK, Khan N, Dar MY, Ali S, Gupta M, Varun TK. 2016. Recent advances in role of chromium and its antioxidant combinations in poultry nutrition: a review. Vet World. 9(12):1392–1399.
  • Hashish IME, Sorour HA, Mohamed FA, El-Medany NM. 2010. Effects of different levels of copper on broiler performance. J. Anim Poultry Prod Mansoura Univ. 1(8):317–323.
  • Hasler CM. 2002. Functional Foods: benefits, concerns and challenges-a position paper from the american council on science and health. J Nutr. 132(12):3772–3781.
  • Hassanpour H, Bahadoran S, Borjian N. 2016. Vitamin E improves morphology and absorptive surface of small intestine in broiler chickens reared at high altitude. Poult Sci J. 4:19–26.
  • Helal NA, Eassa HA, Amer AM, Eltokhy MA, Edafiogho I, Nounou MI. 2019. Nutraceuticals’ novel formulations: the good, the bad, the unknown and patents involved. Recent Pat Drug Delivery Formul. 13(2):105–156.
  • Hernandez-Patlan D, Solis-Cruz B, Pontin KP, Latorre D, Baxter MFA, Hernandez-Velasco XH, Merino-Guzman R, Mendez-Albores A, Hargis BM, Lopez-Areilano R, et al. 2019. Evaluation of the dietary supplementation of a formulation containing ascorbic acid and a solid dispersion of curcumin with boric acid against Salmonella Enteritidis and necrotic eneteris in broiler chickens. Animals. 9(4):184.
  • Hilliar M, Keerqin C, Girish CK, Barekatain R, Wu SB, Swick RA. 2020. Reducing protein and supplementing crystalline amino acids, to alter dietary amino acid profiles in birds challenged for subclinical necrotic enteritis. Poult Sci. 99(4):2048–2060.
  • Holick MF. 2004. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 79(3):362–371.
  • Horvath M, Babinsky L. 2018. Impact of selected antioxidant vitamins (vitamin A, E, and C) and microminerals (Zn, Se) on the antioxidant status and performance under high environmental temperature in poultry; a review. Acta Agric Scand Sect A – Anim Sci. 68(3):152–160.
  • Hossain SM, Barreto SL, Bertechini AG, Rios AM, Silva CG. 1998. Influence of dietary Vitamin E level on egg production of broiler breeders, and on the growth and immune response of progeny in comparison with the progeny from eggs injected with Vitamin E. Anim Feed Sci Technol. 73(3–4):307–317.
  • Huang Y, Li W, Xu D, Li B, Tian Y, Zan L. 2016. Effect of dietary selenium deficiency on the cell apoptosis and the level of thyroid hormones in chicken. Biol Trace Elem Res. 171(2):445–452.
  • Hussain MI, Khan SA, Chaudhary ZI, Aslam A, Ashraf K, Rai MF. 2004. Effect of organic and inorganic selenium with and without vitamin E on immune system of broilers. Pak Vet J. 24:1–4.
  • Ibrahim D, El-Sayed R, Khater SI, Said EN, El-Mandrawy SAMC. 2018. Different oil sources affects performance, behavior, cytokines mRNA exp of broiler chickens. Anim Nutr. 4(1):44–51.
  • Ibrahim D, Kishawy ATY, Khater SI, Arisha AH, Mohammed HA, Abdelaziz AS, El-Rahman GIA, Elabbasy MT. 2019. Effect of dietary modulation of Selenium form and level on performance, tissue retention, quality of frozen stored meat and gene expression of antioxidant status in Ross broiler chicken. Animals. 9(6):342.
  • Jahandideh F, Majumder K, Chakrabarti S, Morton JS, Panahi S, Kaufman S, Davidge ST, Wu J. 2014. Beneficial effects of simulated gastro-intestinal digests of fried egg and its fractions on blood pressure, plasma lipids and oxidative stress in spontaneously hypertensive rats. Plos One. 9(12):e115006.
  • Jampilek J, Kos J, Kralova K. 2019. Potential of nanomaterial applications in dietary supplements and foods for special medical purposes. Nanomaterials. 9(2):296.
  • Jerysz A, Lukaszewicz E. 2013. Effect of dietary selenium and vitamin E on ganders' response to semen collection and ejaculate characteristics. Biol Trace Elem Res. 153(1-3):196–204.
  • Jha R, Singh AK, Yadav S, Berrocoso JFD, Mishra B. 2019. Early nutrition programming (in ovo and post-hatch feeding) as a strategy to modulate gut health of poultry . Front Vet Sci. 6:82.
  • Jong CJ, Azuma J, Schaffer S. 2012. Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids. 42(6):2223–2232.
  • Kabir S. 2009. The role of probiotics in the poultry industry. Int J Mol Sci. 10(8):3531–3546.
  • Kakhki R, Heuthorst T, Mills A, Neijat M, Kiarie E. 2019. Interactive effects of calcium and top-dressed 25-hydroxy vitamin D3 on egg production, egg shell quality, and bones attributes in aged Lohmann LSL-lite layers. Poult Sci. 98(3):1254–1262.
  • Kamalzadeh A, Ila N, Heydarnejad O. 2009. Effects of emulsified vitamins on broiler performance. World J Zool. 4:42–46.
  • Karadas F, Erdoğan S, Kor D, Oto G, Uluman M. 2016. The effects of different types of antioxidants (Se, vitamin E and carotenoids) in broiler diets on the growth performance, skin pigmentation and liver and plasma antioxidant concentrations. Rev Bras Cienc Avic. 18(1):101–116.
  • Karavolias J, Salois MJ, Baker KT, Watkins K. 2018. Raised without antibiotics: impact on animal welfare and implications for food policy. Transl Anim Sci. 2(4):337–348.
  • Kaya S, Yildirim H. 2011. The effect of dried sweet potato (Ipomea batatas) vines on egg yolk color and some egg yield parameters. Int J Agric Biol. 1. 766–770.
  • Kerr BJ, Moran ET Jr, Kidd MT. 2005. Effect of supplementary tryptophan prior to marketing on carcass quality in Broiler. J. Appl. Poult. Res. 14 (2): 306–314.
  • ‏Keerqin C, Wu SB, Svihus B, Swick R, Morgan N, Choct M. 2017. An early feeding regime and a high-density amino acid diet on growth performance of broilers under subclinical necrotic enteritis challenge. Anim Nutr. 3(1):25–32.
  • Khajali F, Wideman RF. 2010. Dietary arginine: metabolic, environmental, immunological and physiological interrelationships. World Poult Sci J. 66(4):751–766.
  • Khanduri U, Sharma A. 2007. Megaloblastic anaemia: prevalence and causative factors. Nat Med J. India. 20(4):172–175.
  • Khatlab A, Del Vesco AP, de Oliveira Neto AR, Fernandes RPM, Gasparino E. 2019. Dietary supplementation with free methionine or methionine dipeptide mitigates intestinal oxidative stress induced by Eimeria spp. challenge in broiler chickens. J Anim Sci Biotechnol. 10(1):58.
  • Khatun A, Chowdhury SD, Roy BC, Dey B, Haque A, Chandran B. 2019. Comparative effects of inorganic and three forms of organic trace minerals on growth performance, carcass traits, immunity, and profitability of broilers. J Adv Vet Anim Res. 6(1):66–73.
  • Kidd MT. 2004. Nutritional modulation of immune function in broilers. Poult Sci. 83(4):650–657.
  • Kidd MT, Ferket PR, Qureshi MA. 1996. Zinc metabolism with special reference to its role in immunity. World Poult Sci J. 52(3):309–323.
  • Kidd MT, Kerr BJ. 1996. L-threonine for poultry: a review. J Appl Poult Res. 5(4):358–367.
  • Kidd MT, McDaniel CD, Branton SL, Miller ER, Boren BB, Fancher BI. 2004. Increasing amino acid density improves live performance and carcass yields of commercial broilers. J Appl Poult Res. 13(4):593–604.
  • Kidd MT, Peebles ED, Whitmarsh SK, Yeatman JB, Wideman RF. Jr 2001. Growth and immunity of broiler chicks as affected by dietary arginine. Poult Sci. 80(11):1535–1542.
  • Kieliszek M, Błażejak S. 2016. Current knowledge on the importance of selenium in food for living organisms: a review. Molecules. 21(5):609.
  • Kita K, Nagao K, Taneda N, Inagaki Y, Hirano K, Shibata T, Yaman MA, Conlon MA, Okumura J-i. 2002. Insulin-like growth factor binding protein-2 gene expression can be regulated by diet manipulation in several tissues of young chickens. J Nutr. 132(2):145–151.
  • Konjufca VH, Pesti GM, Bakalli RI. 1997. Modulation of cholesterol levels in broiler meat by dietary garlic and copper. Poult Sci. 76(9):1264–1271.
  • Kumar P, Biswas A, Bharti VK, Srivastava RB. 2013. Effects of dietary copper supplementation on performance and blood biochemical parameters in broiler chickens at cold desert region in India. J Vet Sci Photon. 114:166–172.
  • Kundu A, Mitra A. 2013. Flavoring extracts of Hemidesmus indicus roots and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities. Plant Foods Hum Nutr. 68(3):247–253.
  • Kwiatkowska K, Winiarska-Mieczan A, Kwiecień M. 2017. Feed additives regulating calcium homeostasis in the bones of poultry–a review. Ann Anim Sci. 17(2):303–316.
  • Laudadio V, Lorusso V, Lastella NMB, Dhama K, Karthik K, Tiwari R, Alam GM, Tufarelli V. 2015. Enhancement of nutraceutical value of table eggs through poultry feeding strategies. Int J Pharmacol. 11(3):201–212.
  • Lavelle PA, LLoyd QP, Gay CV, Leach RM. Jr. 1994. Vitamin K deficiency does not functionally impair skeletal metabolism of laying hens and their progeny. J Nutr. 124(3):371–377.
  • Le Floc'h N, Melchior D, Obled C. 2004. Modifications of protein and amino acid metabolism during inflammation and immune system activation. Livest Prod Sci. 87(1):37–45.
  • Lee KH, Park JH, Kim Ty Kim Hu, Lee SY. 2007. Systems metabolic engineering of Escherichia coli for L‐threonine production. Mole Syst Biol. 3(1)
  • Leeson S, Caston L, Summers JD. 1996. Broiler response to energy or energy and protein dilution in the finisher diet. Poult Sci. 75(4):522–528.
  • Lewis PD. 2004. Responses of domestic fowl to excess iodine: a review. Br J Nutr. 91(1):29–39.
  • Li S, Lin Y, Lu L, Xi L, Wang Z, Hao S, Zhang L, Li K, Luo X. 2011. An estimation of the manganese requirement for broilers from 1 to 21 days of age. Biol Trace Elem Res. 143(2):939–948.
  • Li P, Yin YL, Li D, Kim SW, Wu G. 2007. Amino acids and immune function. Br J Nutr. 98(2):237–252.
  • Lien KA, Sauer WC, Fenton M. 1997. Mucin output in ileal digesta of pigs fed a protein-free diet. Z Ernahrungswiss. 36(2):182–190.
  • Lin H, Wang LF, Song JL, Xie YM, Yang QM. 2002. Effect of dietary supplemental levels of vitamin A on the egg production and immune responses of heat-stressed laying hens. Poult Sci. 81(4):458–465.
  • Liu ZH, Lu L, Li SF, Zhang LY, Xi L, Zhang KY, Luo XG. 2011. Effects of supplemental zinc source and level on growth performance, carcass traits, and meat quality of broilers. Poult Sci. 90(8):1782–1790.
  • Liu NQ, Xu Q, Hou XL, Liu PS, Chai ZF, Zhu L, Zhao ZY, Wang ZH, Li YF. 2001. The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency. Brain Res Bull. 55(2):309–312.
  • Lohakare JD, Ryu MH, Hahn TW, Lee JK, Chae BJ. 2005. Effects of supplemental ascorbic acid on the performance and immunity of commercial broilers. J Appl Poult Res. 14(1):10–19.
  • Lozoff B, Kaciroti N, Walter T. 2006. Iron deficiency in infancy: applying a physiologic framework for prediction. Am J Clin Nutr. 84(6):1412–1421.
  • Lu L, Zhao LL, Dong SY, Liao XD, Dong XY, Zhang LY, Luo XG. 2019. Dietary supplementation of organic or inorganic chromium modulates the immune responses of broilers vaccinated with Avian Influenza virus vaccine. Animal. 13(5):983–991.
  • Lu L, Luo XG, Ji C, Liu B, Yu SX. 2007. Effect of manganese supplementation on carcass traits, meat quality and lipid oxidation in broilers. J Anim Sci. 85(3):812–822.
  • Mahrose KM, Sonbol SM, Abd El-Hack ME. 2012. Response of laying hensto dietary vitamins A, E and selenium supplementation under Egyptian summer conditions. Egypt J Anim Prod. 47(Suppl):167–181.
  • Makarski B, Gortat M, Lechowski J, Zukiewicz-Sobczak W, Sobczak P, Zawislak K. 2014. Impact of copper (Cu) at the dose of 50 mg on haematological and biochemical blood parameters in turkeys, and level of Cu accumulation in the selected tissues as a source of information on product safety for consumers. Ann Agri Environ Med. 21(3).
  • Mandal AB, Kaur S, Johri AK, Elangovan AV, Deo C, Shrivastava HP. 2006. Response of growing Japanese quails to dietary concentration of l-threonine. J. Sci. Food Agric. 86:793–798.
  • Mari M, Morales A, Colell A, García-Ruiz C, Fernández-Checa JC. 2009. Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal. 11(11):2685–2700.
  • Maroufyan E, Kasim A, Yong Meng G, Ebrahimi M, Teck Chwen L, Mehrbod P, Kamalidehghan B, Soleimani Farjam A. 2013. Effect of dietary combination of methionine and fish oil on cellular immunity and plasma fatty acids in infectious bursal disease challenged chickens. ScientificWorldJournal. 2013:531397.
  • Martínez L, Ros G, Nieto G. 2020. Effect of natural extracts obtained from food industry by-products on nutritional quality and shelf life of chicken nuggets enriched with organic Zn and Se provided in broiler diet. Poult Sci. 99(3):1491–1501.
  • Martirosyan DM, Singh J. 2015. A new definition of functional food by FFC: what makes a new definition unque? Funct Foods Health Dis. 5(6):209–223.
  • Maurice DV, Lightsey SF, Abudabos A, Toler JE. 2002. Factors affecting ascorbic acid biosynthesis in chickens: III. Effect of dietary fluoride on L-gulonolactone oxidase activity and tissue ascorbic acid (AsA) concentration . J Anim Physiol Anim Nutr (Berl)). 86(11–12):383–388.
  • McClements DJ. 2012. Edible delivery systems for nutraceuticals: designing functional foods for improved health. Ther Deliv. 3(7):801–803. https://doi.org/http://doi.org/10.4155/tde.12.56.
  • McDowell LR, Ward NE. 2008. Optimum vitamin nutrition for poultry. Int Poultry Prod. 16(4):27–34.
  • McDowell LR. 1989. Vitamin B 12. In: McDowell LR, editor. Vitamins in animal nutrition. San Diego, CA: Academic Press; p. 323–346.
  • McDowell LR. 2003. Zinc. In: McDowell LR, editor. Minerals in animal and human nutrition. Amsterdam, Netherlands: Elsevier Science; p. 357–395.
  • Michalak I, Andrys M, Korczyński M, Opaliński S, Łęska B, Konkol D, Wilk R, Rój E, Chojnacka K. 2020. Biofortification of hens eggs with polyunsaturated fatty acids by new dietary formulation: supercritical microalgal extract. Animals. 10(3):499.
  • Michalak I, Chojnacka K, Dobrzański Z, Górecki H, Zielińska A, Korczyński M, Opaliński S. 2011. Effect of macroalgae enriched with microelements on eggquality parameters and mineral content of eggs, eggshell,blood, feathers and droppings. J Anim Physiol Anim Nutr. 95(3):374–387.
  • Min YN, Niu ZY, Sun TT, Wang ZP, Jiao PX, Zi BB, Chen PP, Tian DL, Liu FZ. 2018. Vitamin E and Vitamin C supplementation improves antioxidant status and immune function in oxidative stressed breeder roosters by up-regulating expression of GSH-Px gene. Poult Sci. 97(4):1238–1244.
  • Mogahid AA, Gad GG, Abdalla EA, El-Wardany I. 2019. Influence of in ovo injection of inorganic iron and its nanoparticles form on growth, and physiological response of broiler chickens. Arab Univ J Agri Sci. 26(6):2369–2376.
  • Moghaddam HS, Emadi M. 2014. The effect of threonine and vitamin A on immune system in broiler chickens. Int J Adv Biol Biomed Res. 26:756–763.
  • Moghaddam HN, Jahanian R. 2009. Immunological responses of broiler chicks can be modulated by dietary supplementation of zinc-methionine in place of inorganic zinc sources. Asian Australas J Anim Sci. 22(3):396–403.
  • Moura LC, Pedroso MA. 2003. Anemia Ferropriva Na Gestacao. Revi Enferm. 4:70–75.
  • Mullin GE. 2011. Vitamin A and immunity. Nutr Clin Pract. 26(4):495–496.
  • Mwangi S, Timmons J, Ao T, Paul M, Macalintal L, Pescatore A, Cantor A, Dawson KA. 2019. Effect of manganese preconditioning and replacing inorganic manganese with organic manganese on performance of male broiler chicks. Poult Sci. 98(5):2105–2113.
  • Narahari D. 2014. Role of nutraceuticals in poultry for designer food production. XXXI Annual Conference of Indian Poultry Science Association and National Symposium on Poultry Production for Global Trade. TANUVAS. p. 127–132.
  • Nasr J, Kheiri F. 2011. Effect of different lysine levels on Arian broiler performances. It J Anim Sci. 10(3):e32.
  • National Research Council (NRC). 1994. Nutrient Requirements for Poultry, 9th ed. Washington, DC, USA: National Academies Press.
  • Newsholme P. 2001. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J Nutr. 131(9 Suppl):2515S–2522S.
  • Nichols NL, Bertolo RF. 2008. Luminal threonine concentration acutely affects intestinal mucosal protein and mucin synthesis in piglets. J Nutr. 138(7):1298–1303.
  • Nikonov IN, Folmanis YG, Folmanis GE, Kovalenko LV, Laptev GY, Egorov IA, Fisinin VI, Tananaev IG. 2011. Iron nanoparticles as a food additive for poultry. Dokl Biol Sci. 440:328–331.
  • Nollet L, Van der Klis JD, Lensing M, Spring P. 2007. The effect of replacing inorganic with organic trace minerals in broiler diets on productive performance and mineral excretion. J Appl Poult Res. 16(4):592–597.
  • Nowaczewski, Kontecka. 2005. Effect of dietary vitamin C supplement on reproductive performance of aviary pheasants. Czech J Anim Sci. 50 (5): 208–212.
  • Obled C. 2003. Amino acid requirements in inflammatory states. Can J Anim Sci. 83(3):365–373.
  • Ognik K, Konieczka P, Mikulski D, Jankowski J. 2020. The effect of different dietary ratios of lysine and arginine in diets with high or low methionine levels on oxidative and epigenetic DNA damage, the gene expression of tight junction proteins and selected metabolic parameters in Clostridium perfringens-challenged turkeys. Vet Res. 51(1):50
  • Olgun O. 2017. Manganese in poultry nutrition and its effect on performance and eggshell quality. World Poult Sci J. 73(1):45–56.
  • Opaliński S, Dolińska B, Korczyński M, Chojnacka K, Dobrzański Z, Ryszka F. 2012. Effect of iodine-enriched yeast supplementation of diet on performance of laying hens, egg traits, and egg iodine content. Poult Sci. 91(7):1627–1632.
  • Panda NC, Pradhan SC. 1967. Effect of vitamin K in hen's diet on hatchability. Indian Vet J. 44(12):1054–1060.
  • Papazyan TT, Lyons MP, Mezes M, Surai PF. 2006. Selenium in poultry nutrition-Effects on fertility and hatchability. Praxis Vet. 54:85–102.
  • Pappas AC, Zoidis E, Surai PF, Zervas G. 2008. Selenoproteins and maternal nutrition. Comp Biochem Physiol B Biochem Mol Biol. 151(4):361–372.
  • Pardue SL, Thaxton JP. 1986. Ascorbic acid in poultry: a review. World Poult Sci J. 42(2):107–123.
  • Perez-Carbajal C, Caldwell D, Farnell M, Stringfellow K, Pohl S, Casco G, Pro-Martinez A, Ruiz-Feria CA. 2010. Immune response of broiler chickens fed different levels of arginine and vitamin E to a coccidiosis vaccine and Eimeria challenge. Poult Sci. 89(9):1870–1877.
  • Perić L, Rodić V, Milošević N. 2011. Production of poultry meat and eggs as functional food - challenges and opportunities. Biotechnol Anim Husb. 27(3):511–520.
  • Pond WG, Church DC, Pond KR. 1995. Folic acid. In: Basic animal nutrition and feeding. 4th ed. New York: Wiley
  • Puthpongsiriporn U, Scheideler SE, Sell JL, Beck MM. 2001. Effects of vitamin E and C supplementation on performance, in vitro lymphocyte proliferation, and antioxidant status of laying hens during heat stress. Poult Sci. 80(8):1190–1200.
  • Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K. 2014. Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int. 2014:761264. https://doi.org/http://dx.doi.org/10.1155/2014/761264.
  • Rajasekaran A, Kalaivani M. 2013. Designer foods and their benefits: a review. J Food Sci Technol. 50(1):1–16.
  • Rajashree K, Muthukumar T, Karthikeyan N. 2014. Comparative study of the effects of organic selenium on hen performance and productivity of broiler breeders. Br Poult Sci. 55(3):367–374.
  • Rao SR, Raju MVLN, Reddy MR, Pavani P. 2006. Interaction between dietary calcium and non-phytate phosphorus levels on growth, bone mineralization and mineral excretion in commercial broilers. Anim Feed Sci Technol. 131(1–2):135–150.
  • Rashid M-U, Weintraub A, Nord CE. 2012. Effect of new antimicrobial agents on the ecological balance of human microflora. Anaerobe. 18(2):249–253.
  • Ravindran V, Elliott S. 2017. Influence of selenium source on the performance, feathering and meat quality of broilers. J Appl Anim Nutr. 5.
  • Ravindran V. 2010. Poultry feed availability and nutrition in developing countries. Poultry Development Review. Food and Agriculture Organization of the United Nations. Available from: http://www.fao.org/3/a-al703e.pdf.
  • Reda FM, Ismail IE, El-Mekkawy MM, Farag MR, Mahmoud HK, Alagawany M 2020. Dietary supplementation of potassium sorbate, hydrated sodium calcium almuniosilicate and methionine enhances growth, antioxidant status and immunity in growing rabbits exposed to aflatoxin B1 in the diet. J Anim Physiol Anim Nutr. 104: 196–203.
  • Rehman AU, Arif M, Husnain MM, Alagawany M, Abd El-Hack ME, Taha AE, Elnesr SS, Abdel-Latif MA, Othman SI, Allam AA. 2019. Growth performance of broilers as influenced by different levels and sources of methionine plus cysteine. Animals. 9(12):1056.
  • Rezaeipour V, Fononi H, Irani M. 2012. Effects of dietary L-threonine and Saccharomyces cerevisiae on performance, intestinal morphology and immune response of broiler chickens. South Afr J Anim Sci. 42(3):266–273.
  • Rinttilä T, Apajalahti J. 2013. Intestinal microbiota and metabolites—Implications for broiler chicken health and performance1. J Appl Poult Res. 22(3):647–658.
  • Rivlin RS. 2010. Riboflavin. In: Coates PM, Betz JM, Blackman MR, editors. Encyclopedia of dietary supplements. 2nd ed. London: Informa Health. p. 691–699.
  • Rizk YS, Ibrahim AF, Mansour MK, Mohamed HS, El-Slamony AE, Soliman AAM. 2017. Effect of dietary source of selenium on productive and reproductive performance of Sinai laying hens under heat stress conditions. Egypt Poult Sci J. 37:461–489.
  • Rizvi S, Raza ST, Ahmed F, Ahmad A, Abbas S, Mahdi F. 2014. The role of vitamin E in human health and some diseases. Sultan Qaboos Univ Med J. 14(2):e157–e165.
  • Rochell SJ, Parsons CM, Dilger RN. 2016. Effects of Eimeria acervulina infection severity on growth performance, apparent ileal amino acid digestibility, and plasma concentrations of amino acids, carotenoids, and α;1-acid glycoprotein in broilers. Poult Sci. 95(7):1573–1581.
  • Rodriguez-Lecompte JC, Yitbarek A, Cuperus T, Echeverry H, Van Dijk A. 2016. The immunomodulatory effect of vitamin D in chickens is dose-dependent and influenced by calcium and phosphorus levels. Poult Sci. 95(11):2547–2556.
  • Ross AC. 2012. Vitamin A and retinoic acid in T cell-related immunity. Am J Clin Nutr. 96(5):1166S–1172S.
  • Ruiz JA, Perez-Vendrell AM, Esteve-Garcia E. 2000. Effect of dietary iron and copper on performance and oxidative stability in broiler leg meat. Br Poult Sci. 41(2):163–167.
  • Rymer C, Givens DI. 2005. n-3 fatty acid enrichment of edible tissue of poultry: a review. Lipids. 40(2):121–130.
  • Ryu YC, Kim BC. 2005. The relationship between muscle fiber characteristics, postmortem metabolic rate, and meat quality of pig longissimus dorsi muscle. Meat Sci. 71(2):351–357.
  • Saeed M, Babazadeh D, Naveed M, Alagawany M, Abd El-Hack ME, Arain MA, Tiwari R, Sachan S, Karthik K, Dhama K, et al. 2019. In ovo delivery of various biological supplements, vaccines and drugs in poultry: current knowledge. J Sci Food Agric. 99(8):3727–3739.
  • Saeid A, Chojnacka K, Opaliński S, Korczyński M. 2016. Biomass of Spirulina maxima enriched by biosorption process as a new feed supplement for laying hens. Algal Res. 19:342–347.
  • Şahin K, Küçük O, Şahin N, Ozbey O. 2001. Effects of dietary chromium picolinate supplementation on egg production, egg quality and serum concentrations of insulin, corticosterone, and some metabolites of Japanese quails. Nutr Res. 21(9):1315–1321.
  • Sahin N, Sahin K, Onderci M, Gursu MF, Cikim G, Vijaya J, Kucuk O. 2005. Chromium picolinate, rather than biotin, alleviates performance and metabolic parameters in heat-stressed quail. Br Poult Sci. 46(4):457–463.
  • Said HM, Ross AC. 2014. Riboflavin. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, editors. Modern nutrition in health and disease. 11th ed. Baltimore, MD: Lippincott Williams & Wilkins. p. 325–330.
  • Saleh AA, Ragab MM, Ahmed EAM, Abudabos AM, Ebeid TA. 2018. Effect of dietary zinc-methionine supplementation on growth performance, nutrient utilization, antioxidative properties and immune response in broiler chickens under high ambient temperature. J Appl Anim Res. 46 (1):820–827.
  • Samanta B, Biswas A, Ghosh PR. 2011. Effects of dietary copper supplementation on production performance and plasma biochemical parameters in broiler chickens. Br Poult Sci. 52(5):573–577.
  • Saripinar-Aksu D, Aksu T, Önel SE. 2012. Does inclusion at low levels of organically complexed minerals versus inorganic forms create a weakness in performance or antioxidant defense system in broiler diets? Int J Poult Sci. 11(10):666–672.
  • Scott GR, Cadena V, Tattersall GJ, Milsom WK. 2008. Body temperature depression and peripheral heat loss accompany the metabolic and ventilatory responses to hypoxia in low and high altitude birds. J Exp Biol. 211(Pt 8):1326–1335.
  • Selim NA, Youssef SF, Abdel-Sala AF, Nada SA. 2013. Evaluations of some natural antioxidant sources in broiler diets: 1-effect on growth, physiological and immunological performance of broiler chicks. Int J Poult Sci. 12(10):561–571.
  • Serafini M, Peluso I. 2016. Functional foods for health: The interrelated antioxidant and anti-inflammatory role of fruits, vegetables, herbs, spices and cocoa in humans. Curr Pharm Des. 22(44):6701–6715.
  • Seven PT. 2008. The effects of dietary Turkish propolis and vitamin C on performance, digestibility, egg production and egg quality in laying hens under different environmental temperatures. Asian Australas J Anim Sci. 21(8):1164–1170.
  • Shewita RS, El-Naggar K, El Naby WSA. 2019. Influence of dietary vitamin c on growth performance, blood biochemical parameters and transcript levels of heat shock proteins in high stocking density reared broiler chickens. Slov Vet Res. 56(22-Suppl).
  • Shi L, Zhao H, Ren Y, Yao X, Song R, Yue W. 2014. Effects of different levels of dietary selenium on the proliferation of spermatogonial stem cells and antioxidant status in testis of roosters. Anim Reprod Sci. 149(3–4):266–272.
  • Shinde PL, Ingale SL, Choi JY, Kim JS, Pak SI, Chae BJ. 2011. Efficiency of inorganic and organic iron sources under iron depleted conditions in broilers. Br Poult Sci. 52(5):578–583.
  • Shojadoost B, Behboudi S, Villanueva AI, Brisbin JT, Ashkar AA, Sharif S. 2015. Vitamin D3 modulates the function of chicken macrophages. Res Vet Sci. 100:45–51.
  • Siegert W, Rodehutscord M. 2019. The relevance of glycine and serine in poultry nutrition: a review . Br Poult Sci. 60(5):579–588.
  • Silva RAM, Pacheco GD, Vinokurovas SL, Oliveira E. R d, Gavioli DF, Lozano AP, Agostini P. d S, Bridi AM, Silva C. A d. 2015. Associação de ractopamina e vitaminas antioxidantes para suínos em terminação. Cienc Rural. 45(2):311–316.
  • Singh AK, Ghosh TK, Haldar S. 2015. Effects of methionine chelate-or yeast proteinate-based supplement of copper, iron, manganese and zinc on broiler growth performance, their distribution in the tibia and excretion into the environment. Biol Trace Elem Res. 164(2):253–260.
  • Słupczyńska M, Jamroz D, Orda J, Wiliczkiewicz A. 2014. Effect of various sources and levels of iodine, as well as the kind of diet, on the performance of young laying hens, iodine accumulation in eggs, egg characteristics, and morphotic and biochemical indices in blood. Poult Sci. 93(10):2536–2547.
  • Soltan M. 2008. Influence of dietary glutamine supplementation on growth performance, small intestinal morphology, immune response and some blood parameters of broiler chickens. Int J Poult Sci. 8(1):60–68.
  • Soomro RN, Abd El-Hack ME, Shah SS, Taha AE, Alagawany M, Swelum AA, Hussein EOS, Ba-Aawdh HA, Saadeldin I, El-Edel MA, et al. 2019. Impact of restricting feed and probiotic supplementation on growth performance, mortality and carcass traits of meat-type quails. Anim Sci J. 90(10):1388–1388.
  • Stanley VG, Bailey JE, Krueger WF. 1989. Research Note: Effect of iodine-treated water on the performance of broiler chickens reared under various stocking densities. Poult Sci. 68(3):435–437.
  • Stipanuk MH. 2004. Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr. 24:539–577.
  • Stoll B. 2006. Intestinal uptake and metabolism of threonine: nutritional impact. Adv Pork Prod. 17:257–263.
  • Su S, Miska KB, Fetterer RH, Jenkins MC, Wong EA. 2015. Expression of digestive enzymes and nutrient transporters in Eimeria-challenged broilers. Exp Parasitol. 150:13–21.
  • Sugiharto S. 2016. Role of nutraceuticals in gut health and growth performance of poultry. J Saudi Soc Agri Sci. 15(2):99–111.
  • Sullivan Å, Edlund C, Nord CE. 2001. Effect of antimicrobial agents on the ecological balance of human microflora. Lancet Inf Dis. 1(2):101–114.
  • Sun Q, Guo Y, Li J, Zhang T, Wen J. 2012. Effects of methionine hydroxy analog chelated Cu/Mn/Zn on laying performance, egg quality, enzyme activity and mineral retention of laying hens. J Poult Sci. 49(1):20–25.
  • Surai PF. 2006. Selenium in nutrition and health. Nottingham, UK: Nottingham University Press.
  • Surai PF, Cerolini S, Wishart GJ, Speake BK, Noble RC, Sparks NHC. 1998b. Lipid and antioxidant composition of chicken semen and its susceptibility to peroxidation. Poult Avian Biol Rev. 9:11–23.
  • Surai PF, Kochish II. 2019. Nutritional modulation of the antioxidant capacities in poultry: the case of selenium. Poult Sci. 98(10):4231–4239.
  • Surai PF, Kostjuk IA, Wishart G, MacPherson A, Speake B, Noble RC, Ionov IA, Kutz E. 1998c. Effect of vitamin E and selenium of cockerel diets on glutathione peroxidase activity and lipid peroxidation susceptibility in sperm, testes and liver. Biol Trace Elem Res. 64(1-3):119–132.
  • Surai PF, Blesbois E, Grasseau I, Chalah T, Brillard JP, Wishart GJ, Cerolini S, Sparks NH. 1998a. Fatty acid composition, glutathione peroxidase and superoxide dismutase activity and total antioxidant activity of avian semen. Comp Biochem Physiol B Biochem Mol Biol. 120(3):527–533.
  • Suttle NF. 2010. Mineral nutrition of livestock. 4th ed. Oxfordshire, UK: CAB International. p. 355–376.
  • Świątkiewicz S, Arczewska-Włosek A, Jozefiak D. 2014. The efficacy of organic minerals in poultry nutrition: review and implications of recent studies. World Poult Sci J. 70(3):475–486.
  • Świątkiewicz S, Koreleski J, Kopowski J. 2006. Effect of phytase and 25-hydroxycholecalciferol on the performance and bone quality in broiler chickens. Med Wet. 62(1):81–84.
  • Talpur MZ, Rind MI, Memon A, Shar FN, Ujjan NA. 2012. Effect of dietary calcium on the performance of commercial chicken. J Vet Anim Sci. 2:101–106.
  • Tan J, Applegate TJ, Liu S, Guo Y, Eicher SD. 2014. Supplemental dietery L-arginine attenuates intestinal mucosal disruption during a coccidial vaccine challenge in broiler chickens. Br J Nutr. 112(7):1098–1109.
  • Tayade C, Jaiswal TN, Mishra SC, Koti M. 2006. L-Arginine stimulates immune response in chickens immunized with intermediate plus strain of infectious bursal disease virus. Vaccine. 24(5):552–560.
  • Travnicek J, Kratochvil P, Kroupova V. 1997. Die Entwicklung der Embryonen iodreicher Bruteier. Mengen-Und Spurenelemente. 17:821–824.
  • Trevisi P, Corrent E, Mazzoni M, Messori S, Priori D, Gherpelli Y, Simongiovanni A, Bosi P. 2015. Effect of added dietary threonine on growth performance, health, immunity and gastrointestinal function of weaning pigs with differing genetic susceptibility to Escherichia coli infection and challenged with E. coli K88ac. J Anim Physiol Anim Nutr. 99(3):511–520.
  • Tufarelli V, Laudadio V. 2015. Feeding of dehulled-micronized Faba Bean (Vicia faba var. minor) as substitute for soyabean meal in guinea fowl broilers: Effect on productive performance and meat quality. Asian Australas J Anim Sci. 28(10):1471–1478.
  • Ullrich C, Langeheine M, Brehm R, Taube V, Rosillo Galera M, Rohn K, Popp J, Visscher C. 2019. Influence of different methionine sources on performance and slaughter characteristics of broilers. Animals (Basel). 9(11):984.
  • Underwood EJ, Suttle NF. 1999. The mineral nutrition of livestock. 3rd ed. Wallingford: CABI Publication. p. 614.
  • Urso UR, Dahlke F, Maiorka A, Bueno IJ, Schneider AF, Surek D, Rocha C. 2015. Vitamin Eand selenium in broiler breeder diets: effect on live performance, hatching process, and chick quality. Poult Sci. 94(5):976–983.
  • Valable AS, Narcy A, Duclos MJ, Pomar C, Page G, Nasir Z, Magnin M, Létourneau-Montminy MP. 2018. Effects of dietary calcium and phosphorus deficiency and subsequent recovery on broiler chicken growth performance and bone characteristics. Animal. 12(8):1555–1563.
  • Valizade MR, Sadeghi AA, Chamani M, Shawrang P, Kashan N. 2016. The effects of increase in threonine to lysine ratio on performance, blood parameters and humoral immune responses of male broiler chickens challenged with Salmonella. Kafkas Üniv Vet Fakül Dergisi. 22(2):165–172.
  • Van Middlesworth L. 1996. Iodinated thyroid proteins which accumulate during iodine deficiency.16. Arbeitstagung” Mengen und Spurenelemente. Friedrich-Schiller-Univ Jena. p. 920–921.
  • Waheed Janabi AH, Kamboh AA, Saeed M, Xiaoyu L, BiBi J, Majeed F, Naveed M, Mughal MJ, Korejo NA, Kamboh R, et al. 2020. Flavonoid-rich foods (FRF): A promising nutraceutical approach against lifespan-shortening diseases. Iran J Basic Med Sci. 23:1–14.
  • Waldroup PW, Jiang Q, Fritts CA. 2005. Effects of supplementing broiler diets low in crude protein with essential and nonessential amino acids. Int J Poult Sci. 4(6):425–431.
  • Wang Z, Cerrate S, Yan F, Sacakli P, Waldroup PW. 2008. Comparison of different concentrations of inorganic trace minerals in broiler diets on live performance and mineral excretion. Int J Poult Sci. 7(7):625–629.
  • Wang J, Yue H, Wu S, Zhang H, Qi G. 2017. Nutritional modulation of health, egg quality and environmental pollution of the layers. Anim Nutr. 3(2):91–96.
  • Weber GM. 2009. Improvement of flock productivity through supply of vitamins for higher laying performance and better egg quality. World Poult Sci J. 65(3):443–458.
  • Wen C, Jiang XY, Ding LR, Wang T, Zhou YM. 2017. Effects of dietary methionine on growth performance, meat quality and oxidative status of breast muscle in fast-and slow-growing broilers. Poult Sci. 96(6):1707–1714.
  • Whitehead CC. 2002. Vitamins in feedstuffs. In: Mc Nab, J, Boorman, N, editors. Poultry feedstuff: supply, composition and nutritive value. Roslin, UK: CABI Publishing, p. 181–190.
  • Wilson DW, Nash P, Buttar HS, Griffiths K, Singh R, De Meester F, Horiuchi R, Takahashi T. 2017. The role of food antioxidants, benefits of functional foods, and influence of feeding habits on the health of the older person: An overview. Antioxidants (Basel). 6(4):81.
  • Witkowska Z, Chojnacka K, Korczyński M, Świniarska M, Saeid A, Opaliński S, Dobrzański Z. 2014. Soybean meal enriched with microelements by biosorption-a new biological feed supplement for laying hens. Part I. Performance and egg traits. Food Chem. 151:86–92.
  • Wu LY, Fang YJ, Guo XY. 2011. Dietary L-arginine supplementation beneficially regulates body fat deposition of meat-type ducks. Br Poult Sci. 52(2):221–226.
  • Xia MS, Hu CH, Xu ZR. 2004. Effects of copper-bearing montmorillonite on growth performance, digestive enzyme activities, and intestinal microflora and morphology of male broilers. Poult Sci. 83(11):1868–1875.
  • Xie C, Elwan HA, Elnesr SS, Dong X, Feng J, Zou XT. 2019b. Effects of iron glycine chelate on laying performance, antioxidant activities, serum biochemical indices, iron concentrations and transferrin mRNA expression in laying hens. J Anim Physiol Anim Nutr. 103(2):547–554.
  • Xie C, Elwan HAM, Elnesr SS, Dong XY, Zou XT. 2019a. Effect of iron glycine chelate supplementation on egg quality and egg iron enrichment in laying hens. Poult Sci. 98(12):7101–7109.
  • Xu YQ, Guo YW, Shi BL, Yan SM, Guo XY. 2018. Dietary arginine supplementation enhances the growth performance and immune status of broiler chickens. Livest Sci. 209:8–13.
  • Xue GD, Barekatain R, Wu SB, Choct M, Swick RA. 2018. Dietary L-glutamine supplementation improves growth performance, gut morphology, and serum biochemical indices of broiler chickens during necrotic enteritis challenge. Poult Sci. 97(4):1334–1341.
  • Yadav S, Jha R. 2019. Strategies to modulate the intestinal microbiota and their effects on nutrient utilization, performance, and health of poultry. J Anim Sci Biotechnol. 10:2.
  • Yadav AS, Kolluri G, Gopi M, Karthik K, Malik YS, Dhama K. 2016. Exploring alternatives to antibiotics as health promoting agents in poultry- a review. J Exp Biol. 4(3s):368–383.
  • Yang Z, Qi XM, Yang HM, Dai H, Xu CX, Wang ZY. 2018. Effects of dietary copper on growth performance, slaughter performance and nutrient content of fecal in growing goslings from 28 to 70 days of age. Rev Bras Cienc Avic. 20(1):45–52.
  • Yaqoob MU, Ali M. 2018. Growth and immune response of broilers in relation to varying dietary levels of methionine and threonine. Int J Biotechnol Recent Adv. 1(1):6–11.
  • Yildiz AO, Cufadar Y, Olgun O. 2011. Effects of dietary organic and inorganic manganese supplementation on performance, egg quality and bone mineralisation in laying hens. Rev Méd Vét. 10:482–488.
  • Yuan D, Zhan XA, Wang YX. 2012. Effect of selenium sources on the expression of cellular glutathione peroxidase and cytoplasmic thioredoxin reductase in the liver and kidney of broiler breeders and their offspring. Poult Sci. 91(4):936–42.
  • Yuan J, Roshdy AR, Guo Y, Wang Y, Guo S. 2014. Effect of dietary vitamin A on reproductive performance and immune response of broiler breeders. PloS One. 9(8):e105677.
  • Zaboli GR, Bilondi HH, Miri A. 2013. The effect of dietary antioxidant supplements on abdominal fat deposition in broilers. Life Sci J. 10:328–333.
  • Zaefarian F, Zaghari M, Shivazad M. 2008. The threonine requirements and its effects on growth performance and gut morphology of broiler chicken fed different levels of protein. Int J Poult Sci. 7(12):1207–1215.
  • Zago MP, Oteiza PI. 2001. The antioxidant properties of zinc: interactions with iron and antioxidants. Free Radic Biol Med. 31(2):266–274.
  • Zarrin-Kavyani S, Khatibjoo A, Fattahnia F, Taherpour K. 2018. Effect of threonine and potassium carbonate supplementation on performance, immune response and bone parameters of broiler chickens. Appl Anim Res. 46(1):1329–1335.
  • Zdanowska-Sasiadek Z, Michalczuk M, Damaziak K, Niemiec J, Polawska E, Gozdowski D, Rozanska E. 2016. Effect of vitamin E supplementation on growth performance and chicken meat quality. Eur Poult Sci. 80:1–14.
  • Zhai W, Peebles ED, Schilling MW, Mercier Y. 2016. Effects of dietary lysine and methionine supplementation on Ross 708 male broilers from 21 to 42 d of age (I): Growth performance, meat yield, and cost effectiveness. J Appl Poult Res. 25(2):197–211.
  • Zhang C, Li D, Wang F, Dong T. 2003. Effects of dietary vitamin K levels on bone quality in broilers. Arch Tierernahr. 57(3):197–206.
  • Zhang TY, Liu JL, Zhang JL, Zhang N, Yang X, Qu HX, Xi L, Han JC. 2018. Effects of dietary zinc levels on the growth performance, organ zinc content, and zinc retention in broiler chickens. Rev Bras Cienc Avic. 20(1):127–132.
  • Zhao J, Robert B, Shirley Ulia J, Dibner J. 2016. Superior growth performance in broiler chicken fed chelated compared to inorganic zinc in presence of elevated dietary copper. Anim Sci Biotechnol. 7(1):13–21.
  • Zittoun J, Zittoun R. 1999. Modern clinical testing strategies in cobalamin and folate deficiency. Sem Hematol. 36:35–46.