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Review of the occurrence and formation of non‐volatile N‐nitroso compounds in foodsFootnote

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Pages 39-69 | Accepted 16 Dec 1991, Published online: 10 Jan 2009

References

  • Ahmad , M. U. , Libbey , L. M. , Barbour , J. F. and Scanlan , R. A. 1985 . Isolation and characterization of products from the nitrosation of the alkaloid gramine . Food and Chemical Toxicology , 23 : 841 – 847 .
  • Ahmad , M. U. , Libbey , L. M. and Scanlan , R. A. 1987 . Identification of minor nitrosation products of the alkaloid gramine by mass spectroscopy . Food and Chemical Toxicology , 25 : 867 – 870 .
  • Altemark , V. D. , Hess , R. and Sommers , H. 1980 . Wege zum nitrosaminfreien Bier . Monatsschrift fur Brauerei , 33 : 415 – 418 .
  • Arjungi , K. N. 1976 . Areca nut—a review . Arzneimittelforschung , 26 : 951 – 956 .
  • Bartsch , H. and Montesano , R. 1984 . Relevance of nitrosamines to human cancer . Carcinogenesis , 5 : 1381 – 1393 .
  • Bartsch , H. , Ohshima , H. , Pignatelli , B. and Calmels , S. 1989 . Human exposure to endogenous N‐nitroso compounds: quantitative estimates in subjects at high risk for cancer of the oral cavity, oesophagus, stomach and urinary bladder . Cancer Surveys , 8 : 335 – 362 .
  • Bavin , P. M. G. , Darkin , D. W. and Viney , N. J. 1982 . “ Total nitroso compounds in gastric juice ” . In N‐Nitroso Compounds, Analysis and Formation , IARC Scientific Publication No. 3 Edited by: Bogouski , P. , Preussmann , R. and Walker , E. A. 337 – 344 . Lyon : International Agency for Research on Cancer .
  • Berry , C. N. and Challis , B. C. 1984 . Denitrosation and deamination of N‐n‐butyl‐N‐nitrosoacetamide in aqueous acids . Journal of the Chemical Society (London), Perkin Transactions II , : 1638 – 1644 .
  • Binkerd , E. F. and Kolari , O. E. 1975 . The history and use of nitrate and nitrite in curing of meat . Food and Cosmetics Toxicology , 13 : 655 – 661 .
  • Blowers , S. D. and Anderson , D. 1988 . The in vivo genotoxic properties of the nitrosodipeptide N‐(N‐acetyl‐L‐prolyl)‐N‐nitrosoglycine . Food and Chemical Toxicology , 26 : 785 – 790 .
  • Bogovski , P. , Castegnaro , M. , Pignatelli , B. and Walker , E. A. 1972 . “ The inhibiting effect of tannins on the formation of nitrosamines ” . In N‐Nitroso Compounds, Analysis and Formation , IARC Scientific Publication No. 3 Edited by: Bogouski , P. , Preussmann , R. and Walker , A. E. 127 – 129 . Lyon : International Agency for Research on Cancer .
  • Bogovski , P. , Rooma , M. , Uibu , J. , Kann , J. and Tauts , O. 1982 . “ Research on environmental N‐nitroso compounds in the USSR ” . In N‐Nitroso Compounds: Occurrence and Biological Effects , IARC Scientific Publication No. 41 Edited by: Bartsch , H. , O'Neill , I. K. , Castegnaro , M. and Okada , M. 259 – 266 . Lyon : International Agency for Research on Cancer .
  • Bonnett , R. and Nicolaidou , P. 1979 . Nitrosation and nitrosylation of hemoproteins and related compounds. Part 2. The reaction of nitrous acid with the side chains of alpha‐acylamino‐acid esters . Journal of the Chemical Society, Perkin I Transactions , : 1969 – 1974 .
  • Bonnett , R. , Holleyhead , R. , Johnson , B. L. and Randall , E. W. 1975 . Reaction of acidified nitrite solutions with peptides derivatives: Evidence for nitrosamine and thiocyanate formation from15N n.m.r. studies . Journal of the Chemical Society (London), Perkin I Transactions , : 2261 – 2264 .
  • Bonnett , R. , Chandra , S. , Charalambides , A. A. , Sales , K. D. and Scourides , P. A. 1980 . Nitrosation and nitrosylation of haemoproteins and related compounds. Part 4. Pentacooridinate nitrosyl protoheme as the pigment of cooked cured meat. Direct evidence from ESR spectroscopy . Journal of the Chemical Society (London), Perkin I Transactions , : 1706 – 1710 .
  • Brunnemann , K. D. and Hoffmann , D. 1981 . Assessment of the carcinogenic N‐nitrosodiethanolamine in tobacco products and tobacco smoke . Carcinogenesis , 2 : 1123 – 1127 .
  • Brunnemann , K. D. and Hoffmann , D. 1991 . Decreased concentrations of N‐nitrosodiethanolamine and of N‐nitrosomorpholine in commercial tobacco products . Journal of Agricultural and Food Chemistry , 39 : 207 – 208 .
  • Brunnemann , K. D. , Scott , J. C. and Hoffmann , D. 1982 . N‐Nitrosomorpholine and other volatile N‐nitrosamines in snuff tobacco . Carcinogenesis , 3 : 693 – 696 .
  • Brunnemann , K. D. , Scott , J. C. and Hoffmann , D. 1983 . N‐Nitrosoproline, an indicator for N‐nitrosation of amines in processed tobacco . Journal of Agricultural and Food Chemistry , 31 : 905 – 909 .
  • Brunnemann , K. D. , Prokopczyk , B. , Hoffmann , D. , Nair , J. , Ohshima , H. and Bartsch , H. 1986 . “ Laboratory studies on oral cancer and smokeless tobacco ” . In Mechanisms in tobacco Carcinogenesis , Banbury Report No. 23 Edited by: Hoffmann , D. and Harris , C. C. 197 – 213 . New York : Cold Spring Harbour Laboratory .
  • Calderbank , J. and Hammond , J. R. M. 1989 . Influence of nitrate and bacterial contamination on the formation of apparent total N‐nitroso compounds (ATNC) during fermentation . Journal of the Institute of Brewing , 95 : 277 – 281 .
  • Castegnaro , M. , Massey , R. C. and Walters , C. L. 1987 . The collaborative evaluation of a procedure for the determination of N‐nitroso compounds as a group . Food Additives and Contaminants , 4 : 37 – 43 .
  • Challis , B. C. and Challis , J. A. 1982 . “ N‐Nitrosamines and N‐nitrosoimines ” . In The Chemistry of Amino, Nitroso, and Nitro‐compounds and Their Derivatives , Edited by: Patai , S. 1151 – 1223 . New York : Wiley .
  • Challis , B. C. , Milligan , J. R. and Mitchell , R. C. 1984 . Synthesis and stability of N‐nitrosodipeptides . Journal of the Chemical Society, Chemical Communications , : 1050 – 1051 .
  • Clydesdale , F. M. and Francis , F. J. 1971 . Colour measurements of foods. XXVII Chemistry of meat colour . Food Production and Development , 5 : 81 – 82 . 87 – 89 .
  • Conboy , J. J. and Hotchkiss , J. H. 1989 . Photolytic interface for high‐performance liquid chromatography‐chemiluminescence detection of non‐volatile N‐nitroso compounds . Analyst , 114 : 155 – 159 .
  • Couglin , J. R. 1979 . Formation of N‐nitrosamines from Maillard reaction products in the presence of nitrite , University of California . PhD Thesis
  • Dennis , M. J. , Cripps , G. S. , Tricker , A. R. , Massey , R. C. and Mcweeny , D. J. 1984 . N‐Nitroso compounds and polycyclic aromatic hydrocarbons in Icelandic smoked mutton . Food and Chemical Toxicology , 22 : 305 – 306 .
  • Douglass , M. L. , Kabacoff , B. L. , Anderson , G. A. and Cheng , M. C. 1978 . The chemistry of nitrosamine formation inhibition and destruction . Journal of the Society of Cosmetic Chemists , 29 : 581 – 606 .
  • Druckrey , H. and Preussmann , R. 1962 . Zur Entstehung carcinogene Nitrosamine und Beispiel des Tabakrauchs . Naturwissenschaften , 49 : 498 – 501 .
  • Dunn , B. P. and Stich , H. F. 1984 . Determination of free and protein‐bound N‐nitrosoproline in nitrite‐cured meat products . Food and Chemical Toxicology , 22 : 609 – 613 .
  • Dutt , M. C. , Lim , H. Y. and Chew , R. K. H. 1987 . Nitrate consumption and the incidence of gastric cancer in Singapore . Food and Chemical Toxicology , 25 : 515 – 520 .
  • Eisenbrand , G. 1981 . N‐Nitrosoverbindungen in Nahrung und Umwelt , Stuttgart, , Germany : Wissenschaftlicher Verlagsgesellschaft mbH .
  • Eisenbrand , G. , Janzowski , C. and Preussmann , R. Analysis, formation and occurrence of volatile and non‐volatile N‐nitroso compounds: Recent results . Proceedings of the 2nd International Symposium on Nitrite in Meat Products . 1976 , Zeist. Edited by: Tinbergen , B. J. and Krol , B. pp. 155 – 169 . Wageningen Center for Agriculture, Public Documentation Wageningen .
  • Ender , F. , Havre , G. , Helgebostad , A. , Koppang , N. , Madsen , R. and Ceh , L. 1964 . Isolation and identification of a hepatotoxic factor in herring meal produced from sodium nitrite preserved herring . Naturwissenschaften , 51 : 637 – 638 .
  • Ernst , H. , Ohshima , H. , Bartsch , H. , Mohr , U. and Reichart , P. 1987 . Tumorigenicity study in Syrian hamsters fed on areca nut together with nitrite . Carcinogenesis , 8 : 1843 – 1845 .
  • Fiddler , W. , Pensabene , J. W. , Piotrowski , E. G. , Doerr , R. C. and Wassermann , A. E. 1973 . Use of sodium ascorbate or erythrobate to inhibit formation of N‐nitrosodimethylamine in frankfurters . Journal of Food Science , 38 : 1084
  • Fine , D. H. , Goff , E. U. , Johnson , R. A. and Roundbehler , D. P. 1987 . “ Thermal energy analysis of N‐nitroso compounds, including ureas, urethanes and guanidines ” . In Relevance of N‐Nitroso Compounds to Human Cancer: Exposures and Mechanisms , IARC Scientific Publication No. 84 Edited by: Bartsch , H. , O'Neill , I. K. and Schulte‐Hermann , R. 216 – 217 . Lyon : International Agency for Research on Cancer .
  • Frouin , A. Nitrates and nitrites: Reinterpretation of analytical data by means of bound nitric oxide . Proceedings of the 2nd International Symposium on Nitrite in Meat Products . 1976 , Zeist. Edited by: Tinbergen , B. J. and Krol , B. pp. 115 – 120 . Wageningen Center for Agriculture, Public Documentation Wageningen .
  • Gao , J. , Hotchkiss , J. H. and Chen , J. 1991 . “ Regional differences in N‐nitrosamine content of traditional Chinese foods ” . In Relevance to Human Cancer of N‐Nitroso Compounds, Tobacco Smoke and Mycotoxins , IARC Scientific Publication No. 105 Edited by: O'Neill , I. K. , Chen , J. and Bartsch , H. 219 – 222 . Lyon : International Agency for Research on Cancer .
  • Gilbert , J. and Knowles , M. E. 1975 . The chemistry of smoked foods . Journal of Food Technology , 10 : 245 – 261 .
  • Goutefongea , R. , Cassens , R. G. and Woolford , G. 1977 . Distribution of sodium nitrite in adipose tissue during curing . Journal of Food Science , 42 : 1637 – 1641 .
  • Gray , J. I. , Macdonald , B. , Pearson , A. M. and Morton , I. D. 1981 . Role of nitrite in cured meat flavour: A review . Journal of Food Protection , 44 : 302 – 312 .
  • Gray , J. I. , Skrypec , D. J. , Mandagere , A. K. , Booren , A. M. and Pearson , A. M. 1984 . “ Further factors influencing N‐nitrosamine formation in bacon ” . In N‐Nitroso Compounds: Occurrence, Biological Effects and Relevance to Human Cancer , IARC Scientific Publication No. 57 Edited by: O'Neill , I. K. , von Borstel , R. C. , Miller , C. T. , Long , J. and Bartsch , H. 301 – 310 . Lyon : International Agency for Research on Cancer .
  • Hansen , T. , Iwaoka , W. , Green , L. and Tannenbaum , S. R. 1977 . Analysis of N‐nitrosoproline in raw bacon—Further evidence that N‐nitrosoproline is not a major precursor of N‐nitrosopyrrolidine . Journal of Agricultural and Food Chemistry , 25 : 1423 – 1426 .
  • Hansen , T. J. , Archer , M. C. and Tannenbaum , S. R. 1979 . Characterization of pyrolysis conditions and interference by other compounds in the chemiluminesence detection of nitrosamines . Analytical Chemistry , 51 : 1526 – 1528 .
  • Hecht , S. S. and Hoffmann , D. 1988 . Tobacco‐specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke . Carcinogenesis , 9 : 875 – 884 .
  • Helgason , T. , Ewen , S. W. B. , Jaffray , B. , Stowers , J. M. , Outram , J. R. and Pollock , J. R. A. 1984 . “ N‐Nitrosamines in smoked meats and their relation to diabetes ” . In N‐Nitroso Compounds: Occurrence, Biological Effects and Relevance to Human Cancer , IARC Scientific Publication No. 57 Edited by: O'Neill , I. K. , von Borstel , R. C. , Miller , C. T. , Long , J. and Bartsch , H. 911 – 920 . Lyon : International Agency for Research on Cancer .
  • Heynes , K. , Röper , S. , R¨per , H. and Meyer , B. 1979 . N‐Nitroso sugar amino acids . Angewandte Chemie International, English Edition , 18 : 878 – 880 .
  • Hoffmann , D. , Lavoie , E. J. and Hecht , S. S. 1985 . Nicotine: A precursor for carcinogens . Cancer Letters , 26 : 67 – 75 .
  • Hoffmann , D. , Adams , J. D. , Lisk , D. , Fisenne , I. and Brunnemann , K. D. 1987 . Toxic and carcinogenic agents in dry and moist snuff . Journal of the National Cancer Institute , 79 : 1282 – 1286 .
  • Hotchkiss , J. A. 1987 . A review of current literature on N‐nitroso compounds in foods . Advances in Food Research , 31 : 53 – 115 .
  • Hotchkiss , J. A. 1989 . Preformed N‐nitroso compounds in foods and beverages . Cancer Suveys , 8 : 295 – 322 .
  • Hotchkiss , J. A. , Scanlan , R. A. and Libbey , L. M. 1977 . Formation of bis(hydroxyalkly)‐N‐nitrosamines as products of the nitrosation of spermidine . Journal of Agricultural and Food Chemistry , 25 : 1183 – 1189 .
  • Hough , J. S. , Briggs , D. E. , Stevens , R. and Young , T. W. 1982 . Malting and Brewing Science, Volume 2, Hopped Wort and Beer , 799 – 801 . London : Chapman & Hall, University Press .
  • Ikins , W. G. , Gray , J. I. , Mandagere , A. K. , Booren , A. M. , Pearson , A. M. and Stachiw , M. A. 1986 . N‐Nitrosamine formation in fried bacon processed with liquid smoke preparations . Journal of Agricultural and Food Chemistry , 34 : 980 – 985 .
  • Ikins , W. G. , Gray , J. I. , Mandagere , A. K. , Booren , A. M. , Pearson , A. M. , Stachiw , M. A. and Buckley , D. J. 1988 . Contribution of wood smoke to in vivo formation of N‐nitrosothiazolidine‐4‐carboxylic acid: Initial studies . Food and Chemical Toxicology , 26 : 15 – 21 .
  • International Agency for Research on Cancer . 1985 . “ IARC Monographs: Evaluation on the carcinogenic risk of chemicals to humans ” . In Tobacco habits other than smoking; betel‐quid and areca‐nut chewing; and some related nitrosamines , Volume 37 , Lyon : International Agency for Research on Cancer .
  • Ito , T. , Cassens , R. B. , Greaser , M. L. , Lee , M. and Izumi , K. 1983 . Lability and reactivity of nonhaem protein bound nitrite . Journal of Food Science , 48 : 1204 – 1207 .
  • Janzowski , C. , Eisenbrand , G. and Preussmann , R. 1978 . Occurrence and detection of N‐nitroso‐3‐hydroxypyrrolidine in cured meat products . Journal of Chromatography , 150 : 216 – 220 .
  • Janzowski , C. , Eisenbrand , G. and Preussmann , R. 1978 . Occurrence of N‐nitrosamino acids in cured meat products and their effect on formation of N‐nitrosamines during heating . Food and Cosmetics Toxicology , 16 : 343 – 348 .
  • Janzowski , C. , Klein , R. and Preussmann , R. 1980 . “ Formation of N‐nitroso compounds of the pesticides atrazine, simazine and carbaryl with nitrogen oxides ” . In N‐Nitroso Compounds, Analysis, Formation and Occurrence , IARC Scientific Publication No. 31 Edited by: Walker , A. E. , Griciute , L. , Castegnaro , M. and Börzsönyi , M. 329 – 339 . Lyon : International Agency for Research on Cancer .
  • Ji , C. , Xu , Z. H. , Li , M. X. , Li , G. Y. and Li , J. L. 1986 . A new N‐nitroso compound, N‐(2‐methylpropyl)‐N‐(1‐methylacetonyl)nitrosamine, in mouldy millet and what flour . Journal of Agricultural and Food Chemistry , 34 : 628 – 632 .
  • Ji , C. , Li , M. H. , Li , J. L. and Lu , S. J. 1986 . Synthesis of nitrosomethylisoamylamine from isoamylamine and sodium nitrite by fungi . Carcinogenesis , 7 : 301 – 303 .
  • Johnson , P. , Pfab , J. , Tricker , A. R. , Key , P. E. and Massey , R. C. 1987 . An investigation into the total apparent N‐nitroso compounds in malt . Journal of the Institute of Brewing , 93 : 319 – 321 .
  • Johnson , P. , Pfab , J. and Massey , R. C. 1988 . Development of methods for the characterisation of non‐volatile N‐nitroso compounds in malt . Journal of the Institute of Brewing , 94 : 19 – 22 .
  • Johnson , P. , Pfab , J. and Massey , R. C. 1988 . A method for the investigation of free and proteinbound N‐nitrosoproline in beer . Food Additives and Contaminants , 5 : 119 – 125 .
  • Kanner , J. and Juven , B. J. 1980 . S‐Nitrosocysteine as an antioxidant, colour‐developing, and anticlostridial agent in comminuted turkey meat . Journal of Food Science , 45 : 1105 – 1108 . 1112
  • Khan , S. V. and Young , J. C. 1977 . N‐Nitrosamine formation in soil from the herbicide glyphosate . Journal of Agricultural and Food Chemistry , 25 : 1430 – 1432 .
  • Knight , T. M. , Forman , D. , Al‐Dabbagh , S. A. and Doll , R. 1987 . Estimation of dietary nitrate and nitrite in Great Britain . Food and Chemical Toxicology , 25 : 277 – 285 .
  • Kubacka , W. , Libbey , L. M. and Scanlan , R. A. 1984 . Formation and chemical characterization of some N‐nitroso dipeptides N‐terminal in proline . Journal of Agricultural and Food Chemistry , 32 : 401 – 404 .
  • Kubacki , S. J. and Kupryszewski , G. 1981 . “ The formation, chemistry and stability of N‐nitrosocarbaryl under simulated gastric conditions ” . In N‐Nitroso Compounds, Analysis, Formation and Occurrence , IARC Scientific Publication No. 31 Edited by: Walker , A. E. , Griciute , L. , Castegnaro , M. and BÖRzsÖNyi , M. 245 – 257 . Lyon : International Agency for Research on Cancer .
  • Kubacki , S. J. , Havery , D. C. and Fazio , T. 1989 . HPLC analysis of N‐nitrosamino acids and N‐nitrosodipeptides N‐terminal in proline . Zietschrift für die Gesamte Hygiene und ihre Grenzgebiete (Berlin) , 35 : 98 – 100 .
  • Kushnir , I. , Feinberg , J. I. , Pensabene , J. W. , Piotrowski , E. G. , Fiddler , W. and Wassermann , E. A. 1975 . Isolation and identification of nitrosoproline in uncooked bacon . Journal of Food Science , 40 : 427 – 428 .
  • Lee , J. S. , Libbey , L. M. , Scanlan , R. A. and Bills , D. D. 1978 . Identification and quantification of 3‐hydroxy‐N‐nitrosopyrrolidine in fried bacon . Bulletin of Environmental Contamination and Toxicology , 19 : 511 – 517 .
  • Lukes , B. , O'Brien , T. J. and Scanlan , R. A. 1980 . Residual sulfur dioxide in finished malt: colorimetric determination and relation to N‐nitrosodimethylamine . Journal of the American Society of Brewing Chemists , 38 : 146 – 148 .
  • MAFF (Ministry of Agriculture, Fisheries and Food) . 1987 . “ Nitrate, nitrite and N‐nitroso compounds in foods ” . In The twentieth report of the steering group on food surveillance, the working party on nitrate and related compounds in food , Food surveillance paper No. 20 London : HMSO .
  • Magee , P. N. 1989 . The experimental basis for the role of nitroso compounds in human cancer . Cancer Surveys , 8 : 207 – 240 .
  • Mandagere , A. K. 1986 . Smoke‐related nitrogen‐nitroso compounds in cured meat systems , Michigan State University . PhD Thesis
  • Mandagere , A. K. , Gray , J. I. , Skrypec , D. J. , Booren , A. M. and Pearson , A. M. 1984 . Role of wood smoke in N‐nitrosothiazolidine formation in bacon . Journal of Food Science , 49 : 658 – 659 . 661
  • Mangino , M. M. , Scanlan , R. A. and O'Brien , T. J. 1981 . N‐Nitrosamines in beer , N‐Nitroso Compounds, ACS Symposium Series 174 Edited by: Scanlan , R. A. and Tannenbaum , S. R. 229 – 245 . Washington, DC : American Chemical Society .
  • Massey , R. C. 1988 . “ Analysis of N‐nitroso compounds in foods and human body fluids ” . In N‐Nitrosamines—Toxicology and Microbiology , Edited by: Hill , M. J. 16 – 47 . Chichester : Ellis Horwood Ltd .
  • Massey , R. C. and Key , P. E. 1989 . Examination of some fermented foods for the presence of apparent total N‐nitroso compounds . Food Additives and Contaminants , 6 : 453 – 458 .
  • Massey , R. C. , Crews , C. and Mcweeny , D. J. 1982 . Methods for high‐performance liquid Chromatographic measurement of N‐nitrosamines in food and beverages . Journal of Chromatography , 241 : 423 – 427 .
  • Massey , R. C. , Crews , C. , Mcweeny , D. J. and Knowles , M. E. 1982 . Analysis of a model ionic nitrosamine by microbore high‐performance liquid chromatography using a thermal energy analyser . Journal of Chromatography , 236 : 527 – 529 .
  • Massey , R. C. , Bayly , J. M. , Key , P. E. , Mcweeny , D. J. and Knowles , M. E. 1984 . Total N‐nitroso group analysis of foods. II. Further studies on the precision and sensitivity of the assay . Food Additives and Contaminants , 1 : 237 – 244 .
  • Massey , R. C. , Key , P. E. , Mcweeny , D. J. and Knowles , M. E. 1984 . The application of a chemical denitrosation and chemiluminescence detection procedure for estimation of the apparent concentration of total N‐nitroso compounds in foods and beverages . Food Additives and Contaminants , 1 : 11 – 16 .
  • Massey , R. C. , Crews , C. , Dennis , M. J. , Mcweeny , D. J. , Startin , J. R. and Knowles , M. E. 1985 . Identification of a major new involatile N‐nitroso compound in smoked bacon . Analytica Chimica Acta , 174 : 327 – 330 .
  • Massey , R. C. , Dennis , M. J. , Pointer , M. and Mcweeny , D. J. 1990 . An investigation of the levels of N‐nitrosodimethylamine, apparent total N‐nitroso compounds and nitrate in beer . Food Additives and Contaminants , 7 : 605 – 615 .
  • Massey , R. C. , Key , P. E. , Jones , R. A. and Logan , G. L. 1991 . Volatile, non‐volatile and total N‐nitroso compounds in bacon . Food Additives and Contaminants , 8 : 585 – 598 .
  • Mende , P. , Spiegelhalder , B. , Wacker , C. D. and Preussmann , R. 1989 . Trapping of reactive intermediates from the nitrosation of primary amines by a new type of scavenger reagent . Food and Chemical Toxicology , 27 : 469 – 473 .
  • Mende , P. , Spiegelhalder , B. and Preussmann , R. 1989 . A sensitive analytical procedure for the detection of N‐nitrosamides via their alkylating activity . Food and Chemical Toxicology , 27 : 475 – 478 .
  • Mende , P. , Spiegelhalder , B. and Preussmann , R. 1991 . Trace analysis of nitrosated foodstuffs for nitrosamides . Food and Chemical Toxicology , 29 : 167 – 172 .
  • Miller , B. J. , Billedeau , S. M. and Miller , D. W. 1989 . Formation of N‐nitrosamines in microwaved versus skillet‐fried bacon containing nitrite . Food and Chemical Toxicology , 27 : 295 – 299 .
  • Mills , A. L. and Alexander , M. 1976 . N‐Nitrosamine formation by cultures of several microorganisms . Applied Environmental Microbiology , 31 : 892 – 895 .
  • Mirvish , S. S. 1971 . Kinetics of nitrosamide formation from alkylureas, N‐alkylurethans and alkylguanidines: Possible implications for the etiology of human gastric cancer . Journal of the National Cancer Institute , 46 : 1183 – 1193 .
  • Mirvish , S. S. 1975 . Formation of N‐nitroso compounds: Chemistry, kinetics and in vivo occurrence . Toxicology and Applied Pharmacology , 31 : 325 – 351 .
  • Mirvish , S. S. , Wallcave , L. , Eagan , M. and Shubik , P. 1972 . Ascorbate‐nitrite reaction: Possible means of blocking the formation of carcinogenic N‐nitroso compounds . Science , 177 : 65 – 88 .
  • Mirvish , S. S. , Nagel , D. L. and Sams , J. 1973 . Methyl‐ and ethyl‐nitrosocyanamide. Some properties and reactions . Journal of Organic Chemistry , 38 : 1325 – 1329 .
  • Mirvish , S. S. , Sams , J. , Fine , D. L. and Tannenbaum , S. R. 1973 . Kinetics of nitrosation of the amino acids proline, hydroxyproline and sarcosine . Journal of the National Cancer Institute , 51 : 1833 – 1839 .
  • Mottram , D. A. 1984 . Organic nitrates and nitrites in the volatiles of cooked cured meats . Journal of Agricultural and Food Chemistry , 32 : 343 – 345 .
  • Nair , J. , Ohshima , H. , Friesen , M. , Croisy , A. , Bhide , S. V. and Bartsch , A. 1985 . Tobacco‐specific and betel‐nut‐specific N‐nitroso compounds: Occurrence in saliva and urine of betel quid chewers and formation in vivo by nitrosation of betel quid . Carcinogenesis , 6 : 295 – 303 .
  • Ohshiman , H. and Bartsch , H. 1981 . Quantitative estimation of endogenous nitrosation in humans by monitoring N‐nitrosoproline excreted in the urine . Cancer Research , 41 : 3658 – 3662 .
  • Ohshima , H. , Nair , J. , Bourgade , M.‐C. , Friesen , M. , Garren , L. and Bartsch , H. 1985 . Identification and occurrence of two new N‐nitrosamino acids in tobacco products: 3‐(N‐Nitroso‐N‐methylamino)propionic acid and 4‐(N‐nitroso‐N‐methylamino)butyric acid . Cancer Letters , 26 : 153 – 162 .
  • Ohshima , H. , Calmels , S. , Pignatelli , B. , Vincent , P. and Bartsch , H. 1987 . “ N‐Nitrosamine formation in urinary tract infections ” . In Relevance of N‐Nitroso Compounds to Human Cancer: Exposures and Mechanisms , IARC Scientific Publication No. 84 Edited by: Bartsch , H. , O'Neill , I. K. and Schulte‐Hermann , R. 384 – 390 . Lyon : International Agency for Research on Cancer .
  • ÖSterdahl , B.‐G. and Alriksson , E. 1990 . Volatile N‐nitrosamines in microwave‐cooked bacon . Food Additives and Contaminants , 7 : 51 – 54 .
  • Papavergou , E. and Clifford , M. N. 1986 . Possible chemical interactions between woodsmoke constituents and foods . Proceedings of the Institute of Food Science and Technology , 19 : 63 – 67 .
  • Pensabene , J. W. and Fiddler , W. 1983 . N‐Nitrosothiazolidine in cured meat products . Journal of Food Science , 48 : 1870 – 1874 .
  • Pensabene , J. W. and Fiddler , W. 1985 . Effect of N‐nitrosothiazolidine‐4‐carboxylic acid on formation of N‐nitrosothiazolidine in uncooked bacon . Journal of the Association of Official Analytical Chemists , 68 : 1077 – 1080 .
  • Pensabene , J. W. , Feinberg , J. I. , Piotrowski , E. G. and Fiddler , W. 1979 . Occurrence and determination of N‐nitrosoproline and N‐nitrosopyrrolidine in cured meat products . Journal of Food Science , 44 : 1700 – 1702 .
  • Pensabene , J. W. , Doerr , R. C. and Fiddler , W. 1987 . Determination by liquid chromatography with electrochemical detection of cysteamine and cysteine, possible precursors of N‐nitrosothiazolidine . Journal of the Association of the Official Analytical Chemists , 70 : 1033 – 1035 .
  • Pensabene , J. W. , Fiddler , W. , Gates , R. A. , Hale , M. , Jahncke , M. and Gooch , J. 1991 . N‐Nitrosothiazolidine and its 4‐carboxylic acid in frankfurters containing Alaska pollack . Journal of Food Science , 56 : 1108 – 1110 .
  • Perciballi , M. , Conboy , J. J. and Hotchkiss , J. H. 1989 . Nitrite‐cured meats as a source of endogenously formed N‐nitrosoproline in the ferret . Food and Chemical Toxicology , 27 : 111 – 116 .
  • Pignatelli , B. , Malaveille , C. , Friesen , M. , Hautefeuille , A. , Bartsch , H. , Piskorska , D. and Descotes , G. 1987 . Synthesis, structural activity relationships and a reaction mechanism for mutagenic N‐nitroso derivatives of glycosylamines and Amadori compounds: model substances for N‐nitrosated early Maillard reaction products . Food chemistry and Toxicology , 25 : 669 – 680 .
  • Pignatelli , B. , Richard , I. , Bourgade , M. C. and Bartsch , H. 1987 . Improved group determination of total N‐nitroso compounds in human gastric juice by chemical denitrosation and thermal energy analysis . Analyst , 112 : 945 – 949 .
  • Pignatelli , B. , Malaveille , C. , Friesen , M. , Hautefeuille , A. , Bartsch , H. , Piskorska , D. and Descotes , G. 1987 . “ Synthesis, analysis and mutagenic activity of N‐nitroso derivatives of glycosylamines and Amadori compounds: Nitrosated model substances for the early Maillard reaction products ” . In Relevance of N‐Nitroso Compounds to Human Cancer: Exposures and Mechanisms , IARC Scientific Publication No. 84 Edited by: Bartsch , H. , O'Neill , I. K. and Schulte‐Hermann , R. 277 – 283 . Lyon : International Agency for Research on Cancer .
  • Pollock , J. R. A. 1981 . Aspects of nitrosation in malts and beers. I. Examination of malts for the presence of N‐nitrosoproline, N‐nitrososarcosine and N‐nitrosopipecolinic acid . Journal of the Institute of Brewing , 87 : 356 – 359 .
  • Pollock , J. R. A. 1985 . Formation of nitrosoiminodialkanoic acids during the nitrosation of dipeptides . Food and Chemical Toxicology , 23 : 701 – 704 .
  • Pool , B. L. , RÖPer , H. , RÖPer , S. and Romruen , K. 1984 . Mutagenic studies of the N‐nitrosated products of the Maillard browning reaction: N‐Nitroso‐fructose‐amino acids . Food and Chemical Toxicology , 22 : 797 – 801 .
  • Poirier , S. , Ohshima , H. , De‐The , G. , Bourgade , M. C. and Bartsch , H. 1987 . Volatile nitrosamine levels in common foods from Tunisia, South China and Greenland, high‐risk areas for nasopharyngeal carcinoma (NPC) . International Journal of Cancer , 39 : 293 – 296 .
  • Preussmann , R. 1981 . “ Vorkommen und Bedeutung chemischer Carcinogene in der menschlichen Umwelt ” . In Maligne Tumoren , Edited by: SchmÄL , D. 160 – 176 . Aulendorf, , FRG : Editor Cantor .
  • Preussmann , R. and Eisenbrand , G. 1984 . N‐Nitroso carcinogens in the environment, ACS Monograph 182 , Washington DC : American Chemical Society .
  • Preussmann , R. , Spiegelhalder , B. and Eisenbrand , G. 1981 . “ Reduction of human exposure to environmental N‐nitroso compounds ” . In N‐Nitroso Compounds , ACS Symposium Series 174 Edited by: Scanlan , R. A. and Tannenbaum , S. R. 217 – 228 . Washington, DC : American Chemical Society .
  • Prokopczyk , B. , Rivenson , A. , Bertinato , P. , Brunnemann , K. D. and Hoffmann , D. 1987 . 3‐(Methylnitrosamino)propionitrile: Occurrence in saliva of betel quid chewers, carcinogenicity, and DNA methylation in F344 rats . Cancer Research , 47 : 467 – 471 .
  • Ridd , J. H. 1961 . Nitrosation, diazotization and deamination . Quarterly Reviews of the Chemical Society (London) , 15 : 418 – 441 .
  • Roper , H. , RÖPer , S. , Heyns , K. and Meyer , B. 1982 . “ N‐Nitroso sugar amino acids (N‐No‐D‐fructose‐L‐amino acids) ” . In N‐Nitroso Compounds: Occurrence and Biological Effects , IARC Scientific Publication No. 41 Edited by: Bartsch , H. , O'neill , I. K. , Castegnaro , M. and Okada , M. 87 – 98 . Lyon : International Agency for Research on Cancer .
  • Russell , G. F. 1983 . “ Nitrite interacts in model Maillard browning systems ” . In The Maillard Reaction in Foods and Nutrition , A CS Symposium Series No. 215 Edited by: Waller , G. R. and Feather , M.S. 83 – 90 . Washington, DC : American Chemical Society .
  • Sakaguchi , M. and Shibamoto , T. 1978 . Formation of heterocyclic compounds from the reaction of cysteamine and D‐glucose, acetaldehyde or glyoxal . Journal of Agricultural and Food Chemistry , 26 : 1179 – 1183 .
  • Sen , N. P. 1991 . “ Recent studies in Canada on the occurrence and formation of N‐nitroso compounds in foods and food contact materials ” . In Relevance to Human Cancer of N‐nitroso Compounds, Tobacco Smoke and Mycotoxins , IARC Scientific Publication No. 105 Edited by: O'Neill , I. K. , Chen , J. and Bartsch , H. 232 – 234 . Lyon : International Agency for Research on Cancer .
  • Sen , N. P. and Kubacki , S. J. 1987 . Review of methodologies for the determination of non‐volatile N‐nitroso compounds in foods . Food Additives and Contaminants , 4 : 357 – 383 .
  • Sen , N. P. and Seaman , S. W. 1984 . “ On‐line combination of high performance liquid chromatography and total N‐nitroso determination apparatus for the determination of N‐nitrosamides and other N‐nitroso compounds, and some recent data on the levels of N‐nitrosoproline in foods and beverages ” . In N‐Nitroso Compounds: Occurrence, Biological Effects and Relevance to Human Cancer , IARC Scientific Publication No. 57 Edited by: O'Neill , I. K. , Von Borstel , R. C. , Miller , C. T. , Long , J. and Bartsch , H. 137 – 143 . Lyon : International Agency for Research on Cancer .
  • Sen , N. P. , Donaldson , B. , Seaman , S. , Iyengar , J. R. and Miles , W. F. 1976 . Inhibition of nitrosamine formation in fried bacon by propyl gallate and L‐ascorbylpalmitate . Journal of Agricultural and Food Chemistry , 22 : 1125 – 1130 .
  • Sen , N. P. , Coffin , D. E. , Seaman , S. , Donaldson , B. and Miles , W. F. Extraction, clean‐up and estimation as methyl ether of 3‐hydroxy‐l‐nitrosopyrrolidine, a non‐volatile nitrosamine in cooked bacon at mass fractions of μg/kg . Proceedings of the 2nd International Symposium on Nitrite in Meat Products . 1976 , Zeist. Edited by: Tinbergen , B. J. and Krol , B. pp. 179 – 185 . Wageningen Center for Agriculture, Public Documentation Wageningen .
  • Sen , N. P. , Tessier , L. and Seaman , S. W. 1983 . Determination of N‐nitrosoproline and N‐nitrososarcosine in malt and beer . Journal of Agricultural and Food Chemistry , 31 : 1033 – 1036 .
  • Sen , N. P. , Tessier , L. , Seaman , S. W. and Baddoo , P. A. 1985 . Volatile and non‐volatile nitrosamines in fish and the effect of deliberate nitrosation under simulated gastric conditions . Journal of Agricultural and Food Chemistry , 33 : 264 – 268 .
  • Sen , N. P. , Baddoo , P. A. and Seaman , S. W. 1986 . N‐Nitrosothiazolidine and N‐nitrosothiazolidine‐4‐carboxylic acid in smoked meats and fish . Journal of Food Science , 51 : 821 – 825 .
  • Sen , N. P. , Baddoo , P. A. and Seaman , S. W. 1987 . Volatile nitrosamines in cured meats packaged in elastic rubber netting . Journal of Agricultural and Food Chemistry , 35 : 346 – 350 .
  • Sen , N. P. , Seaman , S. W. , Baddoo , P. A. and Weber , D. 1988 . Further studies on the formation of nitrosamines in cured pork products packaged in elastic rubber nettings . Journal of Food Science , 53 : 731 – 734 . 738
  • Sen , N. P. , Seaman , S. W. , Baddoo , P. A. and Weber , D. 1989 . Determination and occurrence of 2‐(hydroxymethyl)‐N‐nitrosothiazolidine in fried bacon and other cured meat products . Journal of Agricultural and Food Chemistry , 37 : 717 – 721 .
  • Sen , N. P. , Baddoo , P. A. and Seaman , S. W. 1989 . The analysis and significance of bound N‐nitrosoproline in nitrite‐cured meat products . Food Additives and Contaminants , 6 : 21 – 28 .
  • Sen , N. P. , Baddoo , P. A. , Weber , D. and Helgason , T. 1990 . Detection of a new nitrosamine, N‐nitroso‐N‐methylaniline and other nitrosamines in Icelandic smoked mutton . Journal of Agricultural and Food Chemistry , 38 : 1007 – 1011 .
  • Sen , N. P. , Baddoo , P. A. , Seaman , S. W. and Weber , D. 1991 . 2‐(Hydroxymethyl)‐N‐nitrosothiatolidine‐4‐carboxylic acid in smoked meats and bacon and conversion to 2‐(hydroxymethyl)‐N‐nitrosothiazolidine during the high‐heat cooking . Journal of Food Science , 56 : 913 – 915 .
  • Shephard , S. E. , Schlatter , Ch. and Lutz , W. K. 1987 . Assessment of the risk of formation of carcinogenic N‐nitroso compounds from dietary precursors in the stomach . Food and Chemical Toxicology , 25 : 91 – 108 .
  • Shuker , D. E. G. and Tannenaum , S. R. 1983 . Determination of non‐volatile N‐nitroso compounds in biological fluids by liquid chromatography with post column photohydrolysis detection . Analytical Chemistry , 55 : 2152 – 2155 .
  • Siddiqi , M. A. , Tricker , A. R. and Preussmann , R. 1988 . The occurrence of N‐nitroso compounds in food samples from a high risk area of esophageal cancer in Kashmir, India . Cancer Letters , 39 : 37 – 43 .
  • Singer , G. M. , Ji , C. , Roman , J. , Li , M. H. and Lijinsky , W. 1986 . Nitrosamines and nitrosamine precursors in foods from Linxian, China, a high incidence area for esophageal cancer . Carcinogenesis , 7 : 733 – 736 .
  • Skrypec , D. J. , Gray , J. I. , Mandagere , A. K. , Booren , A. M. , Pearson , A. M. and Cuppett , S. L. 1985 . Effect of bacon composition and processing on N‐nitrosamine formation . Food Technology , 39 : 74 – 79 .
  • Smith , P. A. S. 1966 . The Chemistry of Open‐Chain Organic Nitrogen Compounds , Volume 2 , New York : Benjamin .
  • Spiegelhalder , B. , Eisenbrand , G. and Preussmann , R. 1980 . “ Occurrence of volatile nitrosamines in food: a survey of the West German market ” . In N‐Nitroso compounds, Analysis, Formation and Occurrence , IARC Scientific Publication No. 31 Edited by: Walker , A. E. , Castegnaro , M. , Griciute , L. and BÖRzsÖNyi , M. 467 – 477 . Lyon : International Agency for Research on Cancer .
  • Stich , H. F. , Hornby , A. P. and Dunn , B. P. 1984 . The effect of dietary factors on nitrosoproline levels in human urine . International Journal of Cancer , 33 : 625 – 628 .
  • Stich , H. F. , Rosin , M. P. and Brunnemann , K. D. 1986 . Oral lesions, genotoxicity and nitrosamines in betel quid chewers with no obvious increase in oral cancer risk . Cancer Letters , 31 : 15 – 25 .
  • Toth , L. and Potthast , K. 1984 . Chemical aspects of the smoking of meat and meat products . Advances in Food Research , 29 : 87 – 158 .
  • Tricker , A. R. and Preussmann , R. 1986 . Formation of N‐nitrosoiminodialkanoic acids and their unsuitability as biological monitors for endogenous nitrosation of dipeptides . Carcinogenesis , 7 : 1523 – 1526 .
  • Tricker , A. R. and Preussmann , R. 1988 . “ N‐Nitroso compounds and their precursors in the human environment ” . In N‐Nitrosamines—Toxicology and Microbiology , Edited by: Hill , M. J. 88 – 116 . Chichester : Ellis Horwood Ltd .
  • Tricker , A. R. and Preussmann , R. 1988 . The occurrence of N‐nitroso compounds in zarda tobacco . Cancer Letters , 42 : 113 – 118 .
  • Tricker , A. R. and Preussmann , R. 1989 . “ Preformed nitrosamines in smokeless tobaccos ” . In Tobacco and Cancer, Perspectives in Preventative Research , Edited by: Maskens , A. P. , Molinard , R. , Preussmann , R. and Wilmer , J. W. 35 – 47 . Amsterdam : Elsevier Science Publishers B.V. (Biomedical Division) .
  • Tricker , A. R. and Preussmann , R. 1989 . The occurrence of N‐nitroso compounds in Kiwam tobacco . Cancer Letters , 49 : 221 – 224 .
  • Tricker , A. R. and Preussmann , R. 1991 . Carcinogenic N‐nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential . Mutations Research , 259 : 277 – 289 .
  • Tricker , A. R. and Preussmann , R. 1991 . Volatile and non‐volatile N‐nitrosamines in beer . Journal of Cancer Research and Clinical Oncology , 117 : 130 – 132 .
  • Tricker , A. R. and Preussmann , R. 1991 . “ Occurrence of and exposure to N‐nitroso compounds in tobacco ” . In Relevance to Human Cancer of N‐Nitroso Compounds, Tobacco Smoke and Mycotoxins , IARC Scientific Publication No. 105 Edited by: O'Neill , I. K. , Chen , J. S. and Bartsch , H. 531 – 533 . Lyon : International Agency for Research on Cancer .
  • Tricker , A. R. , Perkins , M. J. , Massey , R. C. and Mcweeny , D. J. 1984 . Synthesis of three N‐nitroso dipeptides N‐terminal in proline and a method for their determination in food . Food Additives and Contaminants , 1 : 307 – 312 .
  • Tricker , A. R. , Perkins , M. J. , Massey , R. C. , Bishop , C. , Key , P. E. and Mcweeny , D. J. 1984 . Incidence of some non‐volatile N‐nitroso compounds in cured meats . Food Additives and Contaminants , 1 : 245 – 252 .
  • Tricker , A. R. , Perkins , M. J. , Massey , R. C. and Mcweeny , D. J. 1985 . Some N‐nitrosamino acids in bacon adipose tissue and their contribution to the total N‐nitroso compound concentration . Zeitschrift für Lebensmittel Untersuchung und Forschung , 180 : 379 – 383 .
  • Tricker , A. R. , Perkins , M. J. , Massey , R. C. and Mcweeny , D. J. 1985 . N‐Nitrosopyrrolidine formation in bacon . Food Additives and Contaminants , 2 : 247 – 252 .
  • Tricker , A. R. , Perkins , M. J. , Massey , R. C. and Mcweeny , D. J. 1986 . Characterization studies on insoluble total N‐nitroso compounds in bacon adipose tissue and connective tissue . Food Additives and Contaminants , 3 : 153 – 159 .
  • Tricker , A. R. , Mostafa , M. H. , Spiegelhalder , B. and Preussmann , R. 1989 . Urinary excretion of nitrate, nitrite and N‐nitroso compounds in schistosomiasis and bilharzial bladder cancer patients . Carcinogenesis , 10 : 547 – 552 .
  • Tricker , A. R. , KÄLble , T. and Preussmann , R. 1989 . Increased urinary nitrosamine excretion in patients with urinary diversions . Carcinogenesis , 10 : 2379 – 2382 .
  • Tricker , A. R. , Pfundstein , B. , Theobald , E. , Spiegelhalder , B. and Preussmann , R. 1991 . The mean daily intake of volatile N‐nitrosamines from foods and beverages in West Germany in 1989–1990 . Food and Chemical Toxicology , 29 : 729 – 732 .
  • Tricker , A. R. , Stickler , D. J. , Chawla , J. C. and Preussmann , R. 1991 . Increased urinary nitrosamine excretion in paraplegic patients . Carcinogenesis , 12 : 943 – 946 .
  • Tsuda , M. , Frank , N. , Sato , S. and Sugimura , T. 1988 . Marked increase in the urinary level of N‐nitrosothioproline after ingestion of cod with vegetables . Cancer Research , 48 : 4049 – 4052 .
  • USDA (United States Department Of Agriculture) . 1978 . Nitrates, nitrites, and ascorbates (or isoascorbates) in bacon . United States Department of Agriculture, Federal Register , 43 : 20992
  • USDA (United States Department Of Agriculture) . 1986 . Nitrite levels in bacon . United States Department of Agriculture, Federal Register , 51 : 21731
  • USEPA (United States Environmental Protection Agency) . 1981 . Maleic hydrazide. Notification of issuance of intent to suspend pesticide registrations . Federal Register , 46 ( 179 ) : 45999 – 46000 .
  • Umano , K. , Shibamoto , T. , Fernando , S. Y. and Wei , C.‐I. 1984 . Mutagenicity of 2‐hydroxyalkyl‐N‐nitrosothiazolidines . Food and Chemical Toxicology , 22 : 253 – 259 .
  • Vecchio , A. J. , Hotchkiss , J. H. and Bisogni , C. A. 1986 . Ingestion of N‐nitrosamines from fried bacon: a consumer survey . Journal of Food Science , 51 : 754 – 756 .
  • Wainright , T. 1981 . Nitrosodimethylamine: Formation and palliative measures . Journal of the Institute of Brewing , 87 : 264 – 265 .
  • Wainright , T. 1986 . The chemistry of nitrosamine formation: Relevance to malting and brewing . Journal of the Institute of Brewing , 92 : 49 – 64 .
  • Wakabayashi , K. , Nagao , M. , Ochiai , M. , Tahira , T. , Yamaizumi , Z. and Sugimura , T. 1985 . A mutagen precursor in Chinese cabbage, indole‐3‐acetonitrile, which becomes mutagenic on nitrite treatment . Mutation Research , 143 : 17 – 21 .
  • Wakabayashi , K. , Nagao , M. , Tahira , T. , Yamaizumi , Z. , Katayama , M. , Marumo , S. and Sugimura , T. 1986 . 4‐Methoxyindole derivatives as nitrosatable precursors of mutagens in Chinese cabbage . Mutagenesis , 1 : 423 – 426 .
  • Walser , A. , Fryer , R. I. , Sternbach , L. H. and Archer , M. C. 1974 . Quinazolines and 1,4‐benzodiazopines. LXV. Some transformations of chlordiazepoxide . Journal of Heterocyclic Chemistry , 11 : 619 – 621 .
  • Walters , C. L. , Downes , M. J. , Edwards , M. W. and Smith , P. L. R. 1978 . Determination of a non‐volatile N‐nitrosamine on a food matrix . Analyst , 103 : 1127 – 1133 .
  • Wenke , G. and Hoffmann , D. 1983 . A study of betel quid carcinogenesis. I. On the in vitro nitrosation of arecoline . Carcinogeneis , 4 : 169 – 172 .
  • Wenke , G. , Brunnemann , K. D. , Hoffmann , D. and Bhide , S. V. 1984 . A study of betel quid carcinogenesis . Journal of Cancer Research and Clinical Oncology , 108 : 110 – 113 .
  • Williams , D. H. L. 1983 . Nitrosation mechanisms . Advances in Physical Organic Chemistry , 19 : 381 – 428 .
  • Woods , L. F. J. and Wood , J. M. 1982 . The effect of nitrite inhibition on the metabolism of Clostridium botulinum . Journal of Applied Bacteriology , 52 : 109 – 110 .
  • Yamamoto , M. , Ishiwata , H. , Yamada , T. , Yoshinira , K. and Tanimura , A. 1987 . Studies in the guinea‐pig stomach on the formation of N‐nitrosomethylurea, from methylurea and sodium nitrite and its disappearance . Food and Cosmetics Toxicology , 25 : 663 – 668 .
  • Yang , D. , Tannenbaum , S. R. , BÜChi , G. and Lee , G. C. M. 1984 . 4‐Chloro‐6‐methoxyindole is the precursor of a potent mutagen (4‐chloro‐6‐methoxy‐2‐hydroxyl‐l‐nitrosoindolin‐3‐one oxime) that forms during nitrosation of the fava bean (Vicia faba) . Carcinogenesis , 5 : 1219 – 1224 .
  • Zhang , W.‐X. , Xu , M.‐S. , Wang , G.‐H. and Wang , M.‐Y. 1983 . Quantitative analysis of Roussin red methyl ester in pickled vegetables . Cancer Research , 43 : 339 – 341 .
  • This review is part of a project on non‐volatile N‐nitroso compounds of the Commission on Food Chemistry (Division VI.I) of the International Union of Pure and Applied Chemistry (IUPAC).

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