Relationship between insulin resistance and adipocytokines: the mediator role of adiposity in children

References

• Agostinis-Sobrinho C, Moreira C, Abreu S, Lopes L, Oliveira-Santos J, Steene-Johannessen J, Mota J, et al. 2017. Serum adiponectin levels and cardiorespiratory fitness in nonoverweight and overweight Portuguese adolescents: the LabMed Physical Activity Study. Pediatr Exerc Sci. 29(2):237–244.
   PubMed Web of Science ®Google Scholar
• Agostinis-Sobrinho C, Santos R, Moreira C, Abreu S, Lopes L, Oliveira-Santos J, Rosário R, et al. 2016. Association between serum adiponectin levels and muscular fitness in Portuguese adolescents: LabMed Physical Activity Study. Nutr Metab Cardiovasc Dis. 26(6):517–524.
   PubMed Web of Science ®Google Scholar
• Agostinis-Sobrinho CA, Lacerda E, Moreira C, Abreu S, Lopes L, Oliveira-Santos J, Skuryydas A, et al. 2017. Association between leptin, adiponectin, and leptin/adiponectin ratio with clustered metabolic risk factors in Portuguese adolescents: the LabMed. Ann Nutr Metab. 70(4):321–328.
   PubMed Web of Science ®Google Scholar
• Agostinis-Sobrinho CA, Ramírez-Vélez R, García-Hermoso A, Moreira C, Lopes L, Oliveira-Santos J, Abreu S, et al. 2018. Low-grade inflammation and muscular fitness on insulin resistance in adolescents: results from LabMed Physical Activity Study. Pediatr Diabetes. 19(3):429–435.
   PubMed Web of Science ®Google Scholar
• Aguilar MJ, González-Jiménez E, Antelo A, Perona JS. 2013. Insulin resistance and inflammation markers: correlations in obese adolescents. J Clin Nurs. 22(13–14):2002–2010.
   PubMed Web of Science ®Google Scholar
• Ai M, Otokozawa S, Asztalos BF, White CC, Cupples LA, Nakajima K, Lamon-Fava S, et al. 2011. Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring study. Atherosclerosis. 217(2):543–548.
   PubMed Web of Science ®Google Scholar
• Al-Daghri NM, Al-Attas OS, Alokail M, Alkharfy K, Wani K, Amer OE, Ul Haq S, et al. 2014. Does visceral adiposity index signify early metabolic risk in children and adolescents?: association with insulin resistance, adipokines, and subclinical inflammation. Pediatr Res. 75(3):459–463.
   PubMed Web of Science ®Google Scholar
• Allison MB, Myers MG. 2014. Connecting leptin signaling to biological function. J Endocrinol. 223(1):T25–T35.
   PubMed Web of Science ®Google Scholar
• Antunes H, Santos C, Carvalho S. 2009. Serum leptin levels in overweight children and adolescents. Br J Nutr. 101(8):1262–1266.
   PubMed Web of Science ®Google Scholar
• Aristizabal JC, Barona J, Hoyos M, Ruiz M, Marín C. 2015. Association between anthropometric indices and cardiometabolic risk factors in pre-school children. BMC Pediatr. 15:170.
   PubMed Web of Science ®Google Scholar
• Aycan Z, Berberoğlu M, Ocal G, Evliyaoglu O, Adiyaman P, Deda G, Caksen H, et al. 2005. Relationship between plasma leptin, insulin and tumor necrosis factor alpha in obese children. J Pediatr Endocrinol Metab. 18(3):275–284.
   PubMed Web of Science ®Google Scholar
• Baron RM, Kenny DA. 1986. The moderator–mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 51(6):1173–1118.
   PubMed Web of Science ®Google Scholar
• Bergmann GG, Bergmann MLA, Castro AAMC, Lorenzi TD, Pinheiro ES, Moreira RB, Marques AC. 2014. Use of the 6-minute walk/run test to predict peak oxygen uptake in adolescents. Rev Bras Ativ Fis Saúde. 19(1):64–73.
   Google Scholar
• Choi SH, Ku EJ, Hong ES, Lim S, Kim KW, Moon JH, Kim KM, et al. 2015. High serum adiponectin concentration and low body mass index are significantly associated with increased all-cause and cardiovascular mortality in an elderly cohort, “adiponectin paradox”: the Korean Longitudinal Study on Health and Aging (KLoSHA). Int J Cardiol. 183:91–97.
   PubMed Web of Science ®Google Scholar
• Esmaili S, Xu A, George J. 2014. The multifaceted and controversial immunometabolic actions of adiponectin. Trends Endocrinol Metab. 25(9):444–451.
   PubMed Web of Science ®Google Scholar
• Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N. 2014. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract. 105(2):141–150.
   PubMed Web of Science ®Google Scholar
• Falcão-Pires I, Castro-Chaves P, Miranda-Silva D, Lourenço AP, Leite-Moreira AF. 2012. Physiological, pathological and potential therapeutic roles of adipokines. Drug Discov Today. 17(15-16):880–889.
   PubMed Web of Science ®Google Scholar
• Finucane FM, Luan J, Wareham NJ, Sharp SJ, O’Rahilly S, Balkau B, Flyvbjerg A, et al. 2009. Correlation of the leptin: adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia. 52(11):2345–2349.
   PubMed Web of Science ®Google Scholar
• Fraser BJ, Blizzard L, Schmidt MD, Juonala M, Dwyer T, Venn AJ, Magnussen CG. 2018. Childhood cardiorespiratory fitness, muscular fitness and adult measures of glucose homeostasis. J Sci Med Sport. 21(9):935–940.
   PubMed Web of Science ®Google Scholar
• Friend A, Craig L, Turner S. 2013. The prevalence of metabolic syndrome in children: a systematic review of the literature. Metab Syndr Relat Disord. 11(2):71–80.
   PubMed Web of Science ®Google Scholar
• Gaya A, Gaya A. 2016. Manual de testes e avaliação do Projeto Esporte Brasil – PROESP-Br. [accessed 2019 July 10]. https://www.ufrgs.br/proesp/arquivos/manual-proesp-br-2016.pdf.
   Google Scholar
• Ghadge AA, Khaire AA, Kuvalekar AA. 2018. Adiponectin: a potential therapeutic target for metabolic syndrome. Cytokine Growth Factor Rev. 39:151–158.
   PubMed Web of Science ®Google Scholar
• González-Jiménez E, Schmidt-RioValle J, Montero-Alonso MA, Padez C, García-García CJ, Perona JS. 2016. Influence of biochemical and anthropometric factors on the presence of insulin resistance in adolescents. Bio Res Nurs. 18(5):541–548.
   PubMed Web of Science ®Google Scholar
• Grøntved A, Ried-Larsen M, Ekelund U, Froberg K, Brage S, Andersen LB. 2013. Independent and combined association of muscle strength and cardiorespiratory fitness in youth with insulin resistance and β-cell function in young adulthood: the European Youth Heart Study. Diabetes Care. 36(9):2575–2581.
   PubMed Web of Science ®Google Scholar
• Huang KC, Lin RCY, Kormas N, Lee LT, Chen CY, Gill TP, Caterson ID. 2004. Plasma leptin is associated with insulin resistance independent of age, body mass index, fat mass, lipids, and pubertal development in nondiabetic adolescents. Int J Obes. 28(4):470–475.
   Web of Science ®Google Scholar
• Kajikawa Y, Ikeda M, Takemoto S, Tomoda J, Ohmaru N, Kusachi S. 2011. Association of circulating levels of leptin and adiponectin with metabolic syndrome and coronary heart disease in patients with various coronary risk factors. Int Heart J. 52(1):17–22.
   PubMed Web of Science ®Google Scholar
• López-Jaramillo P, Gómez-Arbeláez D, López-López J, López-López C, Martínez-Ortega J, Gómez-Rodríguez A, Triana-Cubillos S. 2014. The role of leptin/adiponectin ratio in metabolic syndrome and diabetes. Horm Mol Biol Clin Invest. 18(1):37–45.
   PubMedGoogle Scholar
• Mantovani RM, Rocha NP, Magalhães DM, Barbosa IG, Teixeira AL, Silva AC. 2016. Early changes in adipokines from overweight to obesity in children and adolescents. J Pediatr. 92(6):624–630.
   Google Scholar
• Matthews DR, Hosker JP, Rudenski S, Naylor B, Treacher DF, Turner RC. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28(7):412–419.
   PubMed Web of Science ®Google Scholar
• Medeiros CCM, Ramos AT, Cardoso MAA, França ISX, Cardoso AS, Gonzaga NC, Carvalho DF. 2011. Insulin resistance and its association with metabolic syndrome components. Arq Bras Cardiol. 97(5):380–389.
   PubMed Web of Science ®Google Scholar
• Mirwald RL, Baxter-Jones ADG, Bailey D, Beunen GP. 2002. An assessment of maturity from anthropometric measurements. Med Sci Sports Exerc. 34(4):689–694.
   PubMed Web of Science ®Google Scholar
• Panagopoulou P, Galli-Tsinopoulou A, Fleva A, Pavlitou-Tsiontsi E, Vavatsi-Christaki N, Nousia-Arvanitakis S. 2008. Adiponectin and insulin resistance in childhood obesity. J Pediatr Gastroenterol Nutr. 47(3):356–362.
   PubMed Web of Science ®Google Scholar
• Pittas AG, Joseph NA, Greenberg AS. 2004. Adipocytokines and insulin resistance. J Clin Endocrinol Metab. 89(2):447–452.
   PubMed Web of Science ®Google Scholar
• Preacher KJ, Hayes AF. 2008. Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods. 40(3):879–891.
   PubMed Web of Science ®Google Scholar
• Romualdo M, Nóbrega FJ, Escrivão M. 2014. Insulin resistance in obese children and adolescents. J Pediatr. 90(6):600–607.
   Google Scholar
• Ropelle ER, Flores MB, Cintra DE, Rocha GZ, Pauli JR, Morari J, de Souza CT, et al. 2010. IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKβ and ER stress inhibition. PLoS Biol. 8(8):31–32.
   Web of Science ®Google Scholar
• Ruiz JR, Castro-Piñero J, Artero EG, Ortega FB, Sjöström M, Suni J, Castillo MJ. 2009. Predictive validity of health-related fitness in youth: a systematic review. Br J Sports Med. 43(12):909–923.
   PubMed Web of Science ®Google Scholar
• Skoczen S, Wojcik M, Fijorek K, Siedlar M, Starzyk JB. 2015. Expression of the central obesity and type 2 diabetes mellitus genes is associated with insulin resistance in young obese children. Exp Clin Endocrinol Diabetes. 123(4):252–259.
   PubMed Web of Science ®Google Scholar
• Van Greevenbroek MMJ, Schalkwijk CG, Stehouwer CD. 2013. Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences. Neth J Med. 71(4):174–187.
   PubMed Web of Science ®Google Scholar
• Yadav A, Kataria MA, Saini V, Yadav A. 2013. Role of leptin and adiponectin in insulin resistance. Clin Chim Acta. 417:80–84.
   PubMed Web of Science ®Google Scholar
• Zhu HJ, Li SJ, Pan H, Li N, Zhang DX, Wang LJ, Yang HB, et al. 2016. The changes of serum leptin and kisspeptin levels in Chinese children and adolescents in different pubertal stages. Int J Endocrinol. 2016:1–11.
   Google Scholar