The protoconid: a key cusp in lower molars. Evidence from a recent modern human population

References

• Balic A. 2019. Concise review: cellular and molecular mechanisms regulation of tooth initiation. Stem Cells. 37(1):26–32.
   PubMed Web of Science ®Google Scholar
• Bermúdez de Castro JM., Modesto-Mata M, García-Campos C, Sarmiento S, Martín-Francés L, Martínez de Pinillos M, Martinón-Torres M. 2021. Testing the inhibitory cascade model in a recent human sample. J Anat. 239:1170–1181.
   Google Scholar
• Bermúdez de Castro JM, Nicolás ME. 1995. Posterior dental size reduction in hominids: the Atapuerca evidence. Am J Phys Anthropol. 96(4):335–356.
   PubMed Web of Science ®Google Scholar
• Biggerstaff RH. 1976. Cusp size sexual dimorphism, and the heritability of maxillary molar cusp size in twins. J Dent Res. 55(2):189–195.
   PubMed Web of Science ®Google Scholar
• Blumenberg B, Lloyd AT. 1983. Australopithecus and the origin of the genus Homo: aspects of biometry and systematics with accompanying catalog of tooth metric data. Bio Syst. 16:127–167.
   Google Scholar
• Boccone S, Moggi Cecchi J. 2006. Upper molar cusp dimensions of South African australopithecines. Hum Evol. 21(1):65–70.
   Google Scholar
• Butler PM. 1956. The ontogeny of molar pattern. Biol Rev. 31(1):30–69.
   Web of Science ®Google Scholar
• Butler PM. 1967. Dental merism and tooth development. J Dent Res. 46(5):845–850.
   PubMed Web of Science ®Google Scholar
• Chen J, Lan Y, Baek JA, Gao Y, Jiang R. 2009. Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol. 334(1):174–185.
   PubMed Web of Science ®Google Scholar
• Cho SW, Lee HA, Cai J, Lee MJ, Kim JY, Ohshima H, Jung HS, et al. 2007. The primary enamel knot determines the position of the first buccal cusp in developing mice molars. Differentiation. 75(5):441–451.
   PubMed Web of Science ®Google Scholar
• Dahlberg AA. 1986. Ontogeny and dental genetics in forensic problems. Forensic Sci Int. 30(2–3):163–176.
   PubMed Web of Science ®Google Scholar
• Eizirik E, Murphy WJ, O’Brien SJ. 2001. Molecular dating and biogeography of the early placental mammal radiation. J Hered. 92(2):212–219.
   PubMed Web of Science ®Google Scholar
• Ferguson CA, Tucker AS, Christensen L, Lau AL, Matzuk MM, Sharpe PT. 1998. Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes Dev. 12(16):2636–2649.
   PubMed Web of Science ®Google Scholar
• Gabunia L, Vekua A. 1995. A Plio-Pleistocene hominid from Dmanisi, East Georgia, Caucasus. Nature. 373(6514):509–512.
   PubMed Web of Science ®Google Scholar
• Guatelli-Steinberg D, Hunter JP, Durner RM, Moormann S, Weston TC, Betsinger TK. 2013. Teeth, morphogenesis, and levels of variation in the human Carabelli trait. In: Scott R, Irish JD, editors. Anthropological perspectives on tooth morphology: genetics, evolution, variation. Cambridge: Cambridge University Press; p. 69–91.
   Google Scholar
• Hovorakova M, Lesot H, Peterka M, Peterkova R. 2018. Early development of the human dentition revisited. J Anat. 233(2):135–145.
   PubMed Web of Science ®Google Scholar
• Hunter JP, Guatelli-Steinberg D, Weston TC, Durner R, Betsinger TK. 2010. Model of tooth mophogenesis predicts Carabelli cusp expression, size, and symmetry in humans. PLoS One. 5(7):e11844.
   PubMed Web of Science ®Google Scholar
• Jernvall J. 2000. Linking development with generation of novelty in mammalian teeth. Proc Natl Acad Sci USA. 97(6):2641–2645.
   PubMed Web of Science ®Google Scholar
• Jernvall J, Jung HS. 2000. Genotype, phenotype, and development biology of molar tooth characters. Yrbk Phys Anthropol. 43:171–190.
   Web of Science ®Google Scholar
• Jernvall J, Kettunen P, Karavanova I, Martin LB, Thesleff I. 1994. Evidence for the role of the enamel knot as a control centre in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene. Int J Dev Biol. 38:463–469.
   PubMed Web of Science ®Google Scholar
• Jernvall J, Keränen SVE, Thesleff I. 2000. Evolutionary modification of development in mammalian teeth: quantifying gene expression patterns and topography. Proc Natl Acad Sci USA. 97(26):14444–14448.
   PubMed Web of Science ®Google Scholar
• Jernvall J, Thesleff I. 2000. Reiterative signaling and patterning during mammalian tooth morphogenesis. Mech Dev. 92(1):19–29.
   PubMed Web of Science ®Google Scholar
• Kassai Y, Munne P, Hotta Y, Penttilä E, Kavanagh K, Ohbayashi N, Takada S, et al. 2005. Regulation of Mammalian tooth cusp patterning by ectodin. Science. 309(5743):2067–2070.
   PubMed Web of Science ®Google Scholar
• Keranen S, Aberg T, Kettunen P, Thesleff I, Jernvall J. 1998. Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents. Dev Genes Evol. 208(9):477–486.
   PubMed Web of Science ®Google Scholar
• Kettunen P, Thesleff I. 1998. Expression and function of FGFs-4, -8 and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis. Dev Dyn. 211(3):256–268.
   PubMed Web of Science ®Google Scholar
• Kieser JA. 1990. Human adult odontometrics. Cambridge: Cambridge University Press.
   Google Scholar
• Li Z, Yu M, Tian W. 2013. An inductive signalling network regulates mammalian tooth morphogenesis with implications for tooth regeneration. Cell Prolif. 46(5):501–508.
   PubMed Web of Science ®Google Scholar
• Luckett WP. 1993. Ontogenetic staging of the mamalian dentition, and its value for assessment of homology and heterochrony. J Mammal Evol. 1(4):269–282.
   Google Scholar
• Macho GA, Moggi-Cecchi J. 1992. Reduction of maxillary molars in Homo sapiens sapiens: a different perspective. Am J Phys Anthropol. 87(2):151–159.
   PubMed Web of Science ®Google Scholar
• Matalova E, Antonarakis GS, Sharpe PT, Tucker AS. 2005. Cell lineage of primary and secondary enamel knots. Dev Dyn. 233(3):754–759.
   PubMed Web of Science ®Google Scholar
• Molnar S. 1971. Human tooth wear, tooth function and cultural variability. Am J Phys Anthropol. 34(2):175–190.
   PubMed Web of Science ®Google Scholar
• Moormann S, Guatelli-Steinberg D, Hunter J. 2013. Metamerism, morphogenesis, and the expression of Carabelli and other dental traits in humans. Am J Phys Anthropol. 150(3):400–408.
   PubMed Web of Science ®Google Scholar
• Navsa N. 1992. Tooth and cusp size reduction in second molars. J Dent Assoc South Africa. 47:257–260.
   PubMedGoogle Scholar
• Orban B. 1928. Dental histology and embriology. Chicago (IL): Rogers Printing.
   Google Scholar
• Pereira TV, Salzano FM, Mostowska A, Trzeciak WH, Ruiz-Linares A, Chies JAB, Saavedra C, et al. 2006. Natural selection and molecular evolution in primate PAX9 gene, a major determinant of tooth development. Proc Natl Acad Sci USA. 103(15):5676–5681.
   PubMed Web of Science ®Google Scholar
• Peters H, Neubüser A, Kratochwil K, Balling R. 1998. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 12(17):2735–2747.
   PubMed Web of Science ®Google Scholar
• Pispa J, Jung HS, Jernvall J, Kettunen P, Mustonen T, Tabata MJ, Kere J, Thesleff I. 1999. Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF. Dev Biol. 216(2):521–534.
   PubMed Web of Science ®Google Scholar
• Polly PD. 1998. Variability, selection, and constraints: development and evolution in viverravid (Carnivora, Mammalia) molar morphology. Paleobiology. 24(4):409–429.
   Web of Science ®Google Scholar
• Quam R, Bailey S, Wood BA. 2009. Evolution of M1 crown size and cusp proportions in the genus Homo. J Anat. 214(5):655–670.
   PubMed Web of Science ®Google Scholar
• Rosas A, Bermúdez de Castro JM. 1998. On the taxonomic affinities of the Dmanisi mandible (Georgia). Am J Phys Anthropol. 107(2):145–162.
   PubMed Web of Science ®Google Scholar
• Salazar-Ciudad I, Jernvall J. 2002. A gene network model accounting for development and evolution of mammalian teeth. Proc Natl Acad Sci USA. 99(12):8116–8120.
   PubMed Web of Science ®Google Scholar
• Salazar-Ciudad I, Jernvall J. 2010. A computational model of teeth and the developmental origins of morphological variation. Nature. 464(7288):583–586.
   PubMed Web of Science ®Google Scholar
• Scott GR, Turner CG. II 1997. The anthropology of modern human teeth: dental morphology and its variation in recent human populations. Cambridge: Cambridge University Press.
   Google Scholar
• Skinner MM, Gunz P. 2010. The presence of accessory cusps in chimpanzee lower molars is consistent with a patterning cascade model of development. J Anat. 217(3):245–253.
   PubMed Web of Science ®Google Scholar
• Ten Cate R. 2016. Oral histology: development, structure and function. 9th ed. Amsterdam, the Netherlands: Elsevier.
   Google Scholar
• Thesleff I, Keränen S, Jernvall J. 2001. Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation. Adv Dent Res. 15:14–18.
   PubMedGoogle Scholar
• Tucker AS, Headon DJ, Courtney JM, Overbeek P, Sharpe PT. 2004. The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development. Dev Biol. 268(1):185–194.
   PubMed Web of Science ®Google Scholar
• Turner CG, II Nichol CR, Scott GR. 1991. Scoring procedures for key morphological traits of the permanent dentition: the Arizona State University dental anthropology system. In: Kelley M, Larsen C, editors. Advances in dental anthropology. New York (NY): Wiley-Liss, New York; p. 13–31.
   Google Scholar
• Wood BA, Abbott SA. 1983. Analysis of the dental morphology of Plio-Pleistocene hominids. I. Mandibular molars: crown area measurements and morphological traits. J Anat. 136 (Pt 1):197–219.
   PubMed Web of Science ®Google Scholar
• Wood BA, Abbott SA, Graham SA. 1983. II. Mandibular molars - study of cusp areas, fissure pattern and cross sectional shape of the crown. J Anat. 137:287–314.
   PubMed Web of Science ®Google Scholar
• Yoo HI, Kim JH, Kim SH. 2014. Variations in the cusps of mandibular molars in Koreans. Korean J Phys Anthropol. 27(3):155–163.
   Google Scholar
• Zhang YD, Chen Z, Song YQ, Liu C, Chen YP. 2005. Making a tooth: growth factors, transcription factors, and stem cells. Cell Res. 15(5):301–316.
   PubMed Web of Science ®Google Scholar
• Zhou J, Gao Y, Zhang Z, Zhang Y, Maltby KM, Liu Z, Lan Y, Jiang R. 2011. Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev Biol. 353(2):344–353.
   PubMed Web of Science ®Google Scholar