Plant Sterols, Health Claims and Strategies to Reduce Cardiovascular Disease Risk

REFERENCES

• Williams CL, Bollella MC, Strobino BA, Boccia L, Campanaro L: Health effects of plant stanol ester and bran fiber on lipids, stool weight and stool frequency in young children. J Am Coll Nutr 6: 572–581, 1999.
   Google Scholar
• Pollak OJ: Reduction of blood cholesterol in man. Circulation 7: 702–706, 1953.
   PubMed Web of Science ®Google Scholar
• Jones PJ, MacDougall DE, Ntanios F, Vanstone CA: Dietary phytosterols as cholesterol-lowering agents in humans. Can J Physiol Pharmacol 75: 217–227, 1997.
   PubMed Web of Science ®Google Scholar
• Jones PJ, Ntanios FY, Raeini-Sarjaz M, Vanstone CA: Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am J Clin Nutr 69: 1144–1150, 1999.
   PubMed Web of Science ®Google Scholar
• Best MM, Duncan CH, van Loon EJ, et al.: The effects of sitosterol on serum lipids. Am J Med 19: 61–70, 1955.
   PubMed Web of Science ®Google Scholar
• Best MM, Duncan CH, van Loon EJ, et al.: Lowering of serum cholesterol by administration of a plant sterol. Circulation 10: 201–206, 1954.
   PubMed Web of Science ®Google Scholar
• Farquhar JW, Smith RE, Dempsey ME: The effect of beta sitosterol on the serum lipids of young men with arteriosclerotic heart disease. Circulation 15: 77–82, 1956.
   Web of Science ®Google Scholar
• Lees AM, Mok HY, Lees RS, McClusky MA, Grundy SM: Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis 28: 325–338, 1977.
   PubMed Web of Science ®Google Scholar
• Lees RS, Lees AM: Effects of sitosterol therapy on plasma lipid and lipoprotein concentration. In Greten H: “Lipoprotein Metabolism.” New York: Springer-Verlag, 1976.
   Google Scholar
• Ling WH, Jones PJ: Dietary phytosterols: a review of metabolism, benefits and side effects. Life Sci 57: 195–207, 1995.
   PubMed Web of Science ®Google Scholar
• Becker M, Staab D, von Bergmann K: Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. J Pediatr 122: 292–296, 1993.
   PubMed Web of Science ®Google Scholar
• Miettinen TA, Puska P, Gylling H, Vanhanen H, Vartiainen E: Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med 333: 1308–1312, 1995.
   PubMed Web of Science ®Google Scholar
• Glueck CJ, Speirs J, Tracy T, Streicher P, Illig E, Vandegrift J: Relationships of serum plant sterols (phytosterols) and cholesterol in 595 hypercholesterolemic, and familial aggregation of phytosterols, cholesterol, and premature coronary heart disease in hyperphytosterolemic probands and their first-degree relatives. Metabolism 40: 842–848, 1991.
   PubMed Web of Science ®Google Scholar
• Kuksis A, Myher JJ, Marai L, Little JA, McArthur RG, Roncari DA: Usefulness of gas chromatographic profiles of plasma total lipids in diagnosis of phytosterolemia. J Chromatogr 381: 1–12, 1986.
   PubMed Web of Science ®Google Scholar
• Bhattacharyya AK, Connor WE: β-sitosterolemia and xanthomatosis. A newly described lipid storage disease in two sisters. J Clin Invest 68: 1033–1043, 1974.
   Google Scholar
• Schulman RS, Bhattacharyya AK, Connor WE, Fredrickson DS: β-sitosterolemia and xanthomatosis. N Engl J Med 294: 482–483, 1976.
   PubMed Web of Science ®Google Scholar
• Miettinen TA: Phytosterolaemia, xanthomatosis and premature atherosclerotic arterial disease; a case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis. Eur J Clin Invest 10: 27–35, 1980.
   PubMed Web of Science ®Google Scholar
• Salen G, Shore V, Tint GS, Forte T, Shefer S, Horak I, Horak E, Dayal B, Nguyen L, Batta AK, et al.: Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis. J Lipd Res 30: 1319–1330, 1989.
   PubMed Web of Science ®Google Scholar
• Nguyen L, Salen G, Shefer S, Shore V, Tint GS, Ness G: Unexpected failure of bile acid malabsorption to stimulate cholesterol synthesis in sitosterolemia with xanthomatosis. Arteriosclerosis 10: 289–297, 1990.
   PubMedGoogle Scholar
• Kritchevsky D: Phytosterols. Adv Exp Med Biol 427: 235–243, 1997.
   PubMed Web of Science ®Google Scholar
• Howard BV, Kritchevsky D: Phytochemicals and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 95: 2591–2593, 1997.
   PubMed Web of Science ®Google Scholar
• Brown L, Rosner B, Willett WW, Sacks FM: Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 69: 30–42, 1999.
   PubMed Web of Science ®Google Scholar
• The Expert Panel: Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA 269: 3015–3023, 1993.
   PubMed Web of Science ®Google Scholar
• United States Food and Drug Administration: Food Labeling: Health Claims; Soluble fiber from whole oats and risk of coronary heart disease. Federal Register 62: 15343–15344 [Docket No. 95P-0197], 1997.
   Google Scholar
• United States Food and Drug Administration: Food Labeling: Health Claims; Soluble fiber from certain foods and coronary heart disease. Federal Register: 63: [Docket No. 96P-0338], 1998.
   Google Scholar
• United States Food and Drug Administration: Food Labeling: Health Claims; Soy protein and coronary heart disease: Proposed rule. Federal Register: 63: 62977–63015 [Docket No. 98P-0683], 1998.
   Google Scholar
• Simell O: Plant sterol esters in children. The STRIP Study. Eur Heart J, in press, 1999.
   Google Scholar
• Wood PJ, Braaten JT, Scott FW, Riedel KD, Wolynetz MS, Collins MW: Effect of dose and modification of viscous properties of oat gum on plasma glucose and insulin following an oral glucose load. Br J Nutr 72: 731–743, 1994.
   PubMed Web of Science ®Google Scholar
• Jenkins DJ, Wolever TM, Leeds AR, Gassull MA, Haisman P, Dilawari J, Goff DV, Metz GL: Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity. Br Med J 1: 1392–1394, 1978.
   PubMed Web of Science ®Google Scholar
• Messina M, Barnes S., Setchell KD: Phyto-oestrogens and breast cancer. Lancet 350: 971–972, 1997.
   PubMed Web of Science ®Google Scholar
• Setchell KD: Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 68(Suppl): 1333S–1346S, 1998.
   Google Scholar
• Jenkins DJ, Kendall CW, Garsetti M, Rosenberg-Zand RS, Jackson C-J, Agarwal S, Rao AV, Diamandis EP, Parker T, Faulkner D, Vuksan V, Vidgen E: Effect of soy protein foods on low density lipoprotein oxidation and ex vivo sex hormone receptor activity—a controlled crossover trial. Metabolism, in press, 2000.
   Google Scholar
• Crouse JR 3rd, Morgan T, Terry JG, Ellis J, Vitolins M, Burke GL: A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 159: 2070–2076, 1999.
   PubMed Web of Science ®Google Scholar
• Gillman MW, Cupples LA, Gagnon D, Posner BM, Ellison RC, Castelli WP, Wolf PA: Protective effect of fruits and vegetables on development of stroke in men. JAMA 273: 1113–1117, 1995.
   PubMed Web of Science ®Google Scholar
• Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennekens CH, Spiegelman D, Willett WC: Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 282: 1233–1239, 1999.
   PubMed Web of Science ®Google Scholar
• Kritchevsky D, Tepper SA, Goodman G: Diet, nutrition intake, and metabolism in populations at high and low risk for colon cancer. Relationship of diet to serum lipids. Am J Clin Nutr 40(Suppl): 921S–926S, 1984.
   Google Scholar
• Salmeron J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC: Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA 277: 472–477, 1997.
   PubMed Web of Science ®Google Scholar
• Salmeron J, Ascherio A, Rimm EB, Colditz GA, Spiegelman D, Jenkins DJ, Stampfer MJ, Wing AL: Dietary fiber, glycemic load, and risk of NIDDM in men. Diab Care 20: 545–550, 1997.
   PubMed Web of Science ®Google Scholar
• Jacobs DR Jr, Meyer KA, Kushi LH, Folsom AR: Whole-grain intake may reduce the risk of ischemic heart disease death in postmenopausal women: the Iowa Women’s Health Study. Am J Clin Nutr 68: 248–257, 1998.
   PubMed Web of Science ®Google Scholar
• Liu S, Stampfer MJ, Hu FB, Giovannucci E, Rimm E, Manson JE, Manson JE, Hennekens CH, Willett WC: Whole-grain consumption and risk of coronary heart disease: results from the Nurses’ Health Study. Am J Clin Nutr 70: 412–419, 1999.
   PubMed Web of Science ®Google Scholar
• Westrate JA Meijer GW: Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 52: 334–343, 1998.
   PubMed Web of Science ®Google Scholar
• Jenkins DJ, Kendall CW, Ransom TP: Dietary fiber, the evolution of the human diet and coronary heart disease. Nutr Res 18: 633–652, 1998.
   Web of Science ®Google Scholar