Synthesis of 3′-Thioribouridine, 3′-Thioribocytidine, and Their Phosphoramidites

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• Every new compound was characterized by 1H- and 13C-NMR, and either a satisfictory molecular weight from high resolution mass spectrometry or a satisfactory elemental analysis was obtained. For the final thiouridine phosphoramidite 14 31 P-NMR (90 MHz, in CDCI3, using 85% H3PO4 as external standard): = 168.6, 157.4; Anal. calcd for C45H61N4O8PSSi: C, 61.64; H, 6.96; N, 6.39; S, 3.65. Found: C, 61.38; H, 6.95; N, 6.62; S, 3.49.
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