Methyl-β-cyclodextrin potentiates the BITC-induced anti-cancer effect through modulation of the Akt phosphorylation in human colorectal cancer cells

References

• Simons K, Ehehalt R. Cholesterol, lipid rafts, and disease. J Clin Invest. 2002;110(5):597–603.
   PubMed Web of Science ®Google Scholar
• Lundbaek JA, Andersen OS, Werge T, et al Cholesterol-induced protein sorting: an analysis of energetic feasibility. B Biophys J. 2003;84(3):2080–2089.
   PubMed Web of Science ®Google Scholar
• Miersch S, Espey MG, Chaube R, et al Plasma membrane cholesterol content affects nitric oxide diffusion dynamics and signaling. J Biol Chem. 2008;283(27):18513–18521.
   PubMed Web of Science ®Google Scholar
• Li YC, Park MJ, Ye SK, et al Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents. Am J Pathol. 2006;168(4):1107–1118.
   PubMed Web of Science ®Google Scholar
• Genest J, McPherson R, Frohlich J, et al. Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult-2009 recommendations. Can J Cardiol. 2009;25(10):567–579.
   PubMed Web of Science ®Google Scholar
• De Chaves EP, Narayanaswami V, Christoffersen C, et al Apolipoprotein E and cholesterol in aging and disease in the brain. Future Lipidol. 2008;3(5):505–530.
   PubMed Web of Science ®Google Scholar
• Warner M, Gustafsson JA. On estrogen, cholesterol metabolism, and breast cancer. N Engl J Med. 2014;370(6):572–573.
   PubMed Web of Science ®Google Scholar
• Davis ME, Brewster ME. Cyclodextrin-based pharmaceutics: past, present and future. Nat Rev Drug Discov. 2004;3(12):1023.
   PubMed Web of Science ®Google Scholar
• Morrison PW, Connon CJ, Khutoryanskiy VV. Cyclodextrin-mediated enhancement of riboflavin solubility and corneal permeability. Mol Pharm. 2013;10(2):756–762.
   PubMed Web of Science ®Google Scholar
• Reis-Sobreiro M, Roué G, Moros A, et al Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma. Blood Cancer J. 2013;3(5):e118.
   PubMed Web of Science ®Google Scholar
• Zidovetzki R, Levitan I. Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. Biochim Biophys Acta -Biomembr. 2007;1768(6):1311–1324.
   PubMed Web of Science ®Google Scholar
• Nakamura T, Abe N, Nakamura Y. Physiological relevance of covalent protein modification by dietary isothiocyanates. J Clin Biochem Nutr. 2018;62(1):11–19.
   PubMed Web of Science ®Google Scholar
• Nakamura Y, Miyoshi N. Electrophiles in foods: the current status of isothiocyanates and their chemical biology. Biosci Biotechnol Biochem. 2010;74(2):242–255.
   PubMed Web of Science ®Google Scholar
• Miyoshi N, Uchida K, Osawa T, et al A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation. Cancer Res. 2004;64(6):2134–2142.
   PubMed Web of Science ®Google Scholar
• Abe N, Hou DX, Munemasa S, et al Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells. Cell Death Dis. 2014;5:e1534.
   PubMed Web of Science ®Google Scholar
• Jian J, Xuan F, Qin F, et al Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats. Drug Des Dev Ther. 2015;9:5933–5945.
   PubMedGoogle Scholar
• Liu X, Takano C, Shimizu T, et al Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells. Biochem Biophys Res Commun. 2017;491:209–216.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wade KL, Prestera T, et al Quantitative determination of isothiocyanates, dithiocarbamates, carbon disulfide and related thiocarbonyl compounds by cyclocondensation assay with 1,2-benzenedithiol. Anal Biochem. 1996;239(2):160–167.
   PubMed Web of Science ®Google Scholar
• Henkhaus RS, Roy UKB, Cavallo-Medved D, et al Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells. Neoplasia. 2008;10(2):140–148.
   PubMed Web of Science ®Google Scholar
• Calay D, Vind-Kezunovic D, Frankart A, et al Inhibition of Akt signaling by exclusion from lipid rafts in normal and transformed epidermal keratinocytes. J Invest Dermatol. 2010;130(4):1136–1145.
   PubMed Web of Science ®Google Scholar
• Yang F, Gao JY, Chen H, et al Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer. Onco Targets Ther. 2017;10:4413–4422.
   PubMed Web of Science ®Google Scholar
• Li XL, Oduola WO, Qian L, et al. Integrating multiscale modeling with drug effects for cancer treatment. Cancer Inform. 2016;14(Suppl 5):21–31.
   PubMed Web of Science ®Google Scholar
• Franke TF. PI3K/Akt: getting it right matters. Oncogene. 2008;27(50):6473–6488.
   PubMed Web of Science ®Google Scholar
• Arcaro A, Aubert M, Mee DH, et al Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling. Cell Signal. 2007;19(5):1081–1092.
   PubMed Web of Science ®Google Scholar
• Kim EK, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 2010;1802(4):396–405.
   PubMed Web of Science ®Google Scholar
• Elamin KM, Yamashita Y, Higashi T, et al Supramolecular complex of methyl-β-cyclodextrin with adamantane-grafted hyaluronic acid as a novel antitumor agent. Chem Pharm Bull. 2018;66(3):277–285.
   PubMed Web of Science ®Google Scholar
• Upadhyay AK, Singh S, Chhipa RR, et al Methyl-β-cyclodextrin enhances the susceptibility of human breast cancer cells to carboplatin and 5-fluorouracil: involvement of Akt, NF-κB and Bcl-2. Toxicol Appl Pharmacol. 2006;216(2):177–185.
   PubMed Web of Science ®Google Scholar
• Sarkar P, Chakraborty H, Chattopadhyay A. Differential membrane dipolar orientation induced by acute and chronic cholesterol depletion. Sci Rep. 2017;7(1):4484.
   PubMed Web of Science ®Google Scholar
• Boreddy SR, Pramanik KC, Srivastava SK. Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. Clin Cancer Res. 2011;17(7):1784–1795.
   PubMed Web of Science ®Google Scholar
• Fahy BN, Schlieman M, Virudachalam S, et al AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2. Br J Cancer. 2003;89(2):391–397.
   PubMed Web of Science ®Google Scholar
• Zhang W, Liu HT. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 2002;12(1):9–18.
   PubMed Web of Science ®Google Scholar