Development of a point-of-care radiation biodosimeter: studies using novel protein biomarker panels in non-human primates

References

• Armed Forces Radiobiology Research Institute. 2010. (AFRRI) Special Report 10-1, Medical Management of Radiological Casualties. http://www.dtic.mil/dtic/tr/fulltext/u2/a538656.pdf
   Google Scholar
• Balog R, Bacher R, Chang P, Greenstein M, Jammalamadaka S, Javitz H, Knox S, Lee S, Lin H, Shaler T, et al. 2018. Development of a biodosimeter for radiation triage using novel blood protein biomarker panels in humans and non-human primates. Int J Radiat Biol. (Accepted for publication).
   Google Scholar
• Barrett A, Jacobs A, Kohn J, Raymond J, Powles RL. 1982. Changes in serum amylase and its isoenzymes after whole body irradiation. Br Med J (Clin Res Ed). 285:170–171.
   PubMed Web of Science ®Google Scholar
• Bertho JM, Demarquay C, Frick J, Joubert C, Arenales S, Jacquet N, Sorokine-Durm I, Chau Q, Lopez M, Aigueperse J, et al. 2001. Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia. Int J Radiat Biol. 77:703–712.
   PubMed Web of Science ®Google Scholar
• Blakely WF, Ossetrova NI, Whitnall MH, Sandgren DJ, Krivokrysenko VI, Shakhov A, Feinstein E. 2010. Multiple parameter radiation injury assessment using a non-human primate radiation model-biodosimetry applications. Health Phys. 98:153–159.
   PubMed Web of Science ®Google Scholar
• Cichy J, Potempa J, Chawla RK, Travis J. 1995. Stimulatory effect of inflammatory cytokines on alpha 1-antichymotrypsin expression in human lung-derived epithelial cells. J Clin Invest. 95:2729–2733.
   PubMed Web of Science ®Google Scholar
• Deshmane SL, Kremlev S, Amini S, Sawaya BE. 2009. Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res. 29:313–326.
   PubMed Web of Science ®Google Scholar
• Dressman HK, Muramoto GG, Chao NJ, Meadows S, Marshall D, Ginsburg GS, Nevins JR, Chute JP. 2007. Gene expression signatures that predict radiation exposure in mice and humans. PLoS Med. 4:e106.
   PubMed Web of Science ®Google Scholar
• Farese AM, Brown CR, Smith CP, Gibbs AM, Katz BP, Johnson CS, Prado KL, MacVittie TJ. 2014. The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependent. Health Phys. 106:39–47.
   PubMed Web of Science ®Google Scholar
• Jacob NK, Cooley JV, Yee TN, Jacob J, Alder H, Wickramasinghe P, Maclean KH, Chakravarti A. 2013. Identification of sensitive serum microRNA biomarkers for radiation biodosimetry. PLoS One. 8:e57603
   PubMed Web of Science ®Google Scholar
• Junglee D, Katrak A, Mohiuddin J, Blacklock H, Prentice HG, Dandona P. 1986. Salivary amylase and pancreatic enzymes in serum after total body irradiation. Clin Chem. 32:609–610.
   PubMed Web of Science ®Google Scholar
• Kashima HK, Kirkham WR, Andrews JR. 1965. Post-irradiation sialadentis; A study of the clinical features, histopathologic changes and serum enzyme variations following irradiation of human salivary glands. Am. J. Roentgenol. 94:271–291.
   Web of Science ®Google Scholar
• Kondrat RW, McClusky GA, Cooks RG. 1978. Multiple reaction monitoring in mass spectrometry/mass spectrometry for direct analysis of complex mixtures. Anal Chem. 50:2017–2021.
   Web of Science ®Google Scholar
• Lin S, Shaler TA, Becker CH. 2006. Quantification of intermediate-abundance proteins in serum by multiple reaction monitoring mass spectrometry in a single-quadrupole ion trap. Anal Chem. 78:5762–5767.
   PubMed Web of Science ®Google Scholar
• Marchetti F, Coleman MA, Jones IM, Wyrobek AJ. 2006. Candidate protein biodosimeters of human exposure to ionizing radiation. Int J Radiat Biol. 82:605–639.
   PubMed Web of Science ®Google Scholar
• Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei ZZheng, Ginsburg GS, Ginsburg G, Chao NJ, Nevins JR, et al. 2008. Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One. 3:e1912
   PubMed Web of Science ®Google Scholar
• Menard C, Johann D, Lowenthal M, Muanza T, Sproull M, Ross S, Gulley J, Petricoin E, Coleman CN, Whiteley G, et al. 2006. Discovering clinical biomarkers of ionizing radiation exposure with serum proteomic analysis. Cancer Res. 66:1844–1850.
   PubMed Web of Science ®Google Scholar
• Menon N, Rogers CJ, Lukaszewicz AI, Axtelle J, Yadav M, Song F, Chakravarti A, Jacob NK. 2016. Detection of acute radiation sickness: a feasibility study in non-human primates circulating miRNAs for triage in radiological events. PLoS One. 11:e0167333.
   PubMed Web of Science ®Google Scholar
• Onizuka K, Migita S, Yamada H, Matsumoto I. 1999. Serum protein fractions in patients with laryngeal cancer undergoing radiation therapy. Possibility as a prognostic factor. Hukuoka Acta Medica. 90:46–58.
   PubMedGoogle Scholar
• Ossetrova NI, Blakely WF, Nagy V, McGann C, Ney PH, Christensen CL, Koch AL, Gulani J, Sigal GB, Glezer EN, et al. 2016. Non-human primate total-body irradiation model with limited and full medical supportive care including filgrastim for biodosimetry and injury assessment. Radiat Prot Dosimetry. 172:174–191.
   PubMed Web of Science ®Google Scholar
• Patel S, Wang FH, Whiteside TL, Kasid U. 1998. Ionizing radiation and TNF-a and stimulated expression of a1-antichymotrypsin gene in human squamous carcinoma cells. Acta Oncologica. 37:475–478.
   PubMed Web of Science ®Google Scholar
• Paul S, Amundson SA. 2008. Development of gene expression signatures for practical radiation biodosimetry. Int J Radiat Oncol Biol Phys. 71:1236–1244.
   PubMed Web of Science ®Google Scholar
• Prasanna PGS, Blakely WF, Bertho J-M, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LCHW, et al. 2010. Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. Radiat Res. 173:245–253.
   PubMedGoogle Scholar
• Singh VK, Pollard HB. 2017. Ionizing radiation-induced altered microRNA expression as biomarkers for assessing acute radiation injury. Expert Rev Mol Diagn. 17:871–874.
   PubMed Web of Science ®Google Scholar
• Wang W, Zhou H, Lin H, Roy S, Shaler TA, Hill LR, Norton S, Kumar P, Anderle M, Becker CH. 2003. Quantification of proteins and metabolites by mass spectrometry without isotopic labeling or spiked standards. Anal Chem. 75:4818–4826.
   PubMed Web of Science ®Google Scholar