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Original Articles

Evidence Supporting the use of Probiotics for the Prevention and Treatment of Chemotherapy-Induced Intestinal Mucositis

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Pages 239-247 | Published online: 03 Mar 2011

References

  • Borchers , A. T. , Selmi , C. , Meyers , F. J. , Keen , C. L. and Gershwin , M. E. 2009 . Probiotics and immunity . J Gastroenterol , 44 ( 1 ) : 26 – 46 .
  • Boushey , R. P. , Yusta , B. and Drucker , D. J. 2001 . Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor . Cancer Res , 61 ( 2 ) : 687 – 693 .
  • Bowen , J. M. , Gibson , R. J. , Cummins , A. G. and Keefe , D. M. 2006 . Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage . Support Care Cancer , 14 ( 7 ) : 713 – 731 .
  • Bowen , J. M. , Stringer , A. M. , Gibson , R. J. , Yeoh , A. S. , Hannam , S. and Keefe , D. M. 2007 . VSL#3 probiotic treatment reduces chemotherapy-induced diarrhea and weight loss . Cancer Biol Ther , 6 ( 9 ) : 1449 – 1454 .
  • Caballero-Franco , C. , Keller , K. , De Simone , C. and Chadee , K. 2007 . The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells . Am J Physiol , 292 ( 1 ) : G315 – 322 .
  • Candela , M. , Perna , F. , Carnevali , P. , Vitali , B. , Ciati , R. , Gionchetti , P. , Rizzello , F. , Campieri , M. and Brigidi , P. 2008 . Interaction of probiotic Lactobacillus and Bifidobacterium strains with human intestinal epithelial cells: Adhesion properties, competition against enteropathogens and modulation of IL-8 production . Int J Food Microbiol , 125 ( 3 ) : 286 – 292 .
  • Collado , M. , Meriluoto , J. and Salminen , S. 2007 . In vitro analysis of probiotic strain combinations to inhibit pathogen adhesion to human intestinal mucus . Food Res Int , 40 ( 5 ) : 629 – 636 .
  • Dalmasso , G. , Loubat , A. , Dahan , S. , Calle , G. , Rampal , P. and Czerucka , D. 2006 . Saccharomyces boulardii prevents TNF-alpha-induced apoptosis in EHEC-infected T84 cells . Res Microbiol , 157 ( 5 ) : 456 – 465 .
  • Delia , P. , Sansotta , G. , Donato , V. , Frosina , P. , Salatino , A. , Messina , G. , De Renzis , C. and Famularo , G. 2007 . Use of probiotics for prevention of radiation-induced diarrhea . Tumori , 93 ( 2 suppl ) : 1 – 6 .
  • Duncan , M. and Grant , G. 2003 . Oral and intestinal mucositis - causes and possible treatments . Aliment Pharmacol Ther , 18 ( 9 ) : 853 – 874 .
  • Esposito , E. , Iacono , A. , Bianco , G. , Autore , G. , Cuzzocrea , S. , Vajro , P. , Canani , R. B. , Calignano , A. , Raso , G. M. and Meli , R. 2009 . Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats . Journal Nutr , 139 ( 5 ) : 905 – 911 .
  • Ewaschuk , J. B. , Diaz , H. , Meddings , L. , Diederichs , B. , Dmytrash , A. , Backer , J. , Looijer-van Langen , M. and Madsen , K. L. 2008 . Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function . Am J Physiol , 295 ( 5 ) : G1025 – 1034 .
  • Forsyth , C. B. , Farhadi , A. , Jakate , S. M. , Tang , Y. , Shaikh , M. and Keshavarzian , A. 2009 . Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis . Alcohol. , 43 ( 2 ) : 163 – 172 .
  • Gibson , R. J. , Bowen , J. M. , Alvarez , E. , Finnie , J. and Keefe , D. M. 2007 . Establishment of a single-dose irinotecan model of gastrointestinal mucositis . Chemotherapy , 53 ( 5 ) : 360 – 369 .
  • Gibson , R. J. , Bowen , J. M. , Inglis , M. R. , Cummins , A. G. and Keefe , D. M. 2003 . Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer . J Gastroenterol Hepatol , 18 ( 9 ) : 1095 – 1100 .
  • Gibson , R. J. and Keefe , D. M. 2006 . Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies . Support Care Cancer , 14 ( 9 ) : 890 – 900 .
  • Honeycutt , T. C. , El Khashab , M. , Wardrop , R. M. , III , McNeal-Trice , K., Honeycutt , A. L. , Christy , C. G. , Mistry , K. , Harris , B. D. , Meliones , J. N. and Kocis , K. C. 2007 . Probiotic administration and the incidence of nosocomial infection in pediatric intensive care: a randomized placebo-controlled trial . Pediatr Crit Care Med , 8 ( 5 ) : 452 – 458 .
  • Imaoka , A. , Shima , T. , Kato , K. , Mizuno , S. , Uehara , T. , Matsumoto , S. , Setoyama , H. , Hara , T. and Umesaki . 2008 . Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells . World J Gastroenterol , 14 ( 16 ) : 2511 – 2516 .
  • Kataria , J. , Li , N. , Wynn , J. L. and Neu , J. 2009 . Probiotic microbes: Do they need to be alive to be beneficial . Nutr Rev , 67 ( 9 ) : 546 – 550 .
  • Keefe , D. M. , Brealey , J. Goland and G.J., Cummins , A. G. 2000 . Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans . Gut , 47 ( 5 ) : 632 – 637 .
  • Keefe , D. M. , Cummins , A. G. , Dale , B. M. , Kotasek , D. , Robb , T. A. and Sage , R. E. 1997 . Effect of high-dose chemotherapy on intestinal permeability in humans . Clin Sci (Lond) , 92 ( 4 ) : 385 – 389 .
  • Kim , H. J. , Vazquez Roque , M. I. , Camilleri , M. , Stephens , D. , Burton , D. D. , Baxter , K. , Thomforde , G. and Zinsmeister , A. R. 2005 . A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating . Neurogastroenterol Motil , 17 ( 5 ) : 687 – 696 .
  • Kim , Y. , Kim , S. H. , Whang , K. Y. , Kim , Y. J. and Oh , S. 2008 . Inhibition of Escherichia coli O157:H7 attachment by interactions between lactic acid bacteria and intestinal epithelial cells . J Microbiol Bbiotech , 18 ( 7 ) : 1278 – 1285 .
  • Liong , M. T. 2008 . Safety of probiotics: Translocation and infection . Nutr Rev , 66 ( 4 ) : 192 – 202 .
  • Logan , R. M. , Stringer , A. M. , Bowen , J. M. , Yeoh , A. S. , Gibson , R. J. , Sonis , S. T. and Keefe , D. M. 2007 . The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs . Cancer Treat Rev , 33 ( 5 ) : 448 – 460 .
  • Lutgendorff , F. , Nijmeijer , R. M. , Sandstrom , P. A. , Trulsson , L. M. , Magnusson , K. E. , Timmerman , H. M. , van Minnen , L. P. , Rijkers , G. T. , Gooszen , H. G. , Akkermans , L. M. and Soderholm , J. D. 2009 . Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis . PLoS One , 4 ( 2 ) : 4512
  • MacDermott , R. P. 1999 . Chemokines in the inflammatory bowel diseases . J Clin Immunol , 19 ( 5 ) : 266 – 272 .
  • Mack , D. R. , Michail , S. , Wei , S. , McDougall , L. and Hollingsworth , M. A. 1999 . Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression . Am J Physiol , 276 ( 4 Pt 1 ) : G941 – 950 .
  • Martins , F. S. , Silva , A. A. , Vieira , A. T. , Barbosa , F. H. , Arantes , R. M. , Teixeira , M. M. and Nicoli , J. R. 2009 . Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties . Arch Microbio , 191 ( 8 ) : 623 – 630 .
  • Mauger , C. A. , Butler , R. N. , Geier , M. S. , Tooley , K. L. and Howarth , G. S. 2007 . Probiotic effects on 5-fluorouracil-induced mucositis assessed by the sucrose breath test in rats . Dig Dis Sci , 52 ( 3 ) : 612 – 619 .
  • Mennigen , R. , Nolte , K. , Rijcken , E. , Utech , M. , Loeffler , B. , Senninger , N. and Bruewer , M. 2009 . Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis . Am J Physiol , 296 ( 5 ) : G1140 – 1149 .
  • Miele , E. , Pascarella , F. , Giannetti , E. , Quaglietta , L. , Baldassano , R. N. and Staiano , A. 2009 . Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis . Am J Gastroenterol , 104 ( 2 ) : 437 – 443 .
  • Muller , D. M. , Carrasco , M. S. , Tonarelli , G. G. and Simonetta , A. C. 2009 . Characterization and purification of a new bacteriocin with a broad inhibitory spectrum produced by Lactobacillus plantarum lp 31 strain isolated from dry-fermented sausage . J Appl Microbiol , 106 ( 6 ) : 2031 – 2040 .
  • Myllyluoma , E. , Ahonen , A. M. , Korpela , R. , Vapaatalo , H. and Kankuri , E. 2008 . Effects of multispecies probiotic combination on helicobacter pylori infection in vitro . Clin Vaccine Immunol , 15 ( 9 ) : 1472 – 1482 .
  • Neu , J. 2007 . Perinatal and neonatal manipulation of the intestinal microbiome: a note of caution . Nutr Rev , 65 ( 6 Pt 1 ) : 282 – 285 .
  • Pang , Q. F. , Ji , Y. , Bermudez-Humaran , L. G. , Zhou , Q. M. , Hu , G. and Zeng , Y. 2009 . Protective effects of a heme oxygenase-1-secreting Lactococcus lactis on mucosal injury induced by hemorrhagic shock in rats . J Surg Res , 153 ( 1 ) : 39 – 45 .
  • Peran , L. , Sierra , S. , Comalada , M. , Lara-Villoslada , F. , Bailon , E. , Nieto , A. , Concha , A. , Olivares , M. , Zarzuelo , A. , Xaus , J. and Galvez , J. 2007 . A comparative study of the preventative effects exerted by two probiotics, Lactobacillus reuteri and Lactobacillus fermentum, in the trinitrobenzenesulfonic acid model of rat colitis . Br J Nutr , 97 ( 1 ) : 96 – 103 .
  • Petrof , E. O. , Kojima , K. , Ropeleski , M. J. , Musch , M. W. , Tao , Y. , De Simone , C. and Chang , E. B. 2004 . Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition . Gastroenterology , 127 ( 5 ) : 1474 – 1487 .
  • Pridmore , R. , Pittet , A. , Praplan , F. and Cavadini , C. 2008 . Hydrogen peroxide production by Lactobacillus johnsonii NCC 533 and its role in anti-Salmonella activity . FEMS Microbiol Lett , 283 ( 2 ) : 210 – 215 .
  • Prisciandaro , L. , Geier , M. , Butler , R. , Cummins , A. and Howarth , G. 2009 . Probiotics and their derivatives as treatments for inflammatory bowel disease . Inflamm Bowel Dis , 15 ( 12 ) : 1906 – 1914 .
  • Putaala , H. , Salusjarvi , T. , Nordstrom , M. , Saarinen , M. , Ouwehand , A. C. , Bech Hansen , E. and Rautonen , N. 2008 . Effect of four probiotic strains and Escherichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression . Res Microbiol , 159 ( 9–10 ) : 692 – 698 .
  • Ramiah , K. , van Reenen , C. A. and Dicks , L. M. 2008 . Surface-bound proteins of Lactobacillus plantarum 423 that contribute to adhesion of Caco-2 cells and their role in competitive exclusion and displacement of Clostridium sporogenes and Enterococcus faecalis . Res Microbiol , 159 ( 6 ) : 470 – 475 .
  • Roselli , M. , Finamore , A. , Nuccitelli , S. , Carnevali , P. , Brigidi , P. , Vitali , B. , Nobili , F. , Rami , R. , Garaguso , I. and Mengheri , E. 2009 . Prevention of TNBS-induced colitis by different Lactobacillus and Bifidobacterium strains is associated with an expansion of gammadeltaT and regulatory T cells of intestinal intraepithelial lymphocytes . Inflamm Bowel Dis , 15 ( 10 ) : 1526 – 36 .
  • Sartor , R. B. 2004 . Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: Antibiotics, probiotics, and prebiotics . Gastroenterology , 126 ( 6 ) : 1620 – 1633 .
  • Scully , C. , Epstein , J. and Sonis , S. 2003 . Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis . Head Neck , 25 ( 12 ) : 1057 – 1070 .
  • Seth , A. , Yan , F. , Polk , D. B. and Rao , R. K. 2008 . Probiotics ameliorate the hydrogen peroxide induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism . Am J Phys , 294 ( 4 ) : G1060 – 1069 .
  • Shanahan , F. 2004 . Probiotics in inflammatory bowel disease–therapeutic rationale and role . Adv Drug Deliv Rev , 56 ( 6 ) : 809 – 818 .
  • Smith , C. L. , Geier , M. S. , Yazbeck , R. , Torres , D. M. , Butler , R. N. and Howarth , G. S. 2008 . Lactobacillus fermentum BR11 and fructo-oligosaccharide partially reduce jejunal inflammation in a model of intestinal mucositis in rats . Nutr Cancer , 60 ( 6 ) : 757 – 767 .
  • Sokol , H. , Pigneur , B. , Watterlot , L. , Lakhdari , O. , Bermudez-Humaran , L. G. , Gratadoux , J. J. , Blugeon , S. , Bridonneau , C. , Furet , J. P. , Corthier , G. , Grangette , C. , Vasquez , N. , Pochart , P. , Trugnan , G. , Thomas , G. , Blottiere , H. M. , Dore , J. , Marteau , P. , Seksik , P. and Langella , P. 2008 . Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients . Proc Nat Acad Sci USA , 105 ( 43 ) : 16731 – 16736 .
  • Sonis , S. T. 2002 . The biologic role for nuclear factor-kappaB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy . Crit Rev Oral Biol Med , 13 ( 5 ) : 380 – 389 .
  • Sonis , S. T. 1998 . Mucositis as a biological process: A new hypothesis for the development of chemotherapy-induced stomatotoxicity . Oral Oncol , 34 ( 1 ) : 39 – 43 .
  • Sonis , S. T. , Elting , L. S. , Keefe , D. , Peterson , D. E. , Schubert , M. , Hauer-Jensen , M. , Bekele , B. N. , Raber-Durlacher , J. , Donnelly , J. P. and Rubenstein , E. B. 2004 . Perspectives on cancer therapy-induced mucosal injury: Pathogenesis, measurement, epidemiology, and consequences for patients . Cancer , 100 ( 9 Suppl ) : 1995 – 2025 .
  • Southcott , E. , Tooley , K. L. , Howarth , G. S. , Davidson , G. P. and Butler , R. N. 2008 . Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats . Dig Dis Sci , 53 ( 7 ) : 1837 – 1841 .
  • Spinler , J. K. , Taweechotipatr , M. , Rognerud , C. L. , Ou , C. N. , Tumwasorn , S. and Versalovic , J. 2008 . Human-derived probiotic Lactobacillus reuteri demonstrate antimicrobial activities targeting diverse enteric bacterial pathogens . Anaerobe , 14 ( 3 ) : 166 – 171 .
  • Steidler , L. , Hans , W. , Schotte , L. , Neirynck , S. , Obermeier , F. , Falk , W. , Fiers , W. and Remaut , E. 2000 . Treatment of murine colitis by Lactococcus lactis secreting interleukin-10 . Science , 289 ( 5483 ) : 1352 – 1355 .
  • Stringer , A. M. , Gibson , R. J. , Bowen , J. M. and Keefe , D. M. 2009a . Chemotherapy-induced modifications to gastrointestinal microflora: evidence and implications of change . Curr Drug Metab , 10 ( 1 ) : 79 – 83 .
  • Stringer , A. M. , Gibson , R. J. , Bowen , J. M. , Logan , R. M. , Yeoh , A. S. and Keefe , D. M. 2007a . Chemotherapy-induced mucositis: The role of gastrointestinal microflora and mucins in the luminal environment . J Supp Oncol , 5 ( 6 ) : 259 – 267 .
  • Stringer , A. M. , Gibson , R. J. , Logan , R. M. , Bowen , J. M. , Yeoh , A. S. , Burns , J. and Keefe , D. M. 2007b . Chemotherapy-induced diarrhea is associated with changes in the luminal environment in the DA rat . Exp Biol Med (Maywood) , 232 ( 1 ) : 96 – 106 .
  • Stringer , A. M. , Gibson , R. J. , Logan , R. M. , Bowen , J. M. , Yeoh , A. S. , Hamilton , J. and Keefe , D. M. 2009b . Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis . Exp Biol Med (Maywood) , 234 ( 4 ) : 430 – 441 .
  • Sukhotnik , I. , Shteinberg , D. , Ben Lulu , S. , Bashenko , Y. , Mogilner , J. G. , Ure , B. M. , Shaoul , R. and Coran , A. G. 2008 . Effect of transforming growth factor-alpha on enterocyte apoptosis is correlated with EGF receptor expression along the villus-crypt axis during methotrexate-induced intestinal mucositis in a rat . Apoptosis , 13 ( 11 ) : 1344 – 1355 .
  • Tooley , K. L. , Howarth , G. S. , Lymn , K. A. , Lawrence , A. and Butler , R. N. 2006a . Oral ingestion of streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats . Cancer Biol Ther , 5 ( 6 ) : 593 – 600 .
  • Tooley , K. L. , Saxon , B. R. , Webster , J. , Zacharakis , B. , McNeil , Y. , Davidson , G. P. and Butler , R. N. 2006b . A novel non-invasive biomarker for assessment of small intestinal mucositis in children with cancer undergoing chemotherapy . Cancer Biol Ther , 5 ( 10 ) : 1275 – 1281 .
  • Triantafyllou , K. , Dervenoulas , J. , Tsirigotis , P. and Ladas , S. D. 2008a . The nature of small intestinal mucositis: A video-capsule endoscopy study . Support Care Cancer , 16 ( 10 ) : 1173 – 1178 .
  • Ukena , S. N. , Singh , A. , Dringenberg , U. , Engelhardt , R. , Seidler , U. , Hansen , W. , Bleich , A. , Bruder , D. , Franzke , A. , Rogler , G. , Suerbaum , S. , Buer , J. , Gunzer , F. and Westendorf , A. M. 2007 . Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity . PLoS ONE , 2 ( 12 ) : e1308
  • Von Bultzingslowen , I. , Adlerberth , I. , Wold , A. E. , Dahlen , G. and Jontell , M. 2003 . Oral and intestinal microflora in 5-fluorouracil treated rats, translocation to cervical and mesenteric lymph nodes and effects of probiotic bacteria . Oral Microbiol Immunol , 18 ( 5 ) : 278 – 284 .
  • Wassenaar , T. M. and Klein , G. 2008 . Safety aspects and implications of regulation of probiotic bacteria in food and food supplements . J Food Prot , 71 ( 8 ) : 1734 – 1741 .
  • Whitford , E. J. , Cummins , A. G. , Butler , R. N. , Prisciandaro , L. D. , Fauser , J. K. , Yazbeck , R. , Lawrence , A. , Cheah , K. Y. , Wright , T. H. , Lymn , K. A. and Howarth , G. S. 2009 . Effects of Streptococcus thermophilus TH-4 on intestinal mucositis induced by the chemotherapeutic agent, 5-Fluorouracil (5-FU) . Cancer Biol Ther , 8 ( 6 ) : 505 – 511 .
  • Yan , F. , Cao , H. , Cover , T. L. , Whitehead , R. , Washington , M. K. and Polk , D. B. 2007 . Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth . Gastroenterology , 132 ( 2 ) : 562 – 575 .
  • Yeoh , A. S. , Gibson , R. J. , Yeoh , E. E. , Bowen , J. M. , Stringer , A. M. , Giam , K. A. and Keefe , D. M. 2007 . A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: The role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2 . Mol Cancer Ther , 6 ( 8 ) : 2319 – 2327 .

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