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Original Articles

Tomato and Tomato Byproducts. Human Health Benefits of Lycopene and Its Application to Meat Products: A Review

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Pages 1032-1049 | Received 25 Jul 2011, Accepted 12 Sep 2011, Published online: 05 Feb 2014

REFERENCES

  • Adams , S. M. and Greeley , M. S. 2000 . Ecological indicators of water quality: Using ulti-response indicators to assess the health of aquatic ecosystems . Water Air Soil Pollut. , 123 : 103 – 115 .
  • Agarwal , S. and Rao , A. V. 1998 . Tomato lycopene and low density lipoprotein oxidation: A human dietary intervention study . Lipids , 33 : 981 – 984 .
  • Akinnuga , A. M. , Bamidele , O. , Ebunlomo , O. A. , Adeniyi , O. S. , Adeleyea , G. S. and Ebomuche , L. C. 2010 . Hypoglycaemic effects of dietary intake of ripe and unripe Lycopersicon esculentum (tomatoes) on streptozotocin-induced diabetes mellitus in rats . OnLine J. Biol. Sci. , 10 ( 2 ) : 50 – 53 .
  • Albertini , R. , Moratti , R. and DeLuca , G. 2002 . Oxidation of low-density lipoprotein in atherosclerosis from basic biochemistry to clinical studies . Curr. Mol. Med. , 2 : 579 – 592 .
  • Alshatwi , A. A. , Al-Obaaid , M. A. , Al-Sedairy , S. A. , Al-Assaf , A. H. , Zhang , J. J. and Lei , K. Y. 2010 . Tomato powder is more protective than lycopene supplement against lipid peroxidation in rats . Nutr. Res. , 30 ( 1 ) : 66 – 73 .
  • Ansari , M. S. and Gupta , N P. 2004 . Lycopene: A novel drug therapy in hormone refractory metastatic prostate cancer . Urol. Oncol. Sem. Orig. Investig. , 22 ( 5 ) : 415 – 420 .
  • Arab , L. and Steck , S. 2000 . Lycopene and cardiovascular disease . Am. J. Clin. Nutr. , 71 : 1691 – 1695 .
  • Balestrieri , M. L. , Prisco , R. D. , Nicolaus , B. , Pari , P. , Moriello , V. S. , Strazzullo , G. , Iorio , E. L. , Servillo , L. and Balestrieri , C. 2004 . Lycopene in association with α-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress . Free Rad. Biol. Med. , 36 ( 8 ) : 1058 – 1067 .
  • Ben-Salem , H. and Znaidi , I. A. 2008 . Partial replacement of concentrate with tomato pulp and olive cake-based feed blocks as supplements for lambs fed wheat straw . Animal Feed Sci. Technol. , 147 : 206 – 222 .
  • Bhosale , P. , Ermakov , I. V. , Ermakova , M. R. , Gellermann , W. and Bernstein , P. S. 2004 . Resonance Raman quantification of nutritionally important carotenoids in fruits, vegetables, and their juices in comparison to high-pressure liquid chromatography analysis . J. Agric. Food Chem. , 52 ( 11 ) : 3281 – 3285 .
  • Bicanic , D. , Fogliano , V. , Luterotti , S. , Swarts , J. , Piani , G. and Graziani , G. 2005 . Quantification of lycopene in tomato products: Comparing the performances of a newly proposed direct photothermal method and high-performance liquid chromatography . J. Sci. Food Agric. , 85 : 1149 – 1153 .
  • Böhm , F. , Edge , R. , Burke , M. and Truscott , T. G. 2001 . Dietary uptake of lycopene protects human cells from singlet oxygen and nitrogen dioxide – ROS components from cigarette smoke . J. Photochem. Photobiol. B: Biology. , 64 ( 2–3 ) : 176 – 178 .
  • Boileau , T. W. , Boileau , A. C. and Erdman , J. W. Jr. 2002 . Bioavailability of all-trans and cis-isomers of lycopene . Exp. Biol. Med. , 227 : 914 – 919 .
  • Boileau , A. C. , Merchen , N. R. , Wasson , K. , Atkinson , C. A. and Erdman , J. W. Jr. 1999 . Cis-Lycopene is more bioavailable than trans-lycopene in vitro and in vivo in lymph-cannulated ferrets . J. Nutr. , 129 : 1176 – 1181 .
  • Boosalis , M. G. , Snowdon , D. A. , Tully , C. L. and Gross , M. D. 1996 . Acute phase response and plasma carotenoid concentrations in older women: Findings from the Nun study . Nutr. , 12 : 475 – 478 .
  • Borel , P. 2003 . Factors affecting intestinal absorption of highly lipophilic food microconstituents (fat-soluble vitamins, carotenoids and phytosterols) . Clin. Chem. Lab. Med. , 41 ( 8 ) : 979 – 994 .
  • Botsoglou , N. , Papageorgiou , G. , Nikolakakis , I. , Florou-Paneri , P. , Giannenas , I. , Dotas , V. and Sinapis , E. 2004 . Effect of dietary dried tomato pulp on oxidative stability of Japanese quail meat . J. Agric. Food Chem. , 52 : 2982 – 2988 .
  • Brown , J. P. and Josse , R. G. 2002 . Clinical practice guidelines for the diagnosis and management of osteoporosis in Canada . CMAJ , 167 : 1 – 34 .
  • Bruno , A. K. and Wetzel , C. M. 2004 . The early light-inducible protein (ELIP) gene is expressed during the chloroplast-tochromoplast transition in ripening tomato fruit . J. Exp. Bot. , 55 ( 408 ) : 2541 – 2548 .
  • Bureyko , T. , Hurdle , H. , Metcalfe , J. B. , Clandinin , M. T. and Mazurak , V. C. 2009 . Reduced growth and integrin expression of prostate cells cultured with lycopene, vitamin E and fish oil in vitro . Br. J. Nutr. , 101 : 990 – 997 .
  • Burgess , L. C. , Rice , E. , Fischer , T. , Seekins , J. R. , Burgess , T. P. , Sticka , S. J. and Klatt , K. 2008 . Lycopene has limited effect on cell proliferation in only two of seven human cell lines (both cancerous and noncancerous) in an in vitro system with doses across the physiological range . Toxicol. in Vitro. , 22 : 1297 – 1300 .
  • Cadoni , E. , De Giorgi , M. R. , Medda , E. and Poma , G. 2000 . Supercritical CO2 extraction of lycopene and beta-carotene from ripe tomatoes . Dyes Pigm. , 44 ( 1 ) : 27 – 32 .
  • Calvo , M. M. , García , M. L. and Selgas , M. D. 2008 . Dry fermented sausages enriched with lycopene from tomato peel . Meat Sci. , 80 : 167 – 172 .
  • Calvo , M. M. , Rodríguez , M. J. , Santa-María , J. G. , Selgas , M. D. and García , M. L. 2007 . “ Productos cárnicos y de las pesca enriquecidos en licopeno mediante la adición de piel de tomate ” . Patent (P200701670). Spain
  • Campbell , J. K. , Canene-Adams , K. , Lindshield , B. L. , Boileau , T. W. M. , Clinton , S. K. and Erdman , J. W. 2004 . Tomato phytochemicals and prostate cancer risk . J. Nutr. , 134 ( 12 ) : 3486 – 3492 .
  • Capanoglu , E. , Beekwilder , J. , Boyacioglu , D. , de Vos , R. C. H and Hall , R. D. 2010 . The effect of industrial food processing on potentially health-beneficial tomato antioxidants . Crit. Rev. Food Sci. Nutr. , 50 ( 10 ) : 919 – 930 .
  • Capanoglu , E. , Beekwilder , J. , Boyacioglu , D. , Hall , R. and de Vos , R. C. H. 2008 . Changes in antioxidant and metabolite profiles during production of tomato paste . J. Agric. Food Chem. , 56 ( 3 ) : 964 – 973 .
  • Castenmiller , J. J. M. and West , C. E. 1998 . Bioavailability and bioconversion of carotenoids . Annu. Rev. Nutr. , 18 : 19 – 38 .
  • Chalabi , N. , Le Corre , L. , Maurizis , J. C. , Bignon , Y. J. and Bernard-Gallon , D. J. 2004 . The effects of lycopene on the proliferation of human breast cells and BRCA1 and BRCA2 gene expression . Eur. J. Cancer. , 40 ( 11 ) : 1768 – 1775 .
  • Chalabi , N. , Satih , S. , Delort , L. , Bignon , Y. J. , Dominique , J. and Bernard-Gallon , D. J. 2007 . Expression profiling by whole-genome microarray hybridization reveals differential gene expression in breast cancer cell lines after lycopene exposure . Bioch. Bioph. Acta. , 1769 : 124 – 130 .
  • Chasse , G. A. , Mak , M. L. , Deretey , E. , Farkas , I. , Torday , L. L. , Papp , J. G. , Sarma , D. S. R. , Agarwal , A. , Chakravarthi , S. , Agarwal , S. and Rao , V. A. 2001 . An ab initio computational study on selected lycopene isomers . J. Mol. Struct. , 571 : 27 – 37 .
  • Chen , L. , Stacewicz-Sapuntzakis , M. , Duncan , C. , Sharifi , R. , Ghosh , L. , van Breemen , R. , Ashton , D. and Bowen , P. E. 2001 . Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention . J. Nat. Cancer Inst. , 93 : 1872 – 1879 .
  • Chiang , H. S. , Wu , W. B. , Fang , J. Y. , Chen , D. F. , Chen , B. H. , Huang , C. C. , Chen , Y. T. and Hung , C. F. 2007 . Lycopene inhibits PDGF-BB-induced signaling and migration in human dermal fibroblasts through interaction with PDGF-BB . Life Sci. , 81 : 1509 – 1517 .
  • Choudhari , S. M. and Ananthanarayan , L. 2007 . Enzyme aided extraction of lycopene from tomato tissues . Food Chem. , 102 ( 1 ) : 77 – 81 .
  • Choudhari , S. M. and Singhal , R. S. 2008 . Supercritical carbon dioxide extraction of lycopene from mated cultures of Blakeslea trispora NRRL 2895 and 2896 . J. Food Engin. , 89 : 349 – 354 .
  • Ciurlia , L. , Bleve , M. and Rescio , L. 2009 . Supercritical carbon dioxide co-extraction of tomatoes (Lycopersicum esculentum L.) and hazelnuts (Corylus avellana L.): A new procedure in obtaining a source of natural lycopene . J. Superc. Fluids. , 49 : 338 – 344 .
  • Clark , P. E. , Hall , M. C. , Borden , Jr. L. S. , Miller , A. A. , Hu , J. J. , Lee , W. R. , Stindt , D. , D’Agostino , Jr. R. , Lovato , J. , Harmon , M. and Torti , F. M. 2006 . Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy . Urol , 67 ( 6 ) : 1257 – 1261 .
  • Clinton , S. K. 1998 . Lycopene: Chemistry, biology, and implications for human health and disease . Nutr. Rev. , 56 ( 2 ) : 35 – 51 .
  • Condogan , K. 2002 . The effect of tomato paste on some quality characteristics of beef patties during refrigerated storage . Eur. Food Res. Technol. , 17 : 125 – 133 .
  • Deba , M. S. , Bloukas , J. G. and Fista , G. A. 2007 . Effect of tomato paste and nitrite level on processing and quality characteristics of frankfurters . Meat Sci. , 76 : 501 – 508 .
  • Denek , N. and Can , A. 2006 . Feeding value of wet tomato pomace ensiled with wheat straw and wheat grain for Awassi sheep . Small Rumin. Res. , 65 : 260 – 265 .
  • Desai , A. G. , Qazi , G. N. , Ganju , R. K. , El-Tamer , M. , Singh , J. , Saxena , A. K. , Bedi , Y. S. , Taneja , S. C. and Bhat , H. K. 2008 . Medicinal plants and cancer chemoprevention . Curr. Drug Metab. , 9 : 581 – 591 .
  • Dias , M. C. , Vieiralves , N. F. L. , Gomes , M. I. F. V. , Salvadori , D. M. F. , Rodrigues , M. A. M. and Barbisan , L. F. 2010 . Effects of lycopene, synbiotic and their association on early biomarkers of rat colon carcinogenesis . Food Chem. Toxicol. , 48 ( 3 ) : 772 – 780 .
  • Dillingham , B. L. and Rao , A. V. 2009 . Biologically Active Lycopene in Human Health . Int. J. Naturop. Med. , 4 ( 1 ) : 23 – 27 .
  • Egydio , J. A. , Moraes , A. M. and Rosa , P. T. V. 2010 . Supercritical fluid extraction of lycopene from tomato juice and characterization of its antioxidation activity . J. Superc. Fluids. , 54 : 159 – 164 .
  • El-Rouby , D. H. 2011 . Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline-1-oxide . Arch. Oral Biol. , 56 ( 7 ) : 664 – 671 .
  • Erdman , J. W. Jr. , Fahey , G. C. Jr. and White , C. B. 1986 . Effects of purified dietary fiber sources on β-carotene utilization by the chick . J. Nutr. , 116 : 2415 – 2423 .
  • Ernst , H. 2002 . Recent advances in industrial carotenoid synthesis . Pure. Appl. Chem. , 74 : 2213 – 2226 .
  • Eyiler , E. and Oztan , A. 2011 . Production of frankfurters with tomato powder as a natural additive . LWT-Food Sci. Technol. , 44 ( 1 ) : 307 – 311 .
  • Faisal , W. , O’Driscoll , C. M. and Griffin , B. T. 2010 . Bioavailability of lycopene in the rat: The role of intestinal lymphatic transport . J. Pharm. Pharmacol. , 62 ( 3 ) : 323 – 331 .
  • Felix-Valenzuela , L. , Higuera-Ciapara , I. and Goycoolea-Valencia , F. 2001 . Supercritical CO2/ethanol of astaxanthin from blue crab (Callinectes sapidus) shell waste . J. Food Proc. Engin. , 24 : 101 – 112 .
  • Ford , E. S. , Will , J. C. and Bowman , B. A. 1999 . Narayan KM. Diabetes mellitus and serum carotenoids: Findings from the third National Health and Nutrition Examination Survey . Am. J. Epidemiol. , 149 : 168 – 176 .
  • Fornelli , F. , Leone , A. , Verdesca , I. , Minervini , F. and Zacheo , G. 2007 . The influence of lycopene on the proliferation of human breast cell line (MCF-7) . Toxicol. in Vitro , 21 ( 2 ) : 217 – 223 .
  • Fröhlich , K. , Kaufmann , K. , Bitsch , R. and Böhm , V. 2006 . Effects of ingestion of tomatoes, tomato juice and tomato puree on contents of lycopene isomers, tocopherols and ascorbic acid in human plasma as well as on lycopene isomer pattern . Br. J. Nutr. , 95 : 734 – 741 .
  • Fuhrman , B. , Elis , A. and Aviram , M. 1997 . Hypocholesterolemic effect of lycopene and b-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages . Biochem. Biophys. Res. COM. , 233 : 658 – 662 .
  • Galicia , R. M. , Verde , R. , Ponce , E. , González , R. O. , Saucedo , C. and Guerrero , I. 2008 . Stability of lycopene in cv. saladette tomatoes (Lycopersicon esculentum mill.) stored under different conditions . Rev. Mex. Ing. Quim. , 7 ( 3 ) : 253 – 262 .
  • García , M. L. , Calvo , M. M. and Selgas , M. D. 2009 . Beef hamburgers enriched in lycopene using dry tomato peel as an ingredient . Meat Sci. , 83 : 45 – 49 .
  • Gartner , C. , Stahl , W. and Sies , H. 1997 . Lycopene is more bioavailable from tomato paste than from fresh tomatoes . Am. J. Clin. Nutr. , 66 : 116 – 122 .
  • Georgé , S. , Tourniaire , F. , Gautier , H. , Goupy , P. , Rock , E. and Caris-Veyrat , C. 2011 . Changes in the contents of carotenoids, phenolic compounds and vitamin C during technical processing and lyophilisation of red and yellow tomatoes . Food Chem. , 124 ( 4 ) : 1603 – 1611 .
  • Gerster , H. 1997 . The potential role of lycopene for human health . J. Am. Coll. Nutr. , 16 : 109 – 126 .
  • Ghaffari , M. A. and Ghiasvand , T. 2006 . Effect of lycopene on formation of low density lipoprotein-copper complex in copper peroxidation of low density lipoprotein, as in vitro experiment . Iran Biomed. J. , 10 ( 4 ) : 191 – 196 .
  • Gianetti , J. , Pedrinelli , R. , Petrucci , R. , Lazzerini , G. , De Caterina , M. , Bellomo , G. and De Caterina , R. 2002 . Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis . Am. Heart J. , 143 ( 3 ) : 467 – 474 .
  • Giovannucci , E. , Rimm , E. B. , Liu , Y. , Stampfer , M. J. and Willett , W. C. 2002 . A prospective study of tomato products, lycopene, and prostate cancer risk . J. Nat. Cancer Ins. , 94 : 391 – 398 .
  • Goñi , I. , Serrano , J. and Saura-Calixto , F. 2006 . Bioaccessibility of beta-carotene, lutein, and lycopene from fruits and vegetables . J. Agric. Food Chem. , 54 : 5382 – 5387 .
  • Goula , A. M. , Adamopoulos , K. G. , Chatzitakis , P. C. and Nikas , V. A. 2006 . Prediction of lycopene degradation during a drying process of tomato pulp . J. Food Engin. , 74 : 37 – 46 .
  • Goyal , A. and Yusuf , S. 2006 . The burden of cardiovascular disease in the Indian subcontinent . Indian J. Med. Res. , 124 : 235 – 244 .
  • Granado-Lorencio , F. , Olmedilla-Alonso , B. , Herrero-Barbudo , C. , Perez-Sacristan , B. , Blanco-Navarro , I. and Blazquez-Garcis , S. 2007 . Comparative in vitro bioaccessibility of carotenoids from relevant contributors to carotenoid intake . J. Agric. Food Chem. , 55 : 6387 – 6394 .
  • Hantz , H. L. , Young , L. F. and Martin , K. R. 2005 . Physiologically attainable concentrations of lycopene induce mitochondrial apoptosis in LNCaP human prostate cancer cells . Exp. Biol. Med. , 230 : 171 – 179 .
  • Heber , D. and Lu , Q. Y. 2002 . Overview of mechanisms of action of lycopene . Exp. Biol. Med. , 227 : 920 – 923 .
  • Huang , W. , Li , Z. , Niu , H. , Li , D. and Zhang , J. 2008 . Optimization of operating parameters for supercritical carbon dioxide extraction of lycopene by response surface methodology . J. Food Engin. , 89 : 298 – 302 .
  • Huang , C. S. , Liao , J. W. and Hu , M. L. 2007 . Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice . J. Nutr. , 138 : 538 – 543 .
  • Hwang , E. S. and Bowen , P. E. 2005a . Effects of tomato paste extracts on cell proliferation, cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells . BioFactors. , 23 ( 2 ) : 75 – 84 .
  • Hwang , E. S. and Bowen , P. E. 2005b . Effects of lycopene and tomato paste extracts on DNA and lipid oxidation in LNCaP human prostate cancer cells . BioFactors , 23 ( 2 ) : 97 – 105 .
  • Ilahy , R. , Hdider , C. , Lenucci , M. S. , Tlili , I. and Dalessandro , G. 2011 . Phytochemical composition and antioxidant activity of high-lycopene tomato (Solanum lycopersicum L.) cultivars grown in Southern Italy . Sci. Horticul. , 127 ( 3 ) : 255 – 261 .
  • Ivanov , N. I. , Cowell , S. P. , Brown , P. , Rennie , P. S. , Guns , E. S. and Cox , M. E. 2007 . Lycopene differentially induces quiescence and apoptosis in androgen-responsive and –independent prostate cancer cell lines . Clin. Nutr. , 26 : 252 – 263 .
  • Jain , C. K. , Agarwal , S. and Rao , A. V. 2009 . The effect of dietary lycopene on bioavailability, tissue distribution, in vivo antioxidant properties and colonic preneoplasia in rats . Nutr. Res. , 19 ( 9 ) : 1383 – 1391 .
  • Jatoi , A. , Burch , P. , Hillman , D. , Vanyo , J. M. , Dakhil , S. , Nikcevich , D. , Rowland , K. , Morton , R. , Flynn , P. J. , Young , C. and Tan , W. 2007 . A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: Results of a phase 2 study from the North Central cancer treatment group . Urol. , 69 ( 2 ) : 289 – 294 .
  • Jian , L. , Du , C. J. , Lee , A. H. and Binns , C. W. 2005 . Do dietary lycopene and other carotenoids protect against prostate cancer? . Int. J. Cancer. , 113 : 1010 – 1014 .
  • Jiwan , M. A. , Duane , P. , O’Sullivan , L. , O’Brien , N. M. and Aherne , S. A. 2010 . Content and bioaccessibility of carotenoids from organic and non-organic baby foods . J. Food Comp. Anal. , 23 : 346 – 352 .
  • Kaur , D. , Wani , A. A. , Oberoi , D. P. S. and Sogi , D. S. 2008 . Effect of extraction conditions on lycopene extractions from tomato processing waste skin using response surface methodology . Food Chem. , 108 : 711 – 718 .
  • Kirsh , V. A. , Mayne , S. T. , Peters , U. , Chatterjee , N. , Leitzmann , M. F. , Dixon , L. B. , Urban , D. A. , Crawford , E. D. and Hayes , R. B. 2006 . A prospective study of lycopene and tomato product intake and risk of prostate cancer . Cancer Epidemiol. Biomarkers Prev. , 15 : 92 – 98 .
  • Knoblich , M. , Anderson , B. and Latshaw , D. 2005 . Analyses of tomato peel and seed byproducts and their use as a source of carotenoids . J. Sci. Food Agric. , 85 ( 7 ) : 1166 – 1170 .
  • Koh , M. S. , Hwang , J. S. and Moon , A. 2010 . Lycopene inhibits proliferation, invasion and migration of human breast cancer cells . Biomol. Therap. , 18 ( 1 ) : 92 – 98 .
  • Kohlmeier , L. , Kark , J. D. , Gomez-Gracia , E. , Blaise , C. M. , Steck , S. E. , Kardinaal , A. F. M. , Ringstad , J. , Thamm , M. , Masaev , V. , Riemersma , R. , Martin-Moreno , J. M. , Huttunen , J. K. and Kok , F. J. 1997 . Lycopene and myocardial infarction risk in the EURAMIC Study . Am. J. Epidemiol. , 146 : 618 – 626 .
  • Kong , K. W. , Khoo , H. E. , Prasad , K. N. , Ismail , A. , Tan , C. P. and Rajab , N. F. 2010 . Revealing the power of the natural red pigment lycopene . Molecules , 15 : 959 – 987 .
  • Kucuk , O. , Sarkar , F. H. , Djuric , Z. , Sakr , W. , Pollak , M. N. , Khachik , Y. , Li , Y. W. , Banerjee , M. , Grignon , D. , Bertram , J. S. , Crissman , J. D. , Pontes , E. J. and Wood , D. P. Jr. 2001 . Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy . Cancer Epidemiol. Biomarkers. , 10 ( 8 ) : 864 – 868 .
  • Lavelli , V. and Torresani , M. C. 2011 . Modelling the stability of lycopene-rich by-products of tomato processing . Food Chem. , 125 : 529 – 535 .
  • Li , Z. Z. , Lu , X. Z. , Ma , C. C. and Chen , L. 2010 . Serum lycopene levels in patients with diabetic retinopathy . Eur. J. Ophthalmol. , 20 ( 4 ) : 719 – 723 .
  • Liu , F. , Cao , X. , Wang , H. and Liao , X. 2010 . Changes of tomato powder qualities during storage . Powder Technol. , 204 ( 1 ) : 159 – 166 .
  • Liu , L. H. , Zabaras , D. , Bennett , L. E. , Aguas , P. and Woonton , B. W. 2009 . Effects of UV-C, red light and sun light on the carotenoid content and physical qualities of tomatoes during post-harvest storage . Food Chem. , 115 : 495 – 500 .
  • Livny , O. , Kaplan , I. , Reifen , R. , Polack-Charcon , S. , Madar , Z. and Schwartz , B. 2002 . Lycopene inhibits proliferation and enhances gap-junction communication of KB-1 human oral tumor cells . J. Nutr. , 132 : 3754 – 3759 .
  • Ljubesic , N. , Wrischer , M. and Devide , Z. 1991 . Chromoplasts – the last stages in plastid development . Int. J. Dev. Biol. , 35 : 251 – 258 .
  • Lugasi , A. , Bíró , L. , Hóvárie , J. , Sági , K. V. , Brandt , S. and Barna , E. 2003 . Lycopene content of foods and lycopene intake in two groups of the Hungarian population . Nutr. Res. , 23 ( 8 ) : 1035 – 1044 .
  • Mackinnon , E. S. , Rao , A. V. and Rao , L. G. 2011 . Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women . J. Nutr. Health Aging. , 15 ( 2 ) : 133 – 138 .
  • Mansoori , B. , Modirsanei , M. , Farkhoy , M. , Kiaei , M. M. and Honarzad , J. 2007 . The influence of different single dietary sources on moult induction in laying hens . J. Sci. Food Agric. , 87 ( 14 ) : 2555 – 2559 .
  • Mansoori , B. , Modirsanei , M. , Radfar , M. , Kiaei , M. M. , Farkhoy , M. and Honarzad , J. 2008 . Digestibility and metabolisable energy values of dried tomato pomace for laying and meat type cockerels . An. Feed Sci. Technol. , 141 : 384 – 390 .
  • Marković , K. , Hruškar , M. and Vahčić , N. 2006 . Lycopene content of tomato products and their contribution to the lycopene intake of Croatians . Nutr. Res. , 26 ( 11 ) : 556 – 560 .
  • Martin , K. R. , Wu , D. and Meydani , M. 2000 . The effect of carotenoids on the expression of cell surface adhesion molecules and binding of monocytes to human aortic endothelial cells . Atherosclerosis , 150 : 265 – 274 .
  • Mascio , P. D. , Kaiser , S. and Sies , H. 1989 . Lycopene as the most efficient biological carotenoid singlet oxygen quencher . Arch. Biochem. Biophy. , 274 : 532 – 538 .
  • Mein , J. R. , Lian , F. and Wang , X. D. 2008 . Biological activity of lycopene metabolites: Implications for cancer prevention . Nutr. Rev. , 66 ( 12 ) : 667 – 683 .
  • Mercadante , A. Z. , Capitani , C. D. , Decker , E. A. and Castro , I. A. 2010 . Effect of natural pigments on the oxidative stability of sausages stored under refrigeration . Meat Sci. , 84 : 718 – 726 .
  • Mohanty , N. K. , Saxena , S. , Singh , U. P. , Goyal , N. K. and Arora , R. P. 2005 . Lycopene as a chemopreventive agent in the treatment of high-grade prostate intraepithelial neoplasia . Urol. Oncol.: Sem. Orig. Investig. , 23 ( 6 ) : 383 – 385 .
  • Nagasawa , H. , Mitamura , T. , Sakamoto , S. and Yamamoto , K. 1995 . Effects of lycopene on spontaneous mammary tumour development in SHN virgin mice . Anticancer Res. , 15 : 1173 – 1178 .
  • NFSA . 1992 . Microbiological Guidelines for Food Articles , Oslo : Norwegian Food Safety Authority .
  • Nobre , B. P. , Palavra , A. F. , Pessoa , F. L. P. and Mendes , R. L. 2009 . Supercritical CO2 extraction of trans-lycopene from Portuguese tomato industrial waste . Food Chem. , 116 : 680 – 685 .
  • Noziere , P. , Graulet , B. and Lucas , A. 2006 . Carotenoids for ruminants: From forages to dairy products . An. Feed Sci. Technol. , 131 : 418 – 450 .
  • Obermuller-Jevic , U. C. , Olano-Martin , E. , Corbacho , A. M. , Eiserich , J. P. , van der Vliet , A. , Valacchi , G. , Cross , C. E. and Packer , L. 2003 . Lycopene inhibits the growth of normal human prostate epithelial cells in vitro . J. Nutr. , 133 : 3356 – 3360 .
  • Odriozola-Serrano , I. , Soliva-Fortuny , R. , Hernandez-Jover , T. and Martin-Belloso , O. 2009 . Carotenoid and phenolic profile of tomato juices processed by high intensity pulsed electric fields compared with conventional thermal treatments . Food Chem. , 112 : 258 – 266 .
  • Odriozola-Serrano , I. , Soliva-Fortuny , R. and Martín-Belloso , O. 2008 . Effect of minimal processing on bioactive compounds and color attributes of fresh-cut tomatoes . LWT-Food Sci. Technol. , 41 ( 2 ) : 217 – 226 .
  • O’Neill , M. E. and Thurnham , D. I. 1998 . Intestinal absorption of beta-carotene, lycopene and lutein in men and women following a standard meal: Response curves in the triacylglycerol-rich lipoprotein fraction . Br. J. Nutr. , 79 ( 2 ) : 149 – 159 .
  • Østerlie , M. and Lerfall , J. 2005 . Lycopene from tomato products added minced meat: Effect on storage quality and colour . Food Res. Int. , 38 : 925 – 929 .
  • Paetau , I. , Khachik , F. , Brown , E. D. , Beecher , G. R. , Kramer , T. R. , Chittams , J. and Clevidence , B. A. 1998 . Chronic ingestion of lycopene-rich tomato juice or lycopene supplements significantly increases plasma concentrations of lycopene and related tomato carotenoids in humans . Am. J. Clin. Nutr. , 68 : 1187 – 1195 .
  • Paina , S. and Russell , R. 1999 . Beta-carotene and other carotenoids as antioxidants . J. Am. Coll. Nutr. , 18 : 426 – 433 .
  • Palozza , P. , Parrone , N. , Simona , R. E. and Catalano , A. 2010b . Lycopene in atherosclerosis prevention: An integrated scheme of the potential mechanisms of action from cell culture studies . Arch. Biochem. Biophy. , 504 : 26 – 33 .
  • Palozza , P. , Simone , R. , Catalano , A. , Boninsegna , A. , Böhm , V. , Fröhlich , K. , Mele , M. C. , Monego , G. and Ranelletti , F. O. 2010a . Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages . J. Nutr. Biochem. , 21 ( 1 ) : 34 – 46 .
  • Park , Y. O. , Hwang , E. S. and Moon , T. W. 2005 . The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells . BioFactors , 23 ( 3 ) : 129 – 139 .
  • Pearson , T. A. , Blair , S. N. , Daniels , S. R. , Eckel , R. H. , Fair , J. M. , Fortmann , S. P. , Franklin , B. A. , Goldstein , L. B. , Greenland , P. , Grundy , S. M. , Hong , Y. , Miller , N. H. , Lauer , R. M. , Ockene , I. S. , Sacco , R. L. , Sallis , Jr. J. F. , Smith , S. C. , Stone , N. J. and Taubert , K. A. 2002 . AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update: Consensus panel guide to comprehensive risk reduction for adult patients without coronary or atherosclerotic vascular diseases . Circulation , 106 : 388 – 391 .
  • Pérez-Conesa , D. , García-Alonso , J. , García-Valverde , V. , Iniesta , M. D. , Jacob , K. , Sánchez-Siles , L. M. , Ros , G. and Periago , M. J. 2009 . Changes in bioactive compounds and antioxidant activity during homogenization and thermal processing of tomato puree . Inn. Food Sci. Emerg. Technol. , 10 : 179 – 188 .
  • Porrini , M. and Riso , P. 2000 . Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption . J. Nutr. , 130 : 189 – 192 .
  • Porrini , M. , Riso , P. and Testolin , G. 1998 . Absorption of lycopene from single or daily portions of raw and processed tomato . Br. J. Nutr. , 80 ( 3 ) : 353 – 361 .
  • Rao , A. V. and Agarwal , S. 1998 . Bioavailability and in vivo antioxidant properties of lycopene from tomato products and its possible role in the prevention of cancer . Nutr. Cancer. , 31 : 199 – 203 .
  • Rao , A. V. and Agarwal , S. 1999 . Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: A review . Nutr. Res. , 19 : 305 – 323 .
  • Rao , L. G. , Mackinnon , E. S. , Josse , R. G. , Murray , T. M. , Strauss , A. and Rao , A. V. 2007 . Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women . Osteoporos Int. , 18 : 109 – 115 .
  • Rao , A. V. , Ray , M. R. and Rao , L. G. 2006 . Lycopene . Adv. Food Nutr. Res. , 51 : 99 – 164 .
  • Rao , A. V. and Shen , H. 2002 . Effect of low-dose lycopene intake on lycopene bioavailability and oxidative stress . Nutr. Res. , 22 ( 10 ) : 1125 – 1131 .
  • Reboul , E. , Richelle , M. , Perrot , E. , Desmoulins-Malezet , C. , Pirisi , V. and Borel , P. 2006 . Bioaccessibility of carotenoids and vitamin E from their main dietary sources . J. Agric. Food Chem. , 54 : 8749 – 8755 .
  • Ribayo-Mercado , J. D. , Garmyn , M. , Gilchrest , B. A. and Russel , R. M. 1995 . Skin lycopene is destroyed preferentially over β-carotene during ultraviolet irradiation in humans . J. Nutr. , 125 ( 7 ) : 1854 – 1859 .
  • Ribayo-Mercado , J. D. , Solon , S. F. , Tang , G. , Cabal-Borza , M. , Perfecto , S. C. and Russel , R. M. 2000 . Bioconversion of plant carotenoids to vit-A in Filipino school-aged children varies inversely with vit-A status . Am. J. Clin. Nutr. , 72 : 455 – 465 .
  • Richelle , M. , Bortlik , K. , Lairdet , S. , Hager , C. , Lambelet , P. , Baur , M. , Applegate , L. A. and Offord , E. 2002 . A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste . J. Nutr. , 132 : 404 – 408 .
  • Ried , K. and Fakler , P. 2011 . Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials . Maturitas , 68 ( 4 ) : 299 – 310 .
  • Riso , P. , Visioli , F. , Erba , D. , Testolin , G. and Porrini , M. 2004 . Lycopene and vitamin C concentrations increased in plasma and lymphocytes after tomato intake. Effects on cellular antioxidant protection . Eur. J. Clin. Nutr. , 58 : 1350 – 1358 .
  • Rissanen , T. , Voutilainen , S. , Nyyssönen , K. , Salonen , R. and Salonen , J. T. 2000 . Low plasma lycopene concentration is associated with increased intima-media thickness of the carotid artery wall . Arterioscler. Thromb. Vasc. Biol. , 12 : 2677 – 2681 .
  • Rodriguez-Amaya , D. B. and Kimura , M. 2004 . “ Carotenoids in foods ” . In Harvestplus Handbook for Carotenoid Analysis , 2 – 7 . Washington, DC , , USA : IFPRI and CIAT .
  • Rubio-Diaz , D. E. , De Nardo , T. , Santos , A. , de Jesus , S. , Francis , D. and Rodriguez-Saona , L. E. 2010 . Profiling of nutritionally important carotenoids from genetically-diverse tomatoes by infrared spectroscopy . Food Chem. , 120 : 282 – 289 .
  • Safari , M. R. 2007 . Effects of lycopene on the susceptibility of low-density lipoproteins to oxidative modification . Iran J. Pharma. Res. , 6 ( 3 ) : 173 – 177 .
  • Sahin , N. , Akdemir , F. , Orhan , C. , Kucuk , O. , Hayirli , A. and Sahin , K. 2008 . Lycopene-enriched quail egg as functional food for humans . Food Res. Int. , 41 ( 3 ) : 295 – 300 .
  • Sahin , K. , Onderci , M. , Sahin , N. , Gursu , M. F. , Khachik , F. and Kucuk , O. 2006 . Effects of lycopene supplementation on antioxidant status, oxidative stress, performance and carcass characteristics in heat-stressed Japanese quail . J. Therm. Biol. , 31 ( 4 ) : 307 – 312 .
  • Sahni , S. , Hannan , M. T. , Blumberg , J. , Cupples , L. A. , Kiel , D. P. and Tucker , K. L. 2009 . Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: A 17-year follow-up from the Framingham Osteoporosis Study . J. Bone Mineral Res. , 6 : 1086 – 1094 .
  • Salman , H. , Bergman , M. , Djaldetti , M. and Bessler , H. 2007 . Lycopene affects proliferation and apoptosis of four malignant cell lines . Biomed. Pharmaco. , 61 : 366 – 3669 .
  • Sánchez-Escalante , A. , Torrescano , G. , Djenane , D. , Beltrán , J. A. and Roncalés , P. 2003 . Stabilisation of colour and odour of beef patties by using lycopene-rich tomato and peppers as a source of antioxidants . J. Sci. Food Agric. , 83 : 187 – 194 .
  • Schmidl , M. K. and Labuza , T. P. 2000 . Essentials of Functional Foods , Gaithersburg , MD : Aspen .
  • Schwenke , C. , Ubrig , B. , Thürmann , P. , Eggersmann , C. and Roth , S. 2009 . Lycopene for advanced hormone refractory prostate cancer: A prospective, open phase II pilot study . J. Urol. , 181 ( 3 ) : 1098 – 1103 .
  • Scolastici , C. , Alves de Lima , R. O. , Barbisan , L. F. , Ferreira , A. L. , Ribeiro , D. A. and Salvadori , D. M. F. 2007 . Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells . Toxicol. in Vitro. , 21 ( 5 ) : 840 – 845 .
  • Selgas , M. D. , García , M. L. and Calvo , M. M. 2009 . Effects of irradiation and storage on the physico-chemical and sensory properties of hamburgers enriched with lycopene . Int. J. Food Sci. Technol. , 44 : 1983 – 1989 .
  • Sesso , H. D. , Buring , J. E. , Norkus , E. P. and Gaziano , J. M. 2004 . Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women . Am. J. Clin. Nutr. , 79 : 47 – 53 .
  • Ševčikova , S. , Skřivan , M. and Dlouha , G. 2008 . The effect of lycopene supplementation on lipid profile and meat quality of broiler chickens . Czech J. Animal Sci. , 53 ( 10 ) : 431 – 440 .
  • Sharoni , Y. , Danilenko , M. and Levy , J. 2000 . Molecular mechanisms for the anticancer activity of the carotenoid lycopene . Drug Develop. Res. , 50 ( 3–4 ) : 448 – 456 .
  • Shi , J. and Le Maguer , M. 2000 . Lycopene in tomatoes: Chemical and physical properties affected by food processing . Crit. Rev. Food Sci. Nutr. , 40 ( 1 ) : 1 – 42 .
  • Shi , J. , Le Maguer , M. and Bryan , M. 2002 . “ Lycopene from tomatoes ” . In Functional Foods-Biochemical and Processing Aspects , Edited by: Shi , J. , Mazza , G. and Le Maguer , M. 135 – 168 . USA : CRC Press .
  • Shi , J. , Le Maguer , M. , Kakuda , Y. , Liptay , A. and Niekamp , F. 1999 . Lycopene degradation and isomerization in tomato dehydration . Food Res. Int. , 32 ( 1 ) : 15 – 21 .
  • Shi , J. , Yi , C. , Xue , S. J. , Jiang , Y. , Mac , Y. and Li , D. 2009 . Effects of modifiers on the profile of lycopene extracted from tomato skins by supercritical CO2 . J. Food Engin. , 93 : 431 – 436 .
  • Singh , P. and Goyal , G. K. 2008 . Dietary lycopene: Its properties and anticarcinogenic effects . Comp. Rev. Food Sci. Food Safety. , 7 : 255 – 270 .
  • Skuladottir , H. , Tjoenneland , A. , Overvad , K. , Stripp , C. and Olsen , J. H. 2006 . Does high intake of fruit and vegetables improve lung cancer survival? . Lung Cancer. , 51 ( 3 ) : 267 – 73 .
  • Sogi , D. S. and Bawa , A. S. 1998 . Studies on dehydration of tomato processing waste . Indian Food Packer. , 52 ( 2 ) : 26 – 29 .
  • Srinivasan , M. , Devipriya , N. , Kalpana , K. B. , Venugopal , P. and Menon , V. P. 2009 . Lycopene: An antioxidant and radioprotector against γ-radiation-induced cellular damages in cultured human lymphocytes . Toxicol , 262 ( 1 ) : 43 – 49 .
  • Srinivasan , M. , Sudheer , A. R. , Pillai , K. R. , Kumar , P. R. , Sudhakaran , P. R. and Menon , V. P. 2007 . Lycopene as a natural protector against γ-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes in vitro . Biochim. Biophy. Acta (BBA) - General Subjects. , 1770 ( 4 ) : 659 – 665 .
  • Stacewicz-Sapuntzakis , M. and Bowen , P. E. 2005 . Role of lycopene and tomato products in prostate health . Biochim. Biophy. Acta (BBA)-Mol. Basis. Dis. , 1740 ( 2 ) : 202 – 205 .
  • Stah , W. and Sies , H. 1996 . Lycopene: A biologically important carotenoid for humans? . Arch. Biochem. Biophys. , 336 : 1 – 9 .
  • Talvas , J. , Caris-Veyrat , C. , Guy , L. , Rambeau , M. , Lyan , B. , Minet-Quinard , R. , Lobaccaro , J. M. A. , Vasson , M. P. , Georgé , S. , Mazur , A. and Rock , E. 2011 . Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells . Am. J. Clin. Nutr. , 91 : 1716 – 1724 .
  • Tang , F. Y. , Cho , H. J. , Pai , M. H. and Chen , Y. H. 2009 . Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells . J. Nutr. Biochem. , 20 : 426 – 434 .
  • Tang , G. , Ferreira , A. L. A. , Grusak , M. A. , Qin , J. , Dolnikowski , G. G. , Russell , R. M. and Krinsky , N. I. 2005 . Bioavailability of synthetic and biosynthetic deuterated lycopene in humans . J. Nutr. Biochem. , 16 ( 4 ) : 229 – 235 .
  • Tang , F. Y. , Shih , C. J. , Cheng , L. H. , Ho , H. J. and Chen , H. J. 2008 . Lycopene inhibits growth of human colon cancer cells via suppression of the Akt signaling pathway . Mol. Nutr. Food Res. , 52 ( 2 ) : 646 – 654 .
  • Thompson , K. A. , Marshall , M. R. , Sims , C. A. , Wei , C. I. , Sargent , S. A. and Scott , J. W. 2000 . Cultivar, maturity and heat treatment on lycopene content in tomatoes . J. Food Sci. , 65 : 791 – 795 .
  • Türk , G. , Atessahin , A. and Sönmez , M. 2007 . Lycopene protects against cyclosporine A-induced testicular toxicity in rats . Theriogenol. , 67 : 778 – 785 .
  • Unlu , N. Z. , Bohn , T. , Francis , D. M. , Nagaraja , H. N. , Clinton , S. K. and Schwartz , S. J. 2007 . Lycopene from heat-induced cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects . Br. J. Nutr. , 98 : 140 – 146 .
  • Vági , E. , Simándi , B. , Vásárhelyiné , K. P. , Daood , H. , Kéry , A. , Doleschall , F. and Nagya , B. 2007 . Supercritical carbon dioxide extraction of carotenoids, tocopherols and sitosterols from industrial tomato by-products . J. Supercrit. Fluids. , 40 : 218 – 226 .
  • Van Breemen , R. B. and Pajkovic , N. 2008 . Multitargeted therapy of cancer by lycopene . Cancer Lett. , 269 : 339 – 351 .
  • Van den Berg , H. , Faulks , R. , Granado , F. , Hirsberg , J. , Olmedilla , B. , Sandman , G. , Southon , S. and Stahl , W. 2000 . The potential for the improvement of carotenoid levels in foods and the likely systemic effects . J. Sci. Food Agric. , 80 : 880 – 912 .
  • Van het Hof , K. H. , West , C. E. , Weststrate , J. A. and Hautvast , J. G. A. J. 2000 . Dietary factors 1321 that affect the bioavailability of carotenoids . J. Nutr. , 130 : 503 – 506 .
  • Velmurugana , B. , Mohan , K. V. P. C. , Abraham , S. K. and Nagini , S. 2005 . Combination of S-allylcysteine and lycopene protects against N-methyl-NV-nitro-N-nitrosoguanidine–induced genotoxicity and oxidative stress in mice . Nutr. Res. , 25 : 577 – 586 .
  • Visioli , F. , Riso , P. , Grande , S. , Galli , C. and Porrini , M. 2003 . Protective activity of tomato products on in vivo markers of lipid oxidation . Eur. J. Nutr. , 42 : 201 – 206 .
  • Vita , T. 2007 . Worlds spends more than $50 M on lycopene red . Focus Pigments. , 4 : 3 – 4 .
  • Viuda-Martos , M. , López-Marcos , M. C. , Fernández-López , J. , Sendra , E. , López-Vargas , J. H. and Perez-Álvarez , J. Á. 2010 . Role of fiber in cardiovascular diseases: A review . Comp. Rev. Food Sci. Food Safety. , 9 ( 2 ) : 240 – 258 .
  • Viuda-Martos , M. , Ruiz-Navajas , Y. , Fernández-López , J. and Pérez-Álvarez , J. A. 2009 . Effect of adding citrus waste water, thyme and oregano essential oil on the chemical, physical and sensory characteristics of a bologna sausage . Inno. Food Sci. Emerg. Technol. , 10 : 655 – 660 .
  • Wang , H. , Chen , C. and Chang , C. 2001 . Carbon dioxide extraction of ginseng root hair oil and ginsenosides . Food Chem. , 72 : 505 – 509 .
  • Wang , H. and Leung , L. K. 2010 . The carotenoid lycopene differentially regulates phase I and II enzymes in dimethylbenz[a]anthracene-induced MCF-7 cells . Nutr. , 26 : 1181 – 1187 .
  • Wang , L. , Liu , S. , Pradhan , A. D. , Manson , J. E. , Buring , J. E. , Gaziano , J. M. and Sesso , H. D. 2006 . Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women . Am. J. Epidemiol. , 164 : 576 – 585 .
  • Weiss , W. P. , Frobose , D. L and Koch , M. E. 1997 . Wet tomato pomace ensiled with corn plants for dairy cows . J. Dairy Sci. , 80 : 2896 – 2900 .
  • Weiss , J. , Gibis , M. , Schuh , V. and Salminen , H. 2010 . Advances in ingredient and processing systems for meat and meat products . Meat Sci , 86 : 196 – 213 .
  • Witztum , J. L. and Hörkkö , S. 1997 . The role of oxidised LDL in atherogenesis: Immunological response and anti-phospholipid antibodies . Ann. N. Y. Acad. Sci. , 811 : 88 – 96 .
  • Yang , X. B. , Zhao , Y. , Yang , Y. and Ruan , Y. 2008a . Isolation and characterization of immunostimulatory polysaccharide from an herb tea, Gynostemma pentaphyllum Makino . J. Agric. Food Chem. , 56 : 6905 – 6909 .
  • Yang , Z. , Zhang , Z. , Penniston , K. L. , Binkley , N. and Tanumihardjo , S. A. 2008b . Serum carotenoid concentrations in postmenopausal women from the united states with and without osteoporosis . Int. J. Vitam. Nutr. Res. , 78 ( 3 ) : 105 – 111 .
  • Yeh , S. L. and Hu , M. L. 2000 . Antioxidant and pro-oxidant effects of lycopene in comparison with β-carotene on oxidant-induced damage in Hs68 cells . J. Nutr. Biochem. , 11 ( 11–12 ) : 548 – 554 .
  • Yeum , K. J. and Russell , R. M. 2002 . Carotenoid bioavailability and bioconversion . Ann. Rev. Nutr. , 22 : 483 – 504 .
  • Yi , C. , Shi , J. , Xue , S. , Jiang , Y. and Li , D. 2009 . Effects of supercritical fluid extraction parameters on lycopene yield and antioxidant activity . Food Chem. , 113 : 1088 – 1094 .
  • Yildiz , H. and Baysal , T. 2007 . Color and lycopene content of tomato puree affected by electroplasmolysis . Int. J. Food Prop. , 10 ( 3 ) : 489 – 495 .
  • Yılmaz , I. , Simsek , O. and Isikli , M. 2002 . Fatty acid composition and quality characteristics of low-fat cooked sausages made with beef and chicken meat, tomato juice and sunflower oil . Meat Sci. , 62 : 253 – 258 .
  • Ylönen , K. , Alfthan , G. , Groop , L. , Saloranta , C. , Aro , A. and Virtanen , S. M. 2003 . Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: The Botnia Dietary Study . Am. J. Clin. Nutr. , 77 : 1434 – 1441 .
  • Yonar , M. E. and Sakin , F. 2011 . Ameliorative effect of lycopene on antioxidant status in Cyprinus carpio during pyrethroid deltamethrin exposure . Pesticide Biochem Physiol. , 99 ( 3 ) : 226 – 231 .
  • Yonekura , L. and Nagao , A. 2007 . Intestinal absorption of dietary carotenoids . Mol. Nutr. Food Res. , 51 : 107 – 115 .
  • Zhang , L. and Liu , Z. 2008 . Optimization and comparison of ultrasound/microwave assisted extraction (UMAE) and ultrasonic assisted extraction (UAE) of lycopene from tomatoes . Ultrason. Sonochem. , 15 : 731 – 737 .
  • Zhou , J. R. , Gugger , E. T. and Erdman , J. W. 1996 . The crystalline form of carotenes and the food matrix in carrot root decrease the relative bioavailability of beta- and alpha-carotene in the ferret model . J. Am. Coll. Nutr. , 15 : 84 – 91 .
  • Zini , A. , San Gabriel , M. and Libman , J. 2010 . Lycopene supplementation in vitro can protect human sperm deoxyribonucleic acid from oxidative damage . Fert. Ster. , 94 ( 3 ) : 1033 – 1036 .

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