REFERENCES
- Alcock , R. E. and Busby , J. 2006 . Risk migration and scientific advance: The case of flame-retardant compounds . Risk Anal. , 6 : 369 – 381 .
- Betz , J. M. , Brown , P. N. and Roman , M. C. 2011 . Accuracy, precision, and reliability of chemical measurements in natural products research . Fitoterapia , 82 : 44 – 52 .
- Boobis , A. , Budinsky , R. , Collie , S. , Crofton , K. , Embry , M. , Felter , S. , Hertzberg , R. , Kopp , D. , Mihlan , G. , Mumtaz , M. , Price , P. , Solomon , K. , Teuschler , L. , Yang , R. and Zaleski , R. 2011 . Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment . Crit. Rev. Toxicol. , 41 : 369 – 383 .
- Cheeseman , M. A. , Machuga , E. J. and Bailey , A. B. 1999 . A tiered approach to threshold of regulation . Food Chem. Toxicol. , 37 : 387 – 412 .
- Codex Alimentarius Commission . 2012a . Current official standards Available from http://www.codexalimentarius.net/web/standard_list.do?lang=en. Accessed May 16, 2012
- Codex Alimentarius Commission . 2012b . Pesticide residues in food and feed Available from http://www.codexalimentarius.net/pestres/data/pesticides/index.html. Accessed May 16, 2012
- Cramer , G. M. , Ford , R. A. and Hall , R. L. 1978 . Estimation of toxic hazard–A decision tree approach . Food Cosmet. Toxicol. , 16 : 255 – 276 .
- De Vries , J. W. 2006 . Chasing “zero” in chemical contaminant analysis . Food Safety Magazine , Available from http://foodsafetymagazine.com/article.asp?id=536&sub=sub1. Accessed May 16, 2012
- Dorne , J. L. C. M. , Bordajandi , L. R. , Amzal , B. and Ferrari , P. 2009 . Combining analytical techniques, exposure assessment and biological effects for risk assessment of chemicals in food . Trends Anal. Chem. , 28 : 695 – 707 .
- European Food Safety Authority . 2012 . Scientific Opinion on Exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC) Available from http://www.efsa.europa.eu/en/efsajournal/pub/2750.htm. Accessed November 2, 2012
- European Medicines Agency . 2010 . Questions and answers on the “Guideline on the limits of genotoxic impurities.” Available from http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002907.pdf. Accessed May 16, 2012
- Felter , S. , Lane , R. W. , Latulippe , M. E. , Llewellyn , G. C. , Olin , S. S. , Scimeca , J. A. and Trautman , T. D. 2009 . Refining the threshold of toxicological concern (TTC) for risk prioritization of trace chemicals in food . Food Chem. Toxicol. , 47 : 2236 – 2245 .
- Food Standards Australia New Zealand . 2011 . “ Food safety standards (Australia only) ” . In Food standards code Available from http://www.foodstandards.gov.au/foodstandards/foodstandardscode.cfm. Accessed May 16, 2012
- Fraunhofer . N.D. . RepDose: Database for the analysis of relationship between chemical function groups/categories and target organs in repeated dose studies . Available from http://www.fraunhofer-repdose.de/. Accessed May 18, 2012
- Frawley , J. P. 1967 . Scientific evidence and common sense as a basis for food packaging regulations . Food Chem. Toxicol. , 5 : 293 – 308 .
- Gold , L. S. , Manley , N. B. , Slone , T. H. , Garfinkel , G. B. , Ames , B. N. , Rohrbach , L. , Stern , B. R. and Chow , K. 1995 . Sixth plot of the carcinogenic potency database: Results of animal bioassays published in the general literature 1989–1990 and by the US NTP 1990–1993 . Environ. Health Perspect. , 103 : 3 – 122 .
- Hahn , M. J. 2010 . FDA has the legal authority to adopt a threshold of toxicological concern for substances in food at trace levels . Food Drug Law J. , 65 : 217 – 230 .
- Institute of Food Technologists . 2009 . Making decisions about the risks of chemicals in foods with limited scientific information . Comp. Rev. Food Sci. Food Safety , 8 : 269 – 303 .
- International Agency for Research on Cancer . 2002 . Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans , Vol. 82 , Lyon , , France : IARC .
- Joint Expert Committee on Food Additives . 2007 . Evaluation of Certain Food Additives and Contaminants: 68th Report of the Joint FAO/WHO Expert Committee on Food Additives , Geneva , , Switzerland : World Health Organization .
- Koschier , F. , Gallo , M. A. , Feng , X. , Baxter , G. E. , Preston , R. , Stevens , K. and Powers , W. 2011 . Toxicological studies on 2,4,6-tribromoanisole . Food Chem. Toxicol. , 49 : 2074 – 2080 .
- Koster , S. , Boobis , A. R. , Cubberly , R. , Hollnagel , H. M. , Richling , E. , Wildemann , T. , Würtzen , G. and Galli , C. L. 2011 . Application of the TTC concept to unknown substances found in analysis of foods . Food Chem. Toxicol. , 49 : 1643 – 1660 .
- Kroes , R. , Renwick , A. G. , Cheeseman , M. , Kleiner , J. , Mengelsdorf , I. , Piersma , A. , Schilter , B. , Schlatter , J. , van Schothorst , F. , Vos , J. G. and Wurtzen , G. 2004 . Structure-based thresholds of toxicological concern-guidance for application to substances present at low levels in the diet . Food Chem. Toxicol. , 42 : 65 – 83 .
- Misiwa , N. , Mitsuno , H. , Kansaki , R. and Takeuchi , S. 2010 . Highly sensitive and selective odorant sensor using living cells expressing insect olfactory receptors . Proc. Natl. Acad. Sci. U. S. A. , 107 : 15340 – 15344 .
- Munro , I. C. 1990 . Safety assessment procedures for indirect food additives: An overview . Regul. Toxicol. Pharmacol. , 12 : 2 – 12 .
- Munro , I. C. , Ford , R. A. , Kennepohl , E. and Sprenger , J. G. 1996 . Correlation of structural class with no-observed-effect levels: A proposal for establishing a threshold of concern . Food Chem. Toxicol. , 34 : 829 – 867 .
- Munro , I. C. , Renwick , A. G. and Danielewska-Nikiel , B. 2008 . The threshold of toxicological concern (TTC) in risk assessment . Toxicol. Lett. , 180 : 151 – 156 .
- Organization for Economic Cooperation and Development . 2011 . Assessment of chemicals Available from http://www.oecd.org/document/6/0,3746,en_2649_34379_43087494_1_1_1_1,00.html. Accessed May 16, 2012
- Peterson , M. 2002 . What is a de minimis risk? . Risk Manage. , 4 : 47 – 55 .
- Re , T. A. , Mooney , D. , Antignac , E. , Dufour , E. , Bark , I. , Srinivasan , V. and Nohynek , G. 2009 . Application of the threshold of toxicological concern approach for the safety evaluation of calendula flower (Calendula officinalis) petals and extracts used in cosmetic and personal care products . Food Chem. Toxicol. , 47 : 1246 – 1254 .
- Rennen , M. A. J. , Koster , S. , Krul , C. A. M. and Houlben , G. F. 2011 . Application of the threshold of toxicological concern (TTC) concept to the safety assessment of chemically complex food matrices . Food Chem. Toxicol. , 49 : 933 – 940 .
- Renwick , A. G. 2004 . Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of flavoring agents . Toxicol. Lett. , 149 : 223 – 234 .
- Rulis , A. M. 1986 . “ De minimis and the threshold of regulation ” . In Food Protection Technology , Edited by: Felix , C. W. 29 – 37 . Chelsea , MI : Lewis Publishers Inc. .
- Schecter , A. , Päpke , O. , Tung , K. C. , Staskal , D. and Birnbaum , L. 2004 . Polybrominated diphenyl ethers contamination of United States food . Environ. Sci. Technol. , 38 : 5306 – 5311 .
- Shanklin , A. P. 2009 . Regulatory report. How FDA's “threshold of regulation” program works . Food Safety Magazine , Available from http://www.foodsafetymagazine.com/articleFF.asp?id=2719&sub=sub1. Accessed May 16, 2012
- U.K. Food Standards Agency . 2008 . “ Principles for preventing and responding to food incidents ” . In A guidance document produced by the Food Standards Agency's Taskforce on Incidents Available from http://www.food.gov.uk/multimedia/pdfs/incidentsprinciples.pdf. Accessed May 16, 2012
- U.S. Environmental Protection Agency . 1999 . Threshold of regulation policy—Deciding whether a pesticide with a food use pattern needs a tolerance Available from http://www.epa.gov/fedrgstr/EPA-PEST/1999/October/Day-27/6042.pdf. Accessed May 16, 2012.
- U.S. Food and Drug Administration . 1995 . Food additives; threshold of regulation for substances used in food-contact articles . Fed. Regist. , 60 : 36582 – 36596 . Available from: http://www.gpo.gov/fdsys/pkg/FR-1995-07-17/pdf/95-17435.pdf. Accessed May 21, 2012
- U.S. Food and Drug Administration . 2010a . Agency information collection activities; proposed collection; comment request; threshold of regulation for substances used in food-contact articles . Fed. Regist. , 75 : 18209 – 18210 . Available from http://www.federalregister.gov/articles/2010/04/09/2010-8050/agency-information-collection-activities-proposed-collection-comment-req-uest-threshold-of-regulation#h-8. Accessed May 16, 2012
- U.S. Food and Drug Administration . 2010b . Current good manufacturing practices (CGMPs) Available from http://www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/CurrentGoodManufacturingPracticesCGMPs/default.htm. Accessed May 16, 2012
- U.S. Food and Drug Administration, Department of Health and Human Services . 2012 . “ Title 21 (Part 109)–Food and drugs. Subchapter B–Food for Human Consumption ” . In Part 109–unavoidable contaminants in food for human consumption and food-packaging material Available from http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr&sid=70f8f746d2946610748907097e62eac5&tpl=/ecfrbrowse/Title21/21cfr109_main_02.tpl. Accessed May 16, 2012
- Van Ravenzwaay , B. , Dammann , M. , Buesen , R. and Schneider , S. 2011 . The threshold of toxicological concern for prenatal developmental toxicity . Reg. Toxicol. Pharmacol. , 59 : 81 – 90 .
- Whitfield , F. B. , Hill , J. L. and Shaw , K. J. 1987 . 2,4,6-tribromoanisole: A potential cause of mustiness in packaged food . J. Agric. Food Chem. , 45 : 889 – 893 .