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Original Articles

Interventions targeting child undernutrition in developing countries may be undermined by dietary exposure to aflatoxin

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References

  • Abdulrazzaq, Y. M., Osman, N., Yousif, Z. M. and Trad, O. (2004). Morbidity in neonates of mothers who have ingested aflatoxins. Ann. Trop. Paediatr. 24:145–151.
  • Abia, W. A., Warth, B., Sulyok, M., Krska, R., Tchana, A., Njobeh, P..B., Turner, P..C., Kouanfack, C., Eyongetah, M., Dutton, M., et al. (2013). Bio-monitoring of mycotoxin exposure in Cameroon using a urinary multi-biomarker approach. Food Chem. Toxicol. 62:927–934.
  • Adhikari, M., Ramjee, G. and Berjak, P. (1994). Aflatoxin, kwashiorkor, and morbidity. Nat. Toxins. 2:1–3.
  • Ahmed, T., Hossain, M. and Sanin, K..I. (2012). Global burden of maternal and child undernutrition and micronutrient deficiencies. Ann. Nutr. Metab. 61:8–17.
  • Apeagyei, F., Lamplugh, S. M., Hendrickse, R. G., Affram, K. and Lucas, S. (1986). Aflatoxins in the livers of children with kwashiorkor in Ghana. Trop. Geogr. Med. 38:273–276.
  • Azziz-Baumgartner, E., Lindblade, K., Gieseker, K., Rogers, H. S., Kieszak, S., Njapau, H., Schleicher, R., McCoy, L. F., Misore, A., DeCock, K., et al. (2005). Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environ. Health Perspect. 113:1779–1783.
  • Bhutta, Z. A., Ahmed, T., Black, R. E., Cousens, S., Dewey, K., Giugliani, E., Haider, B. A., Kirkwood, B., Morris, S. S., Sachdev, H. P., et al. (2008). What works? Interventions for maternal and child undernutrition and survival. Lancet. 371:417–440.
  • Black, R. E., Allen, L. H., Bhutta, Z. A., Caulfield, L. E., de Onis, M., Ezzati, M., Mathers, C., Rivera, J. and Maternal and Undernutrition Study Group. (2008). Maternal and child undernutrition: Global and regional exposures and health consequences. Lancet. 371:243–260.
  • Black, R. E., Victora, C. G., Walker, S. P., Bhutta, Z. A., Christian, P., de Onis, M., Ezzati, M., Grantham-McGregor, S., Katz, J., Martorell, R., et al. (2013). Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 382:427–451.
  • Bondy, G. S. and Pestka, J. J. (2000). Immunomodulation by fungal toxins. J. Toxicol. Environ. Health B. Crit. Rev. 3:109–143.
  • Brown, K. H., Peerson, J. M., Baker, S. K. and Hess, S. Y. (2009). Preventive zinc supplementation among infants, preschoolers, and older prepubertal children. Food Nutr. Bull. 30:12–40.
  • Brown, K. H., Peerson, J. M., Rivera, J. and Allen, L. H. (2002). Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: A meta-analysis of randomised controlled trials. Am. J. Clin. Nutr. 75:1062–1071.
  • Castelino, J. M., Dominguez-Salas, P., Routledge, M. N., Prentice, A. M., Moore, S. E., Hennig, B. J., Wild, C. P. and Gong, Y. Y. (2014). Seasonal and gestation stage associated differences in aflatoxin exposure in pregnant Gambian women. Trop. Med. Int. Health. 19:348–354.
  • Castelino, J. M., Routledge, M. N., Wilson, S., Dunne, D. W., Mwatha, J. K., Gachuhi, K., Wild, C. P. and Gong, Y. Y. (2015). Aflatoxin exposure is inversely associated with IGF1 and IGFBP3 levels in vitro and in Kenyan schoolchildren. Mol. Nutr. Food Res. 59:574–581.
  • Chapot, B. and Wild, C. P. (1991). ELISA for quantification of aflatoxin-albumin adducts and their application to human exposure assessment. In: Techniques in Diagnostic Pathology, pp. 135–155. Warhol, M., van Velzen, D. and Bullock, G. R., Eds., Academic Press, San Diego CA.
  • Chhagan, M. K., Van den Broeck, J., Luabeya, K. A., Mpontshane, N., Tomkins, A. and Bennish, M. L. (2010). Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: A randomized controlled trial in children aged 6–24 months. BMC Public Health. 10:145.
  • Coulter, J., Hendrickse, R. G., Lamplugh, S. M., Macfarlane, S. B., Moody, J. B., Omer, M. I., Suliman, G. I. and Williams, T. E. (1986). Aflatoxins and kwashiorkor: Clinical studies in Sudanese children. Trans. R. Soc. Trop. Med. Hyg. 80:945–951.
  • de Benoist, B., Darnton-Hill, I., Davidsson, L., Fontaine, O. and Hotz, C. (2007). Conclusions of the joint WHO/UNICEF/IAEA/lZiNCG interagency meeting on zinc status indicators. Food Nutr. Bull. 28:S480–S484.
  • de Vries, H. R., Lamplugh, S. M. and Hendrickse, R. G. (1987). Aflatoxins and kwashiorkor in Kenya: A hospital-based study in a rural area of Kenya. Ann. Trop. Paediatr. 7:249–251.
  • de Vries, H. R., Maxwell, S. M. and Hendrickse, R. G. (1989). Foetal and neonatal exposure to aflatoxins. Acta Paediatr. Scand. 78:373–378.
  • de Vries, H. R., Maxwell, S. M. and Hendrickse, R. G. (1990). Aflatoxin excretion in children with kwashiorkor or marasmic kwashiorkor – A clinical investigation. Mycopathologia. 110:1–9.
  • Denning, D. W., Allen, R., Wilkinson, A. P. and Morgan, M. R. (1990). Transplacental transfer of aflatoxin in humans. Carcinogenesis. 11:1033–1035.
  • Ediage, E. N., Di Mavungu, J. D., Song, S., Sioen, I. and De Saeger, S. (2013). Multimycotoxin analysis in urines to assess infant exposure: A case study in Cameroon. Environ. Int. 57–58:50–59.
  • Gazala, E., Sarov, B., Hershkovitz, E., Edvardson, S., Sklan, D., Katz, M., Friger, M. and Gorodischer, R. (2003). Retinol concentration in maternal and cord serum: Its relation to birth weight in healthy mother–infant pairs. Early Hum. Dev. 71:19–28.
  • Glahn, R. P., Beers, K. W., Bottje, W. G., Wideman, R. F., Huff, W. E. and Thomas, W. (1991). Aflatoxicosis alters avian renal function, calcium, and vitamin D metabolism. J. Toxicol. Environ. Health. 34:309–321.
  • Gong, Y. Y., Cardwell, K., Hounsa, A., Egal, S., Turner, P., Hall, A. J. and Wild, C. P. (2002). Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: Cross-sectional study. BMJ. 325:20–21.
  • Gong, Y. Y., Egal, S., Hounsa, A., Turner, P. C., Hall, A. J., Cardwell, K. F. and Wild, C. P. (2003). Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: The critical role of weaning. Int. J. Epidemiol. 32:556–562.
  • Gong, Y. Y., Hounsa, A., Egal, S., Turner, P. C., Sutcliffe, A. E., Hall, A. J., Cardwell, K. and Wild, C. P. (2004). Postweaning exposure to aflatoxin results in impaired child growth: A longitudinal study in Benin, West Africa. Environ. Health Perspect. 112:1334–1338.
  • Gong, Y. Y., Turner, P. C., Hall, A. J. and Wild, C. P. (2008). Aflatoxin exposure and impaired child growth in west africa: an unexplored international public health burden? In: Mycotoxins: Detection Methods, Management, Public Health, and Agricultural Trade, pp. 53–66. Leslie, J. F., Bandyopadhyay, R., Visconti, A., Eds., CABI, Wallingford, UK.
  • Gong, Y. Y., Wilson, S., Mwatha, J. K., Routledge, M. N., Castelino, J. M., Zhao, B., Kimani, G., Vennervald, B. J., Dunne, D. W. and Wild, C. P. (2012). Aflatoxin exposure may contribute to chronic hepatomegaly in Kenyan school children. Environ. Health Perspect. 120:893–896.
  • Harvey, R. B., Kubena, L. F., and Elissalde, M. H. (1994). Influence of vitamin E on aflatoxicosis in growing swine. Am. J. Vet. Res. 55:572–577.
  • Hatem, N. L., Hassab, H. M., Abd Al-Rahman, E. M., El-Deeb, S. A. and El-Sayed Ahmed, R. L. (2005). Prevalence of aflatoxins in blood and urine of Egyptian infants with protein-energy malnutrition. Food Nutr. Bull. 26:49–56.
  • Hendrickse, R. G. (1997). Of sick turkeys, kwashiorkor, malaria, perinatal mortality, heroin addicts and food poisoning: Research on the influence of aflatoxins on child health in the tropics. Ann. Trop. Med. Parasitol. 91:787–793.
  • Hendrickse, R. G., Coulter, J. B., Lamplugh, S. M., Macfarlane, S. B., Williams, T. E., Omer, M. I. and Suliman, G. I. (1982). Aflatoxins and kwashiorkor: A study in Sudanese children. BMJ. 285:843–846.
  • Househam, K. C. and Hundt, H. K. (1991). Aflatoxin exposure and its relationship to kwashiorkor in African children. J. Trop. Pediatr. 37:300–302.
  • Imdad, A. and Bhutta, Z. A. (2011). Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: A meta-analysis of studies for input to the lives saved tool. BMC Public Health. 11:S22.
  • International Agency for Research on Cancer (IARC). (2002). Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. IARC monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 82, pp. 171–300. IARC, Lyon, France.
  • Jiang, Y., Jolly, P. E., Ellis, W. O., Wang, J. S., Phillips, T. D. and Williams, J. H. (2005). Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians. Int. Immunol. 17:807–814.
  • Jiang, Y., Jolly, P. E., Preko, P., Wang, J. S., Ellis, W. O., Phillips, T. D. and Williams, J. H. (2008). Aflatoxin-related immune dysfunction in health and in human immunodeficiency virus disease. Clin. Dev. Immunol. 790309.
  • Jonsyn, F. E., Maxwell, S. M. and Hendrickse, R. G. (1995). Human fetal exposure to ochratoxin A and aflatoxins. Ann. Trop. Paediatr. 15:3–9.
  • Khlangwiset, P., Shephard, G. S. and Wu, F. (2011). Aflatoxins and growth impairment: A review. Crit. Rev. Toxicol. 41:740–755.
  • Kimanya, M. E., De Meulenaer, B. and Kolsteren, P. W. (2009). The correlation between fumonisins exposure and growth retardation among infants in Rombo, Tanzania. Ann. Nutr. Metab. 55:614–614.
  • Kimanya, M. E., De Meulenaer, B., Roberfroid, D., Lachat, C. and Kolsteren, P. (2010). Fumonisin exposure through maize in complementary foods is inversely associated with linear growth of infants in Tanzania. Mol. Nutr. Food Res. 54:1659–1667.
  • Kimanya, M. E., De Meulenaer, B., Tiisekwa, B., Ndomondo-Sigonda, M., Devlieghere, F., Van Camp, J. and Kolsteren, P. (2008). Co-occurrence of fumonisins with aflatoxins in home-stored maize for human consumption in rural villages of Tanzania. Food Addit. Contam. A. 25:1353–1364.
  • Kimanya, M. E., Shirima, C. R., Magoha, H., Shewiyo, D. H., De Meulenaer, B., Kolsteren, P. and Gong, Y. Y. (2013). Co-exposures of aflatoxins with deoxynivalenol and fumonisins from maize based complementary foods in Rombo, Northern Tanzania. Food Control. 41:76–81.
  • Lamplugh, S. M., and Hendrickse, R. G. (1982). Aflatoxins in the livers of children with kwashiorkor. Ann. Trop. Paediatr. 2:101–104.
  • Latham, M. C. (1997). Human Nutrition in the Developing World. Food and Nutrition Series No. 29. FAO, Rome.
  • Lenters, L. M., Wazny, K., Webb, P., Ahmed, T. and Bhutta, Z. A. (2013). Treatment of severe and moderate acute malnutrition in low-and middle-income settings: A systematic review, meta-analysis and Delphi process. BMC Public Health. 13:S23.
  • Lima, A. A., Soares, A. M., Lima, N. L., Mota, R. M., Maciel, B. L., Kvalsund, M. P., Barret, L. J., Fitzgerald, R. P., Blaner, W. S. and Guerrant, R. L. (2010). Effects of vitamin A supplementation on intestinal barrier function, growth, total parasitic, and specific Giardia spp. infections in Brazilian children: A prospective randomized, double-blind, placebo-controlled trial. J. Pediatr. Gastroenterol. Nutr. 50:309–315.
  • Lindenmayer, G. W., Stoltzfus, R. J. and Prendergast, A. J. (2014). Interactions between zinc deficiency and environmental enteropathy in developing countries. Adv. Nutr. 5:1–6.
  • Low, M., Farrell, A., Biggs, B. A. and Pasricha, S. R. (2013). Effects of daily iron supplementation in primary-school-aged children: Systematic review and meta-analysis of randomized controlled trials. CMAJ. 185:E791–E802.
  • Mahawithange, S. T., Kannanga, K. K., Wickremasinghe, R., Chandrika, U. G., Jansz, E. R., Karunaweera, N. D. and Wickremasinghe, A. R. (2007). Impact of vitamin A supplementation on health status, and absenteeism of school children in Sri Lanka. Asia Pac. J. Clin. Nutr. 16:94–102.
  • Mann, C. J. (2003). Observational research methods. Research design II: Cohort, cross-sectional, and case-control studies. Emerg. Med. J. 20:54–60.
  • Maxwell, S. M., Apeagyei, F., De Vries, H. R., Mwanmut, D. D. and Hendrickse, R. G. (1989). Aflatoxins in breast milk, neonatal cord blood and sera of pregnant women. J. Toxicol. Toxin Rev. 8:19–29.
  • Mocchegiani, E., Corradi, A., Santarelli, L., Tibaldi, A., DeAngelis, E., Borghetti, P., Bonomi, A., Fabris, N. and Cabassi, E. (1998). Zinc, thymic endocrine activity and mitogen responsiveness (PHA) in piglets exposed to maternal aflatoxicosis B1 and G1. Vet. Immunol. Immunopathol. 62:245–260.
  • Mutegi, C. K., Wagacha, J. M., Christie, M. E., Kimani, J. and Karanja, L. (2013). Effect of storage conditions on quality and aflatoxin contamination of peanuts (Arachis hypogaea L.). Int. J. Agri. Science. 3:746–758.
  • Obuseh, F. A., Jolly, P. E., Kulczycki, A., Ehiri, J., Waterbor, J., Desmond, R. A., Preko, P. O., Jiang, Y. and Piyathilake, C. J. (2011). Aflatoxin levels, plasma vitamins A and E concentrations, and their association with HIV and hepatitis B virus infections in Ghanaians: A cross-sectional study. J. Int. AIDS Soc. 14:53.
  • Onyemelukwe, G. C., Ogoina, D., Ibiam, G. E. and Ogbadu, G. H. (2012). Aflatoxins in body fluids and food of Nigerian children with protein-energy malnutrition. AJFAND. 12:6553–6566.
  • Oyelami, O. A., Maxwell, S. M., Adelusola, K. A., Aladekoma, T. A. and Oyelese, A. O. (1997). Aflatoxins in the lungs of children with kwashiorkor and children with miscellaneous diseases in Nigeria. J. Toxicol. Environ. Health. 51:623–628.
  • Oyelami, O. A., Maxwell, S. M., Adelusola, K. A., Aladekoma, T. A. and Oyelese, A. O. (1998). Aflatoxins in autopsy kidney specimens from children in Nigeria. J. Toxicol. Environ. Health A. 55:317–323.
  • Pasricha, S. R., Hayes, E., Kalumba, K. and Biggs, B..A. (2013). Effect of daily iron supplementation on health in children aged 4–23 months: A systematic review and meta-analysis of randomized controlled trials. Lancet Glob. Health. 1:e77–e86.
  • Pimpukdee, K., Kubena, L. F., Bailey, C. A., Huebner, H. J., Afriyie-Gyawu, E. and Phillips, T. D. (2004). Aflatoxin-induced toxicity and depletion of hepatic vitamin A in young broiler chicks: Protection of chicks in the presence of low levels of NovaSil PLUS in the diet. Poult. Sci. 83:737–744.
  • Pitt, J. I., Taniwaki, M. H. and Cole, M. B. (2013). Mycotoxin production in major crops as influenced by growing, harvesting, storage, and processing with emphasis on the achievement of food safety objectives. Food Control. 32:205–215.
  • Prasad, A. S. (2013). Discovery of human zinc deficiency: Its impact on human health and disease. Adv. Nutr. 4:176–190.
  • Ramakrishnan, U., Aburto, N., McCabe, G. and Martorell, R. (2004). Multimicronutrient interventions but not vitamin A or iron interventions alone improve child growth: Results of 3 meta-analyses. J. Nutr. 134:2592–2602.
  • Ramakrishnan, U., Nguyen, P. and Martorell, R. (2009). Effects of micronutrients on growth of children under 5 y of age: Meta-analyses of single and multiple nutrient interventions. Am. J. Clin. Nutr. 89:191–203.
  • Ramjee, G., Berjak, P., Adhikari, M. and Dutton, M. F. (1992). Aflatoxins and kwashiorkor in Durban, South Africa. Ann. Trop. Paediatr. 12:241–247.
  • Rivera, J.A., Hotz, C., Gonzalez-Cossio, T., Neufeld, L. and Garcia-Guerra, A. (2003). The effect of micronutrient deficiencies on child growth: A review of results from community-based supplementation trials. J. Nutr. 133:4010S–4020S.
  • Routledge, M. N. and Gong, Y. Y. (2011). Developing biomarkers of human exposure to mycotoxins. In: Determining Mycotoxins and Mycotoxigenic Fungi in Food and Feed, pp. 225–244. De Saeger, S., Ed., Woodhead Publishing Limited, Cambridge, UK.
  • Routledge, M. N., Kimanya, M. E., Shirima, C. P., Wild, C. P. and Gong, Y. Y. (2014). Quantitative correlation of aflatoxin biomarker with dietary intake of aflatoxin in Tanzanian children. Biomarkers. 19:430–435.
  • Ruel, M..T., Alderman, H., and Maternal and Child Nutrition Study Group. (2013). Nutrition-sensitive interventions and programmes: how can they help to accelerate progress in improving maternal and child nutrition? Lancet 382:536–531.
  • Sachdev, H., Gera, T. and Nestel, P. (2005). Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutr. 8:117–132.
  • Sachdev, H., Gera, T. and Nestel, P. (2006). Effect of iron supplementation on physical growth in children: Systematic review of randomised controlled trials. Public Health Nutr. 9:904–920.
  • Shephard, G. S., Burger, H. M., Gambacorta, L., Gong, Y. Y., Krska, R., Rheeder, J. P., Solfrizzo, M., Srey, C., Sulyok, M., Visconti, A., et al. (2013). Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa. Food Chem. Toxicol. 62:217–225.
  • Shirima, C. P., Kimanya, M. E., Kinabo, J. L., Routledge, M. N., Srey, C., Wild, C. P. and Gong, Y. Y. (2013). Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers of exposure. Mol. Nutr. Food Res. 57:1874–1881.
  • Shrimpton, R., Victora, C. G., de Onis, M., Lima, R. C., Blossner, M. and Clugston, G. (2001). Worldwide timing of growth faltering: Implications for nutritional interventions. Pediatrics. 107:E75.
  • Shuaib, F. M., Jolly, P. E., Ehiri, J. E., Yatich, N., Jiang, Y., Funkhouser, E., Person, S. D., Wilson, C., Ellis, W. O., Wand, J. S., et al. (2010). Association between birth outcomes and aflatoxin B-1 biomarker blood levels in pregnant women in Kumasi, Ghana. Trop. Med. Int. Health 15:160–167.
  • Smith, L. E., Stoltzfus, R. J. and Prendergast, A. (2012). Food chain mycotoxin exposure, gut health, and impaired growth: A conceptual framework. Adv Nutr 3:526–531.
  • Srey, C., Kimanya, M. E., Routledge, M. N., Shirima, C. P. and Gong, Y. Y. (2014). Deoxynivalenol exposure assessment in young children in Tanzania. Mol. Nutr. Food Res. 58:1574–1580.
  • Stevens, G. A., Finucane, M. M., De-Regil, L. M., Paciorek, C. J., Flaxman, S. R., Branca, F., Pena-Rosas, J. P., Bhutta, Z. A., Ezzati, M. and Nutrition Impact Model Study Group (Anaemia). (2013). Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: A systematic analysis of population-representative data. Lancet Glob. Health. 1:e16–e25.
  • Szajewska, H., Ruszczynski, M. and Chmielewska, A. (2010). Effects of iron supplementation in nonanemic pregnant women, infants, and young children on the mental performance and psychomotor development of children: a systematic review of randomized controlled trials. Am. J. Clin. Nutr. 91:1684–1690.
  • Tang, L., Xu, L., Afriyie-Gyawu, E., Liu,W., Wang, P., Tang, Y., Wang, Y., Huebner, H. J., Ankrah, N. A., Ofori-Adjei, D., et al. (2009). Aflatoxin-albumin adducts and correlation with decreased serum levels of vitamins A and E in an adult Ghanaian population. Food Addit. Contam. A Chem. Anal. Control Expo. Risk Assess. 26:108–118.
  • Tchana, A. N., Moundipa, P. F. and Tchouanguep, F. M. (2010). Aflatoxin contamination in food and body fluids in relation to malnutrition and cancer status in Cameroon. Int. J. Environ. Res. Public Health. 7:178–188.
  • Thibeau, S. and D'Apolito, K. (2012). Review of the relationships between maternal charactersitics and preterm breastmilk immune components. Biol. Res. Nurs. 14:207–216.
  • Thompson, J., Biggs, B. and Pasricha, S..R. (2013). Effects of daily iron supplementation in 2- to 5-year-old children: Systematic review and meta-analysis. Pediatrics. 131:739–753.
  • Thorne-Lyman, A. L. and Fawzi, W. W. (2012). Vitamin A and carotenoids during pregnancy and maternal, neonatal, and infant health outcomes: A systematic review and meta-analysis. Paediatr. Perinat. Epidemiol. 26:36–54.
  • Tielsch, J. M., Rahmathullah, L., Katz, J., Thulasiraj, R. D., Coles, C., Sheeladevi, S. and Prakash, K. (2008). Maternal night blindness during pregnancy is associated with low birthweight, morbidity, and poor growth in south India. J. Nutr. 138:787–792.
  • Turner, P. C., Collinson, A. C., Cheung, Y. B., Gong, Y. Y., Hall, A. J., Prentice, A. M. and Wild, C. P. (2007). Aflatoxin exposure in utero causes growth faltering in Gambian infants. Int. J. Epidemiol. 36:1119–1125.
  • Turner, P. C., Moore, S. E., Hall, A. J., Prentice, A. M. and Wild, C. P. (2003). Modification of immune function through exposure to dietary aflatoxin in Gambian children. Environ. Health Perspect. 111:217–220.
  • UNICEF, UNU and WHO. (2001). Iron Deficiency Anaemia. Assessment, Prevention and Control. A Guide for Programme Managers. World Health Organization, Geneva, Switzerland.
  • UNICEF, WHO and World Bank. (2012). Levels and Trends in Child Malnutrition. Joint Child Malnutrition Estimates. United Nations International Children's Fund, Geneva, Switzerland.
  • Victora, C. G., de Onis, M., Hallal, P. C., Bloessner, M. and Shrimpton, R. (2010). Worldwide timing of growth faltering: Revisiting implications for interventions. Pediatrics. 125:e473–e480.
  • Wessells, K. R. and Brown, K. H. (2012). Estimating the global prevalence of zinc deficiency: Results based on zinc availability in national food supplies and the prevalence of stunting. PLoS One. 7:e50568.
  • Wild, C. P. and Gong, Y. Y. (2010). Mycotoxins and human disease: A largely ignored global health issue. Carcinogenesis. 31:71–82.
  • Wild, C. P., Hudson, G. J., Sabbioni, G., Chapot, B., Hall, A. J., Wogan, G. N., Whittle, H., Montesano, R. and Groopman, J. D. (1992). Dietary intake of aflatoxins and the level of albumin-bound aflatoxin in peripheral blood in the Gambia, West Africa. Cancer Epidemiol. Biomarkers Prev. 1:229–234.
  • Wild, C. P., Rasheed, F. N., Jawla, M. F., Hall, A. J., Jansen, L. A. and Montesano, R. (1991). In-utero exposure to aflatoxin in West Africa. Lancet. 337:1602.
  • Williams, J. H., Phillips, T. D., Jolly, P. E., Stiles, J. K., Jolly, C. M. and Aggarwal, D. (2004). Human aflatoxicosis in developing countries: A review of toxicology, exposure, potential health consequences, and interventions. Am. J. Clin. Nutr. 80:1106–1122.
  • World Health Organization (WHO). (2002). Nutrition for Health and Development: A Global Agenda for Combating Malnutrition. World Health Organization, Geneva, Switzerland.
  • World Health Organization. (2009). Global Prevalence of Vitamin A Deficiency in Populations at Risk 1995–2005: WHO Global Database on Vitamin A Deficiency. World Health Organization, Geneva, Switzerland.
  • World Health Organization Working Group. (1986). Use and interpretation of anthropometric indicators of nutritional status. Bull. WHO. 64:929–941.
  • Zimmermann, M. B. and Hurrell, R. F. (2007). Nutritional iron deficiency. Lancet. 370:511–520.

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